IP Library › Granted Patent US 12,383,147
Granted Patent B2
US 12,383,147 · App. 17/867,155 · Granted Aug 12, 2025

Apparatus and method of assessing a narrowing in a fluid fileld tube

Inventors: Helen Davies (London, GB); Justin Davies (London, GB)
Assignees: MEDSOLVE PTE LTD; IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE
A61B5/02007A61B5/02125A61B5/0215A61B5/0285A61B5/103A61B5/7264A61B5/7278
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Quick Facts
Patent No.
US 12,383,147
App. No.
17/867,155
Granted
Aug 12, 2025
Kind
B2
Abstract

An apparatus and method of assessing a narrowing in a fluid filled tube having a fluid flow pressure wave having a backward-originating pressure component and a forward-originating pressure component without taking a flow velocity measurement, comprising: taking pressure measurements in the tube; separating the pressure components into the backward-originating pressure component and the forward-originating pressure component; identifying a time window when the differential of flow velocity (dU) is minimal or absent; and deriving the backward and forward pressure components for pressure measurements taken in at least the time window.

Claims (52)

1. A system of assessing a narrowing in a blood vessel, the system comprising:

at least one pressure-sensing probe sized and shaped for positioning within the blood vessel; and

a processor in communication with the at least one pressure-sensing probe, the processor configured to:

receive pressure measurements occurring during a cardiac cycle without hyperaemia obtained by the at least one pressure-sensing probe positioned within the blood vessel; and

calculate a pressure ratio using a subset of the pressure measurements occurring during a wave free period of the cardiac cycle, wherein the pressure ratio provides an assessment of a severity of the narrowing in the blood vessel.

2. The system of claim 1 , wherein a start of the wave free period occurs after a first characteristic of a pressure waveform of the received pressure measurements.

3. The system of claim 2 , wherein the first characteristic of the pressure waveform is a peak pressure.

4. The system of claim 2 , wherein an end of the wave free period occurs before a second characteristic of the pressure waveform of the received pressure measurements.

5. The system of claim 4 , wherein the second characteristic is an end of the pressure waveform.

6. The system of claim 1 , wherein the wave free period includes a time window between a peak pressure time (t Pmax ) and an end of pressure waveform time (t Pend ).

7. The system of claim 6 , wherein the time window extends from t Pmax +150 ms to t Pend −50 ms.

8. The system of claim 6 , wherein the time window is a mid-window between t Pmax and t Pend .

9. The system of claim 8 , wherein the time window is a mid 3/5 window between t Pmax and t Pend .

10. The system of claim 1 , wherein the wave free period has a length of at least 100 ms.

11. The system of claim 1 , wherein the wave free period has a predetermined duration.

12. The system of claim 1 , wherein the wave free period corresponds to when a differential of flow velocity (dU) is minimal or absent.

13. The system of claim 1 , wherein the wave free period corresponds to when a differential of flow velocity (dU) is below a threshold.

14. The system of claim 13 , wherein the threshold of the differential of flow velocity (dU) is a predetermined deviation from zero.

15. The system of claim 14 , wherein the predetermined deviation is ±2×10 −4 .

16. The system of claim 13 , wherein the threshold of the differential of flow velocity (dU) is a percentage of a maximum differential of flow velocity (dU max ).

17. The system of claim 13 , wherein the threshold is 20% or less than a maximum differential of flow velocity (dU max ).

18. The system of claim 1 , wherein the at least one pressure-sensing probe comprises a pressure-sensing wire.

19. The system of claim 1 , wherein the at least one pressure-sensing probe comprises a pressure transducer.

20. The system of claim 1 , wherein the processor is in wired communication with the at least one pressure-sensing probe.

21. The system of claim 1 , wherein the processor is in wireless communication with the at least one pressure-sensing probe.

22. The system of claim 1 , wherein the processor is further configured to:

identify the wave free period based on the received pressure measurements.

23. A method of assessing a narrowing in a blood vessel, the method comprising:

receiving, with a processor in communication with at least one pressure-sensing probe, pressure measurements occurring during a cardiac cycle without hyperaemia obtained by the at least one pressure-sensing probe while the at least one pressure-sensing probe is positioned within the blood vessel; and

calculating, with the processor, a pressure ratio using a subset of the pressure measurements occurring during a wave free period of the cardiac cycle, wherein the pressure ratio provides an assessment of a severity of the narrowing in the blood vessel.

24. The method of claim 23 , wherein a start of the wave free period occurs after a first characteristic of a pressure waveform of the received pressure measurements.

25. The method of claim 24 , wherein the first characteristic of the pressure waveform is a peak pressure.

26. The method of claim 24 , wherein an end of the wave free period occurs before a second characteristic of the pressure waveform of the received pressure measurements.

27. The method of claim 26 , wherein the second characteristic is an end of the pressure waveform.

28. The method of claim 23 , wherein the wave free period includes a time window between a peak pressure time (t Pmax ) and an end of pressure waveform time (t Pend ).

29. The method of claim 28 , wherein the time window extends from t Pmax +150 ms to t Pend −50 ms.

30. The method of claim 28 , wherein the time window is a mid-window between t Pmax and t Pend .

31. The method of claim 30 , wherein the time window is a mid 3/5 window between t Pmax and t Pend .

32. The method of claim 23 , wherein the wave free period has a length of at least 100 ms.

33. The method of claim 23 , wherein the wave free period has a predetermined duration.

34. The method of claim 23 , wherein the wave free period corresponds to when a differential of flow velocity (dU) is minimal or absent.

35. The method of claim 23 , wherein the wave free period corresponds to when a differential of flow velocity (dU) is below a threshold.

36. The method of claim 35 , wherein the threshold of the differential of flow velocity (dU) is a predetermined deviation from zero.

37. The method of claim 36 , wherein the predetermined deviation is ±2×10 −4 .

38. The method of claim 35 , wherein the threshold of the differential of flow velocity (dU) is a percentage of a maximum differential of flow velocity (dU max ).

39. The method of claim 35 , wherein the threshold is 20% or less than a maximum differential of flow velocity (dU max ).

40. The method of claim 23 , wherein the at least one pressure-sensing probe comprises a pressure-sensing wire.

41. The method of claim 23 , wherein the at least one pressure-sensing probe comprises a pressure transducer.

42. The method of claim 23 , wherein the processor is in wired communication with the at least one pressure-sensing probe.

43. The method of claim 23 , wherein the processor is in wireless communication with the at least one pressure-sensing probe.

44. The method of claim 23 , further comprising:

identifying, with the processor, the wave free period based on the received pressure measurements.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 18, 2025
From: MEDSOLVE LTD
To: MEDSOLVE PTE LTD
Reel/Frame 070878/0364 →
Priority Claims (1)
GB 1100137 · Jan 6, 2011 · national
Continuity (5)
Continuation 16853523 · Apr 20, 2020
Continuation 15723182 · Oct 3, 2017
Continuation 14701000 · Apr 30, 2015
Continuation 13345495 · Jan 6, 2012
Related Publication 20220354370A1 · Nov 10, 2022
References Cited (197)
US 4821735A · Goor · 1989 [cited by applicant]
US 5775338A · Hastings · 1998 [cited by applicant]
US 6062089A · Ichihashi · 2000 [cited by applicant]
US 6106476A · Corl · 2000 [cited by applicant]
US 6129674A · Ovadia-Blechman · 2000 [cited by applicant]
US 6190355B1 · Hastings · 2001 [cited by applicant]
US 6193669B1 · Degany · 2001 [cited by applicant]
US 6343514B1 · Smith · 2002 [cited by applicant]
US 6354999B1 · Dgany · 2002 [cited by applicant]
US 6396615B1 · Hama · 2002 [cited by applicant]
US 6409677B1 · Tulkki · 2002 [cited by applicant]
US 6471656B1 · Shalman · 2002 [cited by applicant]
US 6558334B2 · Shalman · 2003 [cited by applicant]
US 6565514B2 · Svanerudh · 2003 [cited by applicant]
US 6585660B2 · Dorando · 2003 [cited by applicant]
US 6615667B2 · Smith · 2003 [cited by applicant]
US 6659959B2 · Brockway · 2003 [cited by applicant]
US 6663570B2 · Mott · 2003 [cited by applicant]
US 6697667B1 · Lee · 2004 [cited by applicant]
US 6716178B1 · Kilpatrick · 2004 [cited by applicant]
US 6754608B2 · Svanerudh · 2004 [cited by applicant]
US 6868736B2 · Sawatari · 2005 [cited by applicant]
US 7134994B2 · Alpert · 2006 [cited by applicant]
US 7274956B2 · Mott · 2007 [cited by applicant]
US RE39863E · Smith · 2007 [cited by applicant]
US 7329223B1 · Ainsworth · 2008 [cited by applicant]
US 7481774B2 · Brockway · 2009 [cited by applicant]
US 7532920B1 · Ainsworth · 2009 [cited by applicant]
US 7632304B2 · Park · 2009 [cited by applicant]
US 7693563B2 · Suresh · 2010 [cited by applicant]
US 7775988B2 · Pijs · 2010 [cited by applicant]
US 7783338B2 · Ainsworth · 2010 [cited by applicant]
US 7814635B2 · Gordon · 2010 [cited by applicant]
US 7828841B2 · Mathis · 2010 [cited by applicant]
US 7828842B2 · Nieminen · 2010 [cited by applicant]
US 7828843B2 · Alferness · 2010 [cited by applicant]
US 7853626B2 · Jung · 2010 [cited by applicant]
US 7887582B2 · Mathis · 2011 [cited by applicant]
US 8006594B2 · Hayner · 2011 [cited by applicant]
US 8029447B2 · Kanz · 2011 [cited by applicant]
US 8062358B2 · Mathis · 2011 [cited by applicant]
US 8075608B2 · Gordon · 2011 [cited by applicant]
US 8157742B2 · Taylor · 2012 [cited by applicant]
US 9775524B2 · Davies · 2017 [cited by examiner]
US 10624544B2 · Davies · 2020 [cited by applicant]
US 11389068B2 · Davies · 2022 [cited by examiner]
US 20020052553A1 · Shalman · 2002 [cited by applicant]
US 20020059827A1 · Smith · 2002 [cited by applicant]
US 20020065472A1 · Brockway · 2002 [cited by applicant]
US 20020072880A1 · Svanerudh · 2002 [cited by applicant]
US 20020173724A1 · Dorando · 2002 [cited by applicant]
US 20030032886A1 · Deganv · 2003 [cited by applicant]
US 20030033095A1 · Svanerudh · 2003 [cited by applicant]
US 20030159518A1 · Sawatari · 2003 [cited by applicant]
US 20030163052A1 · Mott · 2003 [cited by applicant]
US 20030191400A1 · Shalman · 2003 [cited by applicant]
US 20030195428A1 · Brockway · 2003 [cited by applicant]
US 20030204160A1 · Kamm · 2003 [cited by examiner]
US 20030216621A1 · Alpert · 2003 [cited by applicant]
US 20040082866A1 · Mott · 2004 [cited by applicant]
US 20040158321A1 · Reuter · 2004 [cited by applicant]
US 20050121734A1 · Degertekin · 2005 [cited by applicant]
US 20060052700A1 · Svanerdh · 2006 [cited by applicant]
US 20060074318A1 · Ahmed · 2006 [cited by applicant]
US 20060106321A1 · Lewinsky · 2006 [cited by applicant]
US 20060241505A1 · Ahmed · 2006 [cited by applicant]
US 20070060822A1 · Alpert · 2007 [cited by applicant]
US 20070078352A1 · Pills · 2007 [cited by applicant]
US 20070225606A1 · Naghavi · 2007 [cited by applicant]
US 20070225614A1 · Naghavi · 2007 [cited by applicant]
US 20070255145A1 · Smith · 2007 [cited by applicant]
US 20080027330A1 · Naghavi · 2008 [cited by applicant]
US 20080081957A1 · Jung · 2008 [cited by applicant]
US 20080082522A1 · Jung · 2008 [cited by applicant]
US 20080082582A1 · Jung · 2008 [cited by applicant]
US 20080101532A1 · Tkaczyk · 2008 [cited by applicant]
US 20080139951A1 · Patangay · 2008 [cited by applicant]
US 20080213165A1 · Lieu · 2008 [cited by applicant]
US 20080228086A1 · Johnson · 2008 [cited by applicant]
US 20080255471A1 · Naghavi · 2008 [cited by applicant]
US 20080269572A1 · Kanz · 2008 [cited by applicant]
US 20080281205A1 · Haghavi · 2008 [cited by applicant]
US 20080292049A1 · Camus · 2008 [cited by applicant]
US 20090018459A1 · Tseng · 2009 [cited by applicant]
US 20090081120A1 · Lieu · 2009 [cited by applicant]
US 20090082678A1 · Smith · 2009 [cited by applicant]
US 20090088650A1 · Corl · 2009 [cited by applicant]
US 20090234231A1 · Knight · 2009 [cited by applicant]
US 20100081941A1 · Naghavi · 2010 [cited by applicant]
US 20100086483A1 · Belardinelli · 2010 [cited by applicant]
US 20100109104A1 · Tiensuu · 2010 [cited by applicant]
US 20100152607A1 · Kassab · 2010 [cited by applicant]
US 20100156898A1 · Voros · 2010 [cited by applicant]
US 20100234698A1 · Manstrom · 2010 [cited by examiner]
US 20100241008A1 · Belleville · 2010 [cited by applicant]
US 20100280396A1 · Zhang · 2010 [cited by applicant]
US 20100286537A1 · Pills · 2010 [cited by applicant]
US 20110066047A1 · Belleville · 2011 [cited by applicant]
US 20110071404A1 · Schmitt · 2011 [cited by applicant]
US 20110071407A1 · Hubinette · 2011 [cited by applicant]
US 20110085977A1 · Rosenmeier · 2011 [cited by applicant]
US 20110137140A1 · Tearney · 2011 [cited by applicant]
US 20110137210A1 · Johnson · 2011 [cited by applicant]
US 20110178383A1 · Kassab · 2011 [cited by applicant]
US 20110178413A1 · Schmitt · 2011 [cited by applicant]
US 20110178417A1 · Kassab · 2011 [cited by applicant]
US 20110196255A1 · Kassab · 2011 [cited by applicant]
US 20110245693A1 · Hastings · 2011 [cited by applicant]
US 20110251497A1 · Corl · 2011 [cited by applicant]
US 20110263986A1 · Park · 2011 [cited by applicant]
US 20110306867A1 · Gopinathan · 2011 [cited by applicant]
US 20110319752A1 · Steinberg · 2011 [cited by applicant]
US 20110319773A1 · Kanz · 2011 [cited by applicant]
US 20120004529A1 · Tolkowsky · 2012 [cited by applicant]
US 20120004537A1 · Tolkowsky · 2012 [cited by applicant]
US 20120029339A1 · Cohen · 2012 [cited by applicant]
US 20120041318A1 · Taylor · 2012 [cited by applicant]
US 20120041319A1 · Taylor · 2012 [cited by applicant]
US 20120041320A1 · Taylor · 2012 [cited by applicant]
US 20120041321A1 · Taylor · 2012 [cited by applicant]
US 20120041322A1 · Taylor · 2012 [cited by applicant]
US 20120041323A1 · Taylor · 2012 [cited by applicant]
US 20120041324A1 · Taylor · 2012 [cited by applicant]
US 20120041735A1 · Taylor · 2012 [cited by applicant]
US 20120041739A1 · Taylor · 2012 [cited by applicant]
US 20120052918A1 · Taylor · 2012 [cited by applicant]
US 20120053918A1 · Taylor · 2012 [cited by applicant]
US 20120053919A1 · Taylor · 2012 [cited by applicant]
US 20120053921A1 · Taylor · 2012 [cited by applicant]
US 20120059246A1 · Taylor · 2012 [cited by applicant]
US 20120065514A1 · Naghavi · 2012 [cited by applicant]
US 20120065623A1 · Nelson · 2012 [cited by applicant]
US 20120071782A1 · Patil · 2012 [cited by applicant]
US 20120072190A1 · Sharma · 2012 [cited by applicant]
US 20120093266A1 · Sun · 2012 [cited by applicant]
US 20120101355A1 · Gopinathan · 2012 [cited by applicant]
US 20120101369A1 · Patil · 2012 [cited by applicant]
US 20120220883A1 · Manstrom · 2012 [cited by applicant]
EP 2298162A1 · 2011 [cited by applicant]
EP 3120762A1 · 2017 [cited by applicant]
WO 200053081A1 · 2000 [cited by applicant]
WO 2006041346A1 · 2006 [cited by applicant]
WO 2012030882A1 · 2010 [cited by applicant]
WO 2010103277A1 · 2010 [cited by applicant]
WO 200113779A1 · 2011 [cited by applicant]
WO 2011038044A1 · 2011 [cited by applicant]
WO 20120093266A1 · 2012 [cited by applicant]
A.W. Khir et al., “Determination of Wave Speed and Wave Separation in the Arteries,” Journal of Biomechanics, vol. 34, No. 9, pp. 1145-1155, Sep. 30, 2001. [cited by applicant]
Justin E. Davies et al., “Evidence of Dominant backward-Propagating ‘Suction’ Wave Responsible for Diastolic Coronary Filling in Humans, Attenuated in Left Ventricular Hypertrophy,” American Heart Association, vol. 113,… [cited by applicant]
Jazmin Aguado-Sierra et al., “Pressure Reservoir-Wave Separation Applied to Coronary Arterial Data,” 29th IEEE EMBS Annual International Conference, Dec. 31, 2007, pp. 2693-2696. [cited by applicant]
The State Intellectual Property Office of the People's Republic of China, “Notification of First Office Action” for Application No. 201280004879.6, mailed Feb. 10, 2015, 22 pages with translation. [cited by applicant]
Canadian Intellectual Property Office, “Office Action” for Application No. 2,823,811, mailed Sep. 11, 2015, 3 pages. [cited by applicant]
Japanese Patent Office, “Notice of Reasons for Refusal” for Application No. 2013-547911, mailed Oct. 6, 2015, 11 pages with translation. [cited by applicant]
The State Intellectual Property Office of the People's Republic of China, “Notification of Second Office Action” for Application No. 201280004879.6, mailed Nov. 4, 2015, 15 pages with translation. [cited by applicant]
Russian Patent Office, “Office Action” for Application No. 2013136699, mailed Dec. 10, 2015, 6 pages with translation. [cited by applicant]
European Patent Office, “Examination Report” for Application No. 12700299.6, mailed Jan. 18, 2016, 4 pages. [cited by applicant]
Chinese State Intellectual Property Office, “Notification of Third Office Action” for Application No. 201280004879.6, mailed May 9, 2016, 10 pages with translation. [cited by applicant]
International Searching Authority/European Patent Office, “International Search Report and The Written Opinion of the International Searching Authority,” for PCT/GB2012/050024, mailed Apr. 19, 2012, 14 pages. [cited by applicant]
Korean Office Action mailed Aug. 21, 2014 in Korean Patent Application No. 2013-7020712, filed Jan. 6, 2012. [cited by applicant]
European Patent Office, “Examination Report” for Application No. 12700299.6, mailed Aug. 31, 2016, 3 pages. [cited by applicant]
Canadian Office Action mailed Oct. 3, 2016 in Canadian Application No. T8477383CA—filed Oct. 3, 2016, 2 pages. [cited by applicant]
Japanese Patent Office, Office Action for Application No. 2013-547911, mailed Jul. 19, 2016, 7 pages with translation. [cited by applicant]
Israeli Patent Office, Office Action for Application No. 227351, mailed Aug. 23, 2016, 2 pages. [cited by applicant]
Chinese State Intellectual Property Office, “Notification of the Fourth Office Action” for Application No. 201280004879.6, mailed Jan. 20, 2017, 6 pages with translation. [cited by applicant]
SmartFlow tm Integrated Lumen Physiology, Version 5.0, Operator's Manual, Apr. 2001, 42 pages. [cited by applicant]
Florence Medical Innovations in Vascular Technology Business Plan, May 2002, 41 pages. [cited by applicant]
Florence Medical SmartFlow, CFR/FFR Manual, Mar. 2002, 50 pages. [cited by applicant]
SmartFlow CFR/FFR, Innovations in Vascular Technology, Model 2000, 2002, 6 pages. [cited by applicant]
Florence Medical, Annual Letter to Shareholders, May 17, 2001, 1 page. [cited by applicant]
Florence Medical LTD, Company Profile, May 2001, 4 pages. [cited by applicant]
SmartFlow tm Integrated Lumen Physiology for the Cathlab, SmartFlow CFR/FFR, Model 2000, Version 5.0 CFR/FFR, 2001, 2 pages. [cited by applicant]
Florence Medical Center 510(k) Summary SmartFlowtm, May 14, 2001, 6 pages and Oct. 2, 2001, 5 pages. [cited by applicant]
EuroPCR Brochure—SmartFlowTm Integrated Lumen Physiology, “Software Design Description” (4 parts)—Apr. 30, 2013. [cited by applicant]
Florence Medical, Inc. News Release, Florence Medical Introduces SmartFlow Multiple Lesion tm Device at American College of Cardiology Meeting, Mar. 14, 2002, 2 pages. [cited by applicant]
The Free Library by Farlex, Florence Medical Introduces SmartFlow Multiple Lesion Device at American College of Cardiology Meeting, Mar. 14, 2002, 3 pages. [cited by applicant]
Florence Medical innovations in vascular technology PowerPoint presentation, 2002, 19 pages. [cited by applicant]
Shalman, E., et al., Pergamon, Numerical modeling of the flow in stenosed coronary artery. The relationship between main hemodynamic parameters, Received Nov. 3, 2000, accepted Oct. 2, 2001, 16 pages. [cited by applicant]
Shalman, E., et al., Pergamon, Pressure-based simultaneous CFR and FFR measurements: understanding the physiology of a stenosed vessel, Received Jul. 18, 2000, accepted Oct. 6, 2000, 11 pages. [cited by applicant]
Grubert, Luis, M.D., et al., Simultaneous Assessment of Coronary Flow Reserve and Fractional Flow Reserve with a Novel Pressure-Based Method, Journal of Interventional Cardiology vol. 13, No. 5, 2000, 8 pages. [cited by applicant]
Young, D.F., et al., Pressure Drop Across Artificially Induced Stenoses in the Femoral Arteries of Dogs, Circulation Research, 1975; 36: 735-743. [cited by applicant]
The International Bureau of WIPO, Notification Concerning Submission, Obtention or Transmittal of Priority Document for International Application No. PCT/GB2012/050024, dated Feb. 16, 2012, 1 page. [cited by applicant]
European Patent Office, The International Searching Authority, Notification of Transmittal of The International Search Report and the Written Opinion of the International Searching Authority, or the Declaration for Inte… [cited by applicant]
International Search Report and Written Opinion received in Patent Cooperation Treaty Application No. PCT/ JS2012/051566, dated Mar. 29, 2013, 9 pages. [cited by applicant]
International Search Report and Written Opinion received in Patent Cooperation Treaty Application No. PCT/ US2013/057647, dated Dec. 12, 2013, 11 pages. [cited by applicant]
Patent Cooperation Treaty, “International Preliminary Report on Patentability,” for Application No. PCT/ JS2013/057647, Mar. 12, 2015, 7 pages. [cited by applicant]
European Patent Office, “European Search Report” for Application No. 12825326.7, (PCT/U.S. Pat. No. 2012051566), Mar. 16, 2015, 7 pages. [cited by applicant]
European Patent Office, “European Search Report” for Application No. 12826470.2, (PCT/U.S. Pat. No. 2012051570), Mar. 16, 2015, 8 pages. [cited by applicant]
Russian Patent Office, “Office Action” for Application No. 2014110701, May 4, 2016, 17 pages with English translation. [cited by applicant]
Russian Patent Office, “Office Action” for Application No. 2014110702, May 4, 2016, 14 pages with English translation. [cited by applicant]
Pijls et al., The Crux of Maximum Hyperemia, The American College of Cardiology Foundation, Elsevier Inc., vol. 4, No. 10, 2011, pp. 1093-1095. [cited by applicant]
Khashaba et al., Intracoronary Versus Intravenous Adenosine-Induced Maximal Coronary Hyperemia for Fractional Flow Reserve Measurements, Clinical Medicine Insights: Cardiology, Libertas Academica 2014:8, pp. 17-21. [cited by applicant]
Schlundt et al., Comparison of Intracoronary Versus Intravenous Administration of Adenosine for Measurement of Coronary Fractional Flow Reserve, Circ Cardiovasc Interv, American Heart Association, Inc., 2015, pp. 1-7. [cited by applicant]
European Patent Office, “Extended European Search Report” for Application No. 16188188.3, Jan. 3, 2017, 10 pages. [cited by applicant]
Mynard JP et al: “Accurate Automatic Detection of End-Diastole From Left Ventricular Pressure Using Peak Curvature”, IEEE Transactions on Biomedical Engineering, Nov. 1, 2008, 7 pages. [cited by applicant]
Javier Escaned, et al., Importance of diastolic fractional flow reserve and dobutamine challenge in physiologic assessment of myocardial bridging, Journal of the American College of Cardiology, vol. 42, pp. 226-233, pub… [cited by applicant]
Masayuki Abe, et al., Diastolic fractional flow reserve to assess the functional severity of moderate coronary artery stenoses, Circulation, vol. 102, pp. 2365-2370, published Nov. 7, 2000. [cited by applicant]
Mamas A. Mamas, et al., Resting Pd/Pa measured with intracoronary pressure wire strongly predicts fractional flow reserve, The Journal of Invasive Cardiology, vol. 22, pp. 260-265, published May 2010. [cited by applicant]