Collagen peptide-based medicament compositions and devices and methods of production and use thereof
The present invention is in the fields of medicinal chemistry, biotechnology and pharmaceuticals. The invention provides compositions comprising one or more collagen mimetic peptides, optionally attached to one or more therapeutic compounds or one or more imaging compounds, for use in methods of treating, preventing, ameliorating, curing and diagnosing certain diseases and physical disorders in humans and veterinary animals, as well as methods of manufacturing such composition. The invention also provides medical devices comprising one or more such compositions of the invention. The invention also provides methods of use of such compositions and devices in treating and diagnosing certain diseases and physical disorders in humans and veterinary animals, including ocular diseases or disorders, skin diseases or disorders, certain cancers, particularly intraluminal cancers, gastrointestinal diseases or disorders, genitourinary tract diseases or disorders, fibrotic diseases/disorders and rheumatic diseases/disorders.
1. A method of treating an ocular disease, disorder or wound selected from the group consisting of cataracts, vitreous adhesions or floaters, macular degeneration, non-infectious corneal ulceration, non-infectious corneal melting, infectious corneal ulceration, infectious corneal melting, Stevens-Johnson Syndrome, scleritis, episcleritis, ectasia, keratoconus, and post-operative afflictions of the eye resulting from eye surgery, in a human or veterinary animal suffering from said ocular disease, disorder or wound, comprising administering a composition comprising (a) at least one collagen mimetic peptide (CMP) comprising the amino acid sequence of SEQ ID NO: 1, and (b) one or more pharmaceutically suitable carriers to an eye of said human or veterinary animal in a dosage sufficient to treat said ocular disease, disorder or wound, monitoring the condition of the eye in said human or veterinary animal over time, and readministering said composition to the eye until said ocular disease, disorder or wound is treated or ameliorated.
2. The method of claim 1 , wherein said ocular disease, disorder or wound is selected from the group consisting of scleritis, episcleritis, keratoconus, cataracts and post-operative afflictions of the eye resulting from eye surgery.
3. The method of claim 2 , wherein said ocular disease, disorder or wound is keratoconus.
4. The method of claim 2 , wherein said ocular disease, disorder or wound is scleritis.
5. The method of claim 2 , wherein said ocular disease, disorder or wound is episcleritis.
6. The method of claim 2 , wherein said ocular disease, disorder or wound is post-operative afflictions of the eye resulting from eye surgery.
7. The method of claim 1 , wherein said composition is administered to the eye conjunctivally or subconjunctivally.
8. The method of claim 7 , wherein said subconjunctival administration is achieved by administering said composition into the subconjunctival fornix.
9. The method of claim 1 , wherein said composition is administered to the eye in the form of one or more drops of solution or a suspension that contains the composition.
10. The method of claim 1 , wherein said composition is administered to the eye via injection.
11. The method of claim 1 , wherein said composition is administered to the eye in the form of a coating on a solid material that is implanted into an eye structure.
12. The method of claim 1 , wherein said composition is administered to the eye in the form of a wafer, film, gel, mesh or patch.
13. The method of claim 1 , wherein said composition is attached to one or more spheres or nanoparticles that are delivered to or into an eye structure.
14. The method of claim 1 , wherein said collagen mimetic peptide is attached to at least one therapeutic compound (TC) to form a CMP-TC conjugate.
15. The method of claim 14 , wherein said at least one therapeutic compound comprises at least one reactive hydroxyl group capable of being cross-linked to said collagen mimetic peptide.
16. The method of claim 15 , wherein said at least one therapeutic compound is directly attached to said collagen mimetic peptide via an amino group on said collagen mimetic peptide linked to a hydroxyl group on said therapeutic compound.
17. The method of claim 14 , wherein said at least one therapeutic compound is selected from the group consisting of a steroidal anti-inflammatory drug, a nonsteroidal anti-inflammatory drug, a topical anesthetic, a vitamin or a derivative or precursor thereof, therapeutic enzyme or a therapeutic fragment thereof, an antibiotic, a therapeutic monoclonal antibody or a therapeutic fragment thereof, a therapeutic fusion protein, a prostaglandin analogue, a growth factor, a neuropeptide, an α-adrenergic antagonist, a β-adrenergic antagonist, a cell surface receptor antagonist, a carbonic anhydrase inhibitor, and pharmaceutically acceptable salts, esters and derivatives thereof.
18. The method of claim 17 , wherein said prostaglandin analogue is selected from the group consisting of latanoprost, travoprost, tafluprost, unoprostone, tatanoprostene bunod and bimatoprost, and pharmaceutically acceptable salts, esters and derivatives thereof.
19. The method of claim 18 , wherein said prostaglandin analogue is latanoprost.
20. The method of claim 14 , wherein said collagen mimetic peptide is covalently attached directly to said at least one therapeutic compound.
21. The method of claim 14 , wherein said collagen mimetic peptide is indirectly attached to said at least one therapeutic compound via use of an attachment means.
22. The method of claim 21 , wherein said attachment means comprises at least one polymeric chain having a first end and a second end.
23. The method of claim 22 , wherein said polymeric chain is a linear polyethyleneglycol chain comprising at least four ethyleneglycol monomers.
24. The method of claim 23 , wherein said polymeric chain comprises from twenty to twenty-five ethyleneglycol monomers.
25. The method of claim 14 , wherein said collagen mimetic peptide comprises at least one biotin moiety and said therapeutic molecule comprises at least one avidin or streptavidin moiety, and wherein said biotin moiety on said collagen mimetic peptide binds to said avidin or streptavidin moiety on said therapeutic compound, thereby attaching said collagen mimetic peptide to said therapeutic compound.
26. The method of claim 14 , wherein said collagen mimetic peptide comprises at least one avidin or streptavidin moiety and said therapeutic molecule comprises at least one biotin moiety, and wherein said avidin or streptavidin moiety on said collagen mimetic peptide binds to said biotin moiety on said therapeutic compound, thereby attaching said collagen mimetic peptide to said therapeutic compound.