COMPOSITIONS AND METHODS FOR TREATING HEADACHES
The present disclosure provides new methods of treating headache disorders with 5-methoxytryptamine or 5-hydroxytryptamine and compositions thereof
1 . A method of treating an acute headache in a patient in need thereof comprising administering a therapeutically effective amount of a tryptamine comprising 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), 5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT) or prodrugs or pharmaceutically acceptable salts thereof.
2 . The method of claim 1 , wherein the acute headache is an acute migraine.
3 . The method of claim 1 , wherein the acute headache is a cluster headache episode.
4 . The method of claim 1 , comprising administering a therapeutically effective amount of 5-MeO-DMT or a prodrug or a pharmaceutically acceptable salt thereof to the patient.
5 . The method of claim 4 , comprising administering between about 0.25 mg to about 50 mg of 5-MeO-DMT.
6 . The method of claim 4 , comprising administering between about 0.25 mg to about 36 mg of 5-MeO-DMT.
7 . The method of claim 4 , comprising administering between about 6 mg to about 30 mg of 5-MeO-DMT.
8 . The method of claim 4 , comprising administering between about 0.25 mg to about 3 mg of 5-MeO-DMT.
9 . The method of claim 4 , comprising administering about 10 mg of 5-MeO-DMT.
10 . The method of any claim 1 , comprising administering a therapeutically effective amount of 5-OH-DMT or a prodrug or a pharmaceutically acceptable salt thereof to the patient.
11 . The method of claim 10 , comprising administering between about 0.25 mg to about 50 mg of 5-OH-DMT.
12 . The method of claim 1 , comprising administering the tryptamine by insufflation.
13 . The method of claim 1 , comprising administering the tryptamine intranasally.
14 . The method of claim 1 , comprising administering the tryptamine orally.
15 . The method of claim 1 , comprising administering the tryptamine subcutaneously.
16 . The method of claim 1 , comprising administering the tryptamine sublingually.
17 . The method of claim 1 , comprising administering the tryptamine buccally.
18 . The method of claim 1 , comprising administering the tryptamine by inhalation.
19 . The method of claim 1 , comprising administering a single dose of the tryptamine to the patient.
20 . The method of claim 19 , further comprising administering a second dose of tryptamine to the patient about 30 minutes after a first administration if the first dose is not therapeutically effective.
21 . The method of claim 1 , comprising administering the tryptamine at the onset of the acute headache.
22 . The method of claim 1 , wherein the administration reduces the patient's pain associated with the acute headache.