APPARATUS, METHOD, SYSTEM FOR THE DETERMINATION OF BLOODBORNE FACTORS INDICATIVE OF INFLAMMATION
An apparatus includes a collection tube for containing a sample, a reading cell container including windows, the collection tube linked to the reading cell container to provide the sample to the reading cell container, a collimated light source composed in such way that light passes through the windows of the reading cell container and is reflected therein, an optical detector for the evaluation of collimated light attenuated by the sample within the reading cell container; and an electronic control device linked to the collection tube, collimated light source and optical detector.
1 . An apparatus comprising:
a collection tube for containing a sample;
a reading cell container including windows, the collection tube linked to the reading cell container to provide the sample to the reading cell container;
a collimated light source composed in such way that light passes through the windows of the reading cell container and is reflected therein;
optical detector for the evaluation of collimated light attenuated by the sample within the reading cell container; and
an electronic control device linked to the collection tube, collimated light source and optical detector.
2 . The apparatus of claim 1 further comprising a mixer device for a low homogenization of the sample inside a collection tube.
3 . The apparatus of claim 2 further comprising:
an aspiration needle positioned within the link between the collection tube and the reading cell container;
a pump device;
a hydraulic circuit connecting the aspiration needle to the reading cell container to enable their filling by the sample, guaranteed by an optical sensor comprising the collimated light source and an optical receiver, and a secondary optical flow sensor controlled by the electronic control device.
4 . The apparatus of claim 3 wherein the reading cell container is equipped with electromechanical actuators to vibrate the sample therein.
5 . The apparatus of claim 5 wherein the reading cell container includes a temperature control system linked to the electronic control device reaction environment standardization.
6 . The apparatus of claim 5 wherein the electronic control device is configured to convert a detected time dependent light variation into an aggregation index and a subsequent erythrocyte sedimentation rate, providing a result of an evaluated phenomenon as a numerical result.
7 . The apparatus of claim 1 wherein the collimated light source includes a light emitting diode (LED).
8 . The apparatus of claim 7 wherein the optical detector includes a charge-coupled device (CCD) sensor.
9 . The apparatus of claim 7 wherein the optical detector includes a linear photodiode array.
10 . The apparatus of claim 1 further comprising a waste reservoir for containing an evacuated sample from the reading cell container.
11 . An apparatus for determining the aggregation rate of red blood cells, and aggregant plasma proteins index, the apparatus comprising:
an optical receiver positioned to detect light from a blood sample portion comprising red blood cells that have aggregated;
a main controller coupled to the optical receiver for recording an aggregation rate of the red blood cells of the blood sample portion upon detected light variation;
a hydraulic circuit for providing the blood sample portion; and
a light emitter source to pass light into the blood sample portion.
12 . The apparatus of claim 11 , further comprising:
a reading cell container connected to the hydraulic circuit for receiving the blood sample portion.
13 . The apparatus of claim 11 , wherein the aggregation rate of the blood cells of the blood sample portion is recorded for a predetermined time based upon detected light variation.
14 . The apparatus of claim 12 , further comprising:
a disruption mechanism connected to the reading cell container for disruption of the red blood cells within the blood sample portion to assist in recording the disruption rate,
wherein the main controller activates the disruption mechanism for the disruption of the red blood cell within the blood sample portion until light detected indicates the disruption of aggregate within the blood sample portion.
15 . The apparatus of claim 12 , further comprising:
a fluid reservoir connected to the reading cell container for receipt of an evacuated blood sample portion from the reading cell container.
16 . The apparatus of claim 12 , wherein the apparatus comprises an evacuation mechanism to evacuate the evacuated blood sample portion from the reading cell container,
wherein the evacuation mechanism is configured to provide ultrasound stress to the reading cell container.
17 . The apparatus of claim 12 , wherein the reading cell container is configured for the optical detection of aggregation reaction.
18 . The apparatus of claim 14 , wherein the apparatus determines a disruption index of the red blood cells as rheological parameters usable for pathologic detection purposes.
19 . The apparatus of claim 11 , wherein the apparatus determines a mean red blood cells shape recovery ability.