IP Library Granted Patent US 12,638,458
Granted Patent B2
US 12,638,458 · App. 17/762,760 · Granted May 26, 2026

SERS method for analyzing a viscous biofluid

Inventors: François Rannou (Paris, FR); Amanda Robinson (Le Kremlin-Bicêtre, FR); Didier Borderie (Paris, FR); François Etienne (Rouen, FR); Cyril Gobinet (Athies-sous-Laon, FR); Christelle Nguyen (Paris, FR); Claire Mangeney (Villejuif, FR); Olivier Piot (Cormontreuil, FR)
Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE; UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE; UNIVERSITE PARIS CITE
G01N33/6887G01N21/658G01N33/54346G01N33/54373G01N2800/10
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Quick Facts
Patent No.
US 12,638,458
App. No.
17/762,760
Granted
May 26, 2026
Kind
B2
Abstract

The invention relates to a SERS method for analyzing a biological sample, the method comprising the following step of: a. obtaining a biological sample which is viscous biofluid, b. depositing at least one droplet of the biological sample onto a microscope slide, and drying the droplet, c. depositing a drop of an aqueous dispersion of metallic nanoparticles above the droplet dried in step b), to have a dense distribution of nanoparticles on the surface of the dried droplet and to obtain a SERS-activated biological sample, d. drying the SERS-activated biological sample, e. irradiating the SERS-activated biological sample using a light source to obtain a SERS spectrum, and f. collecting the SERS spectrum.

Claims (33)

1 . A SERS method for analyzing a biological sample which is a viscous biofluid, the method comprising the step of:

a. depositing at least one droplet of the biological sample onto a microscope slide, and drying the droplet,

b. depositing a drop of an aqueous dispersion of metallic nanoparticles above the droplet dried in step a), to have a dense distribution of nanoparticles on a surface of the dried droplet and to obtain a SERS-activated biological sample,

c. drying the SERS-activated biological sample,

d. irradiating the SERS-activated biological sample using a light source to obtain a SERS spectrum, and

e. collecting the SERS spectrum.

2 . The method according to claim 1 , wherein the biological sample which is a viscous biofluid has a viscosity between 0.6 to 14 poise.

3 . The method according to claim 1 , wherein the dense distribution of nanoparticles is 3×10 16 nanoparticles/m 2 .

4 . The method according to claim 1 , wherein the biological sample which is a viscous biofluid is a synovial fluid previously obtained from a patient.

5 . The method according to claim 1 , wherein the metallic nanoparticles are colloidal metallic nanoparticles.

6 . The method according to claim 5 , wherein the colloidal metallic nanoparticles comprise silver.

7 . The method according to claim 1 , wherein in the step a) of drying the droplet of the biological sample is realized at least two hours before depositing the nanoparticles onto the top of the dried biological sample.

8 . An in vitro method for diagnosing or identifying, from a biological sample which is a viscous biofluid, a joint disease, wherein the method comprises the steps of:

a. depositing at least one droplet of said biological sample onto a microscope slide, and drying the droplet,

b. depositing a drop of an aqueous dispersion of metallic nanoparticles above the droplet dried in step a), to have a dense distribution of nanoparticles on a surface of the dried droplet and to obtain a SERS-activated biological sample,

c. drying the SERS-activated biological sample,

d. irradiating the SERS-activated biological sample using a light source to obtain a SERS spectrum, and

e. collecting and analyzing the SERS spectrum.

9 . The method according to claim 8 , wherein analyzing the SERS spectrum comprises the following sequential steps:

i. a pre-processing step for correcting spectral interferences of said SERS spectrum to normalize them,

ii. a step of selecting features and/or reducing data to identify discriminant wavenumbers, and

iii. a step of construction of a supervised classification model using machine learning for automatic prediction of new samples.

10 . A method utilizing a kit having a SERS substrate, a Raman device, and a computing device configured to determine or identify a joint disease in a biological sample based on a spectral content information, the method including analyzing a biological sample, which is a viscous biofluid, the analyzing, comprising the steps of:

a. depositing at least one droplet of the biological sample onto a microscope slide, and drying the droplet,

b. depositing a drop of an aqueous dispersion of metallic nanoparticles above the droplet dried in step a), to have a dense distribution of nanoparticles on a surface of the dried droplet and to obtain a SERS-activated biological sample,

c. drying the SERS-activated biological sample,

d. irradiating the SERS-activated biological sample using a light source to obtain a SERS spectrum, and

e. collecting the SERS spectrum.

11 . The method of claim 10 , wherein the computing device is further configured to execute the following sequential steps:

i. a pre-processing step for correcting spectral interferences of a SERS spectrum and normalize them,

ii. a step of selecting features and/or reducing data to identify discriminant wavenumbers, and

iii. a step of construction of a supervised classification model using machine learning approaches for automatic prediction of new samples.

12 . The method of claim 10 , further comprising a step of using the kit to diagnose or identify a joint disease in a subject.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE PROPERTY NUMBER 16930208 PREVIOUSLY RECORDED AT REEL: 060390 FRAME: 0122. ASSIGNOR(S) HEREBY CONFIRMS THE CHANGE OF NAME. Recorded Jan 11, 2023
From: UNIVERSITE DE PARIS
To: UNIVERSITÉ PARIS CITÉ
Reel/Frame 062387/0489 →
CHANGE OF NAME Recorded Jun 20, 2022
From: UNIVERSITE DE PARIS
To: UNIVERSITÉ PARIS CITÉ
Reel/Frame 060390/0122 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2022
From: RANNOU, FRANCOIS; ROBINSON, AMANDA; BORDERIE, DIDIER; ETIENNE, FRANCOIS; GOBINET, CYRIL; NGUYEN, CHRISTELLE; MANGENEY, CLAIRE; PIOT, OLIVIER
To: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE; UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE; UNIVERSITE PARIS CITE
Reel/Frame 059480/0350 →
Priority Claims (1)
EP 19306176 · Sep 23, 2019 · regional
Continuity (1)
Related Publication 20220349902A1 · Nov 3, 2022
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