Stable pharmaceutical compositions of cyclophosphamide

1. A stable, ready-to-administer, liquid composition for oral administration comprising:

(i) cyclophosphamide at a concentration of about 10 mg/ml;

(ii) a non-aqueous lipid solvent is selected from a group consisting of phospholipids, medium-chain fatty acids, medium-chain fatty acid esters of glycerol, medium-chain fatty acid esters of polyethylene glycol, medium-chain fatty acid esters of propylene glycol, long-chain fatty acids, long-chain fatty acid esters of glycerol, long-chain fatty acid esters of polyethylene glycol, long-chain fatty acid esters of propylene glycol, or combinations thereof; and

(iii) a co-solvent selected from ethanol and glycerin;

wherein a concentration of the non-aqueous lipid solvent ranges from about 60% to 99% by weight of the composition;

wherein a concentration of the co-solvent is less than 10% by weight of the composition; and

wherein a level of total impurities in said liquid composition is less than 5% as determined by HPLC when stored at 2-8° C. for at least 3 months.

2. The composition of claim 1 , wherein the composition has a RC-A impurity of less than about 1% (w/w) as measured by HPLC, when stored at 2-8° C. for at least 3 months.

3. The composition of claim 1 , wherein the composition has a pH in the range of from about 3 to about 7.5.

4. The composition of claim 1 , wherein the liquid composition is a solution.