DEVICES AND METHODS FOR CONTROLLING DRUG DOSAGE DELIVERY FOR AUTOMATICALLY PROVIDING A DRUG TO A PATIENT
Disclosed are processes and techniques for a drug delivery system to maintain optimal drug delivery for a patient according to a treatment plan. The disclosed techniques enable a drug delivery system to delivery adjusted drug dosages and/or drug delivery cost function aggressiveness factors modified based on clusters or patterns of patient drug dosages and/or response event probabilities. For example, a controller for operating a drug delivery device may operate to determine a plurality of dosage clusters for a patient based on drug dosage patient information, determine an adjustment profile for each of the dosage clusters, determine a current cluster for a dosage cycle, determine an adjusted dosage for the dosage cycle by applying the adjustment profile to a default dosage, and provide a signal to the drug delivery device to deliver the adjusted dosage to the patient for the dosage cycle. Other embodiments are described.
1 . A controller for operating a drug delivery device, comprising:
a processor; and
a memory storing instructions that, when executed by the processor, operate the controller to:
determine a plurality of dosage clusters for a patient based on drug dosage patient information,
determine an adjustment profile for each of the dosage clusters,
determine a current cluster for a dosage cycle,
determine an adjusted dosage for the dosage cycle by applying the adjustment profile to a default dosage, and
provide a signal to the drug delivery device to deliver the adjusted dosage to the patient for the dosage cycle.
2 . The controller of claim 1 , the drug delivery device comprising an automatic insulin delivery (AID) device.
3 . The controller of claim 1 , the drug comprising one of a hormone, a protein, a chemotherapy drug, a medication, glucagon, a glucagon-like peptide, or insulin.
4 . The controller of claim 1 , the instructions, when executed by the processor, to operate the controller to determine the plurality of clusters based on at least one of a time period or a cluster criterion.
5 . The controller of claim 4 , the time period comprising one of a week, a month, or a year.
6 . The controller of claim 5 , the plurality of clusters segmented based on days of the week.
7 . The controller of claim 4 , the at least one cluster criterion comprising a dosage deviation in drug dosages between portions of a time period.
8 . The controller of claim 7 , the time period comprising a month and the dosage deviation comprising a percentage difference in a dose of the drug between consecutive days of the week.
9 . The controller of claim 8 , the percentage difference comprising about 10% to about 100%.
10 . The controller of claim 1 , the instructions, when executed by the processor, to operate the controller to determine the adjustment profile for each of the dosage clusters based on one or more of:
an overall drug dosage mean and a cluster dosage mean, or
(a cluster dosage mean)/(an overall drug dosage mean).
11 . A method for operating a drug delivery device, comprising, via a processor of a controller:
determining a plurality of dosage clusters for a patient based on drug dosage patient information;
determining an adjustment profile for each of the dosage clusters;
determining a current cluster for a dosage cycle;
determining an adjusted dosage for the dosage cycle by applying the adjustment profile to a default dosage; and
providing a signal to the drug delivery device to deliver the adjusted dosage to the patient for the dosage cycle.
12 . The method of claim 11 , the drug delivery device comprising an automatic insulin delivery (AID) device.
13 . The method of claim 11 , the drug comprising one of a hormone, a protein, a chemotherapy drug, a medication, glucagon, a glucagon-like peptide, or insulin.
14 . The method of claim 11 , comprising determining the plurality of clusters based on at least one of a time period or a cluster criterion.
15 . The method of claim 14 , the time period comprising one of a week, a month, or a year.
16 . The method of claim 15 , the plurality of clusters segmented based on days of the week.
17 . The method of claim 14 , the at least one cluster criterion comprising a dosage deviation in drug dosages between portions of a time period.
18 . The method of claim 17 , the time period comprising a month and the dosage deviation comprising a percentage difference in a dose of the drug between consecutive days of the week.
19 . The method of claim 18 , the percentage difference comprising about 10% to about 100%.
20 . The method of claim 11 , comprising determining the adjustment profile for each of the dosage clusters based on one or more of:
an overall drug dosage mean and a cluster dosage mean, or
(a cluster dosage mean)/(an overall drug dosage mean).