IP Library › Patent Application 17964423

Patent Application

App. No. 17/964,423

1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF

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App. No.: 17/964,423

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Abstract

Pyrrolo[2,3-b]pyridine compound for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of pyrrolo[2,3-b]pyridine compound or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Claims (2215)

1 . A compound, or a pharmaceutically acceptable salt thereof, of Formula I:

wherein:

R 1 is pyridinyl substituted with 1-4 R 5 ;

R 2 is selected from the group consisting of H, —OR 7 , 5-membered heteroaryl optionally substituted with 1-3 R 8 , and —NHR 9 .

R 3 is selected from the group consisting of H, CN, —CO 2 H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(CH 2 ) p heterocyclyl optionally substituted with 1-10 R 11 , -(5-9 membered heteroaryl) optionally substituted with 1-10 R 12 ; phenyl optionally substituted with 1-5 R 13 , —NHheteroaryl optionally substituted with 1-10 R 14 ; —C(═O)NHR 15 , —NH(C═O)R 16 , and —C(═O)R 17 ;

R 4 is selected from the group consisting of H, halide, CN, —OR 18 , —CH 2 OH, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), -(5-9 membered heteroaryl) optionally substituted with 1-10 R 19 ; phenyl optionally substituted with 1-5 R 20 , —NHphenyl optionally substituted with 1-5 R 21 , —(CH 2 ) p carbocyclyl optionally substituted with 1-12 R 22 , —C(═O)NHR 23 , —NH(C═O)R 24 , and —C(═O)R 25 ;

with the proviso that at least two of R 2 , R 3 , and R 4 are H;

each R 5 is independently selected from the group consisting of —OR 26 , -heterocyclyl optionally substituted with 1-10 R 27 , and —NHheterocyclyl optionally substituted with 1-10 R 28 ;

R 7 is selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 8 is independently selected from the group consisting of H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

R 9 is —CH 2 (6-membered heteroaryl) optionally substituted with 1-4 R 39 ;

R 10 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 11 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 12 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 37 ;

each R 13 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 37 ;

each R 14 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 37 ;

R 15 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

R 16 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

R 17 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

R 18 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and —(CH 2 ) p carbocyclyl optionally substituted with 1-12 R 38 ;

each R 19 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 20 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 21 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 37 ;

each R 22 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

R 23 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

R 24 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

R 25 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

each R 26 is unsubstituted —(C 1-9 haloalkyl);

each R 27 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 28 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 37 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 38 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 39 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), -heterocyclyl optionally substituted with 1-10 R 37 , and -heteroaryl optionally substituted with 1-10 R 38 ;

each p is independently 0 or 1; and

with the proviso that Formula I is not a structure selected from the group consisting of:

2 . The compound of claim 1 , wherein R 1 is 4-pyridine substituted with one R 5 .

3 . The compound of claim 1 , wherein each R 5 is independently selected from the group consisting of —OMe and -heterocyclyl optionally substituted with one R 27 .

4 . The compound of claim 1 , wherein R 3 and R 4 are H and R 2 is selected from the group consisting of —OMe and a 5-membered heteroaryl optionally substituted with one R 8 .

5 . The compound of claim 1 , wherein R 2 and R 4 are H and R 3 is selected from the group consisting of -heterocyclyl optionally substituted with one R 11 , -(5-6 membered heteroaryl) optionally substituted with 1-2 R 12 ; —C(═O)NHR 15 , —NH(C═O)R 16 , and —C(═O)R 17 .

6 . The compound of claim 1 , wherein R 2 and R 3 are H and R 4 is selected from the group consisting of -carbocyclyl, —C(═O)NHR 23 , and —NH(C═O)R 24 .

7 . A compound, or a pharmaceutically acceptable salt thereof, of Formula Ia:

wherein:

R 1 is selected from the heteroaryl group consisting of:

and optionally substituted with 1-10 R 6 ; and

wherein a carbon atom on an aromatic ring of the heteroaryl form the bond with

each R 6 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —OR 29 , —CH 2 OH, -heterocyclyl optionally substituted with 1-10 R 30 , —NHheterocyclyl optionally substituted with 1-10 R 31 , -heteroaryl optionally substituted with 1-10 R 32 ; —NHheteroaryl optionally substituted with 1-10 R 33 ; —NHCH 2 heteroaryl optionally substituted with 1-10 R 33 ; —CH 2 N(R 34 ) 2 , —C(═O)N(R 35 ) 2 , and —C(═O)R 36 ;

alternatively, two R 6 attached to the same carbon atom are taken together to form a carbonyl group;

alternatively, two R 6 attached to the same carbon atom are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -carbocyclyl optionally substituted with 1-12 R 38 ;

each R 6a is independently selected from the group consisting of —OR 29a , —CH 2 OH, -heterocyclyl optionally substituted with 1-10 R 30 , —CH 2 N(R 34 ) 2 , —C(═O)N(R 35 ) 2 , and —C(═O)R 36 ;

each R 29 is independently selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 37 ;

each R 29a is -heterocyclyl optionally substituted with 1-10 R 37 ;

each R 30 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

alternatively, two R 30 attached to the same carbon atom are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -carbocyclyl optionally substituted with 1-12 R 38 ;

each R 31 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 32 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 33 is independently selected from the group consisting of halide, —OR 45 , unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 37 ;

each R 34 are independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 35 are independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl); —(CH 2 ) p heterocyclyl optionally substituted with 1-10 R 40 , and -heteroaryl optionally substituted with 1-10 R 39 ;

each R 36 is -heterocyclyl optionally substituted with 1-10 R 41 ;

each R 40 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(CH 2 ) m OMe, —(CH 2 ) p carbocyclyl optionally substituted with 1-12 R 38 , and —(CH 2 ) p heteroaryl optionally substituted with 1-10 R 39 ;

each R 41 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), -carbocyclyl optionally substituted with 1-12 R 38 , and -heterocyclyl optionally substituted with 1-10 R 37 ;

alternatively, two R 41 attached to the same carbon atom are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -carbocyclyl optionally substituted with 1-12 R 38 ;

each R 42 is independently selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 45 is independently selected from the group consisting of unsubstituted —(C 2-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 37 ;

each n is independently 0 to 3;

each m is independently 1 to 6;

each p is independently 0 or 1; and

with the proviso that Formula Ia is not a structure selected from the group consisting of:

8 . The compound of claim 7 , wherein R 1 is selected from the group consisting of:

optionally substituted with 1-2 R 6 .

9 . The compound of claim 8 , wherein each R 6 is independently selected from the group consisting of unsubstituted —(C 1-3 alkyl), -heterocyclyl optionally substituted with one R 30 , -(5-6 membered heteroaryl) optionally substituted with 1-2 R 32 , and —C(═O)NHR 35 .

10 . A compound, or a pharmaceutically acceptable salt thereof, of Formula Ib:

R 1 is 7-14-membered heteroaryl optionally substituted with 1-10 R 6 ;

with the proviso that when the heteroaryl is selected from the group consisting of

that the 2-position is substituted with R 42 ;

wherein a carbon atom on an aromatic ring of the heteroaryl form the bond with

R 2 is selected from the group consisting of H, —OR 7 , 5-membered heteroaryl optionally substituted with 1-3 R 8 , and —NHR 9 ;

with the proviso that one of R 2 and R 4 is H and the other of R 2 and R 4 is not H;

alternatively, two R 6 attached to the same carbon atom are taken together to form a carbonyl group;

R 7 is selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

R 9 is —CH 2 (6-membered heteroaryl) optionally substituted with 1-4 R 39 ;

R 23 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

R 24 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

R 25 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

each R 36 is -heterocyclyl optionally substituted with 1-10 R 41 ;

each m is independently 1 to 6;

each p is independently 0 or 1; and

with the proviso that Formula Ib is not a structure selected from the group consisting of:

11 . The compound of claim 10 , wherein R 1 is selected from the group consisting of:

optionally substituted with 1-2 R 6 .

12 . The compound claim 11 , wherein each R 6 is independently selected from the group consisting of unsubstituted —(C 1-3 alkyl), -heterocyclyl optionally substituted with one R 30 , -(5-6 membered heteroaryl) optionally substituted with 1-2 R 32 , and —C(═O)NHR 35 .

13 . The compound of claim 12 , wherein R 4 is H and R 2 is selected from the group consisting of —OMe and a 5-membered heteroaryl optionally substituted with one R 8 .

14 . The compound of claim 12 , wherein R 2 is H and R 4 is selected from the group consisting of -carbocyclyl, —C(═O)NHR 23 , and —NH(C═O)R 24 .

15 . A compound, or a pharmaceutically acceptable salt thereof, of Formula Ie:

wherein:

R 1 is selected from the heteroaryl group consisting of:

and optionally substituted with 1-10 R 6 ; and

with the proviso that when R 1 is

R 3 is not halide or methyl;

wherein a carbon atom on an aromatic ring of the heteroaryl form the bond with

R 3 is selected from the group consisting of halide, CN, —CO 2 H, —OR 10 , unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(CH 2 ) p heterocyclyl optionally substituted with 1-10 R 11 , -(5-9 membered heteroaryl) optionally substituted with 1-10 R 12 ; phenyl optionally substituted with 1-5 R 13 , —NHheteroaryl optionally substituted with 1-10 R 14 ; —C(═O)NHR 15 , —NH(C═O)R 16 , and —C(═O)R 17 ;

alternatively, two R 6 attached to the same carbon atom are taken together to form a carbonyl group;

each R 6a is independently selected from the group consisting of halide, unsubstituted —(C 2-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —OR 29 , —CH 2 OH, -heterocyclyl optionally substituted with 1-10 R 30 , —NHheterocyclyl optionally substituted with 1-10 R 31 , -heteroaryl optionally substituted with 1-10 R 32 ; —NHheteroaryl optionally substituted with 1-10 R 33 ; —NHCH 2 heteroaryl optionally substituted with 1-10 R 33 ; —CH 2 N(R 34 ) 2 , —C(═O)N(R 35 ) 2 , and —C(═O)R 36 ;

each R 6b is independently selected from the group consisting of —OR 29 , —CH 2 OH, -heterocyclyl optionally substituted with 1-10 R 30 , —CH 2 N(R 34 ) 2 , —C(═O)N(R 35 ) 2 , and —C(═O)R 36 ;

R 10 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

R 15 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

R 16 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

R 17 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 37 and -heteroaryl optionally substituted with 1-10 R 39 ;

each R 36 is -heterocyclyl optionally substituted with 1-10 R 41 ;

each R 43 is H;

each R 44 is independently selected from the group consisting of H, unsubstituted —(C 2-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each n is independently 0 to 6;

each m is independently 1 to 6;

each p is independently 0 or 1; and

with the proviso that Formula Ie is not a structure selected from the group consisting of:

16 . The compound of claim 15 , wherein R 1 is selected from the group consisting of:

optionally substituted with 1-2 R 6 .

17 . The compound of claim 16 , wherein each R 6 is independently selected from the group consisting of unsubstituted —(C 1-3 alkyl), -heterocyclyl optionally substituted with one R 30 , -(5-6 membered heteroaryl) optionally substituted with 1-2 R 32 , and —C(═O)NHR 35 .

18 . The compound of claim 17 , wherein R 3 is selected from the group consisting of -heterocyclyl optionally substituted with one R 11 , -(5-6 membered heteroaryl) optionally substituted with 1-2 R 12 ; —C(═O)NHR 15 , —NH(C═O)R 16 , and —C(═O)R 17 .

19 . The compound according to claim 1 , wherein the compound of Formula I is selected from the group consisting of:

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [68];

4-(1-methyl-1H-pyrazol-4-yl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [175];

5-methyl-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [301];

5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [343];

5-(4-methylpiperazin-1-yl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [385];

5-((4-methylpiperazin-1-yl)methyl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [427];

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [469];

(4-methylpiperazin-1-yl)(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [511];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [553];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [595];

1-methyl-N-(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [637];

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [679];

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [721];

N-(5-fluoropyridin-3-yl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [763];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [805];

N-(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [847];

N,3-bis(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [889];

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-phenyl-1H-pyrrolo[2,3-b]pyridine [931];

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridine [973];

5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1015];

5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1060];

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine [1099]; and

5-methyl-3-(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine [1141];

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1183];

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1225];

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1267];

5-(2,4-dimethylpyridin-3-yl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1309];

5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1351];

3,5-bis(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1393];

6-chloro-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1435];

6-methyl-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1477];

5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1522];

6-cyclobutyl-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1561];

6-cyclopentyl-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1603];

6-(cyclobutylmethyl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1645];

6-methoxy-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1687];

6-(difluoromethoxy)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1729];

6-ethoxy-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1771];

(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1813];

1-methyl-N-(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1855];

N-(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1897];

N-(3-(4-methylpiperazin-1-yl)phenyl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1939];

6-(1-methyl-1H-pyrazol-4-yl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1981]; and

3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-6-phenyl-1H-pyrrolo[2,3-b]pyridine [2023]; or a pharmaceutically acceptable salt thereof.

20 . The compound according to claim 7 , wherein the compound of Formula Ia is selected from the group consisting of:

1H,1′H-3,4′-bipyrrolo[2,3-b]pyridine [2];

2-(1H-pyrrolo[2,3-b]pyridin-3-yl)thiazolo[5,4-b]pyridine [4];

2-(1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [5];

1H,1′H-2,3′-bipyrrolo[2,3-b]pyridine [6];

2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one [8];

6,6-dimethyl-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydro-4H-imidazo[1,5-b]pyrazol-4-one [9];

7-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [10];

2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-one [11];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [12];

8-fluoro-2-methyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [13];

N-(1-methylpiperidin-4-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [14];

N-methyl-N-(1-methylpiperidin-4-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [15];

N-(2,2-difluoroethyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [16];

N-(2,2-difluoroethyl)-N-methyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [17];

1-(6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine [18];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [19];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrazine [20];

(6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrazin-3-yl)(4-methylpiperazin-1-yl)methanone [21];

4-fluoro-1-isopropyl-2-methyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [22];

4-fluoro-2-methyl-1-(piperidin-4-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [23];

4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [24];

1-isopropyl-2-methyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [25];

3-isopropyl-2-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3H-imidazo[4,5-b]pyridine [26];

3-isopropyl-2-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3H-imidazo[4,5-b]pyridine [27];

2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-7,8-dihydro-6H-pyrrolo[2′,1′:2,3]imidazo[4,5-b]pyridine [28];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [29];

7-(1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [30];

3-methyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridine [32];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [33];

3-methyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [34];

(6-(1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazin-3-yl)methanol [35];

3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [36];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [37];

3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [38];

N-(2,2-difluoroethyl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [39];

(R)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [40];

N-((3-fluoroazetidin-3-yl)methyl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [41];

N-((3-fluoro-1-methylazetidin-3-yl)methyl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [42];

N-((3R,4R)-3-fluoropiperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [43];

N-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [44];

N-(1-methylpiperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [45];

N-methyl-N-(1-methylpiperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [46];

N-(1-cyclopropylpiperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [47];

N-(1-(cyclopropylmethyl)piperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [48];

N-(1-(2,2-difluoropropyl)piperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [49];

N-(1-(2-methoxyethyl)piperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [50];

N-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [51];

N-(pyridin-3-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [52];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [53];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-(4-methylpiperazin-1-yl)piperidin-1-yl)methanone [54];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [55];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-cyclopropylpiperazin-1-yl)methanone [56];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4,7-diazaspiro[2.5]octan-7-yl)methanone [57];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)methanone [58];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [59];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [60];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(2,6-diazaspiro[3.3]heptan-2-yl)methanone [61];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)methanone [62];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone [63];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone [64];

5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyrimidine [65];

3-(3,3-dimethyl-2,3-dihydrobenzofuran-5-yl)-1H-pyrrolo[2,3-b]pyridine [72];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [73];

1′-methyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [74];

5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [75];

3,3-dimethyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [77];

6′-(1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [78];

3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridine [79];

2,2-dimethyl-7-(1H-pyrrolo[2,3-b]pyridin-3-yl)chroman-4-one [80];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [81];

4,4-dimethyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [82];

7-(1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [83];

8-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [84];

4-methyl-8-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [85];

9-fluoro-8-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [86];

(6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinolin-4-yl)(4,7-diazaspiro[2.5]octan-7-yl)methanone [88];

N-(1-methylpiperidin-4-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline-4-carboxamide [89];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [90];

2-((1-methylpiperidin-4-yl)oxy)-7-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [91];

N-(1-methylpiperidin-4-yl)-7-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxalin-2-amine [92];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [93];

4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [94];

4-(4-methylpiperazin-1-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [95];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4,7-diazaspiro[2.5]octan-7-yl)quinazoline [96];

6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(5,8-diazaspiro[3.5]nonan-8-yl)quinazoline [97];

9-(6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-yl)-6,9-diazaspiro[4.5]decane [98];

4-((1-methylpiperidin-4-yl)oxy)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [99];

N-(1-methylpiperidin-4-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [100];

N-(6-methoxypyridin-3-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [101];

N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [102];

N-(pyridin-3-ylmethyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [103];

N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [104];

N-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)methyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [105];

N-(1-methylpiperidin-4-yl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline-4-carboxamide [106];

(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-morpholinopiperidin-1-yl)methanone [107]; and

(6-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-yl)(4,7-diazaspiro[2.5]octan-7-yl)methanone [108]; or a pharmaceutically acceptable salt thereof.

21 . The compound according to claim 10 , wherein the compound of Formula Ib is selected from the group consisting of:

5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [109];

2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [110];

7-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [111];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [112];

N-(2,2-difluoroethyl)-6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [113];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [114];

4-fluoro-1-isopropyl-6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-benzo[d]imidazole [115];

4-fluoro-6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [116];

1-isopropyl-6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-imidazo[4,5-b]pyridine [117];

1-isopropyl-6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-imidazo[4,5-c]pyridine [118];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [119];

7-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [120];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [121];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [122];

4-methoxy-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [123];

4-methoxy-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [124];

4-methoxy-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [125];

N-(2,2-difluoroethyl)-5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [126];

(R)-5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [127];

5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [128];

5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [129];

(5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [130];

(5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [131];

(5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [132];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [134];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [135];

5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [136];

5-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [137];

6′-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [138];

3-(chroman-6-yl)-4-methoxy-1H-pyrrolo[2,3-b]pyridine [139];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [140];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [141];

7-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [142];

8-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [143];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [144];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [145];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [146];

4-methoxy-6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [147];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [148];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [149];

6-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [150];

2-methyl-5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [151];

2-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [152];

7-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [153];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [154];

N-(2,2-difluoroethyl)-6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [155];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [156];

4-fluoro-1-isopropyl-2-methyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [157];

4-fluoro-2-methyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [158];

1-isopropyl-2-methyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [159];

1-isopropyl-2-methyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [160];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [161];

7-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [162];

1-methyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [163];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [164];

4-(1-methyl-1H-pyrazol-4-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [165];

4-(1-methyl-1H-pyrazol-4-yl)-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [166];

4-(1-methyl-1H-pyrazol-4-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [167];

N-(2,2-difluoroethyl)-5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [168];

(R)-5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [169];

5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [170];

5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [171];

(5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [172];

(5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [173];

(5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [174];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [176];

1′-methyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [177];

5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [178];

3,3-dimethyl-5-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [179];

6′-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [180];

3-(chroman-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine [181];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [182];

4,4-dimethyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [183];

7-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [184];

8-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[1,4]oxazepin-5(2H)-one [185];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [186];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [187];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [188];

4-methoxy-6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [189];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [190];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [191];

6-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [192];

5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [1411];

2-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1412];

7-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1413];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1414];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [1415];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1416];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole [1417];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1418];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [1419];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine [1420];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1421];

7-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1422];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1423];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1424];

6-chloro-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1425];

6-chloro-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1426];

6-chloro-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1427];

5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)pyrazolo[1,5-a]pyridine-3-carboxamide [1428];

(R)-5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1429];

5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1430];

5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1431];

(5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1432];

(5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1433];

(5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1434];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1436];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1437];

5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1438];

5-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1439];

6′-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1440];

6-chloro-3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridine [1441];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1442];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1443];

7-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1444];

8-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1445];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1446];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1447];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1448];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-methoxyquinazoline [1449];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1450];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1451];

6-(6-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1452];

2-methyl-5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1453];

2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1454];

7-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1455];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1456];

N-(2,2-difluoroethyl)-6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1457];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1458];

4-fluoro-1-isopropyl-2-methyl-6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1459];

4-fluoro-2-methyl-6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1460];

1-isopropyl-2-methyl-6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [1461];

1-isopropyl-2-methyl-6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1462];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1463];

7-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1464];

1-methyl-6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1465];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1466];

6-methyl-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1467];

6-methyl-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1468];

6-methyl-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1469];

N-(2,2-difluoroethyl)-5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1470];

(R)-5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1471];

5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1472];

5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1473];

(5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1474];

(5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1475];

(5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1476];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1478];

1′-methyl-6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1479];

5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1480];

3,3-dimethyl-5-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1481];

6′-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1482];

3-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridine [1483];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1484];

4,4-dimethyl-6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1485];

7-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1486];

8-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1487];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1488];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1489];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1490];

4-methoxy-6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1491];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1492];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1493];

6-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1494];

5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [1495];

2-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1496];

7-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1497];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1498];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [1499];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1500];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole [1501];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1502];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [1503];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine [1504];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1505];

7-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1506];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1507];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1508];

6-cyclopropyl-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1509];

6-cyclopropyl-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1510];

6-cyclopropyl-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1511];

5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)pyrazolo[1,5-a]pyridine-3-carboxamide [1512];

(R)-5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1513];

5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1514];

5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1515];

(5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1516];

(5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1517];

(5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1518];

6-cyclopropyl-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1519];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1520];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1521];

5-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1523];

6′-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1524];

3-(chroman-6-yl)-6-cyclopropyl-1H-pyrrolo[2,3-b]pyridine [1525];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1526];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1527];

7-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1528];

8-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1529];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1530];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1531];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1532];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-methoxyquinazoline [1533];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1534];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1535];

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1536];

5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [1537];

2-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1538];

7-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1539];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1540];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [1541];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1542];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole [1543];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1544];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [1545];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine [1546];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1547];

7-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1548];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1549];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1550];

6-cyclobutyl-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1551];

6-cyclobutyl-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1552];

6-cyclobutyl-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1553];

5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)pyrazolo[1,5-a]pyridine-3-carboxamide [1554];

(R)-5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1555];

5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1556];

5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1557];

(5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1558];

(5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1559];

(5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1560];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1562];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1563];

5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1564];

5-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1565];

6′-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1566];

3-(chroman-6-yl)-6-cyclobutyl-1H-pyrrolo[2,3-b]pyridine [1567];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1568];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1569];

7-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1570];

8-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1571];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1572];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1573];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1574];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-methoxyquinazoline [1575];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1576];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1577];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1578];

5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [1579];

2-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1580];

7-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1581];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1582];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [1583];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1584];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole [1585];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1586];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [1587];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine [1588];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1589];

7-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1590];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1591];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1592];

6-cyclopentyl-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1593];

6-cyclopentyl-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1594];

6-cyclopentyl-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1595];

5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)pyrazolo[1,5-a]pyridine-3-carboxamide [1596];

(R)-5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1597];

5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1598];

5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1599];

(5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1600];

(5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1601];

(5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1602];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1604];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1605];

5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1606];

5-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1607];

6′-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1608];

3-(chroman-6-yl)-6-cyclopentyl-1H-pyrrolo[2,3-b]pyridine [1609];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1610];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1611];

7-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1612];

8-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1613];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1614];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1615];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1616];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-methoxyquinazoline [1617];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1618];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1619];

6-(6-cyclopentyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1620];

5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [1621];

2-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1622];

7-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1623];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1624];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [1625];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1626];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole [1627];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1628];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [1629];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine [1630];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1631];

7-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1632];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1633];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1634];

6-(cyclobutylmethyl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1635];

6-(cyclobutylmethyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1636];

6-(cyclobutylmethyl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1637];

5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)pyrazolo[1,5-a]pyridine-3-carboxamide [1638];

(R)-5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1639];

5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1640];

5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1641];

(5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1642];

(5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1643];

(5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1644];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1646];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1647];

5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1648];

5-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1649];

6′-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1650];

3-(chroman-6-yl)-6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridine [1651];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1652];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1653];

7-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1654];

8-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1655];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1656];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1657];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1658];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-methoxyquinazoline [1659];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1660];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1661];

6-(6-(cyclobutylmethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1662];

5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [1663];

2-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1664];

7-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1665];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1666];

N-(2,2-difluoroethyl)-6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1667];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1668];

4-fluoro-1-isopropyl-6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-benzo[d]imidazole [1669];

4-fluoro-6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1670];

1-isopropyl-6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-imidazo[4,5-b]pyridine [1671];

1-isopropyl-6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-imidazo[4,5-c]pyridine [1672];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1673];

7-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1674];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1675];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1676];

6-methoxy-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1677];

6-methoxy-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1678];

6-methoxy-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1679];

N-(2,2-difluoroethyl)-5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1680];

(R)-5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1681];

5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1682];

5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1683];

(5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1684];

(5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1685];

(5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1686];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1688];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1689];

5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1690];

5-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1691];

6′-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1692];

3-(chroman-6-yl)-6-methoxy-1H-pyrrolo[2,3-b]pyridine [1693];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1694];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1695];

7-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1696];

8-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1697];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1698];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1699];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1700];

4-methoxy-6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1701];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1702];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1703];

6-(6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1704];

5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [1705];

2-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1706];

7-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1707];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1708];

N-(2,2-difluoroethyl)-6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1709];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1710];

4-fluoro-1-isopropyl-6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-benzo[d]imidazole [1711];

4-fluoro-6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1712];

1-isopropyl-6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-imidazo[4,5-b]pyridine [1713];

1-isopropyl-6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-imidazo[4,5-c]pyridine [1714];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1715];

7-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1716];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1717];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1718];

6-(difluoromethoxy)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1719];

6-(difluoromethoxy)-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1720];

6-(difluoromethoxy)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1721];

N-(2,2-difluoroethyl)-5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1722];

(R)-5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1723];

5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1724];

5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1725];

(5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1726];

(5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1727];

(5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1728];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1730];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1731];

5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1732];

5-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1733];

6′-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1734];

3-(chroman-6-yl)-6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridine [1735];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1736];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1737];

7-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1738];

8-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1739];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1740];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1741];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1742];

4-methoxy-6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1743];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1744];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1745];

6-(6-(difluoromethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1746];

5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [1747];

2-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1748];

7-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1749];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1750];

N-(2,2-difluoroethyl)-6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1751];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1752];

4-fluoro-1-isopropyl-6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-benzo[d]imidazole [1753];

4-fluoro-6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1754];

1-isopropyl-6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-imidazo[4,5-b]pyridine [1755];

1-isopropyl-6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-imidazo[4,5-c]pyridine [1756];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1757];

7-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1758];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1759];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1760];

6-ethoxy-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1761];

6-ethoxy-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1762];

6-ethoxy-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1763];

N-(2,2-difluoroethyl)-5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1764];

(R)-5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1765];

5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1766];

5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1767];

(5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1768];

(5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1769];

(5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1770];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1772];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1773];

5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1774];

5-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1775];

6′-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1776];

3-(chroman-6-yl)-6-ethoxy-1H-pyrrolo[2,3-b]pyridine [1777];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1778];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1779];

7-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1780];

8-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1781];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1782];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1783];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1784];

4-methoxy-6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1785];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1786];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1787];

6-(6-ethoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1788];

(3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1789];

(3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1790];

7-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1791];

(3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1792];

N-(2,2-difluoroethyl)-6-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1793];

(3-(imidazo[1,2-a]pyrimidin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1794];

(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1795];

(3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1796];

(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1797];

(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1798];

(3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1799];

(3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1800];

(3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1801];

(3-(imidazo[1,2-b]pyridazin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1802];

(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1803];

(3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1804];

(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1805];

N-(2,2-difluoroethyl)-5-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1806];

(R)-5-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1807];

5-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1808];

5-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1809];

(5-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1810];

(5-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1811];

(5-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1812];

6-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1814];

6-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1815];

5-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1816];

5-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1817];

6′-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1818];

(3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1819];

6-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1820];

6-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1821];

7-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1822];

8-(6-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1823];

(3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1824];

(3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1825];

(3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1826];

(3-(4-methoxyquinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1827];

(3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1828];

(3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1829];

(3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)methanol [1830];

1-methyl-N-(3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1831];

1-methyl-N-(3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1832];

1-methyl-N-(3-(1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1833];

N-(3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1834];

N-(2,2-difluoroethyl)-6-(6-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1835];

N-(3-(imidazo[1,2-a]pyrimidin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1836];

N-(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1837];

N-(3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1838];

N-(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1839];

N-(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1840];

N-(3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1841];

N-(3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1842];

1-methyl-N-(3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1843];

N-(3-(imidazo[1,2-b]pyridazin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1844];

1-methyl-N-(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1845];

1-methyl-N-(3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1846];

1-methyl-N-(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1847];

N-(2,2-difluoroethyl)-5-(6-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1848];

(R)-5-(6-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1849];

N-(1-methylpiperidin-4-yl)-5-(6-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1850];

5-(6-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1851];

1-methyl-N-(3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1852];

1-methyl-N-(3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1853];

1-methyl-N-(3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1854];

1-methyl-N-(3-(3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1856];

1-methyl-N-(3-(1′-methyl-3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1857];

1-methyl-N-(3-(1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1858];

N-(3-(3,3-dimethyl-1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1859];

1-methyl-N-(3-(3′-oxospiro[cyclohexane-1,1′-isoindolin]-6′-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1860];

N-(3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1861];

1-methyl-N-(3-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1862];

N-(3-(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1863];

1-methyl-N-(3-(4-oxospiro[chromane-2,4′-piperidin]-7-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1864];

1-methyl-N-(3-(5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1865];

1-methyl-N-(3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1866];

1-methyl-N-(3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1867];

1-methyl-N-(3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1868];

N-(3-(4-methoxyquinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-methylpiperidine-4-carboxamide [1869];

1-methyl-N-(3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1870];

1-methyl-N-(3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1871];

1-methyl-N-(3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-carboxamide [1872];

N-(3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1873];

N-(3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1874];

N-(3-(1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1875];

N-(3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1876];

N-(2,2-difluoroethyl)-6-(6-(isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1877];

N-(3-(imidazo[1,2-a]pyrimidin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1878];

N-(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1879];

N-(3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1880];

N-(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1881];

N-(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1882];

N-(3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1883];

N-(3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1884];

N-(3-(1-methyl-1H-benzo[d][1,2,3]triazol -6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1885];

N-(3-(imidazo[1,2-b]pyridazin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1886];

N-(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1887];

N-(3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1888];

N-(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1889];

N-(2,2-difluoroethyl)-5-(6-(isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1890];

(R)-5-(6-(isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1891];

5-(6-(isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1892];

5-(6-(isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1893];

N-(3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1894];

N-(3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1895];

N-(3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1896];

N-(3-(3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1898];

N-(3-(1′-methyl-3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1899];

N-(3-(1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1900];

N-(3-(3,3-dimethyl-1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1901];

N-(3-(3′-oxospiro[cyclohexane-1,1′-isoindolin]-6′-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1902];

N-(3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1903];

N-(3-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1904];

N-(3-(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1905];

N-(3-(4-oxospiro[chromane-2,4′-piperidin]-7-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1906];

N-(3-(5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1907];

N-(3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1908];

N-(3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1909];

N-(3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1910];

N-(3-(4-methoxyquinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1911];

N-(3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1912];

N-(3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1913];

N-(3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)isonicotinamide [1914];

3-(2-methyl-2H-indazol-5-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1915];

N-(3-(4-methylpiperazin-1-yl)phenyl)-3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1916];

7-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1917];

3-(imidazo[1,2-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1918];

N-(2,2-difluoroethyl)-6-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1919];

3-(imidazo[1,2-a]pyrimidin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1920];

3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1921];

3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1922];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1923];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1924];

3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1925];

3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1926];

3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1927];

3-(imidazo[1,2-b]pyridazin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1928];

N-(3-(4-methylpiperazin-1-yl)phenyl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1929];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1930];

N-(3-(4-methylpiperazin-1-yl)phenyl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1931];

N-(2,2-difluoroethyl)-5-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1932];

(R)-5-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1933];

5-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1934];

5-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1935];

(5-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1936];

(4-methylpiperazin-1-yl)(5-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1937];

(5-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1938];

6-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1940];

1′-methyl-6-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1941];

5-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1942];

3,3-dimethyl-5-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1943];

6′-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1944];

3-(chroman-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1945];

6-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1946];

4,4-dimethyl-6-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1947];

7-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1948];

8-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[1,4]oxazepin-5(2H)-one [1949];

N-(3-(4-methylpiperazin-1-yl)phenyl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1950];

N-(3-(4-methylpiperazin-1-yl)phenyl)-3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1951];

N-(3-(4-methylpiperazin-1-yl)phenyl)-3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1952];

3-(4-methoxyquinazolin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1953];

N-(3-(4-methylpiperazin-1-yl)phenyl)-3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1954];

N-(3-(4-methylpiperazin-1-yl)phenyl)-3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine [1955];

6-(6-((3-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1956];

2-methyl-5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1957];

2-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1958];

7-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1959];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1960];

N-(2,2-difluoroethyl)-6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1961];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1962];

4-fluoro-1-isopropyl-2-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1963];

4-fluoro-2-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1964];

1-isopropyl-2-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [1965];

1-isopropyl-2-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1966];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1967];

7-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1968];

1-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1969];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1970];

6-(1-methyl-1H-pyrazol-4-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1971];

6-(1-methyl-1H-pyrazol-4-yl)-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1972];

6-(1-methyl-1H-pyrazol-4-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1973];

N-(2,2-difluoroethyl)-5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1974];

(R)-5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1975];

5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1976];

5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1977];

(5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1978];

(5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1979];

(5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1980];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1982];

1′-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1983];

5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1984];

3,3-dimethyl-5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1985];

6′-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1986];

3-(chroman-6-yl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine [1987];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1988];

4,4-dimethyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1989];

7-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1990];

8-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[1,4]oxazepin-5(2H)-one [1991];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1992];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1993];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1994];

4-methoxy-6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1995];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1996];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1997];

6-(6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1998];

2-methyl-5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1999];

2-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [2000];

7-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [2001];

6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [2002];

N-(2,2-difluoroethyl)-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [2003];

6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [2004];

4-fluoro-1-isopropyl-2-methyl-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [2005];

4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [2006];

1-isopropyl-2-methyl-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [2007];

1-isopropyl-2-methyl-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [2008];

6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [2009];

7-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [2010];

1-methyl-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [2011];

6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [2012];

6-phenyl-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [2013];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-6-phenyl-1H-pyrrolo[2,3-b]pyridine [2014];

6-phenyl-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [2015];

N-(2,2-difluoroethyl)-5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [2016];

(R)-5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [2017];

N-(1-methylpiperidin-4-yl)-5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [2018];

5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [2019];

(5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [2020];

(4-methylpiperazin-1-yl)(5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [2021];

morpholino(5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [2022];

6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [2024];

1′-methyl-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [2025];

5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [2026];

3,3-dimethyl-5-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [2027];

6′-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [2028];

3-(chroman-6-yl)-6-phenyl-1H-pyrrolo[2,3-b]pyridine [2029];

6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [2030];

4,4-dimethyl-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [2031];

7-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [2032];

8-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [2033];

6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [2034];

6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [2035];

6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [2036];

4-methoxy-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [2037];

4-(4-methylpiperazin-1-yl)-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [2038];

4-((1-methylpiperidin-4-yl)oxy)-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [2039];

N-(1-methylpiperidin-4-yl)-6-(6-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [2040];

6-(6-cyclobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrazine [2042];

4-fluoro-1-isopropyl-6-(6-isopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-1H-benzo[d]imidazole [2045];

3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-6-carboxamide [2048];

N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-amine [2051];

N-((6-(1H-imidazol-1-yl)pyridin-3-yl)methyl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-amine [2052];

6-(6-(cyclopropylmethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [2053];

N-(pyridin-4-yl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-6-carboxamide [2054];

5-(3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)thiazole [2055]; and

6-(6-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [2056]; or a pharmaceutically acceptable salt thereof.

22 . The compound according to claim 15 , wherein the compound of Formula Ie is selected from the group consisting of:

5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [193];

2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [194];

7-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [195];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [196];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [197];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [198];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole [199];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [200];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [201];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine [202];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [203];

7-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [204];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [205];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [206];

5-chloro-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [207];

5-chloro-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [208];

5-chloro-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [209];

5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)pyrazolo[1,5-a]pyridine-3-carboxamide [210];

(R)-5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [211];

5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [212];

5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [213];

(5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [214];

(5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [215];

(5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [216];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [218];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [219];

5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [221];

6′-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [222];

5-chloro-3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridine [223];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [225];

7-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [226];

8-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [227];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [229];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [230];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-methoxyquinazoline [231];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [232];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [233];

6-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [234];

5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [235];

2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [236];

7-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [237];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [238];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [239];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [240];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole [241];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [242];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [243];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine [244];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [245];

7-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [246];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [247];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [248];

5-fluoro-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [249];

5-fluoro-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [250];

5-fluoro-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [251];

5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)pyrazolo[1,5-a]pyridine-3-carboxamide [252];

(R)-5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [253];

5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [254];

5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [255];

(5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [256];

(5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [257];

(5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [258];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [260];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [261];

5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [263];

6′-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [264];

5-fluoro-3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridine [265];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [267];

7-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [268];

8-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [269];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [271];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [272];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-methoxyquinazoline [273];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [274];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [275];

6-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [276];

2-methyl-5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [277];

2-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [278];

7-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [279];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [280];

N-(2,2-difluoroethyl)-6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [281];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [282];

4-fluoro-1-isopropyl-2-methyl-6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [283];

4-fluoro-2-methyl-6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [284];

1-isopropyl-2-methyl-6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [285];

1-isopropyl-2-methyl-6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [286];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [287];

7-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [288];

1-methyl-6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [289];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [290];

5-methyl-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [291];

5-methyl-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [292];

5-methyl-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [293];

N-(2,2-difluoroethyl)-5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [294];

(R)-5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [295];

5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [296];

5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [297];

(5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [298];

(5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [299];

(5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [300];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [302];

1′-methyl-6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [303];

5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [304];

3,3-dimethyl-5-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [305];

6′-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [306];

3-(chroman-6-yl)-5-methyl-1H-pyrrolo[2,3-b]pyridine [307];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [308];

4,4-dimethyl-6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [309];

7-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [310];

8-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [311];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [313];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [314];

4-methoxy-6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [315];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [316];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [317];

6-(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [318];

2-methyl-5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [319];

2-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [320];

7-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [321];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [322];

N-(2,2-difluoroethyl)-6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [323];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [324];

4-fluoro-1-isopropyl-2-methyl-6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [325];

4-fluoro-2-methyl-6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [326];

1-isopropyl-2-methyl-6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [327];

1-isopropyl-2-methyl-6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [328];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [329];

7-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [330];

1-methyl-6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [331];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [332];

5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [333];

5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [334];

5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [335];

N-(2,2-difluoroethyl)-5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [336];

(R)-5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [337];

5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [338];

5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [339];

(5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [340];

(5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [341];

(5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [342];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [344];

1′-methyl-6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [345];

5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [346];

3,3-dimethyl-5-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [347];

6′-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [348];

3-(chroman-6-yl)-5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [349];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [350];

4,4-dimethyl-6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [351];

7-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [352];

8-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [353];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [354];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [355];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [356];

4-methoxy-6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [357];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [358];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [359];

6-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [360];

2-methyl-5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [361];

2-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [362];

7-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [363];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [364];

N-(2,2-difluoroethyl)-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [365];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [366];

4-fluoro-1-isopropyl-2-methyl-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [367];

4-fluoro-2-methyl-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [368];

1-isopropyl-2-methyl-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [369];

1-isopropyl-2-methyl-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [370];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [371];

7-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [372];

1-methyl-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [373];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [374];

5-(4-methylpiperazin-1-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [375];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-1)]pyridine [376];

5-(4-methylpiperazin-1-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [377];

N-(2,2-difluoroethyl)-5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [378];

(R)-5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [379];

5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [380];

5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [381];

(5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [382];

(4-methylpiperazin-1-yl)(5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [383];

(5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [384];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [386];

1′-methyl-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [387];

5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [388];

3,3-dimethyl-5-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [389];

6′-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [390];

3-(chroman-6-yl)-5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine [391];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [392];

4,4-dimethyl-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [393];

7-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [394];

8-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [395];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [396];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [397];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [398];

4-methoxy-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [399];

4-(4-methylpiperazin-1-yl)-6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [400];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [401];

6-(5-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [402];

2-methyl-5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [403];

2-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [404];

7-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [405];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [406];

N-(2,2-difluoroethyl)-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [407];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [408];

4-fluoro-1-isopropyl-2-methyl-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [409];

4-fluoro-2-methyl-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [410];

1-isopropyl-2-methyl-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [411];

1-isopropyl-2-methyl-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [412];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [413];

7-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [414];

1-methyl-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [415];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [416];

5-((4-methylpiperazin-1-yl)methyl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-1)]pyridine [417];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-1)]pyridine [418];

5-((4-methylpiperazin-1-yl)methyl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-1)]pyridine [419];

N-(2,2-difluoroethyl)-5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [420];

(R)-5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [421];

5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [422];

5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [423];

(5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [424];

(4-methylpiperazin-1-yl)(5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [425];

(5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [426];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [428];

1′-methyl-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [429];

5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [430];

3,3-dimethyl-5-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [431];

6′-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [432];

3-(chroman-6-yl)-5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine [433];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [434];

4,4-dimethyl-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [435];

7-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [436];

8-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [437];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [438];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [439];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [440];

4-methoxy-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [441];

4-(4-methylpiperazin-1-yl)-6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [442];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [443];

6-(5-((4-methylpiperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [444];

3-(2-methyl-2H-indazol-5-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [445];

N-(1-methylpiperidin-4-yl)-3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [446];

N-(1-methylpiperidin-4-yl)-3-(1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [447];

3-(imidazo[1,2-a]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [448];

N-(2,2-difluoroethyl)-6-(5-((1-methylpiperidin-4-yl)carbamoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [449];

3-(imidazo[1,2-a]pyrimidin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [450];

3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [451];

3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [452];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [453];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [454];

3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [455];

3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [456];

3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [457];

3-(imidazo[1,2-b]pyridazin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [458];

N-(1-methylpiperidin-4-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [459];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [460];

N-(1-methylpiperidin-4-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [461];

3-(3-((2,2-difluoroethyl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [462];

(R)-N-(1-methylpiperidin-4-yl)-3-(3-((1,1,1-trifluoropropan-2-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [463];

N-(1-methylpiperidin-4-yl)-3-(3-((1-methylpiperidin-4-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [464];

N-(1-methylpiperidin-4-yl)-3-(3-(pyridin-3-ylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [465];

N-(1-methylpiperidin-4-yl)-3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [466];

3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [467];

N-(1-methylpiperidin-4-yl)-3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [468];

N-(1-methylpiperidin-4-yl)-3-(3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [470];

3-(1′-methyl-3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [471];

N-(1-methylpiperidin-4-yl)-3-(1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [472];

3-(3,3-dimethyl-1-oxoisoindolin-5-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [473];

N-(1-methylpiperidin-4-yl)-3-(3′-oxospiro[cyclohexane-1,1′-isoindolin]-6′-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [474];

3-(chroman-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [475];

N-(1-methylpiperidin-4-yl)-3-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [476];

3-(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [477];

N-(1-methylpiperidin-4-yl)-3-(4-oxospiro[chromane-2,4′-piperidin]-7-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [478];

N-(1-methylpiperidin-4-yl)-3-(5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [479];

N-(1-methylpiperidin-4-yl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [480];

N-(1-methylpiperidin-4-yl)-3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [481];

N-(1-methylpiperidin-4-yl)-3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [482];

3-(4-methoxyquinazolin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [483];

3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [484];

N-(1-methylpiperidin-4-yl)-3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [485];

N-(1-methylpiperidin-4-yl)-3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [486];

(3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [487];

(4-methylpiperazin-1-yl)(3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [488];

7-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [489];

(3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [490];

N-(2,2-difluoroethyl)-6-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [491];

(3-(imidazo[1,2-a]pyrimidin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [492];

(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [493];

(3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [494];

(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [495];

(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [496];

(3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [497];

(3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [498];

(3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [499];

(3-(imidazo[1,2-b]pyridazin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [500];

(4-methylpiperazin-1-yl)(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [501];

(3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [502];

(4-methylpiperazin-1-yl)(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [503];

N-(2,2-difluoroethyl)-5-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [504];

(R)-5-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [505];

5-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [506];

5-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [507];

(4-methylpiperazin-1-yl)(3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [508];

(4-methylpiperazin-1-yl)(5-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [509];

(4-methylpiperazin-1-yl)(3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [510];

6-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [512];

1′-methyl-6-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [513];

5-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [514];

3,3-dimethyl-5-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [515];

6′-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [516];

(3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [517];

6-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [518];

4,4-dimethyl-6-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [519];

7-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [520];

8-(5-(4-methylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [521];

(4-methylpiperazin-1-yl)(3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [522];

(4-methylpiperazin-1-yl)(3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [523];

(4-methylpiperazin-1-yl)(3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [524];

(3-(4-methoxyquinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(4-methylpiperazin-1-yl)methanone [525];

(4-methylpiperazin-1-yl)(3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [526];

(4-methylpiperazin-1-yl)(3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [527];

(4-methylpiperazin-1-yl)(3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [528];

(3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [529];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [530];

7-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [531];

(3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [532];

N-(2,2-difluoroethyl)-6-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [533];

(3-(imidazo[1,2-a]pyrimidin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [534];

(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [535];

(3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [536];

(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [537];

(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [538];

(3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [539];

(3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [540];

(3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [541];

(3-(imidazo[1,2-b]pyridazin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [542];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [543];

(3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [544];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [545];

N-(2,2-difluoroethyl)-5-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [546];

5-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-((R)-1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [547];

5-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [548];

5-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [549];

(5-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [550];

(5-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [551];

(5-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [552];

6-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [554];

1′-methyl-6-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [555];

5-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [556];

3,3-dimethyl-5-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [557];

6′-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [558];

(3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [559];

6-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [560];

4,4-dimethyl-6-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [561];

7-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [562];

8-(5-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [563];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [564];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [565];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [566];

(3-(4-methoxyquinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone [567];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [568];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [569];

(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)(3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [570];

(3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [571];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [572];

7-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [573];

(3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [574];

(3-(3-(((2,2-difluoroethyl)amino)methyl)imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [575];

(3-(imidazo[1,2-a]pyrimidin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [576];

(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [577];

(3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [578];

(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [579];

(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [580];

(3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [581];

(3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [582];

(3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [583];

(3-(imidazo[1,2-b]pyridazin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [584];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [585];

(3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [586];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [587];

N-(2,2-difluoroethyl)-5-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [588];

(R)-5-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [589];

5-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [590];

5-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [591];

(5-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [592];

(5-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [593];

(5-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [594];

6-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [596];

1′-methyl-6-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [597];

5-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [598];

3,3-dimethyl-5-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [599];

6′-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [600];

(3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [601];

6-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [602];

4,4-dimethyl-6-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [603];

7-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [604];

8-(5-(2-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carbonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [605];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [606];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [607];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [608];

(3-(4-methoxyquinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methanone [609];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [610];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [611];

(2-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)(3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [612];

1-methyl-N-(3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [613];

1-methyl-N-(3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [614];

1-methyl-N-(3-(1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [615];

N-(3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [616];

N-(2,2-difluoroethyl)-6-(5-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [617];

N-(3-(imidazo[1,2-a]pyrimidin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [618];

N-(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [619];

N-(3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [620];

N-(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [621];

N-(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [622];

N-(3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [623];

N-(3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [624];

1-methyl-N-(3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [625];

N-(3-(imidazo[1,2-b]pyridazin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [626];

1-methyl-N-(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [627];

1-methyl-N-(3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [628];

1-methyl-N-(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [629];

N-(2,2-difluoroethyl)-5-(5-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [630];

(R)-5-(5-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [631];

N-(1-methylpiperidin-4-yl)-5-(5-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [632];

5-(5-(1-methylpiperidine-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [633];

1-methyl-N-(3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [634];

1-methyl-N-(3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [635];

1-methyl-N-(3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [636];

1-methyl-N-(3-(3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [638];

1-methyl-N-(3-(1′-methyl-3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [639];

1-methyl-N-(3-(1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [640];

N-(3-(3,3-dimethyl-1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [641];

1-methyl-N-(3-(3′-oxospiro[cyclohexane-1,1′-isoindolin]-6′-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [642];

N-(3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [643];

1-methyl-N-(3-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [644];

N-(3-(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [645];

1-methyl-N-(3-(4-oxospiro[chromane-2,4′-piperidin]-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [646];

1-methyl-N-(3-(5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [647];

1-methyl-N-(3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [648];

1-methyl-N-(3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [649];

1-methyl-N-(3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [650];

N-(3-(4-methoxyquinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-methylpiperidine-4-carboxamide [651];

1-methyl-N-(3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [652];

1-methyl-N-(3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [653];

1-methyl-N-(3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)piperidine-4-carboxamide [654];

3-(2-methyl-2H-indazol-5-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [655];

N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [656];

3-(1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [657];

3-(imidazo[1,2-a]pyridin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [658];

N-(2,2-difluoroethyl)-6-(5-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)carbamoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [659];

3-(imidazo[1,2-a]pyrimidin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [660];

3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [661];

3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [662];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [663];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [664];

3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [665];

3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [666];

3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [667];

3-(imidazo[1,2-b]pyridazin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [668];

N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [669];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [670];

N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [671];

3-(3-((2,2-difluoroethyl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [672];

(R)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-((1,1,1-trifluoropropan-2-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [673];

3-(3-((1-methylpiperidin-4-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [674];

N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-(pyridin-3-ylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [675];

N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [676];

3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [677];

3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [678];

3-(3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [680];

3-(1′-methyl-3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [681];

3-(1-oxoisoindolin-5-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [682];

3-(3,3-dimethyl-1-oxoisoindolin-5-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [683];

3-(3′-oxospiro[cyclohexane-1,1′-isoindolin]-6′-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [684];

3-(chroman-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [685];

3-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [686];

3-(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [687];

3-(4-oxospiro[chromane-2,4′-piperidin]-7-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [688];

3-(5-oxo-2,3,4,5-tetrahydrobenzo[1,4]oxazepin-8-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [689];

N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [690];

N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [691];

N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [692];

3-(4-methoxyquinazolin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [693];

3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [694];

3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [695];

3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [696];

3-(2-methyl-2H-indazol-5-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [697];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [698];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [699];

3-(imidazo[1,2-a]pyridin-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [700];

N-(2,2-difluoroethyl)-6-(5-((1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)carbamoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [701];

3-(imidazo[1,2-a]pyrimidin-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [702];

3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [703];

3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [704];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [705];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [706];

3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [707];

3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [708];

3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [709];

3-(imidazo[1,2-b]pyridazin-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [710];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [711];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [712];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [713];

3-(3-((2,2-difluoroethyl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [714];

(R)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-((1,1,1-trifluoropropan-2-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [715];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-((1-methylpiperidin-4-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [716];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-(pyridin-3-ylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [717];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [718];

3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [719];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [720];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [722];

3-(1′-methyl-3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [723];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [724];

3-(3,3-dimethyl-1-oxoisoindolin-5-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [725];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(3′-oxospiro[cyclohexane-1,1′-isoindolin]-6′-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [726];

3-(chroman-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [727];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [728];

3-(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [729];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(4-oxospiro[chromane-2,4′-piperidin]-7-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [730];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [731];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [732];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [733];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [734];

3-(4-methoxyquinazolin-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [735];

3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [736];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [737];

N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [738];

N-(5-fluoropyridin-3-yl)-3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [739];

N-(5-fluoropyridin-3-yl)-3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [740];

N-(5-fluoropyridin-3-yl)-3-(1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [741];

N-(5-fluoropyridin-3-yl)-3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [742];

N-(2,2-difluoroethyl)-6-(5-((5-fluoropyridin-3-yl)carbamoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [743];

N-(5-fluoropyridin-3-yl)-3-(imidazo[1,2-a]pyrimidin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [744];

3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [745];

3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [746];

N-(5-fluoropyridin-3-yl)-3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [747];

N-(5-fluoropyridin-3-yl)-3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [748];

3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [749];

3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [750];

N-(5-fluoropyridin-3-yl)-3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [751];

N-(5-fluoropyridin-3-yl)-3-(imidazo[1,2-b]pyridazin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [752];

N-(5-fluoropyridin-3-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [753];

N-(5-fluoropyridin-3-yl)-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [754];

N-(5-fluoropyridin-3-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [755];

3-(3-((2,2-difluoroethyl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [756];

(R)-N-(5-fluoropyridin-3-yl)-3-(3-((1,1,1-trifluoropropan-2-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [757];

N-(5-fluoropyridin-3-yl)-3-(3-((1-methylpiperidin-4-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [758];

N-(5-fluoropyridin-3-yl)-3-(3-(pyridin-3-ylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [759];

N-(5-fluoropyridin-3-yl)-3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [760];

N-(5-fluoropyridin-3-yl)-3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [761];

N-(5-fluoropyridin-3-yl)-3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [762];

N-(5-fluoropyridin-3-yl)-3-(3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [764];

N-(5-fluoropyridin-3-yl)-3-(1′-methyl-3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [765];

N-(5-fluoropyridin-3-yl)-3-(1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [766];

3-(3,3-dimethyl-1-oxoisoindolin-5-yl)-N-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [767];

N-(5-fluoropyridin-3-yl)-3-(3′-oxospiro[cyclohexane-1,1′-isoindolin]-6′-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [768];

3-(chroman-6-yl)-N-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [769];

N-(5-fluoropyridin-3-yl)-3-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [770];

3-(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-N-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [771];

N-(5-fluoropyridin-3-yl)-3-(4-oxospiro[chromane-2,4′-piperidin]-7-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [772];

N-(5-fluoropyridin-3-yl)-3-(5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [773];

N-(5-fluoropyridin-3-yl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [774];

N-(5-fluoropyridin-3-yl)-3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [775];

N-(5-fluoropyridin-3-yl)-3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [776];

N-(5-fluoropyridin-3-yl)-3-(4-methoxyquinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [777];

N-(5-fluoropyridin-3-yl)-3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [778];

N-(5-fluoropyridin-3-yl)-3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [779];

N-(5-fluoropyridin-3-yl)-3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [780];

3-(2-methyl-2H-indazol-5-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [781];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [782];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [783];

3-(imidazo[1,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [784];

N-(2,2-difluoroethyl)-6-(5-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [785];

3-(imidazo[1,2-a]pyrimidin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [786];

3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [787];

3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [788];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [789];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [790];

3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [791];

3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [792];

3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [793];

3-(imidazo[1,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [794];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [795];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [796];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [797];

3-(3-((2,2-difluoroethyl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [798];

(R)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3-((1,1,1-trifluoropropan-2-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [799];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3-((1-methylpiperidin-4-yl)carbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [800];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3-(pyridin-3-ylcarbamoyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [801];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [802];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [803];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [804];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [806];

3-(1′-methyl-3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [807];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [808];

3-(3,3-dimethyl-1-oxoisoindolin-5-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [809];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3′-oxospiro[cyclohexane-1,1′-isoindolin]-6′-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [810];

3-(chroman-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [811];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [812];

3-(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [813];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(4-oxospiro[chromane-2,4′-piperidin]-7-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [814];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [815];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [816];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [817];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [818];

3-(4-methoxyquinazolin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [819];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [820];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [821];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide [822];

N-(3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [823];

2-(piperazin-1-yl)-N-(3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)isonicotinamide [824];

N-(3-(1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [825];

N-(3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [826];

N-(2,2-difluoroethyl)-6-(5-(2-(piperazin-1-yl)isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [827];

N-(3-(imidazo[1,2-a]pyrimidin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [828];

N-(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [829];

N-(3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [830];

N-(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-1)]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [831];

N-(3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [832];

N-(3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [833];

N-(3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [834];

N-(3-(1-methyl-1H-benzo[d][1,2,3]triazol -6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [835];

N-(3-(imidazo[1,2-b]pyridazin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [836];

2-(piperazin-1-yl)-N-(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)isonicotinamide [837];

N-(3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [838];

2-(piperazin-1-yl)-N-(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)isonicotinamide [839];

N-(2,2-difluoroethyl)-5-(5-(2-(piperazin-1-yl)isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [840];

(R)-5-(5-(2-(piperazin-1-yl)isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [841];

N-(1-methylpiperidin-4-yl)-5-(5-(2-(piperazin-1-yl)isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [842];

5-(5-(2-(piperazin-1-yl)isonicotinamido)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [843];

2-(piperazin-1-yl)-N-(3-(3-(piperidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)isonicotinamide [844];

N-(3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [845];

N-(3-(3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [846];

N-(3-(3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [848];

N-(3-(1′-methyl-3-oxo-2,3-dihydrospiro[indene-1,4′-piperidin]-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [849];

N-(3-(1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [850];

N-(3-(3,3-dimethyl-1-oxoisoindolin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [851];

N-(3-(3′-oxospiro[cyclohexane-1,1′-isoindolin]-6′-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [852];

N-(3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [853];

N-(3-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [854];

N-(3-(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [855];

N-(3-(4-oxospiro[chromane-2,4′-piperidin]-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [856];

N-(3-(5-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-8-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [857];

2-(piperazin-1-yl)-N-(3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)isonicotinamide [858];

2-(piperazin-1-yl)-N-(3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)isonicotinamide [859];

2-(piperazin-1-yl)-N-(3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)isonicotinamide [860];

N-(3-(4-methoxyquinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [861];

N-(3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [862];

N-(3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [863];

N-(3-(4-((1-methylpiperidin-4-yl)amino)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(piperazin-1-yl)isonicotinamide [864];

3-(2-methyl-2H-indazol-5-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [865];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [866];

7-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [867];

3-(imidazo[1,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [868];

N-(2,2-difluoroethyl)-6-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [869];

3-(imidazo[1,2-a]pyrimidin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [870];

3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [871];

3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [872];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [873];

3-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [874];

3-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [875];

3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [876];

3-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [877];

3-(imidazo[1,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [878];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [879];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [880];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [881];

N-(2,2-difluoroethyl)-5-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [882];

(R)-5-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [883];

5-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [884];

5-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [885];

(5-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [886];

(4-methylpiperazin-1-yl)(5-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [887];

(5-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [888];

6-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [890];

1′-methyl-6-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [891];

5-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [892];

3,3-dimethyl-5-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [893];

6′-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [894];

3-(chroman-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [895];

6-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [896];

4,4-dimethyl-6-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [897];

7-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [898];

8-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [899];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(quinolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [900];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(quinoxalin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [901];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [902];

3-(4-methoxyquinazolin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [903];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [904];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(4-((1-methylpiperidin-4-yl)oxy)quinazolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-amine [905];

6-(5-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [906];

2-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [908];

7-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [909];

6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [910];

N-(2,2-difluoroethyl)-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [911];

6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [912];

4-fluoro-1-isopropyl-2-methyl-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [913];

4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [914];

1-isopropyl-2-methyl-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [915];

1-isopropyl-2-methyl-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [916];

6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [917];

7-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [918];

1-methyl-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [919];

6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [920];

5-phenyl-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [921];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-phenyl-1H-pyrrolo[2,3-b]pyridine [922];

5-phenyl-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [923];

N-(2,2-difluoroethyl)-5-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [924];

(R)-5-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [925];

N-(1-methylpiperidin-4-yl)-5-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [926];

5-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [927];

(5-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [928];

(4-methylpiperazin-1-yl)(5-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [929];

morpholino(5-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [930];

6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [932];

1′-methyl-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [933];

5-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [934];

3,3-dimethyl-5-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [935];

6′-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [936];

3-(chroman-6-yl)-5-phenyl-1H-pyrrolo[2,3-b]pyridine [937];

6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [938];

4,4-dimethyl-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [939];

7-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [940];

8-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [941];

6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [942];

6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [943];

6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [944];

4-methoxy-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [945];

4-(4-methylpiperazin-1-yl)-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [946];

4-((1-methylpiperidin-4-yl)oxy)-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [947];

N-(1-methylpiperidin-4-yl)-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [948];

2-methyl-5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [949];

2-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [950];

7-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [951];

6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [952];

N-(2,2-difluoroethyl)-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [953];

6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [954];

4-fluoro-1-isopropyl-2-methyl-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [955];

4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [956];

1-isopropyl-2-methyl-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [957];

1-isopropyl-2-methyl-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [958];

6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [959];

7-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [960];

1-methyl-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [961];

6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [962];

3-(pyrazoN-(2,2-difluoroethyl)-5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide lo[1,5-a]pyridin-5-yl)-5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridine [963];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridine [964];

3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridine [965];

N-(2,2-difluoroethyl)-5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [966];

(R)-5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [967];

N-(1-methylpiperidin-4-yl)-5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [968];

N-(pyridin-3-yl)-5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [969];

piperidin-1-yl(5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [970];

(4-methylpiperazin-1-yl)(5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [971];

morpholino (5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [972];

6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [974];

1′-methyl-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [975];

5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [976];

3,3-dimethyl-5-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [977];

6′-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [978];

3-(chroman-6-yl)-5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridine [979];

6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [980];

4,4-dimethyl-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [981];

7-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [982];

8-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [983];

6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [984];

6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [985];

6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [986];

4-methoxy-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [987];

4-(4-methylpiperazin-1-yl)-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [988];

4-((1-methylpiperidin-4-yl)oxy)-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [989];

N-(1-methylpiperidin-4-yl)-6-(5-(o-tolyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [990];

5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [991];

2-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [992];

7-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [993];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [994];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [995];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [996];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole [997];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [998];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [999];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine [1000];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1001];

7-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1002];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1003];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1004];

5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1005];

5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1006];

5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1007];

5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(2,2-difluoroethyl)pyrazolo[1,5-a]pyridine-3-carboxamide [1008];

(R)-5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1009];

5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1010];

5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1011];

(5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1012];

(5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1013];

(5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1014];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1016];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1017];

5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1018];

5-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1019];

6′-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1020];

3-(chroman-6-yl)-5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine [1021];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1022];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1023];

7-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1024];

8-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1025];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1026];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1027];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1028];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-methoxyquinazoline [1029];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1030];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1031];

6-(5-(3,4-difluoro-5-(piperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1032];

2-methyl-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1033];

2-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1034];

7-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1035];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1036];

N-(2,2-difluoroethyl)-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1037];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1038];

4-fluoro-1-isopropyl-2-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1039];

4-fluoro-2-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1040];

1-isopropyl-2-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [1041];

1-isopropyl-2-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1042];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1043];

7-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1044];

1-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1045];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1046];

5-(1-methyl-1H-pyrazol-4-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-1)]pyridine [1047];

5-(1-methyl-1H-pyrazol-4-yl)-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1048];

5-(1-methyl-1H-pyrazol-4-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1049];

N-(2,2-difluoroethyl)-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1050];

(R)-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1051];

5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1052];

5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1053];

(5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-1)]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1054];

(5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-1)]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1055];

(5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-1)]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1056];

5-(1-methyl-1H-pyrazol-4-yl)-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1057];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1058];

1′-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1059];

3,3-dimethyl-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1061];

6′-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-1)]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1062];

3-(chroman-6-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-1)]pyridine [1063];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1064];

4,4-dimethyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1065];

7-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1066];

8-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1067];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1068];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1069];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1070];

4-methoxy-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1071];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1072];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1073];

6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1074];

2-methyl-5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1075];

2-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1076];

7-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1077];

6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1078];

N-(2,2-difluoroethyl)-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1079];

6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1080];

4-fluoro-1-isopropyl-2-methyl-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1081];

4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1082];

1-isopropyl-2-methyl-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-1)]pyridine [1083];

1-isopropyl-2-methyl-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1084];

6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1085];

7-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1086];

1-methyl-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1087];

6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1088];

3-(pyrazolo[1,5-a]pyridin-5-yl)-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-1)]pyridine [1089];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-1)]pyridine [1090];

3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine [1091];

N-(2,2-difluoroethyl)-5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1092];

(R)-N-(1,1,1-trifluoropropan-2-yl)-5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1093];

N-(1-methylpiperidin-4-yl)-5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1094];

N-(pyridin-3-yl)-5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1095];

piperidin-1-yl(5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1096];

(4-methylpiperazin-1-yl)(5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1097];

morpholino(5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1098];

6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1100];

1′-methyl-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1101];

5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1102];

3,3-dimethyl-5-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1103];

6′-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1104];

3-(chroman-6-yl)-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine [1105];

6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1106];

4,4-dimethyl-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1107];

7-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1108];

8-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1109];

6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1110];

6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1111];

6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1112];

4-methoxy-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1113];

4-(4-methylpiperazin-1-yl)-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1114];

4-((1-methylpiperidin-4-yl)oxy)-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1115];

N-(1-methylpiperidin-4-yl)-6-(5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [1116];

5-methyl-3-(3-(2-methyl-2H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine [1117];

2-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1118];

7-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1119];

3-(3-(imidazo[1,2-a]pyridin-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine [1120];

N-(2,2-difluoroethyl)-6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1121];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1122];

3-(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine [1123];

3-(3-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine [1124];

1-isopropyl-2-methyl-6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [1125];

1-isopropyl-2-methyl-6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1126];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1127];

7-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1128];

1-methyl-6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1129];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1130];

5-methyl-3-(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine [1131];

5-methyl-3-(3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine [1132];

5-methyl-3-(3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine [1133];

N-(2,2-difluoroethyl)-5-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1134];

(R)-5-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1135];

5-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1136];

5-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1137];

(5-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1138];

(5-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1139];

(5-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1140];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1142];

1′-methyl-6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1143];

5-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1144];

3,3-dimethyl-5-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1145];

6′-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1146];

3-(3-(chroman-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine [1147];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1148];

4,4-dimethyl-6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1149];

7-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1150];

8-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1151];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1152];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1153];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1154];

4-methoxy-6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1155];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1156];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1157];

6-(5-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1158];

2-methyl-5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1159];

2-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1160];

7-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1161];

6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1162];

N-(2,2-difluoroethyl)-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1163];

6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1164];

4-fluoro-1-isopropyl-2-methyl-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1165];

4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1166];

1-isopropyl-2-methyl-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [1167];

1-isopropyl-2-methyl-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1168];

6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1169];

7-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1170];

1-methyl-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1171];

6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1172];

3-(pyrazolo[1,5-a]pyridin-5-yl)-5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1173];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1174];

5-(pyridin-3-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1175];

N-(2,2-difluoroethyl)-5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1176];

(R)-5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1177];

N-(1-methylpiperidin-4-yl)-5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1178];

N-(pyridin-3-yl)-5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1179];

piperidin-1-yl(5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1180];

(4-methylpiperazin-1-yl)(5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1181];

morpholino(5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1182];

6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1184];

1′-methyl-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1185];

5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1186];

3,3-dimethyl-5-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1187];

6′-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1188];

3-(chroman-6-yl)-5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1189];

6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1190];

4,4-dimethyl-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1191];

7-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1192];

8-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1193];

6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1194];

6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1195];

6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1196];

4-methoxy-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1197];

4-(4-methylpiperazin-1-yl)-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1198];

4-((1-methylpiperidin-4-yl)oxy)-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1199];

N-(1-methylpiperidin-4-yl)-6-(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [1200];

2-methyl-5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1201];

2-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1202];

7-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1203];

6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1204];

N-(2,2-difluoroethyl)-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1205];

6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1206];

4-fluoro-1-isopropyl-2-methyl-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1207];

4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1208];

1-isopropyl-2-methyl-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [1209];

1-isopropyl-2-methyl-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1210];

6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1211];

7-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1212];

1-methyl-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1213];

6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1214];

5-(2-methylpyridin-3-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1215];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1216];

5-(2-methylpyridin-3-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1217];

N-(2,2-difluoroethyl)-5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1218];

(R)-5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1219];

N-(1-methylpiperidin-4-yl)-5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1220];

5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1221];

(5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1222];

(4-methylpiperazin-1-yl)(5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1223];

(5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1224];

6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1226];

1′-methyl-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1227];

5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1228];

3,3-dimethyl-5-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1229];

6′-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1230];

3-(chroman-6-yl)-5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1231];

6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1232];

4,4-dimethyl-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1233];

7-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1234];

8-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1235];

6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1236];

6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1237];

6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1238];

4-methoxy-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1239];

4-(4-methylpiperazin-1-yl)-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1240];

4-((1-methylpiperidin-4-yl)oxy)-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1241];

N-(1-methylpiperidin-4-yl)-6-(5-(2-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [1242];

2-methyl-5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1243];

2-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1244];

7-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1245];

6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1246];

N-(2,2-difluoroethyl)-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1247];

6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1248];

4-fluoro-1-isopropyl-2-methyl-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1249];

4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1250];

1-isopropyl-2-methyl-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [1251];

1-isopropyl-2-methyl-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1252];

6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1253];

7-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1254];

1-methyl-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1255];

6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1256];

5-(4-methylpyridin-3-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1257];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1258];

5-(4-methylpyridin-3-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1259];

N-(2,2-difluoroethyl)-5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1260];

(R)-5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1261];

N-(1-methylpiperidin-4-yl)-5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1262];

5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1263];

(5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1264];

(4-methylpiperazin-1-yl)(5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1265];

(5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1266];

6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1268];

1′-methyl-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1269];

5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1270];

3,3-dimethyl-5-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1271];

6′-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1272];

3-(chroman-6-yl)-5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1273];

6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1274];

4,4-dimethyl-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1275];

7-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1276];

8-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1277];

6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1278];

6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1279];

6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1280];

4-methoxy-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1281];

4-(4-methylpiperazin-1-yl)-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1282];

4-((1-methylpiperidin-4-yl)oxy)-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1283];

N-(1-methylpiperidin-4-yl)-6-(5-(4-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazolin-4-amine [1284];

5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methyl-2H-indazole [1285];

2-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1286];

7-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1287];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1288];

N-(2,2-difluoroethyl)-6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1289];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1290];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole [1291];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1292];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [1293];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine [1294];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1295];

7-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1296];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [1297];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1298];

5-(2,4-dimethylpyridin-3-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1299];

5-(2,4-dimethylpyridin-3-yl)-3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1300];

5-(2,4-dimethylpyridin-3-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1301];

N-(2,2-difluoroethyl)-5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1302];

(R)-5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1303];

5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1304];

5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1305];

(5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1306];

(5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1307];

(5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1308];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1310];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1′-methylspiro[indene-1,4′-piperidin]-3(2H)-one [1311];

5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1312];

5-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,3-dimethylisoindolin-1-one [1313];

6′-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1314];

3-(chroman-6-yl)-5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1315];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1316];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1317];

7-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1318];

8-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[1,4]oxazepin-5(2H)-one [1319];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1320];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1321];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1322];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-methoxyquinazoline [1323];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1324];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1325];

6-(5-(2,4-dimethylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1326];

2-methyl-5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1327];

2-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1328];

7-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1329];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1330];

N-(2,2-difluoroethyl)-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1331];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1332];

4-fluoro-1-isopropyl-2-methyl-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1333];

4-fluoro-2-methyl-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1334];

1-isopropyl-2-methyl-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [1335];

1-isopropyl-2-methyl-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1336];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1337];

7-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1338];

1-methyl-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1339];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1340];

5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1341];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1342];

5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-1)]pyridine [1343];

N-(2,2-difluoroethyl)-5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1344];

(R)-5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1345];

5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1346];

5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1347];

(5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1348];

(4-methylpiperazin-1-yl)(5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1349];

(5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1350];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1352];

1′-methyl-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1353];

5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1354];

3,3-dimethyl-5-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1355];

6′-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1356];

3-(chroman-6-yl)-5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine [1357];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1358];

4,4-dimethyl-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1359];

7-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1360];

8-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[1,4]oxazepin-5(2H)-one [1361];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1362];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1363];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1364];

4-methoxy-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1365];

4-(4-methylpiperazin-1-yl)-6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1366];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1367];

6-(5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1368];

2-methyl-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-indazole [1369];

2-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thieno[2,3-c]pyridine [1370];

7-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one [1371];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine [1372];

N-(2,2-difluoroethyl)-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide [1373];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-a]pyrimidine [1374];

4-fluoro-1-isopropyl-2-methyl-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d]imidazole [1375];

4-fluoro-2-methyl-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazole [1376];

1-isopropyl-2-methyl-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-b]pyridine [1377];

1-isopropyl-2-methyl-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazo[4,5-c]pyridine [1378];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1379];

7-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine [1380];

1-methyl-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-benzo[d][1,2,3]triazole [1381];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)imidazo[1,2-b]pyridazine [1382];

5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1383];

3-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1384];

5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-3-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine [1385];

N-(2,2-difluoroethyl)-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1386];

(R)-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1387];

5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1388];

5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1389];

(5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1390];

(4-methylpiperazin-1-yl)(5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [1391];

(5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(morpholino)methanone [1392];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1394];

1′-methyl-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[indene-1,4′-piperidin]-3(2H)-one [1395];

5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1396];

3,3-dimethyl-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)isoindolin-1-one [1397];

6′-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[cyclohexane-1,1′-isoindolin]-3′-one [1398];

3-(chroman-6-yl)-5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine [1399];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1400];

4,4-dimethyl-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one [1401];

7-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)spiro[chromane-2,4′-piperidin]-4-one [1402];

8-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3,4-dihydrobenzo[1,4]oxazepin-5(2H)-one [1403];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoline [1404];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinoxaline [1405];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1406];

4-methoxy-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1407];

4-(4-methylpiperazin-1-yl)-6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinazoline [1408];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)quinazoline [1409];

6-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine [1410];

(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)(3-(thieno[2,3-c]pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [2041];

3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid [2043];

(3-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)methanone [2044];

3-(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile [2046];

(5-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [2047];

(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)(3-(pyrazolo[1,5-a]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone [2049]; and

(4-methylpiperazin-1-yl)(5-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazolo[1,5-a]pyridin-3-yl)methanone [2050]; or a pharmaceutically acceptable salt thereof.

23 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

24 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 7 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

25 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 10 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

26 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 15 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

27 . A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: a neurological disorder, diabetes, and cancer, the method comprising administering to the patient a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt, or a pharmaceutical composition of claim 23 .

28 . A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: a neurological disorder, diabetes, and cancer, the method comprising administering to the patient a therapeutically effective amount of a compound of claim 7 , or a pharmaceutically acceptable salt, or a pharmaceutical composition of claim 24 .

29 . A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: a neurological disorder, diabetes, and cancer, the method comprising administering to the patient a therapeutically effective amount of a compound of claim 10 , or a pharmaceutically acceptable salt, or a pharmaceutical composition of claim 25 .

30 . A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: a neurological disorder, diabetes, and cancer, the method comprising administering to the patient a therapeutically effective amount of a compound of claim 15 , or a pharmaceutically acceptable salt, or a pharmaceutical composition of claim 26 .

Assignments (6)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 27, 2026

From: BIOSPLICE THERAPEUTICS, INC.

To: TENARX, INC.

Reel/Frame 074209/0693 →

RELEASE OF SECURITY INTEREST Recorded Mar 12, 2026

From: TMF GROUP NEW YORK, LLC, NOT INDIVIDUALLY BUT SOLELY AS COLLATERAL AGENT

To: BIOSPLICE THERAPEUTICS, INC.

Reel/Frame 075109/0434 →

SECURITY INTEREST Recorded May 10, 2024

From: BIOSPLICE THERAPEUTICS, INC.

To: VICKERS VENTURE FUND VI PTE. LTD.; VICKERS VENTURE FUND VI (PLAN) PTE. LTD.; VICKERS-SPLICE CO-INVESTMENT LLC; MED-PATHWAYS II LIMITED