Sphingosine 1 phosphate receptor modulators
Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R is as defined herein. Such compounds serve as modulators of the sphingosine-1-phosphate receptor, and have utility for treatment of a malcondition for which activation of this receptor is medically indicated.
1. A compound having the structure of Formula (I):
or a pharmaceutically acceptable salt, isotope, hydrate or solvate thereof, wherein R is alkyl.
2. The compound of claim 1 wherein alkyl is a straight chain or branched saturated alkyl having from 1 to 8 carbon atoms.
3. The compound of claim 2 wherein alkyl is a straight chain or branched saturated alkyl having from 1 to 4 carbon atoms.
4. The compound of claim 3 wherein alkyl is methyl, ethyl or isopropyl.
5. The compound of claim 1 wherein R is cycloalklyl having from 3 to 8 ring members.
6. The compound of claim 5 wherein cycloalklyl has from 3 to 6 ring members.
7. The compound of claim 6 wherein R is cycloalklyl is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl.
8. The compound of claim 1 wherein the compound has one of the following structures, or a pharmaceutically acceptable salt, homolog, hydrate or thereof: