COMPOSITIONS FOR THE IMPROVED TREATMENT OF ACNE AND RELATED DISORDERS
Methods of treatment and dosage regimes using hydrophobic gel or foam composition comprising a tetracycline antibiotic in treating or alleviating a disorder including, acne, acne related symptoms, a tetracycline antibiotic responsive acne related disorder, skin disorder caused by a bacteria, and a tetracycline antibiotic responsive sebaceous gland disease, P. acnes bacteria associated disorders and other superficial infections, including skin infections wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin.
1 - 34 . (canceled)
35 . A method of treating or alleviating rosacea, comprising topically administering a hydrophobic foam once daily to a target area on the skin or mucosa of a human subject having rosacea, wherein the hydrophobic foam is formed from a pre-foam formulation and a liquefied or compressed gas propellant, wherein the pre-foam formulation comprises:
a) about 60% to about 99% by weight of the pre-foam formulation of at least one hydrophobic solvent comprising a soybean oil;
b) a wax comprising a hydrogenated castor oil;
c) a fatty alcohol having a carbon chain length of 14 to 22 carbons, a fatty acid having a carbon chain length of 12 to 28 carbons, or mixtures of any two or more thereof; and
d) a therapeutically effective amount of a minocycline or a salt thereof;
wherein the wax and/or fatty alcohol constitute about 1% to about 22% by weight of the pre-foam formulation;
wherein the pre-foam formulation has a water activity (Aw) value of less than about 0.9; and
wherein the pre-foam formulation is surfactant free.
36 . A hydrophobic foam formed from a composition comprising a pre-foam formulation and a liquefied or compressed gas propellant, wherein the pre-foam formulation comprises:
a) about 60% to about 99% by weight of the pre-foam formulation of at least one hydrophobic solvent comprising a soybean oil;
b) a wax comprising a hydrogenated castor oil;
c) a fatty alcohol having a carbon chain length of 14 to 22 carbons, a fatty acid having a carbon chain length of 12 to 28 carbons, or mixtures of any two or more thereof; and
d) a therapeutically effective amount of a minocycline or a salt thereof;
wherein the wax and/or fatty alcohol constitute about 1% to about 22% by weight of the pre-foam formulation;
wherein the pre-foam formulation has a water activity (Aw) value of less than about 0.9; and
wherein the pre-foam formulation is surfactant free.
37 . The method of claim 35 , where the Aw value is less than about 0.5.
38 . The method of claim 35 , wherein the hydrophobic solvent comprises two or more of a soybean oil, a coconut oil, a cyclomethicone, and a mineral oil.
39 . The method of claim 35 , wherein the wax comprises two or more of a hydrogenated castor oil, a beeswax, a paraffin wax, and a wax that is solid at room temperature.