Nicotine Pouch
A pouch designed for administration of an active ingredient in the oral cavity is disclosed, the pouch containing a matrix composition including a combination of nicotine and a water-soluble composition.
1 . A pouch designed for administration of an active ingredient in an oral cavity, the pouch containing a matrix composition comprising a water-insoluble composition, and granules consisting of a combination of nicotine and sugar alcohol as a water-soluble carrier for the nicotine.
2 . The pouch according to claim 1 , wherein said nicotine is provided as a complex between nicotine and an ion exchange resin.
3 . The pouch according to claim 2 , wherein said complex between nicotine and the ion exchange resin is nicotine polacrilex resin (NPR).
4 . The pouch according to claim 1 , wherein the nicotine is provided as a salt.
5 . The pouch according to claim 1 , wherein the nicotine is provided as its base form.
6 . The pouch according to claim 1 , wherein the matrix composition comprises a pH controlling agent.
7 . The pouch according to claim 6 , wherein the pH controlling agent is a buffering agent.
8 . The pouch according to claim 6 , wherein the pH controlling agent is a basic pH controlling agent.
9 . The pouch according to claim 1 , wherein the matrix composition further comprises a release controlling composition.
10 . The pouch according to claim 9 , wherein the matrix composition comprises said release controlling composition in an amount of between 1 and 20 percent by weight of said matrix composition.
11 . The pouch according to claim 9 , wherein said matrix composition comprises a first portion and a second portion, wherein said first and second portions have different contents of said release controlling composition.
12 . The pouch according to claim 11 , wherein both of said first and second portions comprises nicotine.
13 . The pouch according to claim 1 , wherein the pouch comprises a water-permeable membrane.
14 . The pouch according to claim 1 , wherein said matrix composition comprises the nicotine in an amount of 0.1 to 30 percent by weight of said matrix composition.
15 . The pouch according to claim 1 , wherein the pouch comprises a humectant.
16 . The pouch according to claim 15 , wherein the humectant is selected from the group consisting of sugar alcohols, alginate, cellulose, microcrystalline cellulose, pectin, xanthan gum, and combinations thereof.
17 . The pouch according to claim 1 , wherein the pouch is free of tobacco.
18 . The pouch according to claim 1 , wherein the water-insoluble composition comprises cellulose.
19 . The pouch according to claim 1 , wherein the water-insoluble composition comprises microcrystalline cellulose.
20 . A pouch designed for administration of an active ingredient in an oral cavity, the pouch containing a matrix composition comprising granules consisting of a combination of nicotine and a water-soluble composition, wherein the water-soluble composition consists of sugar alcohol as a water-soluble carrier for the nicotine.