Diffractive contact lenses
The invention provides a delamination-resistant embedded silicone hydrogel contact lens having an insert that is embedded in a silicone hydrogel bulk material. The insert is made of a crosslinked polymeric material having a refractive index higher than that of the silicone hydrogel bulk material by at least 0.07 and comprises a diffractive structure disposed on one of the front and back curve surfaces of the insert for providing a diffractive power that contributes to the overall optical power of the contact lens.
1. An embedded silicone hydrogel contact lens, comprising:
a silicone hydrogel bulk material and an insert embedded therein,
wherein the insert is made of a crosslinked polymeric material having a first refractive index, wherein the silicone hydrogel bulk material has a second refractive index, wherein the first refractive index is at least 0.07 higher than the second refractive index,
wherein the insert has a front curve surface, an opposite back curve surface and a diameter of less than 13.0 mm, wherein the insert is located in a central portion of the embedded hydrogel contact lens and comprises a diffractive structure disposed on one of the front and back curve surfaces for providing a diffractive power that contributes to the overall optical power of the contact lens, wherein the diffractive structure is buried inside the silicone hydrogel bulk material,
wherein the embedded silicone hydrogel contact lens is not susceptible to delamination as demonstrated by being free of bubble when being inspected under microscopy at interfaces between the insert and the silicone hydrogel bulk material within the embedded silicone hydrogel contact lens after being autoclaved in a packaging solution in a sealed package for about 45 minutes at 121° C., wherein the packaging solution is a phosphate buffered saline having a pH of 7.1±0.2.
2. The embedded silicone hydrogel contact lens of claim 1 , wherein the crosslinked polymeric material of the insert has a refractive index of at least about 1.47 and/or an oxygen permeability of at least about 40 barrers, wherein the crosslinked polymeric material of the insert comprises at least 50% by mole of repeating units (acrylic repeating units) of one or more acrylic monomers and/or crosslinkers.
3. The embedded silicone hydrogel contact lens of claim 2 , wherein the crosslinked polymeric material of the insert comprises repeating units of at least one aryl vinylic monomer and/or repeating units of at least one aryl vinylic crosslinker.
4. The embedded silicone hydrogel contact lens of claim 3 , wherein said at least one aryl vinylic monomer comprises: 2-ethylphenoxy acrylate; 2-ethylphenoxy methacrylate; phenyl acrylate; phenyl methacrylate; benzyl acrylate; benzyl methacrylate; 2-phenylethyl acrylate; 2-phenylethyl methacrylate; 3-phenylpropyl acrylate; 3-phenylpropyl methacrylate; 4-phenylbutyl acrylate; 4-phenylbutyl methacrylate; 4-methylphenyl acrylate; 4-methylphenyl methacrylate; 4-methylbenzyl acrylate; 4-methylbenzyl methacrylate; 2-(2-methylphenyl)ethyl acrylate; 2-(2-methylphenyl)ethyl methacrylate; 2-(3-methylphenyl)ethyl acrylate; 2-(3-methylphenyl)ethyl methacrylate; 2-(4-methylphenyl)ethyl acrylate; 2-(4-methylphenyl)ethyl methacrylate; 2-(4-propylphenyl)ethyl acrylate; 2-(4-propylphenyl)ethyl methacrylate; 2-(4-(1-methylethyl)phenyl)ethyl acrylate; 2-(4-(1-methylethyl)phenyl)ethyl methacrylate; 2-(4-methoxyphenyl)ethyl acrylate; 2-(4-methoxyphenyl)ethyl methacrylate; 2-(4-cyclohexylphenyl)ethyl acrylate; 2-(4-cyclohexylphenyl)ethyl methacrylate; 2-(2-chlorophenyl)ethyl acrylate; 2-(2-chlorophenyl)ethyl methacrylate; 2-(3-chlorophenyl)ethyl acrylate; 2-(3-chlorophenyl)ethyl methacrylate; 2-(4-chlorophenyl)ethyl acrylate; 2-(4-chlorophenyl)ethyl methacrylate; 2-(4-bromophenyl)ethyl acrylate; 2-(4-bromophenyl)ethyl methacrylate; 2-(3-phenylphenyl)ethyl acrylate; 2-(3-phenylphenyl)ethyl methacrylate; 2-(4-phenylphenyl)ethyl acrylate; 2-(4-phenylphenyl)ethyl methacrylate; 2-(4-benzylphenyl)ethyl acrylate; 2-(4-benzylphenyl)ethyl methacrylate; 2-(phenylthio)ethyl acrylate; 2-(phenylthio)ethyl methacrylate; 2-benzyloxyethyl acrylate; 3-benzyloxypropyl acrylate; 2-benzyloxyethyl methacrylate; 3-benzyloxypropyl methacrylate; 2-[2-(benzyloxy)ethoxy]ethyl acrylate; 2-[2-(benzyloxy)ethoxy]ethyl methacrylate; styrene, 2,5-dimethylstyrene, 2-(trifluoromethyl)styrene, 2-chlorostyrene, 3,4-dimethoxystyrene, 3-chlorostyrene, 3-bromostyrene, 3-vinylanisole, 3-methylstyrene, 4-bromostyrene, 4-tert-butylstyrene, p-styryltrimethoxysilane, styrylethyltrimethoxysilane, 2,3,4,5,6-pentanfluorostyrene, 2,4-dimethylstyrene, 1-methoxy-4-vinylbenzene, 1-chloro-4-vinylbenzene, 1-methyl-4-vinylbenzene, 1-(chloromethyl)-4-vinylbenzene, 1-(bromomethyl)-4-vinylbenzene, 3-nitrostyrene, 1,2-vinyl phenyl benzene, 1,3-vinyl phenyl benzene, 1,4-vinyl phenyl benzene, 4-vinyl-1,1′-(4′-phenyl)biphenylene, 1-vinyl-4-(phenyloxy)benzene, 1-vinyl-3-(phenyloxy)benzene, 1-vinyl-2-(phenyloxy)benzene, 1-vinyl-4-(phenyl carbonyl)benzene, 1-vinyl-3-(phenylcarboxy)benzene, 1-vinyl-2-(phenoxycarbonyl)benzene, allyl phenyl ether, 2-biphenylylallyl ether, allyl 4-phenoxyphenyl ether, allyl 2,4,6-tribromophenyl ether, allyl phenyl carbonate, 1-allyloxy-2-trifluoromethylbenzene, allylbenzene, 1-phenyl-2-prop-2-enylbenzene, 4-phenyl-1-butene, 4-phenyl-1-butene-4-ol, 1-(4-methylphenyl)-3-buten-1-ol, 1-(4-chlorophenyl)-3-buten-1-ol, 4-allyltoluene, 1-allyl-4-fluorobenzene, 1-allyl-2-methylbenzene, 1-allyl-3-methylbenzene, 1-allyl-3-methylbenzene, 2-allylanisole, 4-allylanisole, 1-allyl-4-(trifluromethyl)benzene, allylpentafluorobenzene, 1-allyl-2-methoxybenzene, 4-allyl-1,2-dimethoxybenzene, 2-allylphenol, 2-allyl-6-methylphenol, 4-allyl-2-methoxyphenol, 2-allyloxyanisole, 4-allyl-2-methoxyphenyl acetate, 2-allyl-6-methoxyphenol, 1-allyl-2-bromobezene, alpha-vinylbenzyl alcohol, 1-phenyl-3-butene-1-one, allylbenzyl ether, (3-allyloxy)propyl)benzene, allyl phenylethyl ether, 1-benzyloxy-4-pentene, (1-allyloxy)ethyl)benzene, 1-phenylallyl ethyl ether, (2-methyl-2-(2-propenyloxy)propyl)benzene, ((5-hexenyloxy)methyl)benzene, 1-allyloxy-4-propoxybenzene, 1-phenoxy-4-(3-prop-2-enoxypropoxy)benzene, 6-(4′-Hydroxyphenoxy)-1-Hexene, 4-but-3-enoxyphenol, 1-allyloxy-4-butoxybenzene, 1-allyloxy-4-ethoxybenzene, 1-allyl-4-benzyloxybenzene, 1-allyl-4-(phenoxy)benzene, 1-allyl-3-(phenoxy)benzene, 1-allyl-2-(phenoxy)benzene, 1-allyl-4-(phenyl carbonyl)benzene, 1-allyl-3-(phenyl carboxy)benzene, 1-allyl-2-(phenoxycarbonyl)benzene, 1,2-allyl phenyl benzene, 1,3-allyl phenyl benzene, 1,4-allyl phenyl benzene, 4-vinyl-1,1′-(4′-phenyl)biphenylene, 1-allyl-4-(phenyloxy)benzene, 1-allyl-3-(phenyloxy)benzene, 1-allyl-2-(phenyloxy)benzene, 1-allyl-4-(phenyl carbonyl)benzene, 1-allyl-3-(phenyl carboxy)benzene, and 1-allyl-2-(phenoxycarbonyl)benzene, 1-vinyl naphthylene, 2-vinyl naphthylene, 1-allyl naphthalene, 2-allyl naphthalene, allyl-2-naphthyl ether, 2-(2-methylprop-2-enyl)naphthalene, 2-prop-2-enylnaphthalene, 4-(2-naphthyl)-1-butene, 1-(3-butenyl)naphthalene, 1-allyl naphthalene, 2-allyl naphthalene, 1-allyl-4-napthyl naphthalene, 2-(allyloxy)-1-bromonaphthalene, 2-bromo-6-allyloxynaphthalene, 1,2-vinyl(1-naphthyl)benzene, 1,2-vinyl(2-naphthyl)benzene, 1,3-vinyl(1-naphthyl)benzene, 1,3-vinyl(2-naphthyl)benzene, 1,4-vinyl(1-naphthyl)benzene, 1,4-vinyl(2-naphthyl)benzene, 1-naphthyl-4-vinyl naphthalene, 1-allyl naphthalene, 2-allyl naphthalene, 1,2-allyl(1-naphthyl) benzene, 1,2-allyl(2-naphthyl)benzene, 1,3-allyl(1-naphthyl)benzene, 1,3-allyl(2-naphthyl)benzene, 1,4-allyl(1-naphthyl)benzene, 1,4-allyl(2-naphthyl)benzene, 1-allyl-4-napthyl naphthalene, 1-vinyl anthracene, 2-vinyl anthracene, 9-vinyl anthracene, 1-allyl anthracene, 2-allyl anthracene, 9-allyl anthracene, 9-pent-4-enylanthracene, 9-allyl-1,2,3,4-tetrachloroanthracene, 1-vinyl phenanthrene, 2-vinyl phenanthrene, 3-vinyl phenanthrene, 4-vinyl phenanthrene, 9-vinyl phenanthrene, 1-allyl phenanthrene, 2-allyl phenanthrene, 3-allyl phenanthrene, 4-allyl phenanthrene, 9-allyl phenanthrene, or a combination thereof; wherein said at least one aryl vinylic crosslinker comprises divinylbenzene, 2-methyl-1,4-divinylbenzene, bis(4-vinylphenyl)methane, 1,2-bis(4-vinylphenyl)ethane, 1,4-diisopropenylbenzene, 1,2-bis(4-vinylphenyl)-1,2-ethanediol, 1,3-bis-methacryloyloxy-benzene, 1,4-phenylene dimethacrylate, bisphenol A dimethacrylate, bisphenol A glycerolate dimethacrylate, 2,5-bis{[2-(methacryloyloxy)ethoxy]carbonyl}-terephthalic acid, 4-(methacryloyloxy)styrene, 2-[2-(benzyloxy)ethoxy]ethyl acrylate; 2-[2-(benzyloxy)ethoxy]ethyl methacrylate, or a combination thereof.
5. The embedded silicone hydrogel contact lens of claim 2 , wherein the crosslinked polymeric material of the insert comprises repeating units of a high RI polydiorganosiloxane vinylic crosslinker that comprises: (1) a polydiorganosiloxane segment comprising aryl-containing siloxane units each having an organic substituent having up to 45 carbon atoms and at least one aryl moiety linked to Si atom through a linker having at least 2 carbon atoms; and (2) ethylenically-unsaturated groups.
6. The embedded silicone hydrogel contact lens of claim 5 , wherein the polydiorganosiloxane segment comprises at least 30% by mole of the aryl-containing siloxane units, wherein the polysiloxane vinylic crosslinker has a number average molecular weight of at least 1000 Daltons.
7. The embedded silicone hydrogel contact lens of claim 5 , wherein the polydiorganosiloxane vinylic crosslinker is defined by formula (1)
in which:
υ1 is an integer of from 1 to 400;
ω1 is an integer of from 1 to 800;
E 1 is a monovalent radical of
R 0 is hydrogen or methyl;
a1 is zero or 1;
X 0 is O or NR N1 ;
R N1 is hydrogen or a C 1 -C 6 alkyl;
L 0 is a C 2 -C 8 alkylene divalent radical or a divalent radical of
L 0 ′ is a C 2 -C 8 alkylene divalent radical;
L 0 ″ is C 3 -C 8 alkylene divalent radical;
X 1 is —O—, —NR N1 —, —NHCOO—, ˜OCONH—, —CONR N1 —, or —NR N1 CO—;
q1 is an integer of 1 to 10;
AR is an aryl radical;
L AR is a divalent radical of
L e is a divalent radical of
a2 is zero or 1 or 2;
a3 is zero or 1;
R 1 is a linear or branched C 1 -C 10 alkylene divalent radical which is optionally substituted with C 1 -C 4 alkoxy group, hydroxyl group, carboxyl group, amino group, oxo group, or combinations thereof;
R 2 is a linear or branched C 3 -C 10 alkylene divalent radical;
R 3 is a direct bond or a linear or branched C 1 -C 4 alkylene divalent radical;
X AR and each X 2 independently of others are a covalent bond or a covalent linkage of
R N2 is hydrogen, a linear or branched C 1 -C 6 alkyl, cyclohexyl, cyclopentyl, a substituted or unsubstituted phenyl, or a substituted- or unsubstituted-phenyl-C 1 -C 6 alkyl;
each L x independently is a linear or branched C 1 -C 10 alkylene divalent radical which optionally has one or more hydroxyl or C 1 -C 4 -alkoxy groups or C 1 -C 4 -acylamino groups,
or a divalent radical which optionally has one or more hydroxyl or C 1 -C 4 -alkoxy groups and is obtained by removal of two hydrogen atoms from two different atoms of a hydrocarbon that has up to 20 carbon atoms and comprises at least one divalent radical selected from the group consisting of cycloalkylene radical, substituted cycloalkylene radical, phenylene radical, substituted phenylene radical, cycloheteroalkylene radical, and substituted cycloheteroalkylene radical; and
each R 4 , R 5 and R 6 independent of one another are a linear or branched C 1 -C 10 alkylene divalent radical which has zero or one hydroxyl group.
8. The embedded silicone hydrogel contact lens of claim 7 , wherein in formula (1) a1 is zero and X 0 is O or NR N1 .
9. The embedded silicone hydrogel contact lens of claim 8 , wherein in formula (1) ω1/(υ1+ω1) is from about 0.30 to about 0.95.
10. The embedded silicone hydrogel contact lens of claim 9 , wherein in formula (1) AR is a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group, an anthracenyl group, a substituted anthracenyl group, a phenanthryl group, or a substituted phenanthryl group.
11. The embedded silicone hydrogel contact lens of claim 9 , wherein in formula (1) AR is a monovalent radical of
which R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , and R 13 independent of one another are H, Cl, Br, F, CF 3 , CCl 3 , C 1 -C 5 alkyl, C 1 -C 5 alkoxy, C 2 -C 5 acyloxy, OH, phenyl, phenoxy, benzyloxy, phenylcarbonyl, phenoxycarbonyl, phenylcarboxy (phenylcarbonyloxy), or naphthyl.
12. The embedded silicone hydrogel contact lens of claim 10 , wherein the crosslinked polymeric material of the insert further comprises: (a) repeating units of at least one first hydrophobic non-silicone vinylic monomer; (b) repeating units of at least one first non-silicone vinylic crosslinker; (c) repeating units of at least one first polymerizable material selected from the group consisting of a first UV-absorbing vinylic monomer, a first UV/high-energy-violet-light (“HEVL”) absorbing vinylic monomer, a first polymerizable photochromic compound, a first polymerizable tinting agent, and combinations thereof; or (d) combinations thereof.
13. The embedded silicone hydrogel contact lens of claim 10 , wherein the silicone hydrogel bulk material comprises (1) repeating units of at least one silicone-containing polymerizable component that comprises at least 0.5 meq/g of H-bond donors and (2) repeating units of at least one hydrophilic vinylic monomer.
14. The embedded silicone hydrogel contact lens of claim 13 , wherein the silicone-containing polymerizable component comprises a first silicone-containing vinylic monomer, a first silicone-containing vinylic crosslinker, or both, wherein the first silicone-containing vinylic monomer selected from the group consisting of [3-(meth)acryloxy-2-hydroxypropyloxy]propyl-bis(trimethylsiloxy)methylsilane, [3-(meth)acryloxy-2-hydroxypropyloxy]propyl-bis(trimethylsiloxy)butylsilane, 3-(meth)acryloxy-2-(2-hydroxyethoxy)-propyloxy)-propylbis(trimethylsiloxy)methylsilane, 3-(meth)acryloxy-2-hydroxypropyloxy)propyl-tris(trimethylsiloxy)silane, N-[tris(trimethylsiloxy)silylpropyl]-(meth)acrylamide, N-(2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl)-2-methyl (meth)acrylamide, N-(2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)-propyl) (meth)acrylamide, N-(2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl)-2-methyl acrylamide, N-(2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl) (meth)acrylamide, N-[tris(dimethylpropylsiloxy)silylpropyl]-(meth)acrylamide, N-[tris(dimethylphenylsiloxy)-silylpropyl] (meth)acrylamide, N-[tris(dimethylethylsiloxy)-silylpropyl] (meth)acrylamide, N,N-bis[2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)-propyloxy)propyl]-2-methyl (meth)acrylamide, N,N-bis[2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)-propyl] (meth)acrylamide, N,N-bis[2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)-propyl]-2-methyl (meth)acrylamide, N,N-bis[2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)-propyloxy)propyl] (meth)acrylamide, N-[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)-propyl]-2-methyl (meth)acrylamide, N-[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)-propyl] (meth)acrylamide, N,N-bis[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]-2-methyl (meth)acrylamide, N-2-(meth)acryloxyethyl-O-(methyl-bis-trimethylsiloxy-3-propyl)silyl carbamate, 3-[tris(trimethylsiloxy)silyl]propylvinyl carbamate, 3-[tris(trimethylsiloxy)silyl] propyl allyl carbamate, α-(meth)acryloxy-terminated ω-C 1 -C 6 -hydroxyalkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-(meth)acrylamido-terminated ω-C 1 -C 6 -hydroxyalkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-(meth)acryloxy-2-hydroxypropyloxypropyl terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-(2-hydroxyl-methacryloxypropyloxypropyl)-ω-C 1 -C 4 -alkyl-decamethylpentasiloxane, α-[3-(meth)acryloxyethoxy-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acryloxy-propyloxy-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acryloxyisopropyloxy-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxane having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acryloxybutyloxy-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acryloxyethylamino-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acryloxypropylamino-2-hydroxypropyloxy-propyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acryloxy-butylamino-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-(meth)acryloxy-(polyethylenoxy)-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[(meth)acryloxy-2-hydroxypropyloxy-ethoxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[(meth)acryloxy-2-hydroxypropyl-N-ethylaminopropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[(meth)acryloxy-2-hydroxypropyl-aminopropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[(meth)acryloxy-2-hydroxypropyloxy-(polyethylenoxy)propyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-(meth)acrylamidopropyloxypropyl terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acrylamidoethoxy-2-hydroxypropyloxy-propyl]-terminated ω-C 1 -C 4 -alkyl polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acrylamidopropyloxy-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acrylamidoisopropyloxy-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acrylamidobutyloxy-2-hydroxypropyloxypropyl]-terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-(meth)acrylamido-2-hydroxypropyloxypropyl] terminated ω-C 1 -C 4 -alkyl polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, α-[3-[N-methyl-(meth)acrylamido]-2-hydroxypropyloxypropyl] terminated ω-C 1 -C 4 -alkyl terminated polydimethylsiloxanes having a number average molecular weight of 2000 daltons or less, N-(2,3-dihydroxypropane)-N′-(propyltetra(dimethylsiloxy)-dimethylbutylsilane) (meth)acrylamide, (meth)acrylamidopropyltetra(dimethylsiloxy)-dimethylbutylsilane, α-vinyl carbonate-terminated ω-C 1 -C 4 -alkyl-terminated polydimethylsiloxanes, α-vinyl carbamate-terminated ω-C 1 -C 4 -alkyl-terminated polydimethylsiloxane, and combinations thereof, wherein the first silicone-containing vinylic crosslinker selected from the group consisting of di-(meth)acrylamido-terminated polysiloxane vinylic crosslinkers having a number average molecular weight of 4000 Daltons or less, α,ω-bis[3-(meth)acryloxy-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[3-(meth)acryloxyethoxy-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[3-(meth)acryloxypropyloxy-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[3-(meth)acryloxy-isopropyloxy-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[3-(meth)acryloxybutyloxy-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[3-(meth)acrylamidoethoxy-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 8000 Daltons or less, α,ω-bis[3-(meth)acrylamidopropyloxy-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 8000 Daltons or less, α,ω-bis[3-(meth)acrylamidoisopropyloxy-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[3-(meth)acrylamidobutyloxy-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 8000 Daltons or less, α,ω-bis[3-(meth)acryloxyethylamino-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 8000 Daltons or less, α,ω-bis[3-(meth)acryloxypropylamino-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 8000 Daltons or less, α,ω-bis[3-(meth)acryloxybutylamino-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 8000 Daltons or less, α,ω-bis[(meth)acrylamidoethylamino-2-hydroxypropyloxy-propyl]-terminated polydimethylsiloxanes having a number average molecular weight of 12000 Daltons or less, α,ω-bis[3-(meth)acrylamidopropylamino-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[3-(meth)acrylamide-butylamino-2-hydroxypropyloxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[(meth)acryloxy-2-hydroxypropyloxy-ethoxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[(meth)acryloxy-2-hydroxypropyl-N-ethylaminopropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 12000 Daltons or less, α,ω-bis[(meth)acryloxy-2-hydroxypropyl-aminopropyl]-polydimethylsiloxanes having a number average molecular weight of 8000 Daltons or less, α,ω-bis[(meth)acryloxy-2-hydroxypropyloxy-(polyethylenoxy)propyl]-terminated polydimethylsiloxane having a number average molecular weight of 4000 Daltons or less, α,ω-bis[(meth)acryloxyethyl-amino-carbonyloxy-ethoxypropyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, α,ω-bis[(meth)acryloxyethylamino-carbonyloxy-(polyethylenoxy)propyl]-terminated polydimethylsiloxanes having a number average molecular weight of 4000 Daltons or less, di-(meth)acryloyloxy-terminated or di-(meth)acrylamido-terminated chain-extended polysiloxane vinylic crosslinkers each of which comprises at least two polysiloxane segments and linkages between each pair of polysiloxane segments and between one (meth)acryloyloxy group and one polysiloxane segment and each linkage has at least one H-bond donor, a polysiloxane vinylic crosslinkers having dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C 4 -C 40 organic radical substituent having at least one H-bond donor (preferably 2 to 6 hydroxyl groups), and combinations thereof.
15. The embedded silicone hydrogel contact lens of claim 13 , wherein the silicone-containing polymerizable component comprises a first silicone-containing vinylic crosslinker that comprises at least two urethane linkages (—O—CO—NH—), at least two urea linkages (—NH—CO—NH—), at least two hydroxyl groups, or combinations thereof.
16. The embedded silicone hydrogel contact lens of claim 13 , wherein said at least one hydrophilic vinylic monomer comprises at least one alkyl (meth)acrylamide, at least one hydroxyl-containing acrylic monomer, at least one amino-containing acrylic monomer, at least one carboxyl-containing acrylic monomer, at least one N-vinyl amide monomer, at least one methylene-containing pyrrolidone monomer, at least one acrylic monomer having a C 1 -C 4 alkoxyethoxy group, at least one vinyl ether monomer, at least one allyl ether monomer, at least one phosphorylcholine-containing vinylic monomer, N-2-hydroxyethyl vinyl carbamate, N-carboxyvinyl-β-alanine (VINAL), N-carboxyvinyl-α-alanine, or combinations thereof.
17. The embedded silicone hydrogel contact lens of claim 13 , wherein the silicone hydrogel bulk material further comprise: repeating units of at least one second silicone-containing vinylic monomer (other than the first silicone-containing vinylic monomer) and/or a second polysiloxane vinylic crosslinker (other than the first polysiloxane vinylic crosslinker); repeating units of at least one second hydrophobic non-silicone vinylic monomer; repeating units of at least one second non-silicone vinylic crosslinkers; repeating units of at least one second polymerizable material selected from the group consisting of a second UV-absorbing vinylic monomer, a second UV/high-energy-violet-light (“HEVL”) absorbing vinylic monomer, a second polymerizable photochromic compound, a second polymerizable tinting agent (polymerizable dye), and combinations thereof; or combinations thereof.
18. The embedded silicone hydrogel contact lens of claim 17 , wherein said at least one first non-silicone vinylic crosslinker and said at least one second non-silicone vinylic crosslinker independent of each other are selected from the group consisting of allyl methacrylate, allyl acrylate, triallyl isocyanurate, 2,4,6-triallyloxy-1,3,5-triazine, 1,2,4-trivinylcyclohexane, ethylene glycol dimethacrylate; ethylene glycol diacrylate; 1,3-propanediol diacrylate; 1,3-propanediol dimethacrylate; 2,3-propanediol diacrylate; 2,3-propanediol dimethacrylate; 1,4-butanediol dimethacrylate; 1,4-butanediol diacrylate; 1,5-pentanediol dimethacrylate; 1,5-pentanediol diacrylate; 1,6-hexanediol dimethacrylate; 1,6-hexanediol diacrylate; diethylene glycol dimethacrylate; diethylene glycol diacrylate; triethylene glycol dimethacrylate; triethylene glycol diacrylate; tetraethylene glycol dimethacrylate; tetraethylene glycol diacrylate; N,N′-methylene bis(acrylamide); N,N′-methylene bis(methacrylamide); N,N′-ethylene bis(acrylamide); N,N′-ethylene bis(methacrylamide); N,N′-hexamethylene bisacrylamide; N,N′-hexamethylene bismethacrylamide; pentaerythritol triacrylate, pentaerythritol trimethacrylate, trimethyloylpropane triacrylate, trimethyloylpropane trimethacrylate, tris(2-hydroxyethyl)isocyanurate triacrylate, tris(2-hydroxyethyl)isocyanurate trimethacrylate, 1,3,5-triacryloxylhexahydro-1,3,5-triazine, 1,3,5-trimethacryloxylhexahydro-1,3,5-triazine; pentaerythritol tetraacrylate, pentaerythritol tetramethacrylate, di(trimethyloylpropane) tetraacrylate, di(trimethyloylpropane) tetramethacrylate, or combinations thereof.
19. The embedded silicone hydrogel contact lens of claim 12 , wherein said at least one first non-silicone vinylic crosslinker and said at least one second non-silicone vinylic crosslinker independent of each other are selected from the group consisting of allyl methacrylate, allyl acrylate, triallyl isocyanurate, 2,4,6-triallyloxy-1,3,5-triazine, 1,2,4-trivinylcyclohexane, ethylene glycol dimethacrylate; ethylene glycol diacrylate; 1,3-propanediol diacrylate; 1,3-propanediol dimethacrylate; 2,3-propanediol diacrylate; 2,3-propanediol dimethacrylate; 1,4-butanediol dimethacrylate; 1,4-butanediol diacrylate; 1,5-pentanediol dimethacrylate; 1,5-pentanediol diacrylate; 1,6-hexanediol dimethacrylate; 1,6-hexanediol diacrylate; diethylene glycol dimethacrylate; diethylene glycol diacrylate; triethylene glycol dimethacrylate; triethylene glycol diacrylate; tetraethylene glycol dimethacrylate; tetraethylene glycol diacrylate; N,N′-methylene bis(acrylamide); N,N′-methylene bis(methacrylamide); N,N′-ethylene bis(acrylamide); N,N′-ethylene bis(methacrylamide); N,N′-hexamethylene bisacrylamide; N,N′-hexamethylene bismethacrylamide; pentaerythritol triacrylate, pentaerythritol trimethacrylate, trimethyloylpropane triacrylate, trimethyloylpropane trimethacrylate, tris(2-hydroxyethyl)isocyanurate triacrylate, tris(2-hydroxyethyl)isocyanurate trimethacrylate, 1,3,5-triacryloxylhexahydro-1,3,5-triazine, 1,3,5-trimethacryloxylhexahydro-1,3,5-triazine; pentaerythritol tetraacrylate, pentaerythritol tetramethacrylate, di(trimethyloylpropane) tetraacrylate, di(trimethyloylpropane) tetramethacrylate, or combinations thereof.