Cardiac contractility modulation for atrial arrhythmia patients
A cardiac treatment device, including: stimulation circuitry configured to generate a non-excitatory electrical signal which, when applied to ventricular tissue during a ventricular refractory period thereof improves a condition of heart failure in human patients; atrial arrhythmia detection circuitry; and decision circuitry which controls the stimulation circuitry to delivery said signal, also when said atrial arrhythmia detection circuitry detects an atrial arrhythmia.
1 . A cardiac treatment device, comprising:
a stimulation circuitry configured to:
generate a non-excitatory electrical signal, wherein when said signal is configured to be applied to a ventricular tissue during a ventricular refractory period it improves a condition of heart failure in human patients;
an atrial arrhythmia detection circuitry; and
a decision circuitry which controls the stimulation circuitry to deliver said signal during said ventricular refractory period, both when said atrial arrhythmia detection circuitry detects an atrial arrhythmia and when said atrial arrhythmia detection circuitry does not detect said atrial arrhythmia.
2 . A device according to claim 1 , wherein said decision circuitry controls modification of at least one parameter of said signal delivered by said stimulation circuitry in response to a detection of said atrial arrhythmia.
3 . A device according to claim 2 , wherein said modification comprises increasing a spatial range of tissue stimulated by said signal.
4 . A device according to claim 3 , wherein tissue configured to be stimulated by said signal comprises one or more of ventricular septum, right atrium, left atrium, AV node or pulmonary vein's junction with left atria.
5 . A device according to claim 1 , wherein said decision circuitry is configured to avoid said delivery if a ventricular arrhythmia is detected.
6 . A device according to claim 1 , wherein said decision circuitry is configured to allow said delivery if a supra-ventricular arrhythmia is detected.
7 . A device according to claim 1 , wherein said device includes a memory with an indication of a dosage of said signal to be applied and a time duration of application and wherein said decision circuitry is configured to modify an actual duration of signal application according to an actual delivery of signals.
8 . A device according to claim 1 , wherein said device is configured to apply said signal also during a non-refractory time in an atria of said patient.
9 . A device according to claim 1 , wherein said device has no atrial leads.
10 . A device according to claim 1 , wherein said device includes pacing circuitry and wherein said decision circuitry is programmable to selectively prefer applying a non-excitatory signal over applying an increase in pacing in cases of increased cardiac demand.
11 . A device according to claim 1 , wherein said atrial arrhythmia detection circuitry detects atrial arrhythmia from signals measured by one or more ventricular leads.
12 . A device according to claim 1 , wherein said device has no ventricular stimulation leads.
13 . The cardiac treatment device of claim 1 , wherein said non-excitatory electrical signal is configured to be delivered using different parameters when said atrial arrhythmia detection circuitry detects said atrial arrhythmia as compared to when said atrial arrhythmia detection circuitry does not detect said atrial arrhythmia.
14 . A cardiac treatment device, comprising:
a stimulation circuitry configured to:
generate a non-excitatory electrical signal, wherein when said signal is configured to be applied to a ventricular tissue during a ventricular refractory period it improves a condition of heart failure in human patients;
an atrial arrhythmia detection circuitry; and
a decision circuitry which controls the stimulation circuitry to deliver said signal during said ventricular refractory period regardless of detection of presence or absence of said atrial arrhythmia by said atrial arrhythmia detection circuitry.
15 . A cardiac treatment device, comprising:
a stimulation circuitry configured to:
generate a non-excitatory electrical signal, wherein when said signal is configured to be applied to a ventricular tissue during a ventricular refractory period it improves a condition of heart failure in human patients;
an atrial arrhythmia detection circuitry;
a memory with a treatment protocol to deliver said non-excitatory electrical signal according to a schedule, and
a decision circuitry which controls the stimulation circuitry to deliver said treatment during said ventricular refractory period, both when said atrial arrhythmia detection circuitry detects an atrial arrhythmia and when said atrial arrythmia detection circuitry does not detect said atrial arrhythmia.
16 . A method of planning treatment for a patient, comprising:
(a) identifying that a patient has an atrial arrhythmia or a risk to develop thereof; and
(b) planning and implementing a treatment schedule for the patient with an implanted device that generates a non-excitatory electrical signal which, when applied to ventricular tissue during a ventricular refractory period thereof improves a condition of heart failure in human patients, wherein said non-excitatory electrical signal is applied both during an atrial arrhythmia event and in the absence of said atrial arrhythmia event.
17 . A method according to claim 16 , wherein said non-excitatory electrical signal is applied during said atrial arrhythmia event with different parameters than when applied in the absence of said atrial arrhythmia event.
18 . A method according to claim 16 , comprising selecting said patient and performing said planning with a goal of improving a symptom of said atrial arrhythmia by said treating.
19 . A method according to claim 16 , wherein said improving comprises preventing abnormal ventricular activation by said atrial arrhythmia.
20 . A method according to claim 16 , wherein said improving comprising reducing said atrial arrhythmia.
21 . A method according to claim 16 , wherein said planning comprises planning to apply said non-excitatory signal within 20 mm from a ventricular septum.
22 . A method according to claim 16 , wherein said planning comprises planning to apply said non-excitatory signal within an atrium of the heart.
23 . A method according to claim 16 , wherein said planning comprises selecting a power level and an application location to stimulate cardiac tissue in both an atria and a ventricle.
24 . A method according to claim 16 , wherein said identifying comprises selecting for treatment patients with episodic AF or patients with chronic AF.
25 . A method according to claim 24 , wherein said identifying comprises selecting for treatment patients at risk of developing an AA, above 20% in the next year.
26 . A method according to claim 24 , wherein said identifying comprises selecting for treatment patients where at least 50% of beats are treatable using said device when considering safety of the patient.
27 . A method according to claim 16 , wherein said planning comprises planning with a goal to reduce AF episodes in said patient.
28 . A method according to claim 16 , wherein said planning comprises programming the device to apply said signal during a portion of the ventricular refractory period late enough so that said refractory period is extended.
29 . A method according to claim 16 , wherein said planning comprises setting up device parameters to apply said signal to above 20,000 treated beats per day, on the average for a month.
30 . The method of claim 16 , wherein said non-excitatory electrical signal is delivered using different parameters when applied during the atrial arrhythmia event as compared to when applied in the absence of said atrial arrhythmia event.
31 . A method of planning treatment for a patient, comprising:
(a) identifying that a patient has an atrial arrhythmia or a risk to develop thereof; and
(b) planning and implementing a treatment schedule for the patient with an implanted device that generates a non-excitatory electrical signal which, when applied to ventricular tissue during a ventricular refractory period thereof improves a condition of heart failure in human patients, wherein said non-excitatory electrical signal is applied regardless of detection of presence or absence of an event of said atrial arrhythmia.
32 . A method of planning treatment for a patient, comprising:
(a) identifying that a patient has an atrial arrhythmia or a risk to develop thereof; and
(b) planning and implementing a treatment schedule for the patient with an implanted device that generates a non-excitatory electrical signal which, when applied to ventricular tissue during a ventricular refractory period thereof improves a condition of heart failure in human patients, wherein said treatment schedule is a prophylactic treatment according to a schedule, wherein said non-excitatory electrical signal is applied according to said prophylactic treatment schedule, wherein the non-excitatory electrical signal is applied both during an atrial arrhythmia event and in the absence of said atrial arrhythmia event.