MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS
Synthetic cannabinoid medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The synthetic cannabinoid composition/carrier combinations can create administration benefits.
1 .- 37 . (canceled)
38 . A method of providing increased bioavailability within a subject of a synthetic cannabinoid with an aqueous solubility of less than 0.1 mg/ml, the method comprising:
administering an effective amount of a solution to the subject, wherein the solution consists of:
aqueous ethanol;
the synthetic cannabinoid with the aqueous solubility of less than 0.1 mg/ml; and
an N-acylated fatty amino acid or a salt thereof comprising the formula:
wherein X and Z are independently hydrogen, a monovalent cation, a divalent metal cation, or an organic cation,
thereby providing the increased bioavailability of the synthetic cannabinoid within the subject, when compared to the same solution without the added N-acylated fatty amino acid.
39 . The method of claim 38 , wherein the synthetic cannabinoid comprises nabilone.
40 . A solution consisting of:
aqueous ethanol;
a synthetic cannabinoid or a salt thereof having a water solubility of less than 0.1 mg/ml; and
an N-acylated fatty amino acid or a salt thereof having the formula:
wherein X and Z are independently hydrogen, a monovalent cation, a divalent metal cation, or an organic cation, and
wherein the solution increases bioavailability of the synthetic cannabinoid or the salt thereof following administration to a subject as compared to the solution consisting of the synthetic cannabinoid or the salt thereof but lacking the N-acylated fatty amino acid or the salt thereof.
41 . The composition of claim 40 , wherein the N-acylated fatty amino acid or the salt thereof is N-[8-(2-hydroxybenzoyl) amino] caprylate.
42 . The composition of claim 41 , wherein the composition comprises 100-200 mg N-[8-(2-hydroxybenzoyl) amino] caprylate.
43 . The composition of claim 40 , further comprising:
at least one of a flavonoid compound, a terpene, or a terpenoid.
44 . The composition of claim 40 , wherein X is hydrogen, sodium, potassium, calcium, magnesium, ammonium or tetramethylammonium.
45 . The composition of claim 40 , wherein Z is hydrogen, sodium, potassium, calcium or magnesium.
46 . The composition of claim 40 , wherein X is hydrogen and Z is hydrogen.
47 . The composition of claim 40 , wherein X is hydrogen and Z is sodium.
48 . The composition of claim 40 , wherein X is sodium and Z is sodium.
49 . The composition of claim 40 , wherein the N-acylated fatty amino acid or the salt thereof and the synthetic cannabinoid or the salt thereof are present at a weight ratio of between 1:1 and 100:1.
50 . The composition of claim 40 , wherein the synthetic cannabinoid or the salt thereof is nabilone.
51 . A composition formulated for oral delivery, the composition comprising:
aqueous ethanol;
a synthetic cannabinoid or a salt thereof having a water solubility of less than 0.1 mg/ml; and
an absorption enhancer consisting of an N-acylated fatty amino acid or a salt thereof having the formula:
wherein X and Z are independently hydrogen, a monovalent cation, a divalent metal cation, or an organic cation; and
one or more excipients dispersing agents and/or suspending agents.
52 . The composition of claim 51 , wherein the N-acylated fatty amino acid or the salt thereof is N-[8-(2-hydroxybenzoyl) amino] caprylate.
53 . The composition of claim 52 , wherein the amount of the absorption enhancer is 100-200 mg N-[8-(2-hydroxybenzoyl) amino] caprylate.
54 . The composition of claim 51 , wherein X is hydrogen, sodium, potassium, calcium, magnesium, ammonium or tetramethylammonium.
55 . The composition of claim 51 , wherein Z is hydrogen, sodium, potassium, calcium or magnesium.
56 . The composition of claim 51 , wherein the N-acylated fatty amino acid or the salt thereof and the synthetic cannabinoid or the salt thereof are present at a weight ratio of between 1:1 and 100:1.
57 . The composition of claim 51 , wherein the synthetic cannabinoid or the salt thereof is nabilone.