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Patent Application
App. No. 17/846,580

Glycan-Interacting Compounds and Methods of Use

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Quick Facts
Patent No.
US None
App. No.
17/846,580
Abstract

The present disclosure provides antibodies with T cell-interacting regions and/or glycan-interacting regions. Bispecific antibodies capable of recruiting T cells to cancer cells are also provided, including bispecific antibodies capable of recruiting T cells to cancer cells expressing sialyl Tn (STn). The present disclosure also includes methods for killing cells by targeting them with antibodies having T cell-interacting regions.

Claims (4)

1 . An antibody comprising:

a heavy chain variable domain (VH) comprising an amino acid sequence with at least 90% sequence identity to an amino acid sequence selected from the group consisting of SEQ ID NOs: 66, 64, 65, 67, and 68; and

a light chain variable domain (VL) comprising an amino acid sequence with at least 90% sequence identity to an amino acid sequence selected from the group consisting of SEQ ID NOs: 71, 69, 70, and 72.

2 - 50 . (canceled)