METHODS, SYSTEMS, AND APPARATUSES FOR COMBINED TUMOR TREATING FIELDS AND MENTAL HEALTH THERAPY
Methods, systems, and apparatuses are described for using electrical stimulation to combine (e.g., concomitantly) tumor treating fields (TTFIelds) and mental health therapy (e.g., anti-depression therapy, anti-anxiety therapy, etc.).
1 . A method comprising:
causing cyclical application of a first electric field in a first direction via a first transducer array comprising a first plurality of electrodes and a second electric field in a second direction, opposite the first direction, via a second transducer array comprising a second plurality of electrodes, wherein the first electric field and the second electric field are at a first frequency, wherein each electrode of the first plurality of electrodes and each electrode of the second plurality of electrodes comprises a first material with a resonant frequency associated with the first frequency and a second material with a resonant frequency associated with a second frequency; and
causing cyclical application of a third electric field in the first direction via the first plurality of electrodes and a fourth electric field in the second direction, via the second plurality of electrodes, wherein the third electric field and the fourth electric field are at the second frequency.
2 . The method of claim 1 , wherein, based on the first frequency, the cyclical application of the first electric field and the second electric field treats a tumor within the brain of a subject, and wherein, based on the second frequency, the cyclical application of the third electric field and the fourth electric field treats a mood disorder affecting the subject.
3 . The method of claim 1 , wherein the first frequency comprises a frequency between 50 and 500 kHz and the first electric field and the second electric field each comprise an electric field strength of at least 1 V/cm or electric field strength produced by current supplied to the electrode of 0.5-4.0 mA, and the second frequency comprises a frequency of less than 640 Hz.
4 . The method of claim 1 , wherein the first material comprises ceramic and the second material comprises rubber.
5 . The method of claim 1 further comprising:
determining, one or more angles that are orthogonal relative to a geometric center of a region of interest; and
determining, based on the one or more angles, the first direction.
6 . The method of claim 1 further comprising determining, based on a location of a tumor in a brain, one or more implantation positions for the first transducer array and the second transducer array within the brain to treat the tumor.
7 . An apparatus, comprising:
one or more processors; and
memory storing processor-executable instructions that, when executed by the one or more processors, cause the apparatus to perform the method of claim 1 .
8 . One or more non-transitory computer-readable media storing processor-executable instructions thereon that, when executed by a processor, cause the processor to perform the method of claim 1 .
9 . A method comprising:
causing, based on a time interval, cyclical application of a first electric field in a first direction via a first transducer array comprising a first plurality of electrodes and a second electric field in a second direction, opposite the first direction, via a second transducer array comprising a second plurality of electrodes, wherein the first electric field and the second electric field are at a first frequency, wherein each electrode of the first plurality of electrodes and each electrode of the second plurality of electrodes comprises a first material with a resonant frequency associated with the first frequency and a second material with a resonant frequency associated with a second frequency; and
causing, based on the time interval, cyclical application of a third electric field in a third direction via a third transducer array comprising a third plurality of electrodes and a fourth electric field in a fourth direction, opposite the third direction, via a fourth transducer array comprising a fourth plurality of electrodes, wherein each electrode of the third plurality of electrodes and each electrode of the fourth plurality of electrodes comprises the first material with the resonant frequency associated with the first frequency and the second material with the resonant frequency associated with the second frequency, and wherein the third electric field and the fourth electric field are at the second frequency.
10 . The method of claim 9 , wherein, based on the first frequency, the cyclical application of the first electric field and the second electric field treats a tumor within the brain of a subject, and wherein, based on the second frequency, the cyclical application of the third electric field and the fourth electric field treats a mood disorder affecting the subject.
11 . The method of claim 9 , wherein the first frequency comprises a frequency between 50 and 500 kHz and the first electric field and the second electric field each comprise an electric field strength of at least 1 V/cm or electric field strength produced by current supplied to the electrode of 0.5-4.0 mA, and the second frequency comprises a frequency of less than 640 Hz.
12 . The method of claim 9 , further comprising:
determining, one or more angles that are orthogonal relative to a geometric center of a region of interest; and
determining, based on the one or more angles, the first direction and the third direction.
13 . The method of claim 9 , further comprising determining, based on a location of a tumor in a brain, one or more implantation positions for each of the transducer arrays within the brain to treat the tumor.
14 . An apparatus, comprising:
one or more processors; and
memory storing processor-executable instructions that, when executed by the one or more processors, cause the apparatus to perform the method of claim 9 .
15 . One or more non-transitory computer-readable media storing processor-executable instructions thereon that, when executed by a processor, cause the processor to perform the method of claim 9 .