METHODS AND COMPOSITIONS FOR INCREASING CIRCULATION DURING TREATMENT WITH ALTERNATING ELECTRIC FIELDS
Disclosed are methods of increasing blood circulation at a target site of a subject comprising exposing a target site of the subject to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, and exposing the target site of the subject to a vasodilator, wherein the vasodilator increases blood circulation at the target site of the subject. Disclosed are methods of maintaining or decreasing temperature at a target site of a subject comprising exposing a target site of the subject to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, and exposing the target site of the subject to a vasodilator, wherein the vasodilator increases circulation at the target site of the subject, wherein increased circulation maintains or decreases temperature at the target site.
1 . A method of increasing blood circulation at a target site of a subject comprising:
a. exposing a target site of the subject to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, and
b. contacting the target site of the subject to a vasodilator, wherein the vasodilator increases circulation at the target site of the subject.
2 . The method of claim 1 , wherein the frequency of the alternating electric field is between 100 and 500 kHz.
3 . The method of claim 1 , wherein the frequency of the alternating electric field is between 180 and 220 kHz.
4 . The method of claim 1 , wherein the target site comprises a cancer cell.
5 . The method of claim 1 , wherein the cancer cell is a glioblastoma cell or lung metastatic carcinoma cell.
6 . The method of claim 1 , wherein the target site is exposed to the alternating electric field and vasodilator simultaneously.
7 . The method of claim 1 , wherein the target site is exposed to the alternating electric field and vasodilator consecutively.
8 . The method of claim 1 , wherein the vasodilator is nitroprusside, nitroglycerin, minoxidil, or hydralazine.
9 . The method of claim 1 , wherein the increase in blood circulation is 1% greater than blood circulation prior to exposure to the vasodilator.
10 . The method of claim 1 , wherein contacting the target site of the subject to a vasodilator comprises transdermal administration of the vasodilator to the subject at the target site.
11 . The method of claim 1 , wherein the target site is the subject's head, chest, or extremity.
12 . A method of maintaining or decreasing temperature at a target site of a subject comprising:
a. exposing a target site of the subject to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, and
b. contacting the target site of the subject to a vasodilator,
wherein the vasodilator increases circulation at the target site of the subject, wherein increased circulation maintains or decreases temperature at the target site.
13 . The method of claim 12 , wherein the frequency of the alternating electric field is between 100 and 500 kHz.
14 . The method of claim 12 , wherein the target site comprises a cancer cell.
15 .- 17 .
18 . A method of treating cancer in a subject comprising
a. exposing a target site of the subject to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, and
b. contacting the target site of the subject to a vasodilator, wherein the vasodilator increases circulation at the target site of the subject,
wherein the target site comprises one or more cancer cells.
19 . The method of claim 18 , wherein the frequency of the alternating electric field is between 100 and 500 kHz.