Sphingosine 1 phosphate receptor modulators
Compounds are provided having the structure of Formula (I): (Formula (I)) or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R is as defined herein. Such compounds serve as modulators of the sphingosine-1-phosphate receptor, and have utility for treatment of a malcondition for which activation of this receptor is medically indicated.
1. A compound having the structure of Formula (I):
or a pharmaceutically acceptable salt, isotope, hydrate or solvate thereof, wherein:
R is:
alkyl;
alkanediyl-NR 1 R 2 ;
alkanediyl-C(═O)OR 1 ; or
heterocyclylalkyl; and
R 1 and R 2 are independently H or C 1-4 alkyl.
2. The compound of claim 1 wherein R is alkyl.
3. The compound of claim 2 wherein alkyl is methyl, ethyl, isopropyl or tert-butyl.
4. The compound of claim 1 wherein R is alkanediyl-NR 1 R 2 .
5. The compound of claim 4 wherein R 1 and R 2 are independently hydrogen or methyl.
6. The compound of claim 1 wherein R is alkanediyl-C(═O)OR 1 .
7. The compound of claim 6 wherein R 1 is hydrogen or methyl.
8. The compound of claim 1 wherein R is heterocyclylalkyl.
9. The compound of claim 8 wherein heterocyclealkyl is —(CH 2 )-heterocycle.
10. The compound of claim 1 wherein the compound has one of the following structures, or a pharmaceutically acceptable salt, isotope, hydrate or solvate thereof: