IP Library › Granted Patent US 12,558,547
Granted Patent B2
US 12,558,547 · App. 17/824,737 · Granted Feb 24, 2026

Modified high frequency neuromodulation signals, and associated systems and methods

Inventors: Dongchul Lee (Agua Dulce, CA); Kerry Bradley (Glendale, CA)
Assignee: Nevro Corp.
A61N1/36062A61N1/36171A61N1/36175
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Quick Facts
Patent No.
US 12,558,547
App. No.
17/824,737
Granted
Feb 24, 2026
Kind
B2
Abstract

The present technology is directed generally to spinal cord modulation and associated systems and methods for treating pain and other patient conditions. In particular, the present technology includes modified high frequency neuromodulation signals and administration patterns.

Claims (44)

1 . A patient treatment system, comprising:

a signal generator having a computer readable storage medium, wherein, in operation, the signal generator generates an electrical signal having bi-phasic pulses repeating at a frequency within a frequency range of about 1.2 kHz to about 500 kHz, wherein each bi-phasic pulse includes a first pulse phase having a first pulse width and a first polarity, a second pulse phase having a second pulse width and a second polarity opposite the first polarity, and an interphase interval between the first pulse phase and the second pulse phase, and wherein:

the interphase interval has a duration of between about 24 microseconds and about 160 microseconds, and

a ratio of the duration of the interphase interval to the first pulse width is between 2:1 and 6:1; and

a signal delivery element coupleable to the signal generator, wherein the signal delivery element is positionable proximate a target region, and, in operation, delivers the electrical signal to the target region

wherein the signal deliver element includes a first contact and a second contact and a third contact, the first pulse being delivered via the first contact and the second contact, and the second pulse being delivered via the second contact and the third contact,

wherein the first and second pulse delivered via the first, second and third contacts is different than the pair of contacts used to deliver an immediately preceding pulse.

2 . A method of treating a patient, comprising:

programming a signal generator to generate an electrical signal having bi-phasic pulses repeating at a frequency within a frequency range of about 1.2 kHz to about 500 kHz, wherein each bi-phasic pulse includes a first pulse phase having a first pulse width and a first polarity, a second pulse phase having a second pulse width and a second polarity opposite the first polarity, and an interphase interval between the first pulse phase and the second pulse phase, and wherein:

the interphase interval has a duration of between about 24 microseconds and about 160 microseconds, and a ratio of the duration of the interphase interval to the first pulse width is between 2:1 and 6:1,

delivering the electrical signal to the target region, wherein the step of delivering the electrical signal includes providing a signal deliver element having a first contact and a second contact and a third contact, the first pulse being delivered via the first contact and the second contact, and the second pulse being delivered via the second contact and the third contact,

wherein the first and second pulse delivered via the first, second and third contacts is different than the pair of contacts used to deliver an immediately preceding pulse.

3 . The method of claim 2 wherein the ratio of the duration of the interphase interval to the first pulse width is between 2:1 and 5:1.

4 . The method of claim 2 wherein the ratio of the duration of the interphase interval to the first pulse width is between 2:1 and 4:1.

5 . The method of claim 2 wherein the ratio of the duration of the interphase interval to the first pulse width is about 3:1.

6 . The method of claim 2 wherein the duration of the interphase interval is between about 30 microseconds and about 120 microseconds.

7 . The method of claim 2 wherein the duration of the interphase interval is between about 40 microseconds and about 80 microseconds.

8 . The method of claim 2 wherein a ratio of the second pulse width to the first pulse width is between 2:1 and 6:1.

9 . The method of claim 2 wherein the first pulse phase is an anodic pulse phase and the second pulse phase is a cathodic pulse phase.

10 . The method of claim 2 wherein the first pulse phase is a cathodic pulse phase and the second pulse phase is an anodic pulse phase.

11 . The method of claim 2 wherein the first pulse phase is a therapy pulse phase and the second pulse phase is a charge balancing pulse phase.

12 . The method of claim 2 wherein the frequency is in a frequency range of from about 1.2 kHz to about 50 kHz.

13 . The method of claim 2 wherein the frequency is in a frequency range of from about 3 kHz to about 15 kHz.

14 . The method of claim 2 wherein the electrical signal is a first electrical signal, the method further comprising:

programming the signal generator to generate a second electrical signal having bi-phasic pulses repeating at a frequency within a frequency range of about 1.2 kHz to about 500 kHz, wherein the bi-phasic pulses of the second electrical signal have a third pulse phase having a third pulse width and a third polarity, a fourth pulse phase having a fourth pulse width and a fourth polarity opposite the third polarity, and an interphase interval between the third pulse phase and the second pulse phase, and wherein:

(a) the third pulse width is approximately equal to the fourth pulse width; and

(b) the duration of the interphase interval is less than or equal to the third pulse width.

15 . The method of claim 14 wherein programming the signal generator includes programming the signal generator to simultaneously generate the first electrical signal and the second electrical signal.

16 . The method of claim 14 wherein programming the signal generator includes programming the signal generator to generate the first electrical signal before generating the second electrical signal.

17 . The method of claim 14 wherein the first electrical signal preferentially activates a first set of target neurons, and wherein the second electrical signal preferentially activates a second set of target neurons.

18 . The method of claim 17 wherein the first set of target neurons includes excitatory neurons and the second set of target neurons includes inhibitory neurons.

19 . The method of claim 14 wherein the first electrical signal induces a first physiological effect, and wherein the second electrical signal induces a second physiological effect different than the first physiological effect.

20 . A method of treating a patient, comprising:

programming a signal generator to generate an electrical signal having bi-phasic pulses repeating at a frequency within a frequency range of about 1.2 kHz to about 500 kHz, wherein each bi-phasic pulse includes a first pulse phase having a first pulse width and a first polarity, a second pulse phase having a second pulse width and a second polarity opposite the first polarity, and an interphase interval between the first pulse phase and the second pulse phase, and wherein:

the first pulse width is within a pulse width range of from about 1 microsecond to about 416 microseconds, and

a ratio of the second pulse width to the first pulse width is between 2:1 and 6:1

delivering the electrical signal to the target region, wherein the step of delivering the electrical signal includes providing a signal deliver element having a first contact and a second contact and a third contact, the first pulse being delivered via the first contact and the second contact, and the second pulse being delivered via the second contact and the third contact,

wherein the first and second pulse delivered via the first, second and third contacts is different than the pair of contacts used to deliver an immediately preceding pulse.

21 . The method of claim 20 wherein the ratio of the second pulse width to the first pulse width is between 2:1 and 5:1.

22 . The method of claim 20 wherein the ratio of the second pulse width to the first pulse width is between 2:1 and 4:1.

23 . The method of claim 20 wherein the ratio of the second pulse width to the first pulse width is about 3:1.

24 . The method of claim 20 wherein the first pulse width is in a pulse width range of about 1 microsecond to about 416 microseconds, and wherein the second pulse width is in a pulse width range of about 2 microseconds to about 740 microseconds.

25 . The method of claim 20 wherein the first pulse phase has a first amplitude and the second pulse phase has a second amplitude, and wherein the ratio between the second amplitude and the first amplitude is between 1:2 and 1:6.

26 . The method of claim 25 wherein the ratio between the second pulse phase amplitude and the first pulse phase amplitude is the inverse of the ratio between the second pulse width and the first pulse width such that the total charge delivered during the first pulse phase and the total charge delivered during the second pulse phase are equal and opposite.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Apr 4, 2025
From: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
To: NEVRO CORP.
Reel/Frame 070743/0001 →
PATENT SECURITY AGREEMENT Recorded Dec 1, 2023
From: NEVRO CORP.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
Reel/Frame 065744/0302 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 5, 2023
From: LEE, DONGCHUL; BRADLEY, KERRY
To: NEVRO CORP.
Reel/Frame 064797/0918 →
Continuity (2)
Provisional Application 63192998 · May 25, 2021
Related Publication 20220379116A1 · Dec 1, 2022
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