IP Library Granted Patent US 12,121,384
Granted Patent B2
US 12,121,384 · App. 17/910,681 · Granted Oct 22, 2024

Systems and methods for x-ray imaging tissue specimens

Inventors: Filip Nikolas Bundra (Marlborough, MA); Christine Janssen (Marlborough, MA); Zhenxue Jing (Marlborough, MA); Tarpit Patel (Marlborough, MA); Thomas Deyoung (Marlborough, MA)
Assignee: Hologic, Inc.
A61B6/502A61B6/0414A61B6/06A61B6/4035A61B10/0283G21K1/025
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Quick Facts
Patent No.
US 12,121,384
App. No.
17/910,681
Granted
Oct 22, 2024
Kind
B2
Abstract

An x-ray breast imaging system includes a breast support platform including an x-ray receptor, and an x-ray tube head. The x-ray tube head includes an x-ray source configured to emit an x-ray beam in a direction towards the x-ray receptor, and a collimator. A filter assembly including a plurality of filter slots selectively positionable adjacent to the collimator, and a specimen imaging filter disposed within a slot of the plurality of filter slots. The specimen imaging filter includes at least one aperture defined therein. The specimen imaging filter also blocks a portion of the emitted x-ray beam so that the at least one aperture defines a path of the emitted x-ray beam towards the x-ray receptor.

Claims (34)

1. An x-ray breast imaging system comprising:

a breast support platform comprising an x-ray receptor; and

an x-ray tube head comprising:

an x-ray source configured to emit an x-ray beam in a direction towards the x-ray receptor;

a collimator;

a filter assembly comprising a plurality of filter slots selectively positionable adjacent to the collimator; and

a specimen imaging filter disposed within a slot of the plurality of filter slots, wherein the specimen imaging filter comprises at least one aperture defined therein, and wherein the specimen imaging filter blocks a portion of the emitted x-ray beam so that the at least one aperture defines a path of the emitted x-ray beam towards the x-ray receptor.

2. The x-ray breast imaging system of claim 1 , wherein the at least one aperture is substantially rectangular-shaped.

3. The x-ray breast imaging system of claim 1 , wherein the specimen imaging filter is formed from lead material.

4. The x-ray breast imaging system of claim 1 , wherein the at least one aperture comprises a pair of apertures.

5. The x-ray breast imaging system of claim 4 , wherein the collimator comprises at least one collimator blade, and wherein the at least one collimator blade is configured to selectively cover one of the pair of apertures.

6. The x-ray breast imaging system of claim 1 , wherein the filter assembly comprises a rotatable filter wheel having the plurality of filter slots.

7. The x-ray breast imaging system of claim 1 , wherein the x-ray source comprises three or more focal spot sizes.

8. The x-ray breast imaging system of claim 7 , wherein one of the focal spot sizes is less than or equal to 50 μm.

9. The x-ray breast imaging system of claim 1 , further comprising a specimen container configured to retain one or more tissue specimens.

10. The x-ray breast imaging system of claim 9 , wherein the specimen container is removably coupleable to the imaging system and independently rotatable relative to the x-ray tube head.

11. The x-ray breast imaging system of claim 1 , wherein the at least one aperture defines the path of the emitted x-ray beam that corresponds to a specific area on the breast support platform.

12. The x-ray breast imaging system of claim 1 , further comprising a compression paddle configured to compress a patient's breast against the breast support platform, and wherein the at least one aperture defines the path of the emitted x-ray beam that corresponds to a specific area on the compression paddle.

13. The x-ray breast imaging system of claim 1 , further comprising a vacuum assisted biopsy assembly coupled to the imaging system, wherein the vacuum assisted biopsy assembly comprises a reservoir configured to capture a tissue specimen.

14. The x-ray breast imaging system of claim 1 , further comprising a high energy acquisition filter formed from copper.

15. A method of acquiring a tissue specimen image on an x-ray breast imaging system, the method comprising:

compressing a patient's breast between a compression paddle and a support platform;

imaging the patient's breast via an x-ray source disposed in an x-ray tube head and an x-ray receptor disposed in the support platform;

obtaining one or more tissue specimens from the patient's breast;

retaining the one or more tissue specimens in a container;

imaging the one or more tissue specimens via the same x-ray source and x-ray receptor used for imaging the patient's breast, wherein the imaging includes blocking a portion of an emitted x-ray beam from the x-ray source by a specimen imaging filter within the x-ray tube head so that at least one aperture within the specimen imaging filter defines a path of the emitted x-ray beam towards the x-ray receptor.

16. The method of claim 15 , wherein blocking a portion of an emitted x-ray beam further comprises covering one aperture of a pair of apertures via at least one collimator blade of a collimator.

17. The method of claim 15 , wherein imaging the patient's breast and imaging the one or more tissue specimens are performed under the same breast compression procedure.

18. The method of claim 15 , further comprising placing the container on the support platform and within an imaging area that corresponds to the x-ray receptor disposed within the support platform.

19. The method of claim 18 , wherein placing the container on the support platform comprises placing the container within a right anterior area of the imaging area or within a left anterior area of the imaging area.

20. The method of claim 15 , further comprising placing the container on the compression paddle.

21. The method of claim 15 , wherein obtaining one or more tissue specimens comprises excising the one or more tissue specimens via a vacuum assisted biopsy device, and wherein retaining the one or more tissue specimens comprises capturing the one or more tissue specimens in a reservoir.

22. The method of claim 21 , wherein the reservoir is independently moveable relative to the x-ray source and the x-ray receptor.

23. The method of claim 15 , wherein imaging the patient's breast occurs at a first focal spot size of the x-ray source and imaging the one or more tissue specimens occurs at a second focal spot size, and wherein the first focal spot size is greater than the second focal spot size.

Assignments (4)
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 061639/0513 Recorded Apr 24, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC.; GEN-PROBE INCORPORATED; FAXITRON BIOPTICS, LLC; BIOTHERANOSTICS, INC.
Reel/Frame 075457/0268 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 10, 2023
From: BUNDRA, FILIP NIKOLAS; JANSSEN, CHRISTINE; JING, ZHENXUE; PATEL, TARPIT; DEYOUNG, THOMAS
To: HOLOGIC, INC.
Reel/Frame 062331/0368 →
SECURITY INTEREST Recorded Oct 11, 2022
From: HOLOGIC, INC.; FAXITRON BIOPTICS, LLC; BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 061639/0513 →
Continuity (2)
Provisional Application 63002898 · Mar 31, 2020
Related Publication 20230172572A1 · Jun 8, 2023