IP Library › Patent Application 17794637

Patent Application Utility PCT National Stage

App. No. 17/794,637 · Confirmation No. 1796

LEUCINE-RICH REPEAT KINASE 2 (LRRK2) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

Inventors: JAMES D. MCININCH, JASON A. GILBERT, ADAM CASTORENO, LAN THI HOANG DANG, SARAH LEBLANC, HAIYAN PENG, CHARALAMBOS KAITTANIS, MANGALA MEENAKSHI SOUNDARAPANDIAN

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Notice of Allowance Mailed -- Application Received in Office of Publications View Publication ↗

	Code	Description	Pages	PDF
2026-08-13	`NOA`	Notice of Allowance and Fees Due (PTOL-85)	6	View
2026-08-13	`SRFW`	Search information including classification, databases and other search related notes	2	View
2026-08-13	`IIFW`	Issue Information including classification, examiner, name, claim, renumbering, etc.	3	View
2026-08-13	`1449`	List of References cited by applicant and considered by examiner	2	View
2026-08-13	`BIB`	Bibliographic Data Sheet	2	View
2026-08-13	`1449`	List of References cited by applicant and considered by examiner	2	View
2026-08-13	`SRNT`	Examiner's search strategy and results	1	View
2026-08-13	`SRNT`	Examiner's search strategy and results	4	View
2026-08-13	`1449`	List of References cited by applicant and considered by examiner	2	View
2026-08-13	`1449`	List of References cited by applicant and considered by examiner	3	View
2026-08-13	`SRNT`	Examiner's search strategy and results	1	View
2026-08-13	`SRNT`	Examiner's search strategy and results	37	View
2026-06-12	`FOR`	Foreign Reference	484	View
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2026-06-12	`FOR`	Foreign Reference	139	View
2026-06-12	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	2	View
2026-06-12	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	2	View
2026-06-12	`IDS.SIZEFEE`	Assertion regarding Information Disclosure Statement (IDS) Size Fee (SB/08C)	1	View
2026-06-12	`N417`	Electronic Filing System Acknowledgment Receipt	5	View
2026-05-27	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2026-05-27	`FOR`	Foreign Reference	54	View
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2026-05-27	`FOR`	Foreign Reference	146	View
2026-05-27	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	2	View
2026-05-27	`IDS.SIZEFEE`	Assertion regarding Information Disclosure Statement (IDS) Size Fee (SB/08C)	1	View
2026-05-27	`XT/`	Extension of Time	1	View
2026-05-27	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	3	View
2026-05-27	`AMSB`	Amendment Submitted/Entered with Filing of Continued Prosecution Application (CPA)/Request for Continued Examination(RCE)	13	View
2026-05-27	`RCEX`	Request for Continued Examination (RCE)	1	View
2026-05-27	`N417.PYMT`	Electronic Fee Payment	2	View
2026-05-27	`N417`	Electronic Filing System Acknowledgment Receipt	5	View
2026-05-27	`WFEE`	Fee Worksheet (SB06)	1	View
2026-02-26	`CTFR`	Final Rejection	8	View
2026-02-26	`892`	List of references cited by examiner	1	View
2026-02-26	`SRFW`	Search information including classification, databases and other search related notes	2	View
2026-02-26	`SRNT`	Examiner's search strategy and results	1	View
2026-02-26	`SRNT`	Examiner's search strategy and results	7	View
2026-02-26	`1449`	List of References cited by applicant and considered by examiner	5	View
2026-02-26	`SRNT`	Examiner's search strategy and results	4	View
2026-02-26	`BIB`	Bibliographic Data Sheet	2	View
2026-02-26	`SRNT`	Examiner's search strategy and results	1	View
2026-02-26	`SRNT`	Examiner's search strategy and results	19	View
2026-02-11	`N570`	Communication - Re: Power of Attorney (PTOL-308)	1	View
2026-02-11	`N570`	Communication - Re: Power of Attorney (PTOL-308)	1	View
2026-02-06	`PA..`	Power of Attorney	2	View
2026-02-06	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2025-12-02	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2025-12-02	`DRW.SUPP`	Drawings-black and white line and/or other drawings	—	View
2025-12-02	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2025-12-02	`SPEC`	Specification	1	View
2025-12-02	`CLM`	Claims	10	View
2025-12-02	`REM`	Applicant Arguments/Remarks Made in an Amendment	7	View
2025-12-02	`DRW`	Drawings-only black and white line drawings	3	View
2025-12-02	`TRAN.LET`	Transmittal Letter	1	View
2025-12-02	`REF.OTHER`	Other reference-Patent/Application/Search Documents	5	View
2025-12-02	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2025-12-02	`REF.OTHER`	Other reference-Patent/Application/Search Documents	2	View
2025-12-02	`N417.PYMT`	Electronic Fee Payment	2	View
2025-12-02	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2025-12-02	`SCORE`	Placeholder sheet indicating presence of supplemental content in Supplemental Complex Repository for Examiners(SCORE)	1	View
2025-12-02	`WFEE`	Fee Worksheet (SB06)	1	View
2025-09-02	`CTNF`	Non-Final Rejection	16	View
2025-09-02	`892`	List of references cited by examiner	1	View
2025-09-02	`SRFW`	Search information including classification, databases and other search related notes	2	View
2025-09-02	`SRNT`	Examiner's search strategy and results	4	View
2025-09-02	`BIB`	Bibliographic Data Sheet	2	View
2025-09-02	`SRNT`	Examiner's search strategy and results	10	View
2025-09-02	`SRNT`	Examiner's search strategy and results	1	View
2025-09-02	`1449`	List of References cited by applicant and considered by examiner	1	View
2025-09-02	`SRNT`	Examiner's search strategy and results	1	View
2025-09-02	`1449`	List of References cited by applicant and considered by examiner	28	View
2025-09-02	`1449`	List of References cited by applicant and considered by examiner	1	View
2025-09-02	`1449`	List of References cited by applicant and considered by examiner	5	View
2025-07-02	`ELC.`	Response to Election / Restriction Filed	—	View
2025-07-02	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2025-07-02	`CLM`	Claims	11	View
2025-07-02	`REM`	Applicant Arguments/Remarks Made in an Amendment	4	View
2025-07-02	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2025-07-02	`REF.OTHER`	Other reference-Patent/Application/Search Documents	11	View
2025-07-02	`TRAN.LET`	Transmittal Letter	1	View
2025-07-02	`REF.OTHER`	Other reference-Patent/Application/Search Documents	8	View
2025-07-02	`REF.OTHER`	Other reference-Patent/Application/Search Documents	14	View
2025-07-02	`ELC.`	Response to Election / Restriction Filed	1	View
2025-07-02	`WFEE`	Fee Worksheet (SB06)	1	View
2025-05-02	`CTRS`	Requirement for Restriction/Election	17	View
2024-05-08	`FOR`	Foreign Reference	78	View
2024-05-08	`TRAN.LET`	Transmittal Letter	1	View
2024-05-08	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	1	View
2024-05-08	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2024-05-08	`FOR`	Foreign Reference	231	View
2023-08-29	`N417`	Electronic Filing System Acknowledgment Receipt	16	View
2023-08-29	`N417`	Electronic Filing System Acknowledgment Receipt	10	View
2023-08-29	`FOR`	Foreign Reference	27	View
2023-08-29	`FOR`	Foreign Reference	226	View
2023-08-29	`FOR`	Foreign Reference	64	View
2023-08-29	`FOR`	Foreign Reference	169	View
2023-08-29	`TRAN.LET`	Transmittal Letter	1	View
2023-08-29	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	28	View
2023-08-29	`FOR`	Foreign Reference	13	View
2023-08-29	`FOR`	Foreign Reference	170	View
2023-08-29	`FOR`	Foreign Reference	45	View
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2023-08-29	`FOR`	Foreign Reference	298	View
2023-08-29	`N417`	Electronic Filing System Acknowledgment Receipt	10	View
2023-08-29	`FOR`	Foreign Reference	132	View
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2023-04-27	`NTC.PUB`	Notice of Publication	1	View
2023-04-21	`WCLM`	Claims Worksheet (PTO-2022)	2	View
2023-04-21	`WFEE`	Fee Worksheet (SB06)	1	View
2023-04-21	`APP.FILE.REC`	Filing Receipt	4	View
2023-04-21	`M903`	Notice of Designated Office (DO) / Elected Office (EO) Acceptance Mailed	2	View
2023-01-17	`PEFR`	Applicant Response to Pre-Exam Formalities Notice	1	View
2023-01-17	`CLM`	Claims	11	View
2023-01-17	`REM`	Applicant Arguments/Remarks Made in an Amendment	3	View
2023-01-17	`OATH`	Oath or Declaration filed	8	View
2023-01-17	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2023-01-17	`PEFR`	Applicant Response to Pre-Exam Formalities Notice	—	View
2022-11-14	`WCLM`	Claims Worksheet (PTO-2022)	2	View
2022-11-14	`APP.FILE.REC`	Filing Receipt	4	View
2022-11-14	`WFEE`	Fee Worksheet (SB06)	1	View
2022-11-14	`371.FEE.M923`	371 (National Stage) Supplemental Fees Missing - Form M923	2	View
2022-11-09	`WFEE`	Fee Worksheet (SB06)	1	View
2022-11-09	`WFEE`	Fee Worksheet (SB06)	1	View
2022-11-09	`WFEE`	Fee Worksheet (SB06)	1	View
2022-08-01	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	15	View
2022-08-01	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	—	View
2022-07-22	`ABST`	Abstract	2	View
2022-07-22	`CLM`	Claims	12	View
2022-07-22	`SPEC`	Specification	181	View
2022-07-22	`DRW`	Drawings-only black and white line drawings	5	View
2022-07-22	`FRPR`	Certified Copy of Foreign Priority Application	217	View
2022-07-22	`P.N.101.CONV`	PCT/RO/101 - Request form for new International Application - Conventional	6	View
2022-07-22	`ABST`	Abstract	2	View
2022-07-22	`371P`	Documents submitted with 371 (National Stage) Applications	2	View
2022-07-22	`FRPR`	Certified Copy of Foreign Priority Application	189	View
2022-07-22	`371P`	Documents submitted with 371 (National Stage) Applications	1	View
2022-07-22	`SEQ.TXT`	Sequence Listing (Text File)	1	View
2022-07-22	`PA..`	Power of Attorney	1	View
2022-07-22	`R3.73`	Assignee showing of ownership per 37 CFR 3.73	2	View
2022-07-22	`REF.OTHER`	Other reference-Patent/Application/Search Documents	10	View
2022-07-22	`WFEE`	Fee Worksheet (SB06)	2	View
2022-07-22	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2022-07-22	`TRNA`	Transmittal of New Application	4	View
2022-07-22	`ADS`	Application Data Sheet	11	View
2022-07-22	`TRAN.LET`	Transmittal Letter	1	View
2022-07-22	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	1	View
2022-07-22	`FOR`	Foreign Reference	104	View

Inventors

JAMES D. MCININCH BURLINGTON, MA

JASON A. GILBERT HINGHAM, MA

ADAM CASTORENO FRAMINGHAM, MA

LAN THI HOANG DANG ARLINGTON, MA

SARAH LEBLANC CAMBRIDGE, MA

HAIYAN PENG MEDFORD, MA

CHARALAMBOS KAITTANIS CAMBRIDGE, MA

MANGALA MEENAKSHI SOUNDARAPANDIAN CAMBRIDGE, MA

Attorneys & Agents of Record

MANEESH GULATI Reg. 60963 Attorney · LAHIVE & COCKFIELD, LLP

DEBORAH NAGLE Reg. 59978 Agent · MCCARTER & ENGLISH, LLP

SARAH FENDRICK Reg. 66262 Attorney · ALNYLAM PHARMACEUTICALS

PAIGE SMITH Reg. 80495 Agent · MORRISON & FOERSTER, LLP

JOHN CURRAN Reg. 50445 Attorney · MCCARTER & ENGLISH

MARIA LACCOTRIPE ZACHARAKIS Reg. 56266 Attorney · MCCARTER & ENGLISH, LLP

YU LU Reg. 50306 Attorney · MCCARTER & ENGLISH, LLP

JEFFREY SAFRAN Reg. 54689 Attorney · MCCARTER & ENGLISH, LLP

JEFFREY KOPACZ Reg. 54744 Agent · ALNYLAM PHARMACEUTICALS

STEVEN DAVIS Reg. 39652 Attorney · MCCARTER & ENGLISH LLP

JOSEPH CIARDI Reg. 64760 Agent · MCCARTER & ENGLISH, LLP

GEORGE BLAZESKI Reg. 73381 Attorney · MCCARTER & ENGLISH, LLP

THAO NGUYEN Reg. 84194 Agent · MCCARTER & ENGLISH LLP

STEVEN BOSSONE Reg. 51196 Attorney · ALNYLAM PHARMACEUTICALS

XIN ZHANG Reg. 62139 Attorney · MCCARTER & ENGLISH, LLP

DAVID BURNS Reg. 46590 Attorney · MCCARTER & ENGLISH, LLP

SAMANTHA DUNDON Reg. 83311 Agent · MCCARTER & ENGLISH, LLP

JONATHAN SPARKS Reg. 53624 Attorney · MCCARTER & ENGLISH, LLP

JILL MELLO Reg. 55450 Agent · MCCARTER & ENGLISH, LLP

MIAO YU Reg. 79354 Agent · MCCARTER & ENGLISH, LLP

JONATHAN LOVELY Reg. 60821 Attorney · SUNSTEIN KANN MURPHY & TIMBERS LLP

MATTHEW VAN EMAN Reg. 58063 Agent · MCCARTER & ENGLISH, LLP

MARCIE CLARKE Reg. 63723 Attorney · MCCARTER & ENGLISH, LLP

NANDINI MANI Reg. 800082 Agent · MCCARTER & ENGLISH, LLP

DYLAN BLUMENTHAL Reg. 79687 Attorney · MCCARTER & ENGLISH, LLP

KIA FREEMAN Reg. 47577 Attorney · MCCARTER & ENGLISH, LLP

ANITA BOWLES Reg. 61189 Attorney · MCCARTER & ENGLISH, LLP

YANJUN FENG Reg. 80508 Agent · MEUNIER CARLIN & CURFMAN

THAO NGUYEN Reg. L1397 Agent · MCCARTER & ENGLISH LLP

Classification

USPC 514/44A

C12N15/1137 A61K47/56 A61K47/549 A61K47/554 A61P25/28 A61K31/713 A61K45/06 A61K48/005 A61K2300/00 C12N2310/14 C12N2310/312 C12N2310/315 C12N2310/321 C12N2310/343 C12N2310/345 C12N2310/346 C12N2310/3515 C12N2310/3527 C12N2320/11 C12N2320/31 C12N2320/32

Prosecution

Examiner: HUDSON, AMY ROSE
Art Unit: 1636
Customer No.: 103542
Docket No.: 121301-26703
Confirmation No.: 1796

Publication

Pub. No.: US20230126233A1
Pub. Date: 2023-04-27

BANK OF AMERICA, N.A.

from ALNYLAM PHARMACEUTICALS, INC., SIRNA THERAPEUTICS, INC.

SECURITY INTEREST Recorded 2025-10-01

072996/0337 →

ALNYLAM PHARMACEUTICALS, INC.

from LEBLANC, SARAH, PENG, HAIYAN, CASTORENO, ADAM, MCININCH, JAMES D., DANG, LAN THI HOANG, GILBERT, JASON, KAITTANIS, CHARALAMBOS, SOUNDARAPANDIAN, MANGALA MEENAKSHI

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded 2022-08-17

060837/0298 →

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Quick Facts

App. No.: 17/794,637
Filed: 2022-07-22
Pub. No.: US20230126233A1
Examiner: HUDSON, AMY ROSE
Art Unit: 1636

External Links

USPTO Patent Center↗ Pre-Grant Publication PDF↗