IP Library › Patent Application 17779706

Patent Application Utility PCT National Stage

App. No. 17/779,706 · Confirmation No. 4350

SYNTHESIS OF 3 -RNA OLIGONUCLEOTIDES

Inventors: Jayaprakash K. NAIR, Juan C. SALINAS, John Frederick BRIONES, Mark K. SCHLEGEL, Shigeo MATSUDA, Alexander V. KEL'IN, Ligang ZHANG, Martin A. MAIER

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Final Rejection Mailed View Publication ↗

	Code	Description	Pages	PDF
2026-08-13	`CTFR`	Final Rejection	22	View
2026-08-13	`SRFW`	Search information including classification, databases and other search related notes	2	View
2026-08-13	`1449`	List of References cited by applicant and considered by examiner	2	View
2026-08-13	`1449`	List of References cited by applicant and considered by examiner	2	View
2026-08-13	`SRNT`	Examiner's search strategy and results	7	View
2026-08-06	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2026-08-06	`TRAN.LET`	Transmittal Letter	1	View
2026-08-06	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2026-05-28	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2026-05-28	`TRAN.LET`	Transmittal Letter	1	View
2026-05-28	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2026-05-28	`REM`	Applicant Arguments/Remarks Made in an Amendment	11	View
2026-05-28	`XT/`	Extension of Time	2	View
2026-05-28	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2026-05-28	`N417.PYMT`	Electronic Fee Payment	2	View
2026-03-31	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2026-03-31	`TRAN.LET`	Transmittal Letter	1	View
2026-03-31	`FOR`	Foreign Reference	44	View
2026-03-31	`FOR`	Foreign Reference	49	View
2026-03-31	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2026-02-02	`CTNF`	Non-Final Rejection	18	View
2026-02-02	`SRFW`	Search information including classification, databases and other search related notes	2	View
2026-02-02	`SRNT`	Examiner's search strategy and results	8	View
2026-02-02	`SRNT`	Examiner's search strategy and results	7	View
2026-02-02	`SRNT`	Examiner's search strategy and results	1	View
2026-02-02	`BIB`	Bibliographic Data Sheet	1	View
2026-02-02	`SRNT`	Examiner's search strategy and results	80	View
2025-12-22	`A.NE`	Response After Final Action	—	View
2025-12-22	`TRAN.LET`	Transmittal Letter	1	View
2025-12-22	`RCEX`	Request for Continued Examination (RCE)	3	View
2025-12-22	`AMSB`	Amendment Submitted/Entered with Filing of Continued Prosecution Application (CPA)/Request for Continued Examination(RCE)	1	View
2025-12-22	`CLM`	Claims	3	View
2025-12-22	`REM`	Applicant Arguments/Remarks Made in an Amendment	10	View
2025-12-22	`N417.PYMT`	Electronic Fee Payment	2	View
2025-12-22	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2025-12-22	`WFEE`	Fee Worksheet (SB06)	1	View
2025-10-23	`NTC.PUB`	Notice of Publication	1	View
2025-09-24	`CTFR`	Final Rejection	19	View
2025-09-24	`SRFW`	Search information including classification, databases and other search related notes	2	View
2025-09-24	`SRNT`	Examiner's search strategy and results	13	View
2025-09-24	`SRNT`	Examiner's search strategy and results	79	View
2025-09-24	`SRNT`	Examiner's search strategy and results	4	View
2025-07-17	`M327`	Miscellaneous Communication to Applicant - No Action Count	1	View
2025-07-01	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2025-07-01	`SPEC`	Specification	40	View
2025-07-01	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2025-07-01	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2025-07-01	`SPEC`	Specification	1	View
2025-07-01	`DRW`	Drawings-only black and white line drawings	1	View
2025-07-01	`ABST`	Abstract	1	View
2025-07-01	`CLM`	Claims	4	View
2025-07-01	`REM`	Applicant Arguments/Remarks Made in an Amendment	43	View
2025-07-01	`SPEC`	Specification	30	View
2025-07-01	`TRAN.LET`	Transmittal Letter	1	View
2025-07-01	`ABST`	Abstract	1	View
2025-07-01	`DRW`	Drawings-only black and white line drawings	6	View
2025-07-01	`DRW.SUPP`	Drawings-black and white line and/or other drawings	—	View
2025-07-01	`DRW.SUPP`	Drawings-black and white line and/or other drawings	—	View
2025-07-01	`SCORE`	Placeholder sheet indicating presence of supplemental content in Supplemental Complex Repository for Examiners(SCORE)	1	View
2025-07-01	`WFEE`	Fee Worksheet (SB06)	1	View
2025-04-03	`CTNF`	Non-Final Rejection	17	View
2025-04-03	`892`	List of references cited by examiner	1	View
2025-04-03	`SRFW`	Search information including classification, databases and other search related notes	2	View
2025-04-03	`SRNT`	Examiner's search strategy and results	2	View
2025-04-03	`1449`	List of References cited by applicant and considered by examiner	2	View
2025-04-03	`SRNT`	Examiner's search strategy and results	3	View
2025-04-03	`1449`	List of References cited by applicant and considered by examiner	2	View
2025-04-03	`SRNT`	Examiner's search strategy and results	155	View
2025-04-03	`SRNT`	Examiner's search strategy and results	1	View
2025-04-03	`1449`	List of References cited by applicant and considered by examiner	2	View
2025-04-03	`BIB`	Bibliographic Data Sheet	1	View
2025-04-03	`1449`	List of References cited by applicant and considered by examiner	2	View
2025-04-03	`1449`	List of References cited by applicant and considered by examiner	2	View
2024-10-17	`TRAN.LET`	Transmittal Letter	1	View
2024-10-17	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2024-10-17	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2024-10-17	`FOR`	Foreign Reference	208	View
2024-06-05	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2024-06-05	`TRAN.LET`	Transmittal Letter	1	View
2024-06-05	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2024-04-30	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2024-04-30	`TRAN.LET`	Transmittal Letter	1	View
2024-04-30	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2024-03-07	`N570`	Communication - Re: Power of Attorney (PTOL-308)	1	View
2024-02-29	`OATH`	Oath or Declaration filed	8	View
2024-02-29	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2024-02-29	`PA..`	Power of Attorney	1	View
2024-02-29	`TRAN.LET`	Transmittal Letter	1	View
2023-08-08	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2023-08-08	`FOR`	Foreign Reference	39	View
2023-08-08	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-08-08	`TRAN.LET`	Transmittal Letter	1	View
2023-01-26	`NTC.PUB`	Notice of Publication	1	View
2023-01-25	`APP.FILE.REC`	Filing Receipt	4	View
2023-01-20	`WCLM`	Claims Worksheet (PTO-2022)	1	View
2023-01-20	`APP.FILE.REC`	Filing Receipt	4	View
2023-01-20	`WFEE`	Fee Worksheet (SB06)	1	View
2023-01-20	`M903`	Notice of Designated Office (DO) / Elected Office (EO) Acceptance Mailed	2	View
2022-11-30	`PEFR`	Applicant Response to Pre-Exam Formalities Notice	1	View
2022-11-30	`CLM`	Claims	3	View
2022-11-30	`REM`	Applicant Arguments/Remarks Made in an Amendment	1	View
2022-11-30	`LET.`	Miscellaneous Incoming Letter	2	View
2022-11-30	`CFILE`	Request for Corrected Filing Receipt	1	View
2022-11-30	`CFILE`	Request for Corrected Filing Receipt	4	View
2022-11-30	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2022-11-30	`TRAN.LET`	Transmittal Letter	1	View
2022-10-13	`APP.FILE.REC`	Filing Receipt	4	View
2022-10-11	`CFILE`	Request for Corrected Filing Receipt	1	View
2022-10-11	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2022-10-11	`TRAN.LET`	Transmittal Letter	1	View
2022-10-11	`LET.`	Miscellaneous Incoming Letter	4	View
2022-10-05	`WCLM`	Claims Worksheet (PTO-2022)	1	View
2022-10-05	`371.FEE.M923`	371 (National Stage) Supplemental Fees Missing - Form M923	2	View
2022-10-05	`WFEE`	Fee Worksheet (SB06)	1	View
2022-10-05	`APP.FILE.REC`	Filing Receipt	4	View
2022-05-25	`DRW`	Drawings-only black and white line drawings	10	View
2022-05-25	`SPEC`	Specification	12	View
2022-05-25	`ABST`	Abstract	2	View
2022-05-25	`371P`	Documents submitted with 371 (National Stage) Applications	1	View
2022-05-25	`FRPR`	Certified Copy of Foreign Priority Application	37	View
2022-05-25	`CLM`	Claims	3	View
2022-05-25	`P.N.101.CONV`	PCT/RO/101 - Request form for new International Application - Conventional	5	View
2022-05-25	`A.PE`	Preliminary Amendment	1	View
2022-05-25	`SPEC`	Specification	1	View
2022-05-25	`REM`	Applicant Arguments/Remarks Made in an Amendment	1	View
2022-05-25	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2022-05-25	`ADS`	Application Data Sheet	10	View
2022-05-25	`WFEE`	Fee Worksheet (SB06)	2	View
2022-05-25	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2022-05-25	`TRAN.LET`	Transmittal Letter	1	View
2022-05-25	`TRNA`	Transmittal of New Application	4	View
2022-05-25	`371P`	Documents submitted with 371 (National Stage) Applications	2	View
2022-05-25	`371P`	Documents submitted with 371 (National Stage) Applications	4	View

Inventors

Jayaprakash K. NAIR Cambridge, MA

Juan C. SALINAS Cambridge, MA

John Frederick BRIONES Cambridge, MA

Mark K. SCHLEGEL Cambridge, MA

Shigeo MATSUDA Cambridge, MA

Alexander V. KEL'IN Cambridge, MA

Ligang ZHANG Cambridge, MA

Martin A. MAIER Cambridge, MA

Attorneys & Agents of Record

MARK FITZGERALD Reg. 45928 Attorney · NIXON PEABODY LLP

SARAH FENDRICK Reg. 66262 Attorney · ALNYLAM PHARMACEUTICALS

RONALD EISENSTEIN Reg. 30628 Attorney · NIXON PEABODY LLP

DAVID MAY Reg. 58760 Attorney · NIXON PEABODY, LLP

ALISSA YOUNG Reg. 81141 Attorney · NIXON PEABODY LLP

THOMAS PAVELKO Reg. 31689 Attorney · NIXON PEABODY LLP

JEANNE JODOIN Reg. 80219 Agent · NIXON PEABODY, LLP

RAVINDERJIT BRAICH Reg. 81195 Agent · NIXON PEABODY LLP

DAVID RESNICK Reg. 34235 Attorney · NIXON PEABODY LLP

SETH LEVY Reg. 44869 Attorney · NIXON PEABODY LLP

MARY SYLVIA Reg. 37156 Attorney · WOODS ROGERS PLC

ELIZABETH LAUDADIO Reg. 83737 Agent · NIXON PEABODY LLP

JEFFREY COSTELLIA Reg. 35483 Attorney · NIXON PEABODY LLP

NICOLE KLING Reg. 71959 Agent · NIXON PEABODY LLP

COLLEEN MCKIERNAN Reg. 48570 Agent · ALNYLAM PHARMACEUTICALS, INC.

SHAYNE HUFF Reg. 44784 Agent · NIXON PEABODY LLP

STEVEN BOSSONE Reg. 51196 Attorney · ALNYLAM PHARMACEUTICALS

JEFFREY KOPACZ Reg. 54744 Agent · ALNYLAM PHARMACEUTICALS

SUANNE NAKAJIMA Reg. 63207 Attorney · AERA THERAPEUTICS

Classification

USPC 536/25.2

A61K31/704 C07H1/00 C07H21/00 C07H23/00 Y02P20/55 A61P35/00 A61K9/0019 A61K9/127 A61K47/24 A61K47/26 C07H19/067 C07H21/02 C12N15/111 C12N15/113 C12N2310/14 C12N2310/319 C12N2330/30

Prosecution

Examiner: CREWS, JARET JAMES
Art Unit: 1691
Customer No.: 90162
Docket No.: 051058-096630USPX
Confirmation No.: 4350

Publication

Pub. No.: US20230021879A1
Pub. Date: 2023-01-26

BANK OF AMERICA, N.A.

from ALNYLAM PHARMACEUTICALS, INC., SIRNA THERAPEUTICS, INC.

SECURITY INTEREST Recorded 2025-10-01

072996/0337 →

ALNYLAM PHARMACEUTICALS, INC.

from MAIER, MARTIN A., NAIR, JAYAPRAKASH K., SALINAS, JUAN C., SCHLEGEL, MARK K., MATSUDA, SHIGEO, BRIONES, JOHN FREDERICK, KEL'IN, ALEXANDER V., ZHANG, LIGANG

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded 2024-03-29

066954/0611 →

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Quick Facts

App. No.: 17/779,706
Filed: 2022-05-25
Pub. No.: US20230021879A1
Examiner: CREWS, JARET JAMES
Art Unit: 1691

External Links

USPTO Patent Center↗ Pre-Grant Publication PDF↗