Granted Patent B2

US 12,498,325 · App. 17/770,339 · Granted Dec 16, 2025

Inventors: Sharon Pecker (Rehovot, IL); Yochay Shlomo Eshel (Sde Warburg, IL); Amir Zait (Binyamina, IL); Dan Gluck (Kadima, IL); Noam Yorav-Raphael (Tekoa, IL); Arnon Houri Yafin (Jerusalem, IL); Sarah Levy (Jaffa, IL); Joseph Joel Pollak (Neve Daniel, IL); Daniel Levner (Brookline, MA); Yonatan Halperin (Tel-Aviv, IL); Natalie Lezmy (Hod Hasharon, IL); Itamar Weiss (Tel Aviv, IL)

Assignee: S.D. Sight Diagnostics Ltd.

G01N21/6458G01N15/1434G01N33/49G01N33/491G01N33/492G06T7/0012G06V10/143G06V20/69G06V20/698G01N2015/016G01N2015/018G01N2015/1486G06T2207/10064G06T2207/30104

Abstract

Claims (17)

1 . A method comprising:

preparing a blood sample for analysis by:

depositing the blood sample within a sample chamber; and

placing the sample chamber, with the blood sample deposited therein, within a microscopy unit;

acquiring one or more microscopic images of the sample chamber with the blood sample deposited therein, using a microscope of the microscopy unit;

determining whether more than a threshold amount of red blood cells within the sample chamber had already settled within a monolayer within the sample chamber, prior to acquisition of the one or more microscopic images, by analyzing the red blood cells within the one or more microscopic images; and

calibrating measurements that are performed upon the blood sample at least partially in response to determining that more than the threshold amount of red blood cells within the sample chamber had already settled within the monolayer within the sample chamber, prior to acquisition of the one or more microscopic images.

2 . The method according to claim 1 , wherein preparing the blood sample for analysis further comprises staining the blood sample with one or more stains.

3 . The method according to claim 1 , further comprising determining an indication of how long the blood sample has been in the sample chamber prior to acquisition of the one or more microscopic images, based upon the amount of the red blood cells that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images.

4 . The method according to claim 1 , wherein preparing the blood sample for analysis further comprises staining the blood sample with one or more stains, wherein calibrating the measurements comprises calibrating the measurements to account for an amount of staining that entities within the blood sample underwent as indicated by more than the threshold amount of red blood cells within the sample chamber having already settled within the sample chamber, prior to acquisition of the one or more microscopic images.

5 . Apparatus for use with a blood sample that has been deposited within a sample chamber, the apparatus comprising:

a microscopy unit comprising a microscope that is configured to acquire one or more microscopic images of the sample chamber with the blood sample deposited therein; and

at least one computer processor configured to:

determine whether more than a threshold amount of red blood cells within the sample chamber had already settled within a monolayer within the sample chamber, prior to acquisition of the one or more microscopic images, by analyzing the red blood cells within the one or more microscopic images; and

calibrate measurements that are performed upon the blood sample at least partially in response to determining that more than the threshold amount of red blood cells within the sample chamber had already settled within the monolayer within the sample chamber, prior to acquisition of the one or more microscopic images.

6 . The apparatus according to claim 5 , wherein the computer processor is configured to determine an indication of how long the blood sample has been in the sample chamber prior to acquisition of the one or more microscopic images, based upon the amount of the red blood cells that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images.

7 . The apparatus according to claim 5 , wherein the blood sample is stained with one or more stains, and wherein the computer processor is configured to calibrate the measurements to account for an amount of staining that entities within the blood sample underwent as indicated by more than a threshold amount of red blood cells within the sample chamber having already settled within the sample chamber, prior to acquisition of the one or more microscopic images.

Assignments (3)

Continuity (2)

References Cited (400)