System and method for detecting target substances
A method includes capturing a signal of a detection substrate exposed to a sample containing a target substance; determining that the detection substrate is in a testable state; and generating an assessment of the presence of the target substance in the sample.
1. A system comprising:
a test container including:
a chamber having a reagent therein, the chamber configured to receive a sample; and
a detection substrate including a test strip, the detection substrate fluidly coupled to the chamber of the test container, the detection substrate configured to detect an analyte;
a housing including a lumen that is configured to removably receive the test container;
an image sensor coupled to the housing and configured to be optically coupled to the detection substrate when the test container is positioned within the housing, wherein when the test container is removed from the lumen of the housing, the detection substrate is optically decoupled from the image sensor; and
a processor in communication with the image sensor, the processor being configured to:
receive, from the image sensor, an image of the detection substrate;
generate, using the image, an assessment of a presence of the analyte within the sample; and
generate an output indicative of a positive test result or a negative test result of the presence of the analyte within the sample, based on the assessment.
2. The system of claim 1 , wherein the detection substrate includes an active region having an antibody that is complementary with the analyte; and
wherein generating the assessment of the presence of the analyte within the sample includes:
identifying a portion of the image that corresponds to the active region of the detection substrate; and
identifying a peak within the portion of the image that corresponds to the active region.
3. The system of claim 2 , wherein the detection substrate includes a control region; and
wherein the portion of the image is a first portion and the peak is a first peak;
wherein generating the assessment of the presence of the analyte within the sample includes:
identifying a second portion of the image that corresponds to the control region of the detection substrate; and
identifying a second peak within the second portion of the image that corresponds to the control region.
4. The system of claim 1 , wherein the processor is further configured to display the output to a user of the system.
5. The system of claim 1 , further comprising an illuminator coupled to the housing and optically coupled to the detection substrate, the illuminator being configured to illuminate the detection substrate.
6. The system of claim 1 , wherein the output is indicative of the positive test result of the presence of the analyte within the sample;
wherein generating the assessment of the presence of the analyte within the sample includes determining at least one of an amount of the analyte within the sample or a concentration of the analyte within the sample.
7. The system of claim 1 , wherein generating an assessment of the presence of the analyte within the sample includes:
analyzing the image;
detecting the presence of the analyte within the sample, based on the analyzing of the image; and
generate the output indicative of the positive test result, based on the detecting the presence of the analyte within the sample.
8. The system of claim 1 , wherein the image is a test image; and
wherein the processor is further configured to:
compare the test image to a reference image of the detection substrate or another detection substrate;
analyze the test image to determine a degree of liquid saturation of the detection substrate; and
determine that the detection substrate is in a testable state, based on the comparison between the test image and the reference image and the degree of liquid saturation of the detection substrate; and
wherein generating the assessment of the presence of the analyte within the sample is based on the determination that the detection substrate is in a testable state.
9. The system of claim 1 , wherein generating the assessment of the presence of the analyte within the sample includes filtering the image.
10. The system of claim 1 , wherein the analyte is at least one of a food allergen or is gluten.
11. A system comprising:
a test container including:
a body;
a chamber having a reagent therein, the chamber configured to receive a sample;
a detection substrate including a test strip, the detection substrate fluidly coupled to the chamber of the test container, the detection substrate configured to detect an analyte; and
an analysis device including:
an image sensor optically coupled to the detection substrate;
a housing including a lumen that is configured to removably receive the test container, wherein when the test container is removed from the lumen of the housing, the detection substrate is optically decoupled from the image sensor; and
a processor in communication with the image sensor, the processor being configured to:
receive, from the image sensor, an image of the detection substrate;
analyze the image of the detection substrate; and
determine a presence of the analyte within the sample, based on the analyzing of the image of the detection substrate.
12. The system of claim 11 , wherein the detection substrate includes an active region having an antibody that is complementary with the analyte.
13. The system of claim 11 , further comprising an illuminator optically coupled to the detection substrate, the illuminator being configured to illuminate the detection substrate.
14. The system of claim 11 , wherein the processor is further configured to:
generate an output including a positive test result corresponding to the presence of the analyte within the sample; and
provide the output to a user.
15. The system of claim 14 , wherein the processor is further configured to:
determine, using the image of the detection substrate, at least one of an amount or a concentration of the analyte within the sample; and
wherein the output includes at least one of the amount or the concentration of the analyte within the sample.
16. The system of claim 11 ,
wherein the image sensor is coupled to the housing and configured to be optically coupled to the detection substrate when the test container is positioned within the housing.
17. The system of claim 11 , wherein the analyte is at least one of a food allergen or is gluten.
18. A system comprising:
a test container including:
a body;
a chamber having a reagent therein, the chamber configured to receive a sample;
a detection substrate including a test strip, the detection substrate fluidly coupled to the chamber of the test container, the detection substrate configured to detect an analyte;
an analysis device including:
an optical sensor optically coupled to the detection substrate;
a housing including a lumen that is configured to removably receive the test container; and
a processor in communication with the optical sensor, the processor being configured to:
receive, from the optical sensor, an optical signal characterizing the detection substrate exposed to the sample;
analyze the optical signal; and
detect a presence of the analyte within the sample, based on the analyzing of the optical signal.
19. The system of claim 18 , wherein the detection substrate includes an active region that includes an antibody that is complementary with the analyte;
wherein the optical sensor is configured to detect an absorption of light associated with a peak absorption wavelength of the active region; and
wherein the system includes a light source configured to illuminate the detection substrate with light associated with the peak absorption wavelength of the active region.
20. The system of claim 18 , wherein the analyte is at least one of a food allergen or is gluten;
wherein the optical sensor is an image sensor; and
wherein the optical signal is an image.