ANTIBODIES AGAINST LIF AND USES THEREOF
Described herein are antibodies that target Leukemia Inhibitory Factor (LIF). Also described herein are uses of these antibodies for the treatment of cancer.
1 .- 286 . (canceled)
287 . A recombinant antibody that specifically binds Leukemia Inhibitory Factor (LIF), the antibody comprising a heavy chain variable region with an amino acid sequence set forth in SEQ ID NO: 72, and a light chain variable region with an amino acid sequence set forth in SEQ ID NO: 76.
288 . The recombinant antibody of claim 287 , wherein the recombinant antibody binds to glycosylated LIF.
289 . The recombinant antibody of claim 287 , wherein the recombinant antibody is humanized.
290 . The recombinant antibody of claim 287 , wherein the recombinant antibody is deimmunized.
291 . The recombinant antibody of claim 287 , wherein the recombinant antibody comprises two heavy chains and two light chains.
292 . The recombinant antibody of claim 287 , wherein the recombinant antibody is an IgG antibody.