POLYMERIC EMULSION DELIVERY SYSTEMS
Provided herein are compositions comprising an oil-in-water emulsion, wherein the emulsion comprises a liquid oil component; a cross-linked homopolymer based on acrylic acid and/or a cross-linked copolymer of acrylic acid and acrylic acid esters; and water. In some embodiments, the composition is a vehicle for the delivery of an active agent.
1 . A topical composition comprising:
a liquid oil component;
a cross-linked homopolymer based on acrylic acid as a first emulsifier, and
water;
wherein the composition forms a stable oil-in-water emulsion.
2 . The topical composition of claim 1 , wherein the liquid oil component is present in an amount of about 30% or less by weight of the composition.
3 . The topical composition of claim 2 , wherein the liquid oil component is present in an amount of about 20% or less by weight of the composition.
4 . The topical composition of any of claims 1 to 3 , wherein the first emulsifer is present in an amount of about 0.01-5% by weight of the composition.
5 . The topical composition of claim 4 , wherein the first emulsifier is present in an amount of about 0.01-3% by weight of the composition.
6 . The topical composition of any of claims 1 to 5 , wherein the ratio of the amount of the liquid oil component to that of the first emulsifer is in the range of about 1:1 to about 28:1.
7 . The topical composition of claim 6 , wherein the ratio of the amount of the liquid oil component to that of the first emulsifer is in the range of about 1:1 to about 20:1.
8 . The topical composition of claim 6 or 7 , wherein the ratio of the amount of the liquid oil component to that of the first emulsifier is in the range of about 3:1 to about 10:1.
9 . The topical composition of any of claims 1 to 8 , wherein first emulsifer is a carbomer homopolymer type A and/or a carbomer homopolymer type C.
10 . The topical composition of any of claims 1 to 9 , wherein the liquid oil component comprises mineral oil, light mineral oil, a fatty alcohol, a monocarboxylic acid ester, a dicarboxylic acid ester, a medium chain triglyceride, a long chain triglyceride, or a combination thereof.
11 . The topical composition of any of claims 1 to 10 , wherein the composition further comprises a surfactant or a cross-linked copolymer of acrylic acid and acrylic acid esters as a second emulsifier.
12 . The topical composition of claim 11 , wherein the second emulsifier is a cross-linked copolymer of acrylic acid and acrylic acid esters, present in an amount of about 0.01-3% by weight of the composition.
13 . The topical composition of claim 11 or 12 , wherein the second emulsifer is a carbomer copolymer type B and/or a carbomer copolymer type A.
14 . The topical composition of claim 11 , wherein the composition further comprises a nonionic, anionic, or cationic surfactant in an amount up to about 0.5% by weight of the composition.
15 . The topical composition of claim 14 , wherein the nonionic surfactant is selected from the group consisting of sorbitan esters, polyoxyethytene derivatives of a sorbitan ester, glyceryl monostearate, polyoxyethylene monooleate, polyoxyethylene monostearate and polyoxyethylene monolaurate.
16 . The topical composition of claim 14 , wherein the anionic surfactant is selected from the group consisting of an alkali soap, an amine soap, and a detergent.
17 . The topical composition of claim 14 , wherein the cationic surfactant is selected from the group consisting of quaternium ammonium salts and quaternary amine salts.
18 . The topical composition of any of claims 1 to 10 , wherein the composition does not comprise a second emulsifier.
19 . The topical composition of any of claims 1 to 18 , wherein the oil-in-water emulsion is stable for at least 24 hours at 40° C.
20 . The topical composition of any of claims 1 to 19 , further comprising an active agent.
21 . The topical composition of claim 20 , comprising two or more active agents.
22 . A topical composition, wherein the composition comprises an oil-in-water emulsion, wherein the emulsion comprises:
a liquid oil component, wherein the liquid oil component is in an amount of about 30% or less by weight of the composition;
a polymer selected from the group consisting of a cross-linked homopolymer based on acrylic acid in an amount of about 0.01-5% by weight of the composition, a cross-linked copolymer of acrylic acid and acrylic acid esters in an amount of about 0.01-5% by weight of the composition, and combinations thereof; and
water.
23 . The topical composition of claim 22 , wherein the liquid oil component is present in an amount of about 20% or less by weight of the composition.
24 . The topical composition of claim 22 or 23 , wherein the composition comprises a cross-linked homopolymer based on acrylic acid in an amount of about 0.01-3% by weight of the composition.
25 . The topical composition of claim 22 or 23 , wherein the composition comprises a cross-linked copolymer of acrylic acid and acrylic acid esters in an amount of about 0.01-3% by weight of the composition.
26 . The topical composition of any of claims 22 to 25 , wherein the ratio of the amount of the liquid oil component to that of the polymer is in the range of about 1:1 to about 28:1.
27 . The topical composition of claim 26 , wherein the ratio of the amount of the liquid oil component to that of the polymer is in the range of about 1:1 to about 20:1.
28 . The topical composition of claim 26 or 27 , wherein the ratio of the amount of the liquid oil component to that of the polymer is in the range of about 3:1 to about 10:1.
29 . The topical composition of any of claims 22 to 28 , wherein the liquid oil component comprises mineral oil, light mineral oil, a fatty alcohol, a monocarboxylic acid ester, a dicarboxylic acid ester, a medium chain triglyceride, a long chain triglyceride, or a combination thereof.
30 . The topical composition of any of claims 22 , 23 , or 26 to 29 , wherein the polymer is a cross-linked homopolymer based on acrylic acid.
31 . The topical composition of claim 30 , wherein the cross-linked homopolymer based on acrylic acid is a carbomer homopolymer type A, a carbomer homopolymer type B, or a carbomer homopolymer type C.
32 . The topical composition of claim 31 , wherein the carbomer homopolymer is a carbomer homopolymer type A.
33 . The topical composition of any of claims 22 , 23 , or 26 to 29 , wherein the polymer is a cross-linked copolymer of acrylic acid and acrylic acid esters.
34 . The topical composition of claim 33 , wherein the cross-linked copolymer of acrylic acid and acrylic acid esters is a carbomer copolymer type B and/or a carbomer copolymer type A.
35 . The topical composition of any of claims 22 , 23 , or 26 to 29 , wherein the polymer is a combination of a cross-linked homopolymer based on acrylic acid and a cross-linked copolymer of acrylic acid and acrylic acid esters.
36 . The topical composition of claim 35 , wherein the polymer is a combination of a carbomer homopolymer type A and a carbomer copolymer type B.
37 . The topical composition of claim 35 , wherein the ratio of the amount of the cross-linked homopolymer based on acrylic acid to that of the cross-linked copolymer of acrylic acid and acrylic acid esters is in the range of 0.1:1 to about 100:1.
38 . The topical composition of claim 37 , wherein the ratio of the amount of the cross-linked homopolymer based on acrylic acid to that of the cross-linked copolymer of acrylic acid and acrylic acid esters is in the range of 1.6:1 to about 100:1.
39 . The topical composition of any of claims 22 to 37 , further comprising an active agent.
40 . The topical composition of claim 39 , comprising two or more active agents.