IP Library › Granted Patent US 12,653,776
Granted Patent B2
US 12,653,776 · App. 17/962,608 · Granted Jun 16, 2026

Methods of treatment of cancer by continuous infusion of coenzyme Q10

Inventors: Niven Rajin Narain (Cambridge, MA); Rangaprasad Sarangarajan (Boylston, MA); Thomas Mitchell Gray (Mt. Juliet, TN); John Patrick McCook (Frisco, TX); Joaquin J. Jimenez (Miami, FL)
Assignee: BPGbio, Inc.
A61K9/0019A61K31/122A61K31/337A61K31/513A61K31/519A61K31/704A61K31/7068A61K31/7076A61K38/43
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Quick Facts
Patent No.
US 12,653,776
App. No.
17/962,608
Granted
Jun 16, 2026
Kind
B2
Abstract

The invention provides regimens and methods for the treatment of cancer comprising continuous infusion of coenzyme Q10. The coenzyme Q10 may be administered as a monotherapy, or in combination with an additional agent, such as an anticancer agent, a chemotherapeutic agent, or an anti-angiogenic agent. The coenzyme Q10 may be administered at two or more different rates.

Claims (23)

1 . A method of treating cancer in a subject, comprising administering to the subject a composition comprising a dose of coenzyme Q10 by continuous intravenous infusion for at least 48 hours, thereby treating the cancer in the subject.

2 . The method of claim 1 , wherein the coenzyme Q10 is administered by continuous intravenous infusion for at least 72 hours.

3 . The method of claim 1 , wherein the coenzyme Q10 is administered by continuous intravenous infusion for at least 96 hours.

4 . The method of claim 1 , wherein the coenzyme Q10 is administered by continuous intravenous infusion for at least 144 hours.

5 . The method of claim 1 , wherein the continuous intravenous infusion is administered once per week.

6 . The method of claim 1 , wherein the continuous infusion is administered twice per week.

7 . A method of treating cancer in a subject, comprising

(a) administering to the subject a composition comprising a dose of coenzyme Q10 by continuous intravenous infusion for at least 48 hours;

(b) monitoring the subject for decreased coagulation; and

(c) discontinuing treatment with coenzyme Q10 in a subject identified as having decreased coagulation, thereby treating the cancer in the subject.

8 . A method of treating cancer in a subject, comprising

(a) administering to the subject a composition comprising a dose of coenzyme Q10 by continuous intravenous infusion for at least 48 hours;

(b) monitoring the subject for decreased coagulation;

(c) administering an agent to increase coagulation in a subject identified as having decreased coagulation;

(d) confirming the subject has normal coagulation; and

(e) continuing treatment with coenzyme Q10, thereby treating the cancer in the subject.

9 . A method of treating cancer in a subject, comprising

(a) administering to the subject a composition comprising a dose of coenzyme Q10 by continuous intravenous infusion for at least 48 hours;

(b) monitoring the subject for decreased coagulation; and

(c) continuing treatment with coenzyme Q10 in a subject identified as having normal coagulation, thereby treating the cancer in the subject.

10 . The method of claim 1 , further comprising administering to the subject an agent to increase coagulation in the subject.

11 . The method of claim 10 , wherein the agent to increase coagulation comprises vitamin K.

12 . The method of claim 8 , wherein the agent to increase coagulation comprises vitamin K.

Assignments (5)
SECURITY INTEREST Recorded Aug 29, 2025
From: BPGBIO INC.
To: BERG SURVIVOR’S TRUST; BERG, KARA ANN; THLIVERIS, ANDREW T.
Reel/Frame 072805/0303 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 8147825 WAS ADDED PREVIOUSLY RECORDED AT REEL: 70903 FRAME: 693. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Apr 30, 2025
From: BPGBIO INC.
To: PHOENIX GENESIS LLC
Reel/Frame 071285/0001 →
SECURITY INTEREST Recorded Apr 21, 2025
From: BPGBIO INC.
To: PHOENIX GENESIS LLC
Reel/Frame 070903/0693 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2023
From: BERG LLC
To: BPGBIO, INC.
Reel/Frame 063842/0405 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 22, 2022
From: NARAIN, NIVEN RAJIN; SARANGARAJAN, RANGAPRASAD; GRAY, THOMAS MITCHELL; MCCOOK, JOHN PATRICK; JIMENEZ, JOAQUIN J.
To: BERG LLC
Reel/Frame 061852/0721 →
Continuity (7)
Continuation 17686569 · Mar 4, 2022
Continuation 15869630 · Jan 12, 2018
Continuation 14477828 · Sep 4, 2014
Provisional Application 61912770 · Dec 6, 2013
Provisional Application 61901351 · Nov 7, 2013
Provisional Application 61873510 · Sep 4, 2013
Related Publication 20230285272A1 · Sep 14, 2023
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