Aerosol delivery of at least two liquid compositions
The invention relates to the field of inhalation methods and inhalation devices for liquids. In particular, the invention relates to an inhalation method using an inhalation device adapted to separately eject at least two liquid compositions each having different properties, and to a method for the generation of an aerosol of at least two medicinal formulations by means of such inhalation device.
1 . An inhalation device for the generation of an aerosol of at least two liquid compositions, the device comprising at least a first and second reservoir containing at least a first and a second liquid composition, wherein the inhalation device is a pump-actuated inhaler adapted to release upon actuation a metered dose of the first liquid composition from the first reservoir and a metered dose of the second liquid composition from the second reservoir, wherein the first and second reservoir for storing the first and second liquid composition are fluidically connected to at least a first and second pumping chamber for generation of a first pressure inside said first pumping chamber and a second pressure inside said second pumping chamber, a first and second riser pipe, each of which is able to be received with a reservoir-facing, interior end in said first and second pumping chamber, wherein the interior volume of the first and second pumping chamber is changeable by means of relative motion of the first and second pumping chamber to the first and second riser pipe, at least a first exit area and a second exit area adapted to separately eject the first and second liquid composition from the inhalation device, a first potential energy storage unit coupled with one end of the first pumping chamber, and a second potential energy storage unit coupled with one end of the second pumping chamber, wherein the first and the second potential energy storge units are configured to separately generate the first and the second pressures, respectively, for releasing the at least two liquid compositions.
2 . The inhalation device according to claim 1 , wherein each of the first and second riser pipe is immobile and firmly attached to the device and/or to the first and second exit area, and each of the first and second pumping chamber is movable relative to the device and/or to the first and second exit area.
3 . The inhalation device according to claim 1 , wherein the first potential energy storage unit and the second potential energy storage unit each produce the same force.
4 . The inhalation device according to claim 3 , wherein the force is about 5 newtons (N) to about 200 newtons (N).
5 . The inhalation device according to claim 1 , wherein the first potential energy storage unit and the second potential energy storage unit each produce a different force.
6 . The inhalation device according to claim 1 , wherein the first potential energy storage unit and the second potential energy storage unit each comprise a spring.
7 . The inhalation device according to claim 1 , wherein the metered dose of the first liquid composition has a same volume as the metered dose of the second liquid composition.
8 . The inhalation device according to claim 1 , wherein the metered dose of the first liquid composition has a different volume than the metered dose of the second liquid composition.
9 . The inhalation device according to claim 1 , wherein the first liquid composition comprises a long-acting beta agonist and the second liquid composition comprises an inhaled corticosteroid.
10 . The inhalation device according to claim 9 , wherein the first liquid composition comprises a mixture of the long-acting beta agonist and a long-acting muscarinic antagonist and the second liquid composition comprises the inhaled corticosteroid.
11 . The inhalation device according to claim 10 , wherein the long-acting muscarinic antagonist is tiotropium bromide, the long-acting beta agonist is olodaterol, and the inhaled corticosteroid is ciclesonide.
12 . The inhalation device according to claim 1 , wherein the first exit area and the second exit area are incorporated into a single nozzle.
13 . The inhalation device according to claim 1 , wherein the first exit area is incorporated into a first nozzle and the second exit area is incorporated into a second nozzle.
14 . The inhalation device according to claim 1 , wherein the first reservoir and the second reservoir are incorporated into a single cartridge unit.
15 . The inhalation device according to claim 1 , wherein the first reservoir is incorporated into a first cartridge unit and the second reservoir is incorporated into a second cartridge unit.
16 . The inhalation device according to claim 1 , wherein the inhalation device is a soft-mist-inhaler.
17 . The inhalation device according to claim 16 , wherein the soft-mist inhaler comprises at least two impingement-type nozzles, each impingement-type nozzle having two ejection channels with two corresponding ejection trajectories, wherein the two ejection trajectories of one impingement-type nozzle have one collision point in which the two ejection trajectories intersect.
18 . A method of treating or preventing a disease or condition in a subject in need thereof, the method comprising a step of administering the metered dose of the first liquid composition and the metered dose of the second liquid composition using the inhalation device according to claim 1 .
19 . The first reservoir containing the first liquid composition comprising a long-acting beta agonist and the second reservoir containing the second liquid composition comprising an inhaled corticosteroid, wherein the first and second reservoirs are adapted for use with the inhalation device according claim 1 .