IP Library Granted Patent US 12,643,062
Granted Patent B2
US 12,643,062 · App. 17/937,690 · Granted Jun 2, 2026

Fluid filtration system with single use filter and integrated integrity test device and method of using same

Inventors: Bernhard Anton Meyer (Dreieich, DE); Jens Bretschneider (Dreieich, DE)
Assignee: Cytiva US LLC
B01D35/143B01D29/606B01D29/902B01D35/1573B01D2201/54
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Quick Facts
Patent No.
US 12,643,062
App. No.
17/937,690
Granted
Jun 2, 2026
Kind
B2
Abstract

A fluid filtration system includes a single use filter removably mounted to a cabinet of a workstation. The upstream end of the single use filter is in fluid communication with a pump via a fluid supply conduit that includes a test junction. An integrity test device is supported by the cabinet and is in fluid communication with the upstream end of the single use filter via a test conduit fluidly connected to the single use filter via the test junction of the fluid supply conduit. The integrity test device adapted to be connected to a source of pressurized gas and to selectively direct a flow of pressurized gas through the test conduit and the single use filter to perform a test operation on the single use filter.

Claims (32)

1 . A fluid filtration system comprising:

a workstation, the workstation comprising a cabinet;

a pump, the pump supported by the cabinet and adapted to selectively produce a flow of fluid;

a single use filter and a fluid supply conduit, the single use filter having an upstream end and a downstream end, the single use filter removably mounted to the workstation, the upstream end of the single use filter being in fluid communication with the pump via the fluid supply conduit, the fluid supply conduit comprising a test junction;

an integrity test device and a test conduit, the integrity test device supported by the cabinet and in fluid communication with the upstream end of the single use filter via the test conduit, the test conduit fluidly connected to the single use filter via the test junction of the fluid supply conduit, the integrity test device adapted to be connected to a source of pressurized gas and to selectively direct a flow of pressurized gas through the test conduit and the single use filter;

a control unit, the control unit comprising a processor and a non-transitory computer readable medium bearing an integrity test program, the processor arranged with the computer readable medium to execute the integrity test program, the processor being in electrical communication with the integrity test device to selectively operate the integrity test device to perform a test operation on the single use filter using the flow of pressurized gas based upon instructions from the integrity test program.

2 . The fluid filtration system according to claim 1 , wherein the fluid supply conduit comprises a fluid supply valve, the test conduit comprises a test conduit valve, and the integrity test program is configured to perform the following steps as part of the test operation when executed by the processor:

close the fluid supply valve to occlude the fluid supply conduit,

open the test conduit valve to open the test conduit,

operate the integrity test device to direct the flow of pressurized gas through the test conduit and through the single use filter.

3 . The fluid filtration system according to claim 1 , wherein the test conduit comprises an air filter disposed between the integrity test device and the single use filter.

4 . The fluid filtration system according to claim 1 , wherein the test conduit comprises a liquid sensor disposed between the integrity test device and the test junction.

5 . The fluid filtration system according to claim 1 , wherein the test conduit comprises an air filter disposed between the integrity test device and the single use filter, a liquid sensor disposed between the air filter and the test junction, and a test conduit valve disposed between the air filter and the liquid sensor.

6 . The fluid filtration system according to claim 1 , wherein the test conduit comprises a vent junction, the system further comprising:

a vent conduit, the vent conduit in fluid communication with the test conduit via the vent junction, the vent conduit comprising a vent valve;

wherein the integrity test program is configured to perform the following step as part of the test operation when executed by the processor:

close the vent valve to occlude the vent conduit.

7 . The fluid filtration system according to claim 1 , further comprising:

a discharge conduit, the discharge conduit in fluid communication with the downstream end of the single use filter, the discharge conduit comprising a first outlet and a second outlet and a first outlet valve and a second outlet valve respectively associated with the first outlet and the second outlet, the first outlet adapted for fluid connection to a product container and the second outlet adapted for fluid connection to a waste repository;

wherein the integrity test program is configured to perform the following steps as part of the test operation when executed by the processor:

close the first outlet valve to occlude the first outlet,

open the second outlet valve to open the second outlet.

8 . The fluid filtration system according to claim 7 , wherein the discharge conduit comprises a pressure sensor configured to measure a pressure within the discharge conduit, the pressure sensor configured to generate a pressure signal indicative of the pressure measured within the discharge conduit, the processor in electrical communication with the pressure sensor to receive the pressure signal therefrom.

9 . The fluid filtration system according to claim 8 , wherein the integrity test device includes a FIT pressure sensor, the FIT pressure sensor configured to generate a pressure signal indicative of the pressure measured within the test conduit upstream of the single use filter, the processor in electrical communication with the FIT pressure sensor to receive the pressure signal therefrom, and wherein the integrity test program is configured to perform the following steps as part of the test operation when executed by the processor:

receive the pressure signal from the FIT pressure sensor,

determine whether a test condition of the test operation is satisfied based upon the pressure signal.

10 . The fluid filtration system according to claim 1 , further comprising:

a display device, the display device in operable arrangement with the processor;

wherein the integrity test program is configured to perform the following steps as part of the test operation when executed by the processor:

determine whether the single use filter satisfied the test operation,

generate a graphical display containing a graphical indication of whether the single use filter satisfied the test operation,

display the graphical display on the display device.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 22, 2023
From: PALL CORPORATION
To: CYTIVA US LLC
Reel/Frame 063144/0716 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 16, 2023
From: MEYER, BERNHARD ANTON; BRETSCHNEIDER, JENS
To: PALL GMBH
Reel/Frame 063006/0573 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 16, 2023
From: PALL GMBH
To: PALL INTERNATIONAL SÀRL
Reel/Frame 063006/0658 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 16, 2023
From: PALL INTERNATIONAL SÀRL
To: PALL CORPORATION
Reel/Frame 063006/0730 →
Continuity (2)
Provisional Application 63295830 · Dec 31, 2021
Related Publication 20230211263A1 · Jul 6, 2023
References Cited (22)
US 4340479A · Pall · 1982 [cited by applicant]
US 4925572A · Pall · 1990 [cited by applicant]
US 5152905A · Pall et al. · 1992 [cited by applicant]
US 5443743A · Gsell · 1995 [cited by applicant]
US 5472621A · Matkovich et al. · 1995 [cited by applicant]
US 6074869A · Pall et al. · 2000 [cited by applicant]
US 8354029B2 · Hank · 2013 [cited by examiner]
US 20110138936A1 · Collins et al. · 2011 [cited by applicant]
US 20170284584A1 · Kesselaar et al. · 2017 [cited by applicant]
US 20200353414A1 · Diel · 2020 [cited by examiner]
CN 108120560A · 2018 [cited by applicant]
CN 111356520A · 2020 [cited by applicant]
EP 2260919A2 · 2010 [cited by applicant]
JP H10225628A · 1998 [cited by applicant]
JP 2007283297A · 2007 [cited by applicant]
JP 2013513470A · 2013 [cited by applicant]
KR 1020130051693A · 2013 [cited by applicant]
KR 1020190011338A · 2019 [cited by applicant]
European Patent Office, Extended European Search Report in European Patent Application No. 22216935.1 (May 8, 2023). [cited by applicant]
Japan Patent Office, Notice of Reasons for Rejection in Japanese Patent Application No. 2022-209790 (Jan. 30, 2024). [cited by applicant]
China National Intellectual Property Administration, First Office Action, regarding Chinese Patent Application No. 202211722521.9, dated Apr. 22, 2025. [cited by applicant]
Korean Intellectual Property Office, Notice of Preliminary Rejection, regarding Korean Patent Application No. 10-2022-0190856, dated Jul. 30, 2025. [cited by applicant]