Surface modified polyethersulfone membranes and method of making thereof
The present disclosure is related to a polymeric membrane, comprising a modified surface obtained from coating with hydrophilic monomers and curing the hydrophilic monomers with electron beam, wherein the hydrophilic monomers comprise at least one amino moiety, at least one polyoxyalkylene unit, and at least one (meth)acrylate moiety.
1. A polymeric membrane, comprising a modified surface obtained from coating with hydrophilic monomers and curing the hydrophilic monomers with electron beam,
wherein the hydrophilic monomers comprise:
(i) at least one amino moiety;
(ii) at least one polyoxyalkylene unit; and
(iii) at least one (meth)acrylate moiety;
wherein said polymeric membrane is a porous polymer membrane; and
wherein the hydrophilic monomers are according to any one of formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI), (XII), (XIII), or (XIV):
wherein R is a linear or branched alkyl or alkoxy,
wherein m and n may be different or the same,
wherein m and n may each be in a range of from 1 to 100,
wherein x, y, z may be different or the same,
wherein x, y, z may be each in a range of from 1 to 100.
2. The polymeric membrane according to claim 1 , wherein the polymeric membrane is selected from polymeric sulfone membranes, polyethylene membranes, polypropylene membranes, polyvinylidene difluoride membranes and polyacrylonitrile membranes.
3. The polymeric membrane according to claim 1 , wherein the at least one polyoxyalkylene unit of the hydrophilic monomers is selected from polyethers.
4. The polymeric membrane according to claim 1 , wherein the at least one amino moiety of the hydrophilic monomers is at least one secondary amino moiety and/or at least one tertiary amino moiety.
5. The polymeric membrane according to claim 1 , wherein the hydrophilic monomers comprise acrylate moieties in an amount of from 1 to 10, preferably from 1 to 8, more preferably from 1 to 6.
6. The polymeric membrane according to claim 1 , wherein, when an amount of immunoglobulin G (IgG) is adsorbed to said modified surface of said polymeric membrane, the amount of the IgG adsorbed to said modified surface of the polymeric membrane is lower than 16 μg/cm 2 , preferably lower than 15 μg/cm 2 , and more preferably lower than 14 μg/cm 2 .