Fluid connector
Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.
1. A method of transferring fluid, comprising:
coupling a first port of a first connector to a second port of a second connector;
transitioning each of the first port and the second port from a closed configuration to an open configuration;
translating a first valve of the first connector relative to a second valve of the second connector;
transitioning each of the first valve and the second valve from a closed configuration to an open configuration such that the first connector is in fluid communication with the second connector.
2. The method of claim 1 , further comprising flowing a sterilant into the first connector and the second connector.
3. The method of claim 1 , further comprising transferring fluid between the first connector and the second connector.
4. The method of claim 3 , wherein the fluid is a cell processing reagent.
5. The method of claim 2 , wherein the sterilant is vaporized hydrogen peroxide or ethylene oxide.
6. The method of claim 1 , wherein at least one of the first or second connectors comprises a robot engagement feature.
7. The method of claim 1 , wherein at least one of the first or second connectors is coupled to a controller.
8. The method of claim 7 , wherein the controller is configured to generate a signal to translate the first valve relative to the second valve.
9. The method of claim 1 , wherein at least one of the first or second connectors further comprises a sealed enclosure.
10. The method of claim 1 , wherein at least one end of the first or second connectors is coupled to a fluid device.
11. The method of claim 10 , wherein the fluid device is selected from the group consisting of a vessel, cartridge, bioreactor, enclosed vessel, and sealed chamber.
12. The method of claim 2 , wherein at least one of the first or second connectors further comprises a sterilant port and sterilant is flowed into the first and second connectors via the sterilant port.
13. The method of claim 1 , wherein a robot is used to couple the first port of the first connector to the second port of a second connector.
14. The method of claim 1 , wherein the first and second connectors are within an automated cell processing workcell.
15. The method of claim 1 , wherein at least one of the first or second connectors are reusable.
16. The method of claim 3 , wherein the transferred fluid is sterile.