IP Library Granted Patent US 12,414,815
Granted Patent B2
US 12,414,815 · App. 17/806,539 · Granted Sep 16, 2025

Radiometric tissue contact and tissue type detection

Inventors: Dorin Panescu (San Jose, CA); Jessi E. Johnson (Santa Clara, CA); Josef Vincent Koblish (Santa Clara, CA); John F. McCarthy (Newbury, NH)
Assignee: EPIX THERAPEUTICS, INC.
A61B18/1492A61B5/0507A61B5/6843A61B5/6852A61B18/1206A61B2017/00061A61B2018/00357A61B2018/00577A61B2018/00648A61B2018/00708A61B2018/00738A61B2018/00785A61B2018/00791A61B2018/00809A61B2018/00904A61B2090/065
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Quick Facts
Patent No.
US 12,414,815
App. No.
17/806,539
Granted
Sep 16, 2025
Kind
B2
Abstract

Radiometric systems may comprise a radiometer, an antenna and a processor communicatively coupled together. The processor may provide a contact-focused output based on filtering or other processing of a raw radiometric output signal. The contact-focused output may facilitate determination of whether contact has been achieved and/or assessment of contact. A miniaturized reflectometer may be configured to determine an amount of reflected power from the antenna. The processor may be configured to determine a reflection coefficient of the reflected power determined by the reflectometer and to identify tissue type based on the reflection coefficient. Systems and methods for facilitating deeper temperature measurements of a radiometer are described.

Claims (19)

1. A system for determining tissue type, the system comprising:

a cardiac ablation catheter comprising:

an elongate body having a proximal end and a distal end;

an antenna positioned at the distal end of the elongate body;

an electrode positioned at the distal end of the elongate body adapted to contact cardiac tissue of a subject and to deliver ablative energy sufficient to ablate the cardiac tissue;

a radiometer positioned at the distal end of the elongate body, the radiometer configured to measure tissue data; and

a reflectometer positioned at the distal end of the elongate body, the reflectometer configured to determine an amount of reflected power received from the antenna,

wherein the reflected power received from the antenna is filtered by a band-stop filter to avoid frequencies in an operating bandwidth of the radiometer; and

a processor configured to determine a reflection coefficient of the reflected power and to identify a type of tissue based on the determined reflection coefficient.

2. The system of claim 1 , wherein the processor is further configured to determine whether the distal end of the elongate body is in contact with a target tissue to be ablated based on the identified type of tissue.

3. The system of claim 1 , wherein the processor is further configured to automatically adjust or calibrate measurements obtained by the radiometer based on the reflection coefficient determined by the reflectometer.

4. The system of claim 1 , wherein the type of tissue is selected from a group consisting of: non-ablated tissue, normal infarct tissue and ablated tissue.

5. The system of claim 1 , wherein the processor is configured to provide an output indicative of the tissue type, wherein the output indicative of the tissue type is selected from a group consisting of: a live reading of a magnitude of the reflection coefficient plotted as a bar graph or a live reading of the magnitude and a phase of the reflection coefficient plotted on a Smith chart or polar plot.

6. The system of claim 1 , wherein the processor is configured to provide an output indicative of contact.

7. The system of claim 6 , wherein the output comprises an indication that contact has occurred.

8. The system of claim 6 , wherein the output comprises an indication of a level or quality of contact.

9. The system of claim 5 , wherein the output is configured to be output on a display in communication with the processor.

10. The system of claim 1 , wherein the reflectometer is configured to determine reflection coefficients at multiple frequencies outside an operation band of the radiometer.

11. The system of claim 10 , wherein the processor is configured to determine a reflection coefficient at an operating frequency of the radiometer based on interpolation using the determined reflection coefficients at said multiple frequencies.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 8, 2022
From: PANESCU, DORIN; KOBLISH, JOSEF VINCENT; MCCARTHY, JOHN F.; JOHNSON, JESSI E.
To: ADVANCED CARDIAC THERAPEUTICS, INC.
Reel/Frame 062028/0532 →
CHANGE OF NAME Recorded Dec 8, 2022
From: ADVANCED CARDIAC THERAPEUTICS, INC.
To: EPIX THERAPEUTICS, INC.
Reel/Frame 062098/0783 →
Continuity (5)
Continuation 15527924
Provisional Application 62105366 · Jan 20, 2015
Provisional Application 62087678 · Dec 4, 2014
Provisional Application 62081697 · Nov 19, 2014
Related Publication 20220323146A1 · Oct 13, 2022
References Cited (17)
US 4479498A · Toftness · 1984 [cited by applicant]
US 4557272A · Carr et al. · 1985 [cited by applicant]
US 5344435A · Turner et al. · 1994 [cited by applicant]
US 5974343A · Brevard et al. · 1999 [cited by applicant]
US 5992419A · Sterzer et al. · 1999 [cited by applicant]
US 6847848B2 · Sterzer · 2005 [cited by examiner]
US 8206380B2 · Lenihan et al. · 2012 [cited by applicant]
US 8731684B2 · Carr et al. · 2014 [cited by applicant]
US 9277961B2 · Panescu et al. · 2016 [cited by applicant]
US 20070299488A1 · Carr · 2007 [cited by examiner]
US 20080314894A1 · Cronin · 2008 [cited by applicant]
US 20090012417A1 · Carr · 2009 [cited by applicant]
US 20110295247A1 · Schlesinger et al. · 2011 [cited by applicant]
US 20120108988A1 · Ludwin et al. · 2012 [cited by applicant]
US 20130204240A1 · McCarthy et al. · 2013 [cited by applicant]
US 20150094608A1 · Allison et al. · 2015 [cited by applicant]
International Search Report for Application No. PCT/US2015/061347 dated Mar. 16, 2016 (4 pages). [cited by applicant]