Patent Application

App. No. 17/783,220

Abstract

Claims (26)

1 - 15 . (canceled)

16 . A method for treating or protecting a ruminant animal from Bovicola spp. chewing lice infestation comprising a single subcutaneous administration of a composition comprising an effective amount of at least one isoxazoline compound of Formula (I)

wherein

R 1 is halogen, CF 3 , OCF 3 , CN,

n is an integer from 0 up to and including 3, preferably 1, 2 or 3,

R 2 is C 1 -C 3 -haloalkyl, preferably CF 3 or CF 2 Cl,

T is a 5 to 12 membered mono or bicyclic ring system, which is optionally substituted by one or more radicals Y,

Y is methyl, halomethyl, halogen, CN, NO 2 , NH 2 —C═S, or two adjacent radicals Y form together a chain, especially a three or four-membered chain;

Q is X—NR 3 R 4 , NR 5 —NR 6 —X—R 3 , X—R3 or a 5-membered N-heteroaryl ring, which is optionally substituted by one or more radicals;

X is CH 2 , CH(CH 3 ), CH(CN), CO, CS,

R 3 is hydrogen, methyl, haloethyl, halopropyl, halobutyl, methoxymethyl, methoxyethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, N-phenyl-N-methyl-amino, haloethylaminocarbonylmethyl, haloethylaminocarbonylethyl, tetrahydrofuryl, methylaminocarbonylmethyl, (N,N-dimethylamino)-carbonylmethyl, propylaminocarbonylmethyl, cyclopropylaminocarbonylmethyl, propenylaminocarbonylmethyl, haloethylaminocarbonylcyclopropyl, alkylsulfanyl, alkylsufinalkyl, alkylsulfonalkyl, cycloalkyl

wherein Z A is hydrogen, halogen, cyano, halomethyl, preferably CF 3 ;

R 4 is hydrogen, ethyl, methoxymethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, methylcarbonyl, ethylcarbonyl, propylcarbonyl, cyclopropylcarbonyl, methoxycarbonyl, methoxymethylcarbonyl, aminocarbonyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, haloethylaminocarbonylmethyl, cyanomethylaminocarbonylmethyl, or haloethylaminocarbonylethyl;

R 5 is hydrogen, alkyl or haloalkyl;

R 6 is hydrogen, alkyl or haloalkyl;

or R 3 and R 4 together form a substituent selected from the group consisting of:

or a salt or solvate thereof.

17 . The method according to claim 16 , wherein the ruminate animal is a cattle and the Bovicola spp. is Bovicola bovis chewing lice.

18 . The method according to claim 16 , wherein the isoxazoline compound of formula (I) is fluralaner.

19 . The method according to claim 16 , wherein the effective amount of the isoxazoline compound is between 1 and 3 mg/kg bodyweight of the animal.

20 . The method according to claim 16 , wherein the composition is administered once to the ruminant animal wherein the ruminant animal is in a group of animals with at least one animal diagnosed with chewing lice infestation.

21 . The method according to claim 16 , wherein the effective amount of the isoxazoline compound is sufficient to eliminate an existing chewing lice infestation within 15 days after administration.

22 . The method according to claim 21 , wherein the effective amount of the isoxazoline compound is sufficient after a single subcutaneous administration to eliminate all live lice from the treated cattle when investigated 56 days after treatment.

23 . The method according to claim 16 , wherein the chewing lice are resistant to any one of organophosphates, synthetic pyrethroids, neonicotinoids, spinosyn or benzoyl phenyl urea compounds.

24 . The method according to claim 16 , wherein the composition comprises another active pharmaceutical ingredient.

25 . The method according to claim 24 , wherein the composition comprises at least one endoparasiticide.

Assignments (10)