Granted Patent
B2
US 12,702,638 · App. 17/833,304 · Granted Aug 11, 2026
Cosmetic compositions for skin health and methods of using same
Assignee:
LOCUS SOLUTIONS IPCO, LLC
A61K8/99A61K8/347A61K8/60A61K8/602A61K8/64A61K8/66A61K8/735A61K8/8147A61K8/9794A61K9/0014A61K9/06A61K9/08A61K9/10A61K9/107A61K9/12A61K31/05A61K31/728A61K38/47A61K47/32A61P17/02A61P17/10A61P17/12A61Q5/00A61Q15/00A61Q17/00A61Q19/00A61Q19/007A61Q19/008A61Q19/02A61Q19/08
View Patent ↗
Loading inventors, assignments & file history…
Abstract
The topical cosmetic compositions and methods of the subject invention can be used to treat and/or prevent a variety of skin conditions, including, for example, age spots, acne, scars, body odor, aging-related conditions (e.g., wrinkles, looseness and dryness), and scalp issues (e.g., dandruff, seborrheic dermatitis and hair loss). In preferred embodiments, the compositions according to the subject invention comprise biological amphiphilic molecules produced by microorganisms.
Claims (6)
1 . A method for treating a skin condition, wherein the method comprises applying a topical composition to human skin having said skin condition, wherein:
said skin condition is acne; and
the topical composition comprises a broth resulting from cultivation of a Bacillus amyloliquefaciens bacterium, and further comprising a mannosylerythritol lipid and a sophorolipid, wherein the composition is applied to skin in an amount from about 0.1 to about 10 mg/cm 2 , or the composition comprises the sophorolipid in an amount of about 0.1% to 1% by weight and the mannosylerythritol lipid in an amount of about 0.5% to 2.0% by weight.
2 . The method of claim 1 , wherein the topical composition further comprises resveratrol, hyaluronic acid and/or polyacrylic acid.
3 . The method of claim 1 , wherein the topical composition is formulated as a liquid, cream, gel, ointment, lotion, or spray.
4 . The method of claim 1 , wherein the topical composition is formulated as a cream.
Assignments (8)
RELEASE OF SECURITY INTEREST
Recorded Nov 18, 2024
From: U.S. BANK TRUST COMPANY
To: LOCUS SOLUTIONS, LLC; LOCUS MANAGEMENT GP, INC.; LOCUS MANAGEMENT, LLC; LOCUS IP COMPANY, LLC; LOCUS OIL HOLDING, LLC,; LOCUS BIO-ENERGY SOLUTIONS, LLC; LOCUS OIL IP COMPANY, LLC; LOCUS AGRICULTURE HOLDING, LLC; LOCUS AGRICULTURAL SOLUTIONS, LLC; LOCUS AGRICULTURE IP COMPANY, LLC,; LOCUS SOLUTIONS IPCO, LLC; LOCUS SOLUTIONS IPHOLDCO, LLC; LOCUS CONSUMER BRANDS HOLDING, LLC; ARCTIVA WELLNESS, LLC
Reel/Frame 069386/0272 →
SECURITY INTEREST
Recorded Nov 11, 2024
From: LOCUS SOLUTIONS IPCO, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 069333/0911 →
RELEASE OF SECURITY INTEREST
Recorded Oct 30, 2024
From: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 069273/0361 →
SECURITY INTEREST
Recorded Dec 8, 2023
From: LOCUS SOLUTIONS IPCO, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS THE COLLATERAL AGENT
Reel/Frame 065836/0868 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 17, 2023
From: LOCUS IP COMPANY, LLC
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 065615/0905 →
SECURITY INTEREST
Recorded Dec 7, 2022
From: LOCUS SOLUTIONS, LLC; LOCUS MANAGEMENT GP, INC.; LOCUS MANAGEMENT, LLC; LOCUS IP COMPANY, LLC; LOCUS OIL HOLDING, LLC; LOCUS BIO-ENERGY SOLUTIONS, LLC; LOCUS OIL IP COMPANY, LLC; LOCUS AGRICULTURE HOLDING, LLC; LOCUS AGRICULTURAL SOLUTIONS, LLC; LOCUS AGRICULTURE IP COMPANY, LLC; LOCUS SOLUTIONS IPCO, LLC; LOCUS SOLUTIONS IPHOLDCO, LLC; LOCUS CONSUMER BRANDS HOLDING, LLC; ARCTIVA WELLNESS, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 062079/0829 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 3, 2022
From: LOCUS IP COMPANY, LLC
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 062054/0132 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 8, 2022
From: FARMER, SEAN; ALIBEK, KEN
To: LOCUS IP COMPANY, LLC
Reel/Frame 060132/0281 →
Continuity (4)
Provisional Application
62502714
· May 7, 2017
Provisional Application
62537057
· Jul 26, 2017
Related Publication
20220304920A1
· Sep 29, 2022
References Cited (91)
US 4902512A
· Ishigami et al.
· 1990
[cited by applicant]
US 5756471A
· Hillion et al.
· 1998
[cited by applicant]
US 5981497A
· Maingault
· 1999
[cited by applicant]
US 6057302A
· Borzeix
· 2000
[cited by applicant]
US 6403108B1
· Abdullah
· 2002
[cited by applicant]
US 6509021B1
· Weiss et al.
· 2003
[cited by applicant]
US 20030050277A1
· Kajimoto et al.
· 2003
[cited by applicant]
US 20080187593A1
· Bluth
· 2008
[cited by examiner]
US 20080311234A1
· Yoneda et al.
· 2008
[cited by applicant]
US 20090029879A1
· Soni et al.
· 2009
[cited by applicant]
US 20090203649A1
· Kato et al.
· 2009
[cited by applicant]
US 20100004472A1
· Kitagawa et al.
· 2010
[cited by applicant]
US 20100143316A1
· Hsieh et al.
· 2010
[cited by applicant]
US 20100168405A1
· Suzuki
· 2010
[cited by examiner]
US 20100267684A1
· Seong et al.
· 2010
[cited by applicant]
US 20110044972A1
· Fieldhouse et al.
· 2011
[cited by applicant]
US 20110257116A1
· Kitagawa
· 2011
[cited by examiner]
US 20120039853A1
· Corveleyn et al.
· 2012
[cited by applicant]
US 20130331466A1
· Gross et al.
· 2013
[cited by applicant]
US 20140127257A1
· Schiemann et al.
· 2014
[cited by applicant]
US 20140296168A1
· Schilling et al.
· 2014
[cited by applicant]
US 20140323757A1
· Kim
· 2014
[cited by applicant]
US 20140364381A1
· Ju et al.
· 2014
[cited by applicant]
US 20150037302A1
· Bralkowski et al.
· 2015
[cited by applicant]
US 20150044317A1
· Farmer
· 2015
[cited by examiner]
US 20150045290A1
· Coutte
· 2015
[cited by examiner]
US 20160083757A1
· Fonesca et al.
· 2016
[cited by applicant]
US 20160199530A1
· Ploger et al.
· 2016
[cited by applicant]
US 20160213757A1
· Edelson et al.
· 2016
[cited by applicant]
US 20160235661A1
· Changoer et al.
· 2016
[cited by applicant]
US 20160324747A1
· Ito et al.
· 2016
[cited by applicant]
US 20160375071A1
· Figueroa et al.
· 2016
[cited by applicant]
US 20170071842A1
· Schelges et al.
· 2017
[cited by applicant]
US 20170119638A1
· Kondo et al.
· 2017
[cited by applicant]
US 20180264051A1
· Prabhune et al.
· 2018
[cited by applicant]
US 20190231668A1
· Yoo et al.
· 2019
[cited by applicant]
US 20190307788A1
· Wakayama
· 2019
[cited by applicant]
CN 102078282A
· 2011
[cited by applicant]
CN 103800224A
· 2014
[cited by applicant]
CN 104232528A
· 2014
[cited by examiner]
EP 0540074A1
· 1993
[cited by applicant]
EP 1228752A2
· 2002
[cited by applicant]
EP 1964546A1
· 2008
[cited by applicant]
EP 2931237B1
· 2018
[cited by applicant]
JP H10501260A
· 1998
[cited by applicant]
JP 11512092A
· 1999
[cited by applicant]
JP 2003113040A
· 2003
[cited by applicant]
JP 2005306863A
· 2005
[cited by applicant]
JP 2008044855A
· 2008
[cited by applicant]
JP 2009029788A
· 2009
[cited by applicant]
JP 2009149566A
· 2009
[cited by applicant]
KR 20110012699A
· 2011
[cited by applicant]
KR 101485896B1
· 2015
[cited by examiner]
WO 2004020647A1
· 2004
[cited by applicant]
WO 2007060956A1
· 2007
[cited by applicant]
WO 2011127101A1
· 2011
[cited by applicant]
WO 2012010407A1
· 2012
[cited by applicant]
WO 2013092421A1
· 2013
[cited by applicant]
WO 2014095367A1
· 2014
[cited by applicant]
WO 2015034007A1
· 2015
[cited by applicant]
WO 2015153476A1
· 2015
[cited by applicant]
WO 2017044953A1
· 2017
[cited by applicant]
WO 2017051433A1
· 2017
[cited by applicant]
WO 2018049182A2
· 2018
[cited by applicant]
WO 2018129299A1
· 2018
[cited by applicant]
WO 2019022997A1
· 2019
[cited by applicant]
English translation for KR10-2011-0012699 A (Year: 2011).
[cited by examiner]
Ishii et al (abstract for “Transdermal administration of lactoferrin with sophorolipid”, Biochemistry and Cell Biology, vol. 90 (3) (2012), p. 504-512) (Year: 2012).
[cited by examiner]
Morita et al (“Mannosylerythritol Lipids: Production and Applications”, Journal of Oleo Science, vol. 64(2), p. 133-141 (2015)) (Year: 2015).
[cited by examiner]
English translation for KR10-1485896 B1 (2015).
[cited by examiner]
English translation for CN 104232528A (Year: 2014).
[cited by examiner]
De Brito, D., Biosurfactants from renewable raw materials, Universidade do Minho Departamento de Engenharia Biologica, Nov. 2013, pp. 1-93.
[cited by applicant]
De Oliveira, M., et al., “Review: Sophorolipids A Promising Biosurfactant and it's Applications.” International Journal of Advanced Biotechnology and Research, 2015, 6(2): pp. 161-174.
[cited by applicant]
Gharaei-Fathabad, E., “Biosurfactants in Pharmaceutical Industry (A Mini-Review).” American Journal of Drug Discovery and Development, 2010, 1(1): pp. 58-69.
[cited by applicant]
Kurtzman, C.P., et al., “Production of sophorolipid biosurfactants by multiple species of the Starmerella (Candida) bombicolayeast clade.” FEMS Microbiol Lett, 2010, 311: pp. 140-146.
[cited by applicant]
Nitschke, M., et al., “Production and properties of a surfactant obtained from Bacillus subtilis grown on cassava wastewater.” Bioresource Technology, 2006, 97: pp. 336-341.
[cited by applicant]
Santos, D.K.F., et al., “Biosurfactants: Multifunctional Biomolecules of the 21st Century.” International Journal of Molecular Sciences, 2016, 17(401): pp. 1-31.
[cited by applicant]
Sen, R., “Biosurfactants: Advances in Experimental Medicine and Biology.” Landes Bioscience and Springer Science +Business Media, LLC, 2010, 672: pp. 1-331.
[cited by applicant]
Sharma, A. et al., “A study on biosurfactant production in Lactobacillus and
[cited by applicant]
Shen, C., et al., “Targeted killing of myofibroblasts by biosurfactant di-rhamnolipid suggests a therapy against scar formation.” Scientific Reports, 2016, 6: 37553, pp. 1-10.
[cited by applicant]
Silva, R., et al., “Applications of Biosurfactants in the Petroleum Industry and the Remediation of Oil Spills.” International Journal of Molecular Sciences, 2014, 15: pp. 12523-12542.
[cited by applicant]
Takahashi, M., et al., “Production of Sophorolipid Glycolipid Biosurfactants from Sugarcane Molasses Using Starmerella bombicola NBRC 10243.” Journal of Oleo Science, 2011, 60(5): pp. 267-273.
[cited by applicant]
Torres Faria, N., et al., “Production of glycolipid biosurfactants, mannosylerythritol lipids, from pentoses and D-glucose/D-xylose mixtures by
[cited by applicant]
Bhadoriya, S.S., et al., “Biosurfactants: A New Pharmaceutical Additive for Solubility Enhancement and Pharmaceutical Development.” Biochem Pharmacol, 2013, 2(2): 1000113, pp. 1-5.
[cited by applicant]
Imura, T., et al., “Spontaneous Vesicle Formation from Sodium Salt of Acidic Sophorolipid and Its Application as a Skin Penetration Enhancer.” Journal of Oleo Science, 2014, 63(2): 141-147.
[cited by applicant]
Ines, M., et al., “Glycolipids biosurfactants; Potential related Biomedical and Biotechnical Applications.” Carbohydrate Research, 2015, 416: 59-69.
[cited by applicant]
Kim, K., et al. “Characteristics of Sophorolipid as an Antimicrobial Agent.” J. Microbiol. Biotechnol., 2002, 12(2): 235-241.
[cited by applicant]
Kitamoto, D., et al., “Self-assembling properties of glycolipid biosurfactants and their potential applications.” Current Opinion in Colloid & Interface Science, 2009, 14: 315-328.
[cited by applicant]
Office Action issued in Canadian Patent Application No. 3,062,432, dated Jun. 17, 2025.
[cited by applicant]