IP Library › Patent Application 17937948
Patent Application
App. No. 17/937,948

COMPOSITIONS AND METHODS COMPRISING CELECOXIB OR RELATED COMPOUNDS AND DEXTROMETHORPHAN

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Quick Facts
Patent No.
US None
App. No.
17/937,948
Abstract

Neurological disorders may be treated by administering a therapeutically effective amount of dextromethorphan and a therapeutically effective amount of a compound that inhibits the metabolism of dextromethorphan, to a person in need thereof. The two compounds may be administered separately, or in a single dosage form or composition as described herein.

Claims (20)

1 . A dosage form containing dextromethorphan and a CYP2D6 inhibitor.

2 . The dosage form of claim 1 , wherein the CYP2D6 inhibitor is celecoxib.

3 . The dosage form of claim 1 , wherein the CYP2D6 inhibitor is levomilnacipran.

4 . The dosage form of claim 1 , wherein the CYP2D6 inhibitor is vilazodone.

5 . The dosage form of claim 1 , wherein the CYP2D6 inhibitor is vortioxetine.

6 . A method of treating a neurological disorder, comprising administering a dosage form according to claim 1 to a human being in need thereof.

7 . The method of claim 6 , wherein the neurological disorder comprises pseudobulbar affect, depression, a disorder related to memory or cognition, schizophrenia, Parkinson's disease, amyotrophic lateral sclerosis (ALS), Rhett's syndrome, or seizures.

8 . The method of claim 6 , wherein the neurological disorder comprises pseudobulbar affect.

9 . The method of claim 6 , wherein the neurological disorder comprises depression.

10 . The method of claim 6 , wherein the neurological disorder comprises a disorder related to memory or cognition.

11 . The method of claim 6 , wherein the neurological disorder comprises schizophrenia.

12 . The method of claim 6 , wherein the neurological disorder comprises Parkinson's disease.

13 . The method of claim 6 , wherein the neurological disorder comprises ALS.

14 . The method of claim 6 , wherein the neurological disorder comprises Rhett's syndrome.

15 . The method of claim 6 , wherein the neurological disorder comprises seizures.

16 . The method of claim 6 , wherein about 30 mg to about 350 mg of dextromethorphan is administered to the human being daily.

17 . The method of claim 6 , wherein the CYP2D6 inhibitor is celecoxib.

18 . The method of claim 6 , wherein the CYP2D6 inhibitor is levomilnacipran.

19 . The method of claim 6 , wherein the CYP2D6 inhibitor is vilazodone.

20 . The method of claim 6 , wherein the CYP2D6 inhibitor is vortioxetine.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 6, 2023
From: TABUTEAU, HERRIOT
To: ANTECIP BIOVENTURES II LLC
Reel/Frame 062296/0621 →