Occlusion device
Provided herein is an occlusion device for implantation into a body lumen or aneurysm comprising, a continuous compressible mesh structure comprising axial mesh carriages configured end to end, wherein each end of each carriage is a pinch point in the continuous mesh structure. Also provided herein is a kit comprising the occlusion device disclosed herein and a means for delivery thereof. Methods of manufacture and use of the occlusion device are also disclosed.
1. An occlusion device for implantation into a body lumen or aneurysm comprising:
a continuous mesh structure, wherein the continuous mesh structure comprises a plurality of axial mesh carriages configured end to end, wherein the continuous mesh structure is compressible; and
a plurality of markers encircling the continuous mesh structure at a plurality of pinch points in the continuous mesh structure,
wherein each end of each axial mesh carriage is (i) at a respective pinch point of the plurality of pinch points in the continuous mesh structure and (ii) encircled by a respective marker of the plurality of markers,
wherein the continuous mesh structure comprises a plurality of strands that each continuously extend across all of the plurality of axial mesh carriages, and
wherein each axial mesh carriage has a width (y) and length (x) that is different from the length and width of adjacent carriages of the plurality of axial mesh carriages.
2. The occlusion device of claim 1 , wherein the continuous mesh structure is configured so that a first carriage of the plurality of axial mesh carriages to enter the aneurysm has a width y that is larger than a largest measured diameter of the aneurysm to be treated.
3. The occlusion device of claim 1 , wherein the plurality of axial mesh carriages are segmented.
4. The occlusion device of claim 1 , wherein a number of the plurality of axial mesh carriages is equal to (n) and (n) is selected from the group consisting of two axial carriages, three axial carriages, four axial carriages, and five axial carriages.
5. The occlusion device of claim 1 , wherein the continuous mesh structure is configured to expand in a deployed shape and fill the body lumen or aneurysm, and
wherein the deployed shape compresses an axial length (x) of each axial mesh carriage to about 5% to about 50% of an axial length of the axial mesh carriage in free air.
6. The occlusion device of claim 1 , wherein each marker is radiopaque.
7. The occlusion device of claim 1 , wherein at least one axial mesh carriage is an outer axial carriage which comprises at least one inner coaxial mesh carriage.
8. The occlusion device of claim 7 , wherein the at least one inner coaxial mesh carriage comprises a different material than the outer axial carriage.
9. The occlusion device of claim 1 , wherein the continuous mesh structure comprises a metal braid comprising nitinol or a nitinol alloy.
10. The occlusion device of claim 1 , wherein each marker comprises a solid ring or a solid band.
11. The occlusion device of claim 10 , wherein each marker is formed from a least one material selected from the group consisting of: gold, platinum and stainless steel.
12. The occlusion device of claim 1 , wherein a width (y) of each axial mesh carriage in free air is between about 2 millimeters and about 50 millimeters.
13. A system for delivering an occlusion device to a body lumen or aneurysm, comprising:
an occlusion device comprising:
a continuous mesh structure, wherein the continuous mesh structure comprises a plurality of axial mesh carriages configured end to end, wherein the continuous mesh structure is compressible; and
a plurality of markers encircling the continuous mesh structure at a plurality of pinch points in the continuous mesh structure,
wherein each end of each axial mesh carriage is (i) at a respective pinch point of the plurality of pinch points in the continuous mesh structure and (ii) encircled by a respective marker of the plurality of markers,
wherein the continuous mesh structure comprises a plurality of strands that each continuously extend across all of the plurality of axial mesh carriages, and
wherein each axial mesh carriage has a width (y) and length (x) that is different from the length and width of adjacent carriages of the plurality of axial mesh carriages; and
a delivery system that is configured to deliver the occlusion device to the body lumen or aneurysm.
14. The occlusion device of claim 13 , wherein the delivery system is a microcatheter, catheter, guide wire or pusher wire.
15. The system of claim 13 , wherein the continuous mesh structure is configured so that a first carriage of the plurality of axial mesh carriages to enter the aneurysm has a width y that is larger than a largest measured diameter of the aneurysm to be treated.
16. The system of claim 13 , wherein the continuous mesh structure is configured to expand in a deployed shape and fill the body lumen or aneurysm, and
wherein the deployed shape compresses an axial length (x) of each axial mesh carriage to about 5% to about 50% of an axial length of the axial mesh carriage in free air.
17. The system of claim 13 , wherein a width (y) of each axial mesh carriage in free air is between about 2 millimeters and about 50 millimeters.
18. The system of claim 13 , wherein at least one axial mesh carriage is an outer axial carriage which comprises at least one inner coaxial mesh carriage.
19. The system of claim 18 , wherein the at least one inner coaxial mesh carriage comprises a different material than the outer axial carriage.
20. The system of claim 13 , wherein the continuous mesh structure comprises a metal braid comprising nitinol or a nitinol alloy.