IP Library › Patent Application 17964470

Patent Application

App. No. 17/964,470

7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US None
App. No.: 17/964,470

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

7H-Pyrrolo[2,3-d]pyrimidine compound for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Claims (3869)

1 . A compound, or a pharmaceutically acceptable salt thereof, of Formula I:

wherein:

R 1 is 8-11-membered bicyclic heteroaryl optionally substituted with 1-10 R 4 ;

wherein a carbon atom on an aromatic ring of the heteroaryl forms the bond with

R 2 is selected from the group consisting of H, —OR 7 , 5-membered heteroaryl optionally substituted with 1-3 R 8 , and —NHR 9 ;

R 3 is selected from the group consisting of H, —OR 10 , unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), -heterocyclyl optionally substituted with 1-10 R 11 , —(5-10 membered heteroaryl) optionally substituted with 1-10 R 12 , —(CH 2 ) p carbocyclyl optionally substituted with 1-12 R 13 , and —NHR 14 ;

with the proviso that R 2 and R 3 are not both H;

each R 4 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 9alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —OR 15 , —CH 2 OH, -heterocyclyl optionally substituted with 1-10 R 16 , -heteroaryl optionally substituted with 1-10 R 17 , —carbocyclyl optionally substituted with 1-12 R 8 , —C(═O)N(R 19 )2, and —C(═O)R 20 ;

alternatively, two R 4 attached to the same carbon atom are taken together to form a carbonyl group;

R 7 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 1-2 -alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-5 alkylene)OR 32 , and —(CH 2 )heterocyclyl optionally substituted with 1-10 R 21 ;

R 9 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 -alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(CH 2 ) p carbocyclyl optionally substituted with 1-12 R 22 , and -heterocyclyl optionally substituted with 1-10 R 23 ;

R 10 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 -alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 11 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and —(C 1-5 alkylene)OR 32 ;

each R 12 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 13 is independently selected from the group consisting of H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

R 14 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-5 alkylene)OMe, —(C 1-3 alkylene)pcarbocyclyl optionally substituted with 1-12 R 1 ', —(C 1-3 alkylene) p heteroaryl optionally substituted with 1-10 R 24 , —(C 1-3 alkylene) p phenyl optionally substituted with 1-10 R 25 , and —(C 1-3 alkylene) p heterocyclyl optionally substituted with 1-10 R 26 , wherein each —(C 1-3 alkylene) is, independently, optionally substituted with 1-5 halide and/or 1-5 unsubstituted —(C 1-3 alkyl);

each R 15 is independently selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 16 ;

each R 16 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 1 ' is independently selected from the group consisting of halide, —OR 31 , —NHC(═O)R 33 , —C(═O)R 34 , unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 35 ;

each R 8 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl); each R 19 are independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl); —(CH 2 ) p carbocyclyl optionally substituted with 1-12 R 27 , -heterocyclyl optionally substituted with 1-10 R 28 , and -heteroaryl optionally substituted with 1-10 R 29 ;

each R 20 is -heterocyclyl optionally substituted with 1-10 R 28 ;

each R 21 is independently selected from the group consisting of halide, unsubstituted —(C alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 22 is selected from the group consisting of halide, —OMe, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 23 is independently selected from the group consisting of halide, —OMe, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 16 ;

each R 24 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 16 ;

each R 25 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 16 ;

each R 26 is independently selected from the group consisting of halide, —OR 32 , —C(═O)R 36 , —SO 2 Me, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 28 ;

alternatively, two R 26 attached to the same carbon atom are taken together to form a carbonyl group;

each R 27 is independently selected from the group consisting of halide, —OMe, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 28 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 29 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 31 is independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and —(C1-5 alkylene)OR 32 ;

each R 32 is independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 33 is independently selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 34 is independently selected from the group consisting of —N(R 37 ) 2 , and -heterocyclyl optionally substituted with 1-10 R 28 ;

each R 35 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

alternatively, two R 35 attached to the same carbon atom are taken together to form a carbonyl group;

each R 36 is independently selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 37 is independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each p is independently 0 or 1;

wherein each H atom is optionally independently replaced by 2 H (D) (deuterium); and

with the proviso that Formula I is not a structure selected from the group consisting of:

2 . The compound of claim 1 , wherein R 2 is selected from the group consisting of H, —OR 7 , and —NHR 9 .

3 . The compound of claim 2 , wherein R 7 is selected from the group consisting of unsubstituted —(C 1-3 alkyl) and unsubstituted —(C 1-3 haloalkyl).

4 . The compound of claim 2 , wherein R 9 is selected from the group consisting of unsubstituted —(C 1-3 alkyl) and unsubstituted —(C 1-3 haloalkyl).

5 . The compound of claim 2 , wherein R 1 is 9-10-membered bicyclic heteroaryl optionally substituted with 1-2 R 4 .

6 . The compound of claim 5 , wherein R 1 is 9-10-membered bicyclic heteroaryl optionally substituted with 1-2 R 4 , wherein 1-2 R 4 is selected from the group consisting of halide, unsubstituted —(C 1-3 alkyl), or unsubstituted —(C 1-3 haloalkyl).

7 . The compound of claim 6 , wherein R 1 is selected from the group consisting of:

optionally substituted with 1-2 R 4 .

8 . The compound of claim 7 , wherein R 1 selected from the group consisting of:

optionally

substituted with 1-2 R 4 .

9 . The compound of claim 8 , wherein R 1 selected from the group consisting of:

10 . The compound of claim 9 , wherein R 3 is selected from the group consisting of -carbocyclyl optionally substituted with 1-2 R 13 and —NHR 14 .

11 . The compound of claim 10 , wherein R H is selected from the group consisting of -carbocyclyl optionally substituted with 1-5 R 17 and -heterocyclyl optionally substituted with 1-5 R 26 .

12 . A compound, or a pharmaceutically acceptable salt thereof, of Formula Ic:

wherein:

R 1 is selected from the heteroaryl group consisting of:

optionally substituted with 1-10 R 4 ;

wherein a carbon atom on an aromatic ring of the heteroaryl forms the bond with

each R 4 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —OR 15 , —CH 2 OH, -heterocyclyl optionally substituted with 1-10 R 16 , -heteroaryl optionally substituted with 1-10 R 17 , —carbocyclyl optionally substituted with 1-12 R 11 , —C(═O)N(R 19 )2, and —C(═O)R 20 ;

alternatively, two R 4 attached to the same carbon atom are taken together to form a carbonyl group;

each R 17 is independently selected from the group consisting of halide, —OR 31 , —NHC(═O)R 33 , —C(═O)R 34 , unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 35 ;

each R 18 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 19 are independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl); —(CH 2 ) p carbocyclyl optionally substituted with 1-12 R 27 , -heterocyclyl optionally substituted with 1-10 R 28 , and -heteroaryl optionally substituted with 1-10 R 29 ;

each R 20 is -heterocyclyl optionally substituted with 1-10 R 28 ;

each R 28 is independently selected from the group consisting of halide, unsubstituted —(C alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 29 is independently selected from the group consisting of halide, unsubstituted —(C alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 3 ° is independently selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 34 is independently selected from the group consisting of —N(R 37 )2, and -heterocyclyl optionally substituted with 1-10 R 28 ;

alternatively, two R 35 attached to the same carbon atom are taken together to form a carbonyl group;

each p is independently 0 or 1; and

wherein each H atom is optionally independently replaced by 2 H (D) (deuterium).

13 . The compound of claim 12 , wherein R 1 is selected from the group consisting of:

optionally

substituted with 1-2 R 4 .

14 . The compound of claim 13 , wherein R 1 is selected from the group consisting of:

optionally

substituted with 1-2 R 4 .

15 . A compound, or a pharmaceutically acceptable salt thereof, of Formula I:

wherein:

R 1 is selected from the group consisting of phenyl substituted with 1-5 R 5 , 6-membered heteroaryl optionally substituted with 1-4 R 6 , and

optionally substituted with 1-4 R 6 ;

R 2 is selected from the group consisting of H, 5-membered heteroaryl optionally substituted with 1-3 R 8 , and —NHR 9 ,

with the proviso that either R 2 or R 3 is H but R 2 and R 3 are not both H;

each R 5 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 1-9 haloalkyl),

—OR 15 , —CH 2 OH, -heterocyclyl optionally substituted with 1-10 R 16 , -heteroaryl optionally substituted with 1-10 R 17 , —carbocyclyl optionally substituted with 1-12 R 8 , —C(═O)N(R 19 )2, and —C(═O)R 20 ;

each R 6 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —OR 15a , —CH 2 OH, -heterocyclyl optionally substituted with 1-10 R 16a , -heteroaryl optionally substituted with 1-10 R 17a , —carbocyclyl optionally substituted with 1-12 R 18a , —C(═O)N(R 19 a) 2 , and —C(═O)R 20a ;

R 7 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-5 alkylene)OR 32 , and —(CH 2 )heterocyclyl optionally substituted with 1-10 R 21 ;

R 9 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(CH 2 ) p carbocyclyl optionally substituted with 1-12 R 22 , and -heterocyclyl optionally substituted with 1-10 R 23 ;

R 10 is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

R 14 is selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-5 alkylene)OMe, —(C 1-3 alkylene) p carbocyclyl optionally substituted with 1-12 R 17 , —(C 1-3 alkylene) p heteroaryl optionally substituted with 1-10 R 24 , —(C 1-3 alkylene) p phenyl optionally substituted with 1-10 R 25 , and —(C 1-3 alkylene) p heterocyclyl optionally substituted with 1-10 R 26 , wherein each —(C 1-3 alkylene) is, independently, optionally substituted with 1-5 halide and/or 1-5 unsubstituted —(C 1-3 alkyl);

each R 15a is independently selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 16a ;

each R 16a is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 17a is independently selected from the group consisting of halide, —OMe, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl) ;

each R 18a is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 19a are independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl); —(CH 2 ) p carbocyclyl optionally substituted with 1-12 R 27a , -heterocyclyl optionally substituted with 1-10 R 28a , and -heteroaryl optionally substituted with 1-10 R 29a ;

each R 20 is -heterocyclyl optionally substituted with 1-10 R 28 ;

each R 26a is -heterocyclyl optionally substituted with 1-10 R 28a ;

each R 22 is independently selected from the group consisting of halide, —OMe, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 24 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 9alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 16 ;

each R 25 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 9alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 16 ;

each R 26 is independently selected from the group consisting of halide, —01e, —C(═O)12_ 36 , —SO 2 Me, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), and -heterocyclyl optionally substituted with 1-10 R 28 ;

alternatively, two R 26 attached to the same carbon atom are taken together to form a carbonyl group;

each R 27a is independently selected from the group consisting of halide, —OMe, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 28a is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 29a is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), and unsubstituted —(C 1-9 haloalkyl);

each R 34 is independently selected from the group consisting of —N(R 37 )2, and -heterocyclyl optionally substituted with 1-10 R 28 ;

alternatively, two R 35 attached to the same carbon atom are taken together to form a carbonyl group;

each p is independently 0 or 1;

wherein each H atom is optionally independently replaced by 2 H (D) (deuterium); and

with the proviso that Formula I is not a structure selected from the group consisting of:

16 . The compound of claim 15 , wherein R 2 is selected from the group consisting of H, —OR 7 , and —NHR 9 .

17 . The compound of claim 16 , wherein R 7 is selected from the group consisting of unsubstituted —(C 1-3 alkyl) and unsubstituted —(C 1-3 haloalkyl).

18 . The compound of claim 16 , wherein R 9 is selected from the group consisting of unsubstituted —(C 1-3 alkyl) and unsubstituted —(C 1-3 haloalkyl).

19 . The compound of claim 16 , wherein R 1 is selected from the group consisting of 6-membered heteroaryl optionally substituted with 1-2 R 6 and

optionally substituted with 1-2 R 6 .

20 . The compound of claim 19 , wherein R 1 is selected from the group consisting of pyridine and

optionally substituted with one —OR 15a or one unsubstituted —(C 1-3 alkyl).

21 . The compound of claim 20 , wherein R 1 is selected from the group consisting of

optionally substituted with one —OR 15a or one unsubstituted —(C 1-3 alkyl).

22 . The compound of claim 21 , wherein R 3 is selected from the group consisting of unsubstituted —(C1.5 alkyl) and —NHR 14 .

23 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

5-(2-(((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-ypisoindolin-1-one [10];

2-methyl-6-(7H-pyrrolo [2,3-d] pyrimidin-5-yl)benzo [d]thiazole [11];

6-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2-methylbenzo [d] thiazole [12];

2-methyl-6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)benzo[d]thiazole [13];

6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2-methylbenzo[d]thiazole [14];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2-methylbenzo [d]thiazole [15];

6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2-methylbenzo [d]thiazole [16];

5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [17];

N-methyl-5-(2-methylbenzo [d]thiazol -6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [18];

N-ethyl-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [19];

N-isopropyl-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [20];

N-isobutyl-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [21];

5-(2-methylbenzo [d]thiazol-6-yl)-N-ne opentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [22];

(S)-N-(sec-butyl)-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [23];

N-(2-fluoro-2-methylpropyl)-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [24];

N-(2,2-difluoropropyl)-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [25];

5-(2-methylbenzo [d]thiazol-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [26];

(R)-5-(2-methylbenzo [d]thiazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [27];

(S)-5-(2-methylbenzo [d]thiazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [28];

5-(2-methylbenzo [d]thiazol-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [29];

(S)-N-(1-methoxypropan-2-yl)-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [30];

6-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2-methylbenzo [d]thiazole [31];

N-((1-fluorocyclopropyl)methyl)-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [32];

(R)-N-(1-cyclopropylethyl)-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [33];

5-(2-methylbenzo [d]thiazol-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [34];

5-(2-methylbenzo [d]thiazol-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [35];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [36];

N-(3,3-difluorocyclobutyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [37];

N-((1-fluorocyclobutyl)methyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [38];

N-(4,4-difluorocyclohexyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [39];

N-(cis-4-methoxycyclohexyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [40];

N-((1-fluorocyclohexyl)methyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [41];

N-((4,4-difluorocyclohexyl)methyl)-5-(2-methylbenzo[d]thiazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [42];

5-(2-methylbenzo [d]thiazol-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [43];

5-(2-methylbenzo [d]thiazol-6-yl)-N-((1-methylpiperidin-4-yl)me thyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [44];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [45];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [46];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [47];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [48];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [49];

5-(2-methylbenzo [d]thiazol-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)me thyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [50];

2-methyl-6-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzo[d]thiazole [51];

2-methyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzo[d]thiazole [52];

5-(2-methylbenzo[d]thiazol-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [53];

N-(2-fluoro-2-methylpropyl)-5-(2-methylthiazolo [5,4-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [54];

2-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)thieno [3,2-c]pyridine [56];

2-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)thieno [3,2-c]pyridine [57];

2-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)thieno [3,2-c] pyridine [58];

2-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)thieno [3,2-c]pyridine [59];

2-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yOthieno [3,2-c]pyridine [60];

5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [61];

N-methyl-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [62];

N-ethyl-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [63];

N-isopropyl-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [64];

N-isobutyl-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [65];

N-neopentyl-5-(thieno [3,2-c] pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [66];

(S)-N-(sec-butyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [67];

N-(2-fluoro-2-methylpropyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [68];

N-(2,2-difluoropropyl)-5-(thieno [3,2-c] pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [69];

5-(thieno [3,2-c]pyridin-2-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [70];

(R)-5-(thieno [3,2-c]pyridin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [71];

(S)-5-(thieno [3,2-c]pyridin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [72];

5-(thieno [3,2-c]pyridin-2-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [73];

(S)-N-(1-methoxypropan-2-yl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [74];

2-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)thieno [3,2-c]pyridine [75];

N-((1-fluorocyclopropyl)methyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [76];

(R)-N-(1-cyclopropylethyl)-5-(thieno [3,2-c] pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [ 77 ];

N-((1-methylcyclopropyl)methyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [78];

5-(thieno [3,2-c]pyridin-2-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [79];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [80];

N-(3,3-difluorocyclobutyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [81];

N-((1-fluorocyclobutyl)methyl)-5-(thieno [3,2-c] pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [82];

N-(4,4-difluorocyclohexyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [83];

N-(cis-4-methoxycyclohexyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [84];

N-((1-fluorocyclohexyl)methyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [85];

N-((4,4-difluorocyclohexyl)methyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [86];

N-(1-methylpiperidin-4-yl)-5-(thieno [3,2-c] pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [87];

N-((l-methylpiperidin-4-yl)methyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [88];

N-(tetrahydro-2H-pyran-4-yl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [89];

N-(3-(4-methylpiperazin-1-yl)phenyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [90];

N-(pyridin-4-yl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [91];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [92];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [93];

N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-5-(thieno [3,2-c] pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [94];

2-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)thieno [3,2-c] pyridine [95];

2-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)thieno [3,2-c] pyridine [96];

N-(trans-4-morpholinocyclohexyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [97];

5-(imidazo [1,2-a] pyridin-6-yl)-2-i sobutyl-7H-pyrrolo [2,3-d]pyrimidine [100];

5-(imidazo [1,2-a] pyridin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [101];

2-cyclopropyl-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [102];

2-cyclobutyl-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [103];

2-(cyclobutylmethyl)-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [104];

5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [105];

5-(imidazo [1,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [106];

N-ethyl-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [107];

5-(imidazo [1,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [108];

5-(imidazo [1,2-a] pyridin-6-yl)-N-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [109];

5-(imidazo [1,2-a] pyridin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [110];

(S)-N-(sec-butyl)-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [111];

N-(2-fluoro-2-methylpropyl)-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [112];

N-(2,2-difluoropropyl)-5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine

[113];

5-(imidazo [1,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine

[114];

(R)-5-(imidazo [1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [115];

(S)-5-(imidazo [1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [116];

5-(imidazo [1,2-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine

[117];

(S)-5-(imidazo [1,2-a] pyridin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine

[118];

2-ethoxy-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [119];

N-((1-fluorocyclopropyl)methyl)-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine

[120];

(R)-N-(1-cyclopropylethyl)-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine

[121];

5-(imidazo [1,2-a] pyridin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [122];

5-(imidazo [1,2-a] pyridin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)me thyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [123];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [124];

N-(3,3-difluorocyclobutyl)-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [125];

N-((1-fluorocyclobutyl)methyl)-5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [126];

N-(4,4-difluorocyclohexyl)-5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [127];

5-(imidazo [1,2-a] pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [128];

N-((1-fluorocyclohexyl)methyl)-5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [129];

N-((4,4-difluorocyclohexyl)methyl)-5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [130];

5-(imidazo [1,2-a] pyridin-6-yl)-N-(1-methylpipe ridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine

[131];

5-(imidazo [1,2-a] pyridin-6-yl)-N-((1-methylpipe ridin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [132];

5-(imidazo [1,2-a] pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [133];

5-(imidazo [1,2-a] pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [134];

5-(imidazo [1,2-a] pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [135];

5-(imidazo [1,2-a] pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [136];

5-(imidazo [1,2-a] pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [137];

5-(imidazo [1,2-a] pyridin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [138];

6-(5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [139];

5-(imidazo [1,2-a] pyridin-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidine [140];

5-(imidazo [1,2-a] pyridin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [141];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-2-isobutyl-7H-pyrrolo [2,3-d]pyrimidine [143];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-2-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [144];

2-cyclopropyl-5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [145];

2-cyclobutyl-5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [146];

2-(cyclobutylmethyl)-5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [147];

5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [148];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [149];

N-ethyl-5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [150];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-i sopropyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [151];

5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-N-i sobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [152];

5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [153];

(S)-N-(sec-butyl)-5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [154];

N-(2-fluoro-2-methylpropyl)-5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [155];

N-(2,2-difluoropropyl)-5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [156];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [157];

(R)-5-(3-fluoroimidazo[1,2-a] pyridin-6-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [158];

(S)-5-(3-fluoroimidazo[1,2-a] pyridin-6-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [159];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [160];

(S)-5-(3-fluoroimidazo[1,2-a] pyridin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [161];

2-ethoxy-5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [162];

N-((1-fluorocyclopropyl)methyl)-5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [163];

(R)-N-(1-cyclopropylethyl)-5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [164];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [165];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-4 1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [166];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [167];

N-(3,3-difluorocyclobutyl)-5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [168];

N-((1-fluorocyclobutyl)methyl)-5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [169];

N-(4,4-difluorocyclohexyl)-5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [170];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [171];

N-((1-fluorocyclohexyl)methyl)-5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [172];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [173];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [174];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-((1-methylpipe ridin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [175];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(tetrahydro -2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [176];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [177];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine

[178];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [179];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [180];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [181];

6-(5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [182];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidine [183];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [184];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-2-isobutyl-7H-pyrrolo [2,3-d]pyrimidine [186];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-2-isobutyl-4-methoxy-7H-pyrrolo [2,3-d]pyrimidine [187];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine

[188];

2-cyclopropyl-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [189];

2-cyclobutyl-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [190];

2-(cyclobutylmethyl)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [191];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [192];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [193];

N-ethyl-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [194];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [195];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [196];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [197];

(S)-N-(sec-butyl)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [198];

N-(2-fluoro-2-methylpropyl)-5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [199];

N-(2,2-difluoropropyl)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [200];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [201];

(R)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [202];

(S)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [203];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [204];

(S)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [205];

2-ethoxy-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [206];

N-(cyclopropylmethyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [207];

N-((1-fluorocyclopropyl)methyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [208];

(R)-N-(1-cyclopropylethyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [209];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [210];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [211];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [212];

N-(3,3-difluorocyclobutyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [213];

N-((1-fluorocyclobutyl)methyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [214];

N-(4,4-difluorocyclohexyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [215];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [216];

N-((1-fluorocyclohexyl)methyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [217];

N-((4,4-difluorocyclohexyl)methyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [218];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [219];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [220];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [221];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [222];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[223];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [224];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [225];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [226];

6-(5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [227];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidine [228];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [229];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-2-i sobutyl-7H-pyrrolo [2,3-d]pyrimidine [231];

5-(8-fluoro-2-methylimidazo [1,2-a]pyridin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [232];

2-cyclopropyl-5-(8-fluoro-2-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [233];

2-cyclobutyl-5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine

[234];

2-(cyclobutylmethyl)-5-(8-fluoro-2-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [235];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [236];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine

[237];

N-ethyl-5-(8-fluoro-2-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine

[238];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-i sopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [239];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-i sobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine

[240];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [241];

(S)-N-(sec-butyl)-5-(8-fluoro-2-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [242];

5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [243];

N-(2,2-difluoropropyl)-5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [244];

5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [245];

(R)-5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [246];

(S)-5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [247];

5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [248];

(S)-5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [249];

2-ethoxy-5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [250];

5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [251];

(R)-N-(1-cyclopropylethyl)-5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [252];

5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [253];

5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [254];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [255];

N-(3,3-difluorocyclobutyl)-5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [256];

5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-((1-fluorocyclobutypmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [257];

N-(4,4-difluorocyclohexyl)-5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [258];

5-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [259];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-((1-fluorocyclohexyl)me thyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [260];

N-((4,4-difluorocyclohexyl)methyl)-5-(8-fluoro-2-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [261];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [262];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [263];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [264];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-(3-(4-me thylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [265];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [266];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-(2-(4-methylpipe razin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [267];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-(6-(4-methylpipe razin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [268];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [269];

6-(5-(8-fluoro-2-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline

[270];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidine [271];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [272];

5-(8-fluoro-3-methylimidazo [1,2-a] pyridin-6-yl)-24 sobutyl-7H-pyrrolo [2,3-d]pyrimidine [274];

5-(8-fluoro-3-methylimidazo [1,2-a] pyridin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [275];

2-cyclopropyl-5-(8-fluoro-3-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine

[276];

2-cyclobutyl-5-(8-fluoro-3-methylimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine

[277];

2-(cyclobutylmethyl)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [278];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [279];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine ;

N-ethyl-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine ;

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [282];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine ;

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [284];

(S)-N-(sec-butyl)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [285];

N-(2-fluoro-2-methylpropyl)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [286];

N-(2,2-difluoropropyl)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [287];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [288];

(R)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [289];

(S)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [290];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [291];

(S)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [292];

2-ethoxy-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [293];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [294];

(R)-N-(1-cyclopropylethyl)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [295];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [296];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [297];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [298];

N-(3,3-difluorocyclobutyl)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [299];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-((1-fluorocyclobutypmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [300];

N-(4,4-difluorocyclohexyl)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [301];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [302];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [303];

N-((4,4-difluorocyclohexyl)methyl)-5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [304];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [305];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [306];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [307];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [308];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [309];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [310];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [311];

5-(8-fluoro-3-methylimidazo[1,2-a]pyridin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [312];

6-(5-(8-fluoro-3-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [313];

5-(8-fluoro-3-methylimidazo [1,2-a] pyridin-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidine [314];

5-(8-fluoro-3-methylimidazo [1,2-a] pyridin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [315];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-2-isobutyl-7H-pyrrolo [2,3-d]pyrimidine [317];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [318];

2-cyclopropyl-5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [319];

2-cyclobutyl-5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine

[320];

2-(cyclobutylmethyl)-5-(3-(difluoromethyl)imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine

[321];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [322];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-methyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine

[323];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-ethyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine

[324];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [325];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [326];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [327];

(S)-N-(sec-butyl)-5-(3-(difluoromethyl)imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [328];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [329];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [330];

5-(3-(difluoromethyl)imidazo [1,2-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [331];

(R)-5-(3-(difluoromethyl)imidazo [1,2-a] pyridin-6-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [332];

(S)-5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [333];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [334];

(S)-5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [335];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-2-ethoxy-7H-pyrrolo [2,3-d]pyrimidine [336];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [337];

(R)-N-(1-cyclopropylethyl)-5-(3-(difluoromethyl)imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [338];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [339];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-4 1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [340];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-(difluoromethyl)imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [341];

N-(3,3-difluorocyclobutyl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [342];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-((1-fluorocyclobutypmethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [343];

N-(4,4-difluorocyclohexyl)-5-(3-(difluoromethyl)imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [344];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [345];

5-(3-(difluoromethyl)imidazo [1,2-a]pyridin-6-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [346];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-(difluorome thyl)imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [347];

5-(3-(difluoromethyl)imidazo [1,2-a]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [348];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [349];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [350];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [351];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [352];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(2-(4-methylpipe razin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [353];

5-(3-(difluoromethyl)imidazo [1,2-a]pyridin-6-yl)-N-(6-(4-methylpipe razin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [354];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-46-(4-me thylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [355];

6-(5-(3-(difluoromethyl)imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline

[356];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-44 1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidine [357];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-((trans-4-morpho linocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [358];

2-cyclopropyl-5-(3-(difluoromethyl)-8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [359];

(8-fluoro-6-(2-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1 ,2-a]pyridin-3-yl)methanol [361];

(8-fluoro-6-(2-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [362];

(6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoroimidazo [1,2-a]pyridin-3-yl)methanol [363];

(6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoroimidazo [1,2-a]pyridin-3-yl)methanol [364];

(6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoroimidazo [1,2-a]pyridin-3-yl)methanol [365];

(6-(2-amino-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoroimidazo [1,2-a] pyridin-3-yl)methanol [366];

(8-fluoro-6-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [367];

(6-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[1,2-a]pyridin-3-yl)methanol [368];

(8-fluoro-6-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-y0imidazo[1,2-a]pyridin-3-yl)methanol [369];

(8-fluoro-6-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [370];

(8-fluoro-6-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [371];

(S)-(6-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[1,2-a]pyridin-3-yl)methanol [372];

(8-fluoro-6-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-y0imidazo[1,2-a]pyridin-3-yl)methanol [373];

(6-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[1,2-a]pyridin-3-yl)methanol [374];

(8-fluoro-6-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [375];

(R)-(8-fluoro-6-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [376];

(S)-(8-fluoro-6-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [377];

(8-fluoro-6-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [378];

(S)-(8-fluoro-6-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [379];

(6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[1,2-a]pyridin-3-yl)methanol [380];

(8-fluoro-6-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [381];

(R)-(6-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-8-fluoroimidazo[1,2-a]pyridin-3-yl)methanol [382];

(8-fluoro-6-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [383];

(8-fluoro-6-(2-(((1-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [384];

(6-(2-((2-cyclopropyl-2,2-difluoroethypamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoroimidazo [1,2-a]pyridin-3-yl)methanol [385];

(6-(2-((3,3-difluorocyclobutypamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-8-fluoroimidazo [1,2-a] pyridin-3-yl)methanol [386];

(8-fluoro-6-(2-(((1-fluorocyclobutypmethypamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [387];

(6-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoroimidazo [1,2-a] pyridin-3-yl)methanol [388];

(8-fluoro-6-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-y0imidazo [1,2-a] pyridin-3-yl)methanol [389];

(8-fluoro-6-(2-(((1-fluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [390];

(6-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-8-fluoroimidazo [1,2-a]pyridin-3-yl)methanol [391];

(8-fluoro-6-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a] pyridin-3-yl)methanol [392];

(8-fluoro-6-(2-(((l-methylpipe ridin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [393];

(8-fluoro-6-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a] pyridin-3-yl)methanol [394];

(8-fluoro-6-(2-((3-(4-me thylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [395];

(8-fluoro-6-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [396];

(8-fluoro-6-(2-((2-(4-me thylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [397];

(8-fluoro-6-(2-((6-(4-me thylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [398];

(8-fluoro-6-(2-(((6-(4-methylpiperazin-1-yl)pyridin-3-yl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [399];

(8-fluoro-6-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [400];

(8-fluoro-6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)imidazo [1,2-a] pyridin-3-yl)methanol [401];

(8-fluoro-6-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [402];

2-cyclopropyl-5-(8-fluoro-3-(1-methylpiperidin-4-yl)imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [403];

N-(2,2-difluoroethyl)-6-(24 sobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridine-3-carboxamide [405];

N-(2,2-difluoroethyl)-6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-5-y0imidazo [1,2-a] pyridine-3-carboxamide [406];

6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo [1,2-a] pyridine-3-carboxamide [407];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo [1,2-a]pyridine-3-carboxamide [408];

6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo [1,2-a] pyridine-3-carboxamide [409];

6-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo [1,2-a] pyridine-3-carboxamide [410];

N-(2,2-difluoroethyl)-6-(2-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)imidazo [1,2-a] pyridine-3-carboxamide [411];

N-(2,2-difluoroethyl)-6-(2-(ethylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)imidazo [1,2-a] pyridine-3-carboxamide [412];

N-(2,2-difluoroethyl)-6-(2-(i sop ropylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a] pyridine-3-carboxamide [413];

N-(2,2-difluoroethyl)-6-(2-(isobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a] pyridine-3-carboxamide [414];

N-(2,2-difluoroethyl)-6-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-y0imidazo [1,2-a] pyridine-3-carboxamide [415];

(S)-6-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo [1,2-a] pyridine-3-carboxamide [416];

N-(2,2-difluoroethyl)-6-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [417];

N-(2,2-difluoroethyl)-6-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [418];

N-(2,2-difluoroethyl)-6-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [419];

(R)-N-(2,2-difluoroethyl)-6-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [420];

(S)-N-(2,2-difluoroethyl)-6-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [421];

N-(2,2-difluoroethyl)-6-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [422];

(S)-N-(2,2-difluoroethyl)-6-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [423];

N-(2,2-difluoroethyl)-6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [424];

N-(2,2-difluoroethyl)-6-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [425];

(R)-6-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [426];

N-(2,2-difluoroethyl)-6-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [427];

N-(2,2-difluoroethyl)-6-(2-(((1-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [428];

6-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [429];

6-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [430];

N-(2,2-difluoroethyl)-6-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [431];

6-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [432];

N-(2,2-difluoroethyl)-6-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [433];

N-(2,2-difluoroethyl)-6-(2-(((1-fluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [434];

6-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyl)imidazo[1,2-a]pyridine-3-carboxamide [435];

N-(2,2-difluoroethyl)-6-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [436];

N-(2,2-difluoroethyl)-6-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [437];

N-(2,2-difluoroethyl)-6-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [438];

N-(2,2-difluoroethyl)-6-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [439];

N-(2,2-difluoroethyl)-6-(2-(pyridin-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [440];

N-(2,2-difluoroethyl)-6-(2-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [441];

N-(2,2-difluoroethyl)-6-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [442];

N-(2,2-difluoroethyl)-6-(2-(46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [443];

N-(2,2-difluoroethyl)-6-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [444];

N-(2,2-difluoroethyl)-6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [445];

N-(2,2-difluoroethyl)-6-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [446];

5-(imidazo[1,2-a]pyrimidin-6-yl)-2-isobutyl-7H-pyrrolo[2,3-d]pyrimidine [448];

5-(imidazo[1,2-a]pyrimidin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidine [449];

2-cyclopropyl-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [450];

2-cyclobutyl-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [451];

2-(cyclobutylmethyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [452];

5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [453];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [454];

N-ethyl-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [455];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [456];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [457];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [458];

(S)-N-(sec-butyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [459];

N-(2-fluoro-2-methylpropyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [460];

N-(2,2-difluoropropyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [461];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[462];

(R)-5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [463];

(S)-5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [464];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [465];

(S)-5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[466];

2-ethoxy-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [467];

N-((1-fluorocyclopropyl)methyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [468];

(R)-N-(1-cyclopropylethyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [469];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [470];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [471];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [472];

N-(3,3-difluorocyclobutyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [473];

N-((1-fluorocyclobutyl)methyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [474];

N-(4,4-difluorocyclohexyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [475];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [476];

N-((1-fluorocyclohexyl)methyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [477];

N-((4,4-difluorocyclohexyl)methyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [478];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [479];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [480];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [481];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [482];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [483];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [484];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [485];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [486];

6-(5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline [487];

5-(imidazo[1,2-a]pyrimidin-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine [488];

5-(imidazo[1,2-a]pyrimidin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [489];

5-(imidazo[1,2-a]pyrimidin-6-yl)-2-neopentyl-7H-pyrrolo[2,3-d]pyrimidine [490];

N-(2-fluoro-2-methylpropyl)-5-(2-methyl-2H-indazol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

[492];

5-(4-fluoro-1,2-dimethyl-1H-benzo[d]imidazol-6-yl)-N-((1-methylazetidin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [493];

2-(azetidin-1-yl)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [494];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-2-isobutyl-7H-pyrrolo[2,3-d]pyrimidine [496];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-2-isobutyl-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine [497];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidine [498];

2-cyclopropyl-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [499]; and

2-cyclobutyl-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [500]; or a pharmaceutically acceptable salt thereof

24 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

2-(cyclobutylmethyl)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [501];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [502];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [503];

N-ethyl-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [504];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-N-isopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [505];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-N-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [506];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [507];

(S)-N-(sec-butyl)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [508];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [509];

N-(2,2-difluoropropyl)-5-(4-fluoro-1-isopropyl-2-methyl-lH-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [510];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [511];

(R)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [512];

(S)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [513];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [514];

(S)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [515];

2-ethoxy-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [516];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [517];

(R)-N-(1-cyclopropylethyl)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [518];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [519];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [520];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [521];

N-(3,3-difluorocyclobutyl)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [522];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((1-fluorocyclobutyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [523];

N-(4,4-difluorocyclohexyl)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [524];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [525];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [526];

N-((4,4-difluorocyclohexyl)methyl)-5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [527];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [528];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [529];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [530];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [531];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [532];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [533];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [534];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [535];

6-(5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline [536];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine [537];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [538];

2-cyclopropyl-5-(5-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [539];

2-cyclopropyl-5-(7-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [540];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-2-isobutyl-7H-pyrrolo[2,3-d]pyrimidine [542];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidine [543];

2-cyclopropyl-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [544];

2-cyclobutyl-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [545];

2-(cyclobutylmethyl)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [546];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [547];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [548];

N-ethyl-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [549];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [550];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [551];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [552];

(S)-N-(sec-butyl)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [553];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [554];

N-(2,2-difluoropropyl)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [555];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [556];

(R)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [557];

(S)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [558];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [559];

(S)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [560];

2-ethoxy-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [561];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [562];

(R)-N-(1-cyclopropylethyl)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [563];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [564];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [565];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [566];

N-(3,3-difluorocyclobutyl)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [567];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-((1-fluorocyclobutyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [568];

N-(4,4-difluorocyclohexyl)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [569];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [570];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [571];

N-((4,4-difluorocyclohexyl)methyl)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [572];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [573];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [574];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [575];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [576];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [577];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(2-(4-methylpiperazin-1-yppyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [578];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-(6-(4-methylpiperazin-1-yppyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [579];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [580];

6-(5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [581];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo [d]imidazol-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidine [582];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo [d] imidazol-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-4-amine [583];

6-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-1-isopropyl-2-methyl-1H-imidazo [4,5-b] pyridine [585];

1-i sopropyl-2-methyl-6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridine [586];

6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridine [587];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridine [588];

6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-b]pyridine [589];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [590];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [591];

N-ethyl-5-(1-i sop ropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [592];

N-isopropyl-5-(1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [593];

N-i sobutyl-5-(1-i sop ropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [594];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-ne opentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [595];

(S)-N-(sec-butyl)-5-(1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [596];

N-(2-fluoro-2-methylpropyl)-5-(1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [597];

N-(2,2-difluoropropyl)-5-(1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [598];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [599];

(R)-5-(1-i sop ropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [600];

(S)-5-(1-i sop ropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [601];

5-(1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [602];

(S)-5-(1-i sop ropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [603];

6-(2-ethoxy-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridine [604];

N-((1-fluorocyclopropyl)methyl)-5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [605];

(R)-N-(1-cyclopropylethyl)-5-(1-i sop ropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [606];

5-(1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [607];

5-(1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-4 1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [608];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(1-i sop ropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [609];

N-(3,3-difluorocyclobutyl)-5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [610];

N-((1-fluorocyclobutyl)methyl)-5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [611];

N-(4,4-difluorocyclohexyl)-5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [612];

5-(1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [613];

N-((1-fluorocyclohexyl)methyl)-5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [614];

N-((4,4-difluorocyclohexyl)methyl)-5-(1-i sop ropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [615];

5-(1-isopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [616];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [617];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [618];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [619];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [620];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [621];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [622];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-46-(4-methylpipe razin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [623];

6-(5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [624];

1-i sopropyl-2-methyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1H-imidazo [4,5-b]pyridine [625];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [626];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-i sopropyl-2-methyl-1H-imidazo [4,5-c] pyridine [628];

5-(2,3-dimethyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [629];

3-(2,2-difluoroethyl)-5-(2-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2-methyl-3H-imidazo [4,5-b]pyridine [631];

3-(2,2-difluoroethyl)-2-methyl-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3H-imidazo [4,5-b]pyridine [632];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridine [633];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridine [634];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridine [635];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [636];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [637];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-ethyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [638];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-isopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [639];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [640];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [641];

(S)-N-(sec-butyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [642];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [643];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [644];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [645];

(R)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [646];

(S)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [647];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [648];

(S)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [649];

3-(2,2-difluoroethyl)-5-(2-ethoxy-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2-methyl-3H-imidazo [4,5-b]pyridine [650];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [651];

(R)-N-(1-cyclopropylethyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [652];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [653];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-4 1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [654];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [655];

N-(3,3-difluorocyclobutyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [656];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-((1-fluorocyclobutyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [657];

N-(4,4-difluorocyclohexyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [658];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [659];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [660];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [661];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(1-methylpipe ridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [662];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [663];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [664];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [665];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [666];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [667];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [668];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-((6-(4-methylpipe razin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [669];

6-(5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-1)] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [670];

3-(2,2-difluoroethyl)-2-methyl-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3H-imidazo [4,5-b]pyridine [671];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-4-amine [672];

5-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3-isopropyl-2-methyl-3H-imidazo [4,5-b] pyridine [674];

3-isopropyl-2-methyl-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3H-imidazo [4,5-b] pyridine [675];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3-isopropyl-2-methyl-3H-imidazo [4,5]-14yridine [676];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3-isopropyl-2-methyl-3H-imidazo [4,5]-14yridine [677];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3-isopropyl-2-methyl-3H-imidazo [4,5-b] pyridine [678];

5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [679];

5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [680];

N-ethyl-5-(3-isop ropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [681];

N-i sopropyl-5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [682];

N-i sobutyl-5-(3-isop ropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [683];

5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [684];

(S)-N-(sec-butyl)-5-(3-i sopropyl-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [685];

N-(2-fluoro-2-methylpropyl)-5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [686];

N-(2,2-difluoropropyl)-5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [687];

5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [688];

(R)-5-(3-i sop ropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [689];

(S)-5-(3-i sop ropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [690];

5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [691];

(S)-5-(3-i sop ropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [692];

5-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridine [693];

N-((1-fluorocyclopropyl)methyl)-5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [694];

(R)-N-(1-cyclopropylethyl)-5-(3-i sop ropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [695];

5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [696];

5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-4 1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [697];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-i sop ropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [698];

N-(3,3-difluorocyclobutyl)-5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [699];

N-((1-fluorocyclobutypmethyl)-5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [700];

N-(4,4-difluorocyclohexyl)-5-(3-isopropyl-2-methyl-3H-imidazo [4,5-1)] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [701];

5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [702];

N-((1-fluorocyclohexyl)methyl)-5-(3-isopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [703];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-i sop ropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [704];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [705];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [706];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [707];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [708];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [709];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [710];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [711];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-46-(4-methylpipe razin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [712];

6-(5-(3-i sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [713];

3-i sopropyl-2-methyl-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3H-imidazo[4,5-b]pyridine [714];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [715];

6-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a] pyridine [717];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(tert-butyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [718];

6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a]pyridine [719];

6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a]pyridine [720];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a]pyridine [721];

6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a]pyridine [722];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [723];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-methyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [724];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-ethyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [725];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [726];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [727];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [728];

(S)-5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-N-(sec-butyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [729];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(2,2-difluoroethyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [730];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [731];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [732];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [733];

(R)-5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [734];

(S)-5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [735];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [736];

(S)-5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [737];

6-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a]pyridine [738];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [739];

(R)-5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-N-(1-cyclopropylethyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [740];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [741];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [742];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(2-cyclopropyl-2,2-difluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [743];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(3,3-difluorocyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [744];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-fluorocyclobutyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [745];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(4,4-difluorocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [746];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [747];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [748];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((4,4-difluorocyclohexyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [749];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [750];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [751];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [752];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(3-(4-methylpipe razin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [753];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [754];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(2-(4-methylpipe razin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [755];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(6-(4-methylpipe razin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [756];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [757];

6-(5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [758];

6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a] pyridine [759];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [760];

8-fluoro-6-(2-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a] pyridine [762];

8-fluoro -64243,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a]pyridine [763];

6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoro-[1,2,4]triazolo [1,5-a] pyridine [764];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoro-[1,2,4]triazolo [1,5-a]pyridine [765];

6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoro-[1,2,4]triazolo [1,5-a]pyridine [766];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [767];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [768];

N-ethyl-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [769];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-isopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [770];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [771];

5-(8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [772];

(S)-N-(sec-butyl)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [773];

N-(2-fluoro-2-methylpropyl)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [774];

N-(2,2-difluoropropyl)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [775];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [776];

(R)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [777];

(S)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [778];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [779];

(S)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [780];

6-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-8-fluoro-[1,2,4]triazolo [1,5-a]pyridine [781];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [782];

(R)-N-(1-cyclopropylethyl)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [783];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [784];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [785];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [786];

N-(3,3-difluorocyclobutyl)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [787];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-fluorocyclobutyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [788];

N-(4,4-difluorocyclohexyl)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [789];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [790];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [791];

N-((4,4-difluorocyclohexyl)methyl)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [792];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(1-methylpipe ridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [793];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [794];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [795];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [796];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [797];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [798];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [799];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [800];

6-(5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)quinoline [801];

8-fluoro-6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)41,2,41triazolo [1,5-a] pyridine [802];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [803];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-N-isopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [804];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [805];

(R)-5-([1,2,4]triazolo [1,5-a] pyridin-7-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [806];

(S)-5-([1,2,4]triazolo [1,5-a] pyridin-7-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [807];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [808];

6-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-1-methyl-1H-benzo [d] [1,2,3]triazole [810];

1-methyl-6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1H-benzo[d] [1,2,3]triazole [811];

6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-methyl-1H-benzo [d] [1,2,3]triazole [812];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-methyl-1H-benzo [d] [1,2,3]triazole [813];

6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-methyl-1H-benzo [d] [1,2,3]triazole [814];

5-(1-methyl-1H-benzo[ d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [815];

N-methyl-5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [816];

N-ethyl-5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [817];

N-isopropyl-5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [818];

N-isobutyl-5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [818];

5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [819];

(S)-N-(sec-butyl)-5-(1-methyl-1H-benzo[d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [821];

N-(2-fluoro-2-methylpropyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [822];

N-(2,2-difluoropropyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [823];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [824];

(R)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [825];

(S)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [826];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [827];

(S)-N-(1-methoxypropan-2-yl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [828];

6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1-methyl-1H-benzo[d][1,2,3]triazole [829];

N-((1-fluorocyclopropyl)methyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [830];

(R)-N-(1-cyclopropylethyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [831];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [832];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [833];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [834];

N-(3,3-difluorocyclobutyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [835];

N-((1-fluorocyclobutyl)methyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [836];

N-(4,4-difluorocyclohexyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [837];

N-(cis-4-methoxycyclohexyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [838];

N-((1-fluorocyclohexyl)methyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [839];

N-((4,4-difluorocyclohexyl)methyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [840];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [841];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [842];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [843];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [844];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [845];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [846];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [847];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [848];

6-(5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline [849];

1-methyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-benzo[d][1,2,3]triazole [850];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [851];

1-ethyl-6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-benzo[d][1,2,3]triazole [853];

1-ethyl-6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-benzo[d][1,2,3]triazole [854];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1-ethyl-1H-benzo[d][1,2,3]triazole [855];

6-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1-ethyl-1H-benzo[d][1,2,3]triazole [856];

6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1-ethyl-1H-benzo[d][1,2,3]triazole [857];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [858];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [859];

N-ethyl-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [860];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [861];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [862];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [863];

(S)-N-(sec-butyl)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [864];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [865];

N-(2,2-difluoropropyl)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [866];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [867];

(R)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [868];

(S)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [869];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [870];

(S)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [871];

6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1-ethyl-1H-benzo[d][1,2,3]triazole [872];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [873];

(R)-N-(1-cyclopropylethyl)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [874];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [875];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [876];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [877];

N-(3,3-difluorocyclobutyl)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [878];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-((1-fluorocyclobutyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [879];

N-(4,4-difluorocyclohexyl)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [880];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [881];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [882];

N-((4,4-difluorocyclohexyl)methyl)-5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [883];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [884];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [885];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [886];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [887];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [888];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [889];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [890];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [891];

6-(5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline [892];

1-ethyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-benzo[d][1,2,3]triazole [893];

5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [894];

N-(2-fluoro-2-methylpropyl)-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [895];

5-(imidazo [1,2-b]pyridazin-6-yl)-2-isobutyl-7H-pyrrolo [2,3-d] pyrimidine [897];

5-(imidazo [1,2-b]pyridazin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidine [898];

2-cyclopropyl-5-(imidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [899];

2-cyclobutyl-5-(imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [900];

2-(cyclobutylmethyl)-5-(imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [901];

5-(imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [902];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-methyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [903];

N-ethyl-5-(imidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [904];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-i sopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [905];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-i sobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [906];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-ne opentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [907];

(S)-N-(sec-butyl)-5-(imidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [908];

N-(2-fluoro-2-methylpropyl)-5-(imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [909];

N-(2,2-difluoropropyl)-5-(imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [910];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [911];

(R)-5-(imidazo [1,2-b] pyridazin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [912];

(S)-5-(imidazo [1,2-b] pyridazin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [913];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine ;

(S)-5-(imidazo [1,2-b] pyridazin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [915];

2-ethoxy-5-(imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [916];

N-((1-fluorocyclopropyl)methyl)-5-(imidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [917];

(R)-N-(1-cyclopropylethyl)-5-(imidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [918];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [919];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [920];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [921];

N-(3,3-difluorocyclobutyl)-5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [922];

N-((1-fluorocyclobutyl)methyl)-5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [923];

N-(4,4-difluorocyclohexyl)-5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [924];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [925];

N-((1-fluorocyclohexyl)methyl)-5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [926];

N-((4,4-difluorocyclohexyl)methyl)-5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [927];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [928];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [929];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [930];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [931];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [932];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [933];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [934];

5-(imidazo[1,2-b]pyridazin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [935];

6-(5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)quinoline [936];

5-(imidazo [1,2-b]pyridazin-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidine [937];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [938];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-2-isobutyl-7H-pyrrolo [2,3-d]pyrimidine [940];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [941];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidine [942];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidine [943];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidine [944];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [945];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-methyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [946];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-ethyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [947];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-isopropyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [948];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [949];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [950];

(S)-N-(sec-butyl)-5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [951];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [952];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [953];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [954];

(R)-5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [955];

(S)-5-(3-chloroimidazo[1,2-b]pyridazin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [956];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [957];

(S)-5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [958];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-2-ethoxy-7H-pyrrolo [2,3-d] pyrimidine [959];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [960];

(R)-5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(1-cyclopropylethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [961];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [962];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [963];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(2-cyclopropyl-2,2-difluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [964];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(3,3-difluorocyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [965];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-((1-fluorocyclobutypmethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [966];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(4,4-difluorocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [967];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [968];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [969];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-((4,4-difluorocyclohexyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [970];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [971];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [972];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(tetrahydro -2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [973];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(3-(4-methylpipe razin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [974];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [975];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [976];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [977];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-46-(4-me thylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [978];

6-(5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [979];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidine [980];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [981];

2-i sobutyl-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [983];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [984];

2-cyclopropyl-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [985];

2-cyclobutyl-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [986];

2-(cyclobutylmethyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [987];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [988];

N-methyl-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [989];

N-ethyl-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [990];

N-isopropyl-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [991];

N-isobutyl-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [992];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [993];

(S)-N-(sec-butyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [994];

N-(2-fluoro-2-methylpropyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [995];

N-(2,2-difluoropropyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [996];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [997];

(R)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [998];

(S)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [999]; and

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1000]; or a pharmaceutically acceptable salt thereof.

25 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

(S)-N-(1-methoxypropan-2-yl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1001];

2-ethoxy-5-(2-methylimidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [1002];

N-((1-fluorocyclopropyl)methyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1003];

(R)-N-(1-cyclopropylethyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1004];

N-((1-methylcyclopropyl)methyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1005];

5-(2-methylimidazo [1,2-b] pyridazin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)me thyl) -7H-pyrrolo [2,3-d]pyrimidin-2-amine [1006];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1007];

N-(3,3-difluorocyclobutyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1008];

N-((1-fluorocyclobutypmethyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1009];

N-(4,4-difluorocyclohexyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1010];

N-(cis-4-methoxycyclohexyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1011];

N-((1-fluorocyclohexyl)methyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1012];

N-((4,4-difluorocyclohexyl)methyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1013];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1014];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1015];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1016];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1017];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1018];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1019];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1020];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1021];

6-(5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [1022];

4-(1-methyl-1H-pyrazol-4-yl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [1023];

5-(2-methylimidazo [1,2-b] pyridazin-6-yl)-N-(trans-4-morpho linocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [1024];

2-i sobutyl-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [1026];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [1027];

2-cyclopropyl-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [1028];

2-cyclobutyl-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [1029];

2-(cyclobutylmethyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [1030];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1031];

N-methyl-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1032];

N-ethyl-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1033];

N-isopropyl-5-(3-methylimidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1034];

N-isobutyl-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1035];

5-(3-methylimidazo [1,2-b] pyridazin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1036];

(S)-N-(sec-butyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1037];

N-(2-fluoro-2-methylpropyl)-5-(3-methylimidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1038];

N-(2,2-difluoropropyl)-5-(3-methylimidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1039];

5-(3-methylimidazo [1,2-b] pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1040];

(R)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1041];

(S)-5-(3-methylimidazo [1,2-b] pyridazin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1042];

5-(3-methylimidazo [1,2-b] pyridazin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1043];

(S)-N-(1-methoxypropan-2-yl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1044];

2-ethoxy-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [1045];

N-((1-fluorocyclopropyl)methyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1046];

(R)-N-(1-cyclopropylethyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1047];

N-((l-methylcyclopropyl)methyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1048];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)me thyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1049];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1050];

N-(3,3-difluorocyclobutyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1051];

N-((1-fluorocyclobutypmethyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1052];

N-(4,4-difluorocyclohexyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1053];

N-(cis-4-methoxycyclohexyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1054];

N-((1-fluorocyclohexyl)methyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1055];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1056];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1057];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1058];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1059];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1060];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1061];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1062];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1063];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1064];

6-(5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [1065];

4-(1-methyl-1H-pyrazol-4-yl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [1066];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [1067];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-2-isobutyl-7H-pyrrolo [2,3-d]pyrimidine [1069];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-2-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [1070];

2-cyclopropyl-5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [1071];

2-cyclobutyl-5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [1072];

2-(cyclobutylmethyl)-5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [1073];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1074];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1075];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-ethyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1076];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-i sopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1077];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-i sobutyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1078];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1079];

(S)-N-(sec-butyl)-5-(3-(difluoromethyl)imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1080];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(2-fluoro-2-me thylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1081];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1082];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1083];

(R)-5-(3-(difluoromethyl)imidazo [1,2-b]pyridazin-6-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1084];

(S)-5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1085];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1086];

(S)-5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1087];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-2-ethoxy-7H-pyrrolo [2,3-d]pyrimidine ;

5-(3-(difluoromethyl)imidazo[1,2-b] pyridazin-6-yl)-N-((1-fluorocyclopropyl)me thyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1089];

(R)-N-(1-cyclopropylethyl)-5-(3-(difluoromethyl)imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1090];

5-(3-(difluoromethyl)imidazo [1,2-b] pyridazin-6-yl)-N-((1-methylcyclopropyl)me thyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1091];

5-(3-(difluoromethyl)imidazo[1,2-b] pyridazin-6-yl)-N-4 1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1092];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-(difluoromethyl)imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1093];

N-(3,3-difluorocyclobutyl)-5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1094];

5-(3-(difluoromethyl)imidazo [1,2-b] pyridazin-6-yl)-N-((1-fluorocyclobu tyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1095];

N-(4,4-difluorocyclohexyl)-5-(3-(difluoromethyl)imidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1096];

5-(3-(difluoromethyl)imidazo [1,2-b]pyridazin-6-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1097];

5-(3-(difluoromethyl)imidazo[1,2-b] pyridazin-6-yl)-N-((1-fluorocyclohexyl)me thyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1098];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-(difluoromethyl)imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1099];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1100];

5-(3-(difluoromethyl)imidazo[1,2-b] pyridazin-6-yl)-N-((1-methylpiperidin-4-yl)me thyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1101];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1102];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(3-(4-me thylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1103];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1104];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(2-(4-me thylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1105];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(6-(4-me thylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1106];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1107];

6-(5-(3-(difluoromethyl)imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [1108];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidine [1109];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(trans-4-morpho linocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [1110];

2-i sobutyl-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1112];

2-i sobutyl-4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidine [1113];

5-(pyrazolo [1,5-a]pyridin-5-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [1114];

2-cyclopropyl-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1115];

2-cyclobutyl-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1116];

2-(cyclobutylmethyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidine [1117];

5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1118];

N-methyl-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1119];

N-ethyl-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1120];

N-isopropyl-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1121];

N-isobutyl-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1122];

N-neopentyl-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1123];

(S)-N-(sec-butyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1124];

N-(2-fluoro-2-methylpropyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1125];

N-(2,2-difluoropropyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1126];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1127];

(R)-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1128];

(S)-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1129];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1130];

(S)-N-(1-methoxypropan-2-yl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1131];

2-ethoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1132];

N-((1-fluorocyclopropyl)methyl)-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1133];

(R)-N-(1-cyclopropylethyl)-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1134];

N-((1-methylcyclopropyl)methyl)-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1135];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-4 1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1136];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1137];

N-(3,3-difluorocyclobutyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1138];

N-((1-fluorocyclobutypmethyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1139];

N-(cis-3-methoxycyclobutyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1140];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(2-oxaspiro [3 . 3 ]heptan-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1141];

N-(4,4-difluorocyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1142];

N-(cis-4-methoxycyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1143];

N-((1-fluorocyclohexyl)methyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1144];

N-((4,4-difluorocyclohexyl)methyl)-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1145];

N-(1-methylpiperidin-4-yl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1146];

N-((1-methylpiperidin-4-yl)methyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1147];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(tetrahydro -2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1148];

N-(3-(4-methylpiperazin-1-yl)phenyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1149];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1150];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1151];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1152];

N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1153];

6-(5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [1154];

4-(1-methyl-1H-pyrazol-4-yl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidine [1155];

N-(trans-4-morpholinocyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [1156];

N-(2-fluoro-2-methylpropyl)-5-(3-fluoropyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1157];

2-i sobutyl-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1159];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [1160];

2-cyclopropyl-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1161];

2-cyclobutyl-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1162];

2-(cyclobutylmethyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidine [1163];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1164];

N-methyl-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1165];

N-ethyl-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1166];

N-isopropyl-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1167];

N-isobutyl-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1168];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-neopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1169];

(S)-N-(sec-butyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1170];

N-(2-fluoro-2-methylpropyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1171];

N-(2,2-difluoropropyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1172];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1173];

(R)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1174];

(S)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1175];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1176];

(S)-N-(1-methoxypropan-2-yl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1177];

2-ethoxy-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidine [1178];

N-((1-fluorocyclopropyl)methyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1179];

(R)-N-(1-cyclopropylethyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1180];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1181];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1182];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1183];

N-(3,3-difluorocyclobutyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1184];

N-((1-fluorocyclobutyl)methyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1185];

N-(4,4-difluorocyclohexyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1186];

N-(cis-4-methoxycyclohexyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1187];

N-((1-fluorocyclohexyl)methyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1188];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1189];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1190];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1191];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1192];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1193];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1194];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1195];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-5-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1196];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-N-46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1197];

6-(5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [1198];

4-(1-methyl-1H-pyrazol-4-yl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1199];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [1200];

(5-(2-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1202];

piperidin-1-yl(5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)methanone [1203];

(5-(2-cyclopropyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1204];

(5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1205];

(5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(piperidin-1-yl)methanone [1206];

(5-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1207];

(5-(2-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1208];

(5-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1209];

(5-(2-(isopropylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1210];

(5-(2-(isobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1211];

(5-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1212];

(S)-(5-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1213];

(5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1214];

(5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1215];

piperidin-1-yl(5-(2-((2,2,2-trifluoroethyDamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)methanone [1216];

(R)-piperidin-1-yl(5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)methanone [1217];

(S)-piperidin-1-yl(5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)methanone [1218];

piperidin-1-yl(5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)methanone [1219];

(S)-(5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1220];

(5-(2-ethoxy-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1221];

(5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1222];

(R)-(5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1223];

(5-(2-(((1-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1224];

piperidin-1-yl(5-(2-(41-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)methanone [1225];

(5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1226];

(5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(piperidin-1-yl)methanone [1227];

(5-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1228];

(5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1229];

(5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1230];

(5-(2-(((1-fluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1231];

(5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1232];

(5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1233];

(5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1234];

piperidin-1-yl(5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)methanone [1235];

(5-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1236];

piperidin-1-yl(5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)methanone [1237];

(5-(2-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1238];

(5-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1239];

(5-(2-(((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [1240];

piperidin-1-yl(5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)methanone [1241];

(5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(piperidin-1-yl)methanone [1242];

(5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(pipe ridin-1-yl)methanone [1243];

(5-(4-((cyclopropylmethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [1244];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N,N-dimethylpyrazolo [1,5-a]pyridine-3-carboxamide [1245];

N-(2,2-difluoroethyl)-5-(24 sobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1247];

N-(2,2-difluoroethyl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1248];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyppyrazolo [1,5-a] pyridine-3-carboxamide [1249];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2,2-difluoroethyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1250];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyppyrazolo [1,5-a] pyridine-3-carboxamide [1251];

5-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2,2-difluoroethyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1252];

N-(2,2-difluoroethyl)-5-(2-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1253];

N-(2,2-difluoroethyl)-5-(2-(ethylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1254];

N-(2,2-difluoroethyl)-5-(2-(i sop ropylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1255];

N-(2,2-difluoroethyl)-5-(2-(isobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1256];

N-(2,2-difluoroethyl)-5-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1257];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2,2-difluoroethyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1258];

N-(2,2-difluoroethyl)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1259];

N-(2,2-difluoroethyl)-5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1260];

N-(2,2-difluoroethyl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1261];

(R)-N-(2,2-difluoroethyl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1262];

(S)-N-(2,2-difluoroethyl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1263];

N-(2,2-difluoroethyl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1264];

(S)-N-(2,2-difluoroethyl)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1265];

N-(2,2-difluoroethyl)-5-(2-ethoxy-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1266];

N-(2,2-difluoroethyl)-5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1267];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyppyrazolo [1,5-a]pyridine-3-carboxamide [1268];

N-(2,2-difluoroethyl)-5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1269];

N-(2,2-difluoroethyl)-5-(2-(((1-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1270];

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyppyrazolo [1,5-a]pyridine-3-carboxamide [1271];

5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyppyrazolo [1,5-a]pyridine-3-carboxamide [1272];

N-(2,2-difluoroethyl)-5-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1273];

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2,2-difluoroethyppyrazolo [1,5-a]pyridine-3-carboxamide [1274];

N-(2,2-difluoroethyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1275];

N-(2,2-difluoroethyl)-5-(2-(((1-fluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1276];

5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2,2-difluoroethyppyrazolo [1,5-a]pyridine-3-carboxamide [1277];

N-(2,2-difluoroethyl)-5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1278];

N-(2,2-difluoroethyl)-5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1279];

N-(2,2-difluoroethyl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1280];

N-(2,2-difluoroethyl)-5-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1281];

N-(2,2-difluoroethyl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1282];

N-(2,2-difluoroethyl)-5-(2-42-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1283];

2,2-difluoroethyl)-5-(2-46-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1284];

N-(2,2-difluoroethyl)-5-(2-(46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1285];

N-(2,2-difluoroethyl)-5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1286];

N-(2,2-difluoroethyl)-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1287];

N-(2,2-difluoroethyl)-5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1288];

N-(2-fluoro-2-methylpropyl)-5-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1290];

N-(2-fluoro-2-methylpropyl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1291];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1292];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1293];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1294];

5-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1295];

N-(2-fluoro-2-methylpropyl)-5-(2-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1296];

5-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1297];

N-(2-fluoro-2-methylpropyl)-5-(2-(isopropylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1298];

N-(2-fluoro-2-methylpropyl)-5-(2-(isobutylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1299];

N-(2-fluoro-2-methylpropyl)-5-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1300];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1301];

N-(2-fluoro-2-methylpropyl)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1302];

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1303];

N-(2-fluoro-2-methylpropyl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1304];

(R)-N-(2-fluoro-2-methylpropyl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1305];

(S)-N-(2-fluoro-2-methylpropyl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1306];

N-(2-fluoro-2-methylpropyl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1307];

(S)-N-(2-fluoro-2-methylpropyl)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1308];

5-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1309];

N-(2-fluoro-2-methylpropyl)-5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1310];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1311];

N-(2-fluoro-2-methylpropyl)-5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1312];

N-(2-fluoro-2-methylpropyl)-5-(2-(((1-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1313];

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1314];

5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1315];

N-(2-fluoro-2-methylpropyl)-5-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1316];

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1317];

N-(2-fluoro-2-methylpropyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1318];

N-(2-fluoro-2-methylpropyl)-5-(2-(((1-fluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1319];

5-(2-4(4,4-difluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1320];

N-(2-fluoro-2-methylpropyl)-5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1321];

N-(2-fluoro-2-methylpropyl)-5-(2-(((l-methylpiperidin-4-yl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1322];

N-(2-fluoro-2-methylpropyl)-5-(2-((tetrahydro -2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1323];

N-(2-fluoro-2-methylpropyl)-5-(2-((3-(4-methylpipe razin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1324];

N-(2-fluoro-2-methylpropyl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1325];

N-(2-fluoro-2-methylpropyl)-5-(2-((2-(4-methylpipe razin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1326];

N-(2-fluoro-2-methylpropyl)-5-(2-((6-(4-methylpipe razin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1327];

N-(2-fluoro-2-methylpropyl)-5-(2-(46-(4-me thylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1328];

N-(2-fluoro-2-methylpropyl)-5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1329];

N-(2-fluoro-2-methylpropyl)-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1330];

N-(2-fluoro-2-methylpropyl)-5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1331];

(R)-5-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1333];

(R)-N-(1,1,1-trifluoropropan-2-yl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1334];

(R)-5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1335];

(R)-5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1336];

(R)-5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1337];

(R)-5-(2-amino-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1338];

(R)-5-(2-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1339];

(R)-5-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1340];

(R)-5-(2-(isopropylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1341];

(R)-5-(2-(isobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1342];

(R)-5-(2-(neopentylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1343];

5-(2-(((S)-sec-butyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((R)-1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1344];

(R)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1345];

(R)-5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1346];

(R)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1347];

N-((R)-1,1,1-trifluoropropan-2-yl)-5-(2-(((R)-1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1348];

N-((R)-1,1,1-trifluoropropan-2-yl)-5-(2-(((S)-1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1349];

(R)-N-(1,1,1-trifluoropropan-2-yl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1350];

5-(2-(((S)-1-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((R)-1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1351];

(R)-5-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1352];

(R)-5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1353];

5-(2-(((R)-1-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((R)-1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1354];

(R)-5-(2-(((1-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1355];

(R)-5-(2-(((1-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1356];

(R)-5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1357];

(R)-5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1358];

(R)-5-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1359];

(R)-5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1360];

5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((R)-1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1361];

(R)-5-(2-(((1-fluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1362];

(R)-5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1363];

(R)-5-(2-((1-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1364];

(R)-5-(2-(((1-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1365];

(R)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1366];

(R)-5-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1367];

(R)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1368];

(R)-5-(2-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1369];

(R)-5-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1370];

(R)-5-(2-(((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1371];

(R)-5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1372];

(R)-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1373];

5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-((R)-1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1374];

N-(3,3-difluorocyclobutyl)-5-(2-i sobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1376];

N-(3,3-difluorocyclobutyl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1377];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(3,3-difluorocyclobutyppyrazolo [1,5-a] pyridine-3-carboxamide [1378];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(3,3-difluorocyclobutyl)-N-methylpyrazolo [1,5-a]pyridine-3-carboxamide [1379];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(3,3-difluorocyclobutyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1380];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(3,3-difluorocyclobutyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1381];

5-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(3,3-difluorocyclobutyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1382];

N-(3,3-difluorocyclobutyl)-5-(2-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1383];

N-(3,3-difluorocyclobutyl)-5-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1384];

N-(3,3-difluorocyclobutyl)-5-(2-(i sop ropylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1385];

N-(3,3-difluorocyclobutyl)-5-(2-(i sobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1386];

N-(3,3-difluorocyclobutyl)-5-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1387];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(3,3-difluorocyclobutyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1388];

N-(3,3-difluorocyclobutyl)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1389];

N-(3,3-difluorocyclobutyl)-5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1390];

N-(3,3-difluorocyclobutyl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1391];

(R)-N-(3,3-difluorocyclobutyl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1392];

(S)-N-(3,3-difluorocyclobutyl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1393];

N-(3,3-difluorocyclobutyl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1394];

(S)-N-(3,3-difluorocyclobutyl)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1395];

N-(3,3-difluorocyclobutyl)-5-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1396];

N-(3,3-difluorocyclobutyl)-5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1397];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(3,3-difluorocyclobutyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1398];

N-(3,3-difluorocyclobutyl)-5-(2-(((l-methylcyclopropyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1399];

N-(3,3-difluorocyclobutyl)-5-(2-(((1-(trifluorome thyl)cyclopropyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1400];

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(3,3-difluorocyclobutyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1401];

N-(3,3-difluorocyclobutyl)-5-(2-((3,3-difluorocyclobutypamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1402];

N-(3,3-difluorocyclobutyl)-5-(2-(((1-fluorocyclobu tyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1403];

N-(3,3-difluorocyclobutyl)-5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1404];

N-(3,3-difluorocyclobutyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1405];

N-(3,3-difluorocyclobutyl)-5-(2-(((1-fluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1406];

N-(3,3-difluorocyclobutyl)-5-(2-4(4,4-difluorocyclohexyl)methypamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1407];

N-(3,3-difluorocyclobutyl)-5-(2-((1-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1408];

N-(3,3-difluorocyclobutyl)-5-(2-(((1-methylpiperidin-4-yl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1409];

N-(3,3-difluorocyclobutyl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1410];

N-(3,3-difluorocyclobutyl)-5-(2-43-(4-me thylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1411];

N-(3,3-difluorocyclobutyl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1412];

N-(3,3-difluorocyclobutyl)-5-(2-42-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1413];

N-(3,3-difluorocyclobutyl)-5-(2-46-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1414];

N-(3,3-difluorocyclobutyl)-5-(2-(46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1415];

N-(3,3-difluorocyclobutyl)-5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1416];

N-(3,3-difluorocyclobutyl)-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1417];

N-(3,3-difluorocyclobutyl)-5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1418];

N-((3,3-difluorocyclobutypmethyl)-5-(2-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1420];

N-((3,3-difluorocyclobutypmethyl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1421];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((3,3-difluorocyclobutyl)methyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1422];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-((3,3-difluorocyclobutyl)methyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1423];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((3,3-difluorocyclobutypmethyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1424];

5-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-((3,3-difluorocyclobutyl)methyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1425];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1426];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1427];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(isopropylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1428];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(isobutylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1429];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(neopentylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1430];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-((3,3-difluorocyclobutyl)methyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1431];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1432];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1433];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1434];

(R)-N-((3,3-difluorocyclobutyl)methyl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1435];

(S)-N-((3,3-difluorocyclobutyl)methyl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1436];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1437];

(S)-N-((3,3-difluorocyclobutyl)methyl)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1438];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-ethoxy-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1439];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1440];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((3,3-difluorocyclobutyl)methyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1441];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1442];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((1-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1443];

5-(2-((2-cyclopropyl-2,2-difluoroethypamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((3,3-difluorocyclobutyl)methyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1444];

5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((3,3-difluorocyclobutyl)methyl)pyrazolo [1,5-a]pyridine-3-carboxamide [1445];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((1-fluorocyclobutyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1446];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1447];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1448];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((1-fluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1449];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1450];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((l-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1451];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1452];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1453];

N-((3,3-difluorocyclobutypmethyl)-5-(2-43-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1454];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1455];

N-((3,3-difluorocyclobutypmethyl)-5-(2-42-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1456];

N-((3,3-difluorocyclobutypmethyl)-5-(2-46-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1457];

N-((3-difluorocyclobutypmethyl)-5-(2-(46-(4-me thylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1458];

N-((3-difluorocyclobutypmethyl)-5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1459];

N-((3,3-difluorocyclobutyl)methyl)-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1460];

N-((3-difluorocyclobutypmethyl)-5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1461];

5-(2-i sobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1463];

N-(trans-4-methoxycyclohexyl)-5-(243,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1464];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1465];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1466];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1467];

5-(2-amino-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1468];

N-(trans-4-methoxycyclohexyl)-5-(2-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1469];

5-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1470];

5-(2-(i sop ropylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1471];

5-(2-(i sobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1472];

N-(trans-4-methoxycyclohexyl)-5-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1473];

5-(2-(((S)-se c-butyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1474];

5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1475];

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1476];

N-(trans-4-methoxycyclohexyl)-5-(2-((2,2,2-trifluoroethypamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1477];

N-(trans-4-methoxycyclohexyl)-5-(2-4(R)-1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1478];

N-(trans-4-methoxycyclohexyl)-5-(2-4(S)-1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1479];

N-(trans-4-methoxycyclohexyl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1480];

N-(trans-4-methoxycyclohexyl)-5-(2-4(S)-1-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1481];

5-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1482];

5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1483];

5-(2-(((R)-1-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1484];

N-(trans-4-methoxycyclohexyl)-5-(2-(((1-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1485];

N-(trans-4-methoxycyclohexyl)-5-(2-(41-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1486];

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1487];

5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1488];

5-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1489];

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1490];

N-(trans-4-methoxycyclohexyl)-5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1491];

5-(2-(((1-fluorocyclohexyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1492];

5-(2-(((4,4-difluorocyclohexyl)methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(trans-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [1493];

N-(trans-4-methoxycyclohexyl)-5-(2-((1-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1494];

N-(trans-4-methoxycyclohexyl)-5-(2-(((1-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1495];

N-(trans-4-methoxycyclohexyl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1496];

N-(trans-4-methoxycyclohexyl)-5-(2-43-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1497];

N-(trans-4-methoxycyclohexyl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1498];

N-(trans-4-methoxycyclohexyl)-5-(2-42-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1499]; and

N-(trans-4-methoxycyclohexyl)-5-(2-46-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1500]; or a pharmaceutically acceptable salt thereof.

26 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

N-(trans-4-methoxycyclohexyl)-5-(2-(46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1501];

N-(trans -4-methoxycyclohexyl)-5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1502];

N-(trans-4-methoxycyclohexyl)-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1503];

N-(trans-4-methoxycyclohexyl)-5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1504];

5-(2-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1506];

N-(1-methylpiperidin-4-yl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1507];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1508];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1509];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpipe ridin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1510];

5-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1511];

5-(2-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1512];

5-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1513];

5-(2-(i sop ropylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1514];

5-(2-(isobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1515];

N-(1-methylpiperidin-4-yl)-5-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1516];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1-methylpipe ridin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1517];

5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1518];

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1519];

N-(1-methylpiperidin-4-yl)-5-(2-((2,2,2-trifluoroethypamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1520];

(R)-N-(1-methylpiperidin-4-yl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1521];

(S)-N-(1-methylpiperidin-4-yl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1522];

N-(1-methylpiperidin-4-yl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1523];

(S)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1524];

5-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1525];

5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1526];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1527];

5-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1528];

N-(1-me thylpiperidin-4-yl)-5-(2-(41-(trifluorome thyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1529];

5-(2-((2-cyclopropyl-2,2-difluoroethypamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1530];

5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpipe ridin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1531];

5-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1532];

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1533];

5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpipe ridin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1534];

5-(2-(((1-fluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1535];

5-(2-(((4,4-difluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1536];

N-(1-methylpiperidin-4-yl)-5-(2-((1-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1537];

N-(1-methylpiperidin-4-yl)-5-(2-(((1-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1538];

N-(1-methylpiperidin-4-yl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1539];

5-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1540];

N-(1-methylpiperidin-4-yl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1541];

5-(2-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1542];

5-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1543];

5-(2-(((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1544];

N-(1-methylpiperidin-4-yl)-5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1545];

5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1546];

N-(1-methylpiperidin-4-yl)-5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1547];

5-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1549];

N-(tetrahydro-2H-pyran-4-yl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1550];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1551];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-methyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1552];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1553];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1554];

5-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1555];

5-(2-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1556];

5-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1557];

5-(2-(i sop ropylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1558];

5-(2-(isobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro -2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1559];

5-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1560];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1561];

5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1562];

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1563];

N-(tetrahydro-2H-pyran-4-yl)-5-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1564];

(R)-N-(tetrahydro-2H-pyran-4-yl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1565];

(S)-N-(tetrahydro-2H-pyran-4-yl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1566];

N-(tetrahydro-2H-pyran-4-yl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1567];

(S)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1568];

5-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro -2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1569];

5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1570];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [1571];

5-(2-(((l-me thylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1572];

N-(tetrahydro-2H-pyran-4-yl)-5-(2-(((1-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1573];

5-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1574];

5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1575];

5-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1576];

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro -2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1577];

5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1578];

5-(2-(((1-fluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1579];

5-(2-4(4,4-difluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1580];

5-(2-((l-methylpipe ridin-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro -2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1581];

5-(2-(((l-me thylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1582];

N-(tetrahydro-2H-pyran-4-yl)-5-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1583];

5-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1584];

5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1585];

5-(2-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1586];

5-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1587];

5-(2-(((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1588];

5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1589];

5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1590];

5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1591];

5-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1593];

N-(pyridin-3-yl)-5-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1594];

5-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1595];

5-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1596];

5-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1597];

5-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1598];

5-(2-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1599];

5-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1600];

5-(2-(i sop ropylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1601];

5-(2-(isobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1602];

5-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1603];

(S)-5-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1604];

5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1605];

5-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1606];

N-(pyridin-3-yl)-5-(2-((2,2,2-trifluoroethypamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1607];

(R)-N-(pyridin-3-yl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1608];

(S)-N-(pyridin-3-yl)-5-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1609];

N-(pyridin-3-yl)-5-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1610];

(S)-5-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1611];

5-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1612];

5-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1613];

(R)-5-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1614];

5-(2-(((l-me thylcyclopropyl)me thyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1615];

N-(pyridin-3-yl)-5-(2-(41-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1616];

5-(2-((2-cyclopropyl-2,2-difluoroethypamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1617];

5-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1618];

5-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1619];

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1620];

5-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1621];

5-(2-(((1-fluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1622];

5-(2-(((4,4-difluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1623];

5-(2-((l-methylpipe ridin-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1624];

5-(2-(((1-me thylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1625];

N-(pyridin-3-yl)-5-(2-((tetrahydro -2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1626];

5-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1627];

N-(pyridin-3-yl)-5-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1628];

5-(2-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1629];

5-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1630];

5-(2-(((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1631];

N-(pyridin-3-yl)-5-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1632];

5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1633];

5-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1634];

2-i sobutyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1636];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [1637];

2-cyclopropyl-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidine [1638];

2-cyclobutyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1639];

2-(cyclobutylmethyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1640];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1641];

N-methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1642];

N-ethyl-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1643];

N-isopropyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1644];

N-isobutyl-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1645];

N-neopentyl-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1646];

(S)-N-(sec-butyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1647];

N-(2-fluoro-2-methylpropyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1648];

N-(2,2-difluoropropyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1649];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1650];

(R)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1651];

(S)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1652];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(3 ,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1653];

(S)-N-(1-methoxypropan-2-yl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1654];

2-ethoxy-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1655];

N-((1-fluorocyclopropyl)methyl)-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1656];

(R)-N-(1-cyclopropylethyl)-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1657];

N-((1-methylcyclopropyl)methyl)-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1658];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-4 1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1659];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1660];

N-(3,3-difluorocyclobutyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1661];

N-((1-fluorocyclobutypmethyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1662];

N-(4,4-difluorocyclohexyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1663];

N-(cis-4-methoxycyclohexyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1664];

N-((1-fluorocyclohexyl)me thyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1665];

N-((4,4-difluorocyclohexyl)methyl)-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1666];

N-(1-methylpiperidin-4-yl)-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1667];

N-((1-methylpiperidin-4-yl)methyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1668];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1669];

N-(3-(4-methylpiperazin-1-yl)phenyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1670];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1671];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1672];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1673];

N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1674];

6-(5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [1675];

4-(1-methyl-1H-pyrazol-4-yl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidine [1676];

N-(trans-4-morpholinocyclohexyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [1677];

N-(2-fluoro-2-methylpropyl)-5-(3-fluoropyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1678];

(R)-5-(3-fluoropyrazolo [1,5-a]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1679];

5-(3-chloropyrazolo [1,5-a] pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1680];

(R)-5-(3-chloropyrazolo [1,5-a]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1681];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-24 sobutyl-7H-pyrrolo [2,3-d]pyrimidine [1683];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidine [1684];

2-cyclopropyl-5-(3-cyclopropylpyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1685];

2-cyclobutyl-5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1686];

2-(cyclobutylmethyl)-5-(3-cyclopropylpyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1687];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1688];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-methyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1689];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-ethyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1690];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-isopropyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1691];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-2-amine ;

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1693];

(S)-N-(sec-butyl)-5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1694];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1695];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(2,2-difluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1696];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1697];

(R)-5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1698];

(S)-5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1699];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1700];

(S)-5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1701];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-2-ethoxy-7H-pyrrolo [2,3-d]pyrimidine [1702];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-((1-fluorocyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1703];

(R)-N-(1-cyclopropylethyl)-5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1704];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-((1-methylcyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1705];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-4 1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1706];

N-(2-cyclopropyl-2,2-difluoroethyl)-5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1707];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(3,3-difluorocyclobutyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1708];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-((1-fluorocyclobutyl)methyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1709];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(4,4-difluorocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1710];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(cis-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1711];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-((1-fluorocyclohexyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1712];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-((4,4-difluorocyclohexyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1713];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(1-methylpipe ridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1714];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-((1-methylpiperidin-4-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1715];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1716];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1717];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1718];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1719];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1720];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-((6-(4-methylpipe razin-1-yl)pyridin-3-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1721];

6-(5-(3-cyclopropylpyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)quinoline [1722];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidine [1723];

5-(3-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [1724];

8-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1726];

8-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1727];

8-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1728];

8-(2-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1729];

8-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1730];

8-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1731];

8-(2-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1732];

8-(2-(ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1733];

8-(2-(isopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1734];

8-(2-(isobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1735];

8-(2-(neopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1736];

(S)-8-(2-(sec-butylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one [1737];

8-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1738];

8-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1739];

8-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1740];

(R)-8-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [1,4]oxazepin-5(2H)-one [1741];

(S)-8-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1742];

8-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1743];

(S)-8-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1744];

8-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1745];

8-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1746];

(R)-8-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1747];

8-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1748];

8-(2-(((1-(trifluoromethyl)cyclopropyl)me thyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1749];

8-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1750];

8-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1751];

8-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1752];

8-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1753];

8-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1754];

8-(2-(((1-fluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1755];

8-(2-(((4,4-difluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1756];

8-(2-((l-methylpipe ridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1757];

8-(2-(((l-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1758];

8-(2-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1759];

8-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1760];

8-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1761];

8-(2-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1762];

8-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1763];

8-(2-(((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1764];

8-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3,4-dihydrobenzo [f][1,4] oxazepin-5(2H)-one [1765];

8-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1766];

8-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [1767];

5-(chroman-6-yl)-N-(2-(4-me thylpiperazin-1-yl)pyridin-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1768];

7-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1770];

2,2-dimethyl-7-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1771];

7-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1772];

7-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1773];

7-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1774];

7-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1775];

2,2-dimethyl-7-(2-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1776];

7-(2-(ethylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1777];

7-(2-(i sop ropylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1778];

7-(2-(isobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1779];

2,2-dimethyl-7-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1780];

(S)-7-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1781];

7-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1782];

7-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1783];

2,2-dimethyl-7-(2-((2,2,2-trifluoroethyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)chroman-4-one [1784];

(R)-2,2-dimethyl-7-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1785];

(S)-2,2-dimethyl-7-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1786];

2,2-dimethyl-7-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1787];

(S)-7-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1788];

7-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1789];

7-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1790];

(R)-7-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1791];

2,2-dimethyl-7-(2-(((l-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1792];

2,2-dimethyl-7-(2-(((1-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1793];

7-(2-((2-cyclopropyl-2,2-difluoroethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1794];

7-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1795];

7-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1796];

7-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1797];

7-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1798];

7-(2-(((1-fluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1799];

7-(2-4(4,4-difluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [1800];

2,2-dimethyl-7-(2-((1-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1801];

2,2-dimethyl-7-(2-4(1-methylpipe ridin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1802];

2,2-dimethyl-7-(2-((tetrahydro -2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1803];

2,2-dimethyl-7-(2-43-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1804];

2,2-dimethyl-7-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yOchroman-4-one [1805];

2,2-dimethyl-7-(2-42-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1806];

2,2-dimethyl-7-(2-46-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1807];

2,2-dimethyl-7-(2-(46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1808];

2,2-dimethyl-7-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yOchroman-4-one [1809];

2,2-dimethyl-7-(44 1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yOchroman-4-one [1810];

2,2-dimethyl-7-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1811];

6-(2-isobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3 ,4-dihydroisoquinolin-1 (2H)-one [1813];

4,4-dimethyl-6-(2-(3 ,3 ,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3 ,4-dihydroisoquinolin-1 (2H)-one [1814];

6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3 ,4-dihydroisoquinolin-1 (2H)-one [1815];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3 ,4-dihydroisoquinolin-1 (2H)-one [1816];

6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3 ,4-dihydroisoquinolin-1 (2H)-one [1817];

6-(2-amino-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroi soquinolin-1(2H)-one [1818];

4,4-dimethyl-6-(2-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1819];

6-(2-(ethylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroi soquinolin-1(2H)-one [1820];

6-(2-(i sop ropylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroi soquinolin-1(2H)-one [1821];

6-(2-(isobutylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroi soquinolin-1(2H)-one [1822];

4,4-dimethyl-6-(2-(neopentylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroi soquinolin-1(2H)-one [1823];

(S)-6-(2-(sec-butylamino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1824];

6-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1825];

6-(2-((2,2-difluoropropyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1826];

4,4-dimethyl-6-(2-((2,2,2-trifluoroethyDamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1827];

(R)-4,4-dimethyl-6-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1828];

(S)-4,4-dimethyl-6-(2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1829];

4,4-dimethyl-6-(2-((3,3,3-trifluoropropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1830];

(S)-6-(2-((l-methoxypropan-2-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1831];

6-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroi soquinolin-1(2H)-one [1832];

6-(2-(((1-fluorocyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1833];

(R)-6-(2-((l-cyclopropylethyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1834];

4,4-dimethyl-6-(2-(((1-methylcyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1835];

4,4-dimethyl-6-(2-(41-(trifluoromethyl)cyclopropyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1836];

6-(2-((2-cyclopropyl-2,2-difluoroethypamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroi soquinolin-1(2H)-one [1837];

6-(2-((3,3-difluorocyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1838];

6-(2-(((1-fluorocyclobutyl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1839];

6-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1840];

6-(2-((cis-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1841];

6-(2-(((1-fluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [1842];

6-(2-(((4,4-difluorocyclohexyl)me thyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroi soquinolin-1(2H)-one [1843];

4,4-dimethyl-6-(2-((1-methylpiperidin-4-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1844];

4,4-dimethyl-6-(2-(((1-methylpiperidin-4-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1845];

4,4-dimethyl-6-(2-((tetrahydro -2H-pyran-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1846];

4,4-dimethyl-6-(2-43-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroi soquinolin-1(2H)-one [1847];

4,4-dimethyl-6-(2-(pyridin-4-ylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1848];

4,4-dimethyl-6-(2-42-(4-methylpiperazin-1-yl)pyridin-4-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1849];

4,4-dimethyl-6-(2-46-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1850];

4,4-dimethyl-6-(2-(46-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroi soquinolin-1(2H)-one [1851];

4,4-dimethyl-6-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1852];

4,4-dimethyl-6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1853];

4,4-dimethyl-6-(4-((trans-4-morpholinocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1854];

6-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)quinoline [1856];

6-(2-isobutyl-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)quinoline [1857];

6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoline [1858];

6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoline [1859];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoline [1860];

6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoline [1861];

5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1862];

N-methyl-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1863];

N-ethyl-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1864];

N-isopropyl-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1865];

N-isobutyl-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1866];

N-ne opentyl-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1867];

(S)-N-(sec-butyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1868];

N-(2-fluoro-2-methylpropyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1869];

N-(2,2-difluoropropyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1870];

5-(quinolin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1871];

(R)-5-(quinolin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1872];

(S)-5-(quinolin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1873];

5-(quinolin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1874];

(S)-N-(1-methoxypropan-2-yl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1875];

6-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)quinoline [1876];

N-((1-fluorocyclopropyl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1877];

(R)-N-(1-cyclopropylethyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1878];

N-((l-methylcyclopropyl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1879];

5-(quinolin-6-yl)-N-41-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1880];

N-(2-cyclopropyl-2,2-difluoroe thyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [ 1881 ];

N-(3,3-difluorocyclobutyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1882];

N-((1-fluorocyclobutypmethyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1883];

N-(4,4-difluorocyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1884];

N-(cis-4-methoxycyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1885];

N-((1-fluorocyclohexyl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1886];

N-((4,4-difluorocyclohexyl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1887];

N-(1-methylpiperidin-4-yl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1888];

N-((1-methylpiperidin-4-yl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1889];

5-(quinolin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1890];

N-(3-(4-methylpiperazin-1-yl)phenyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1891];

N-(pyridin-4-yl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1892];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1894];

N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1895];

6,6′-(7H-pyrrolo [2,3-d] pyrimidine -2,5-diyl)diquinoline [1896];

6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)quinoline [1897];

N-(trans-4-morpholinocyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [1898];

6-(2-methyl-4-((1-methylpiperidin-4-yl)methoxy)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoline [1899];

6-(2-isobutyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)quinoxaline [1901];

6-(2-(3 ,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoxaline [1902];

6-(2-cyclopropyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoxaline [1903];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoxaline [1904];

6-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoxaline [1905];

5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1906];

N-methyl-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1907];

N-ethyl-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1908];

N-isopropyl-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1909];

N-isobutyl-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1910];

N-neopentyl-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1911];

(S)-N-(sec-butyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1912];

N-(2-fluoro-2-methylpropyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1913];

N-(2,2-difluoropropyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1914];

5-(quinoxalin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1915];

(R)-5-(quinoxalin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1916];

(S)-5-(quinoxalin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1917];

5-(quinoxalin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1918];

(S)-N-(1-methoxypropan-2-yl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1919];

6-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)quinoxaline [1920];

N-((1-fluorocyclopropyl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1921];

(R)-N-(1-cyclopropylethyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1922];

N-((1-methylcyclopropyl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1923];

5-(quinoxalin-6-yl)-N-((1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1924];

N-(2-cyclopropyl-2,2-difluoroe thyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1925];

N-(3,3-difluorocyclobutyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1926];

N-((1-fluorocyclobutyl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1927];

N-(4,4-difluorocyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1928];

N-(cis-4-methoxycyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1929];

N-((1-fluorocyclohexyl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1930];

N-((4,4-difluorocyclohexyl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1931];

N-(1-methylpiperidin-4-yl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1932];

N-((1-methylpiperidin-4-yl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1933];

5-(quinoxalin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1934];

N-(3-(4-methylpiperazin-1-yl)phenyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1935];

N-(pyridin-4-yl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1936];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1937];

N-(6-(4-methylpipe razin-1-yl)pyridin-3-yl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1938];

N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1939];

6-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1940];

6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1941];

N-(trans-4-morpholinocyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [1942];

6-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1944];

6-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1945];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1946];

6-(2-cyclobutyl-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinazoline [1947];

6-(2-(cyclobutylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1948];

5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1949];

N-methyl-5-(quinazolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1950];

N-ethyl-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1951];

N-isopropyl-5-(quinazolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1952];

N-isobutyl-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1953];

N-neopentyl-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1954];

(S)-N-(sec-butyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1955];

N-(2-fluoro-2-methylpropyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1956];

N-(2,2-difluoropropyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1957];

5-(quinazolin-6-yl)-N-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1958];

(R)-5-(quinazolin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1959];

(S)-5-(quinazolin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1960];

5-(quinazolin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1961];

(S)-N-(1-methoxypropan-2-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1962];

6-(2-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1963];

N-((1-fluorocyclopropyl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1964];

(R)-N-(1-cyclopropylethyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1965];

N-((1-methylcyclopropyl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1968];

5-(quinazolin-6-yl)-N-((1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1967];

N-(2-cyclopropyl-2,2-difluoroe thyl)-5-(quinazolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [1974];

N-(3,3-difluorocyclobutyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1969];

N-((1-fluorocyclobutypmethyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1970];

N-(4,4-difluorocyclohexyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1971];

N-(cis-4-methoxycyclohexyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1972];

N-((1-fluorocyclohexyl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1973];

N-((4,4-difluorocyclohexyl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1974];

N-(1-methylpiperidin-4-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1975];

N-((1-methylpiperidin-4-yl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1976];

5-(quinazolin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1977];

N-(3-(4-methylpiperazin-1-yl)phenyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1978];

N-(pyridin-4-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1979];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1980];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1981];

N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1982];

6-(2-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1983];

6-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinazoline [1984];

N-(trans-4-morpholinocyclohexyl)-5-(quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [1985];

5-(4-(4-methylpiperazin-1-yl)quinazolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1986];

6-(2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-(4-methylpiperazin-1-yl)quinazoline [1987];

7-(2-isobutyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-((1-methylpiperidin-4-yl)oxy)quinoxaline

2-((l-methylpiperidin-4-yl)oxy)-7-(2-(3,3,3-trifluoropropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)quinoxaline [1989];

7-(2-cyclopropyl-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2-((1-methylpipe ridin -4-yl)oxy)quinoxaline [1991];

7-(2-cyclobutyl-7H-pyrrolo [2,3-d] pyrimidin -5-yl)-2-((1-methylpiperidin-4-yl)oxy)quinoxaline [1992];

7-(2-(cyclobutylmethyl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2-((1-methylpiperidin-4-yl)oxy)quinoxaline [1993];

5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [1994];

N-methyl-5-(3-((1-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1995];

N-ethyl-5-(3-((l-methylpiperidin -4-yl)oxy)quinoxalin-6-yl) -7H-pyrrolo [2,3-d] pyrimidin-2-amine [1996];

N-isopropyl-5-(3-((1-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1997];

N-i sobutyl-5-(3-((1-methylpiperidin-4-yl)oxy)quinoxalin-6-yl) -7H-pyrrolo [2,3-d] pyrimidin-2-amine [1998];

5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-neopentyl-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1999]; and

(S)-N-(sec-butyl)-5-(3-((1-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2000]; or a pharmaceutically acceptable salt thereof.

27 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

N-(2-fluoro-2-methylpropyl)-5-(3-((1-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2001];

N-(2,2-difluoropropyl)-5-(3-((1-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2002];

5-(3-((l-methylpipe ridin-4-yl)oxy)quinoxalin -6-yl)-N-(2,2,2-trifluoroe thyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2003];

(R)-5-(3-((l-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2004];

(S)-5-(3-((l-methylpipe ridin-4-yl)oxy)quinoxalin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2005];

5-(3-((l-methylpipe ridin-4-yl)oxy)quinoxalin-6-yl)-N-(3,3,3-trifluoropropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2006];

(S)-N-(1-methoxypropan-2-yl)-5-(3-((l-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2007];

7-(2-ethoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2-((1-methylpiperidin-4-yl)oxy)quinoxaline [2008];

N-((1-fluorocyclopropyl)methyl)-5-(3-((1-methylpipe ridin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2009];

(R)-N-(1-cyclopropylethyl)-5-(3-((1-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2010];

N-((1-methylcyclopropyl)methyl)-5-(3-((1-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2011];

5-(3-((l-methylpipe ridin-4-yl)oxy)quinoxalin-6-yl)-N-((1-(trifluoromethyl)cyclopropyl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2012];

N-(2-cyclopropyl-2,2-difluoroe thyl)-5-(3-((1-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2013];

N-(3,3-difluorocyclobutyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2014];

N-((1-fluorocyclobutyl)me thyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2015];

N-(4,4-difluorocyclohexyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2016];

N-(cis-4-methoxycyclohexyl)-5-(3-((l-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2017];

N-((1-fluorocyclohexyl)methyl)-5-(3-((1-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2018];

N-((4,4-difluorocyclohexyl)methyl)-5-(3-((l-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2019];

N-(1-methylpiperidin-4-yl)-5-(3-((l-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2020];

N-((1-methylpiperidin-4-yl)methyl)-5-(3-((1-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2021];

5-(3-((l-methylpipe ridin-4-yl)oxy)quinoxalin-6-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2022];

N-(3-(4-methylpiperazin-1-yl)phenyl)-5-(3-((1-methylpiperidin-4-ypoxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2023];

5-(3-((l-methylpipe ridin-4-yl)oxy)quinoxalin-6-yl)-N-(pyridin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2024];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(3-((1-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2025];

N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-5-(3-((1-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2026];

N-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)-5-(3-((1-me thylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2027];

2-((l-methylpiperidin-4-yl)oxy)-7-(2-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoxaline [2028];

7-(4-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-2-((1-methylpiperidin-4-yl)oxy)quinoxaline [2029];

5-(3-((l-methylpipe ridin-4-yl)oxy)quinoxalin-6-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [2030];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(3-(pyridin-3-yl)pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2031];

(5-(2-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(4-methylpiperazin-1-yl)methanone [2032];

N-(cis-3-methoxycyclobutyl)-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2033];

N-(cis-3-methoxycyclobutyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine ;

5-(imidazo [1,2-a] pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2035];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2036];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2037];

5-(8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2038];

5-(8-fluoro-3-methylimidazo [1,2-a] pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2039];

5-(3-(difluoromethyl)imidazo[1,2-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2040];

(8-fluoro-6-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a] pyridin-3-yl)methanol [2041];

N-(2,2-difluoroethyl)-6-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [2042];

5-(imidazo [1,2-a] pyrimidin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2043];

5-(4-fluoro-14 sop ropyl-2-methyl-1H-benzo [d]imidazol-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2044];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo [d] imidazol-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2045];

5-(14 sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2046];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2047];

5-(3 sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2048];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2049];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2050];

N-(cis-3-methoxycyclobutyl)-5-(1-methyl-1H-benzo[d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2051];

5-(1-ethyl-1H-benzo [d] [1,2,3]triazol-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2052];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2053];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2054];

N-(cis-3-methoxycyclobutyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2055];

N-(cis-3-methoxycyclobutyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2056];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2057];

N-(cis-3-methoxycyclobutyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2058];

N-(cis-3-methoxycyclobutyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2059];

(5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a] pyridin-3-yl)(piperidin-1-yl)methanone [2060];

N-(2,2-difluoroethyl)-5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2061];

N-(2-fluoro-2-methylpropyl)-5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2062];

5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((R)-1, 1, 1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2063];

N-(3,3-difluorocyclobutyl)-5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [2064];

N-((3-difluorocyclobutypmethyl)-5-(2-((cis-3-methoxycyclobutypamino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2065];

5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(cis-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [2066];

5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2067];

5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [2068];

5-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2069];

N-(cis-3-methoxycyclobutyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2070];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(cis-3-methoxycyclobutyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2071];

8-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [2072];

7-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [2073];

6-(2-((cis-3-methoxycyclobutyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one [2074];

N-(cis-3-methoxycyclobutyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2075];

N-(cis-3-methoxycyclobutyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2076];

N-(cis-3-methoxycyclobutyl)-5-(quinazolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2077];

N-(cis-3-methoxycyclobutyl)-5-(3-((1-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2078];

5-(2-methylbenzo [d]thiazol-6-yl)-N-(ci s-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2079];

5-(thieno [3,2-c]pyridin-2-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2080];

5-(imidazo [1,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2081];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2082];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2083];

5-(8-fluoro-2-methylimidazo [1,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2084];

5-(8-fluoro-3-methylimidazo [1,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2085];

5-(3-(difluoromethyl)imidazo [1,2-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2086];

(8-fluoro-6-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridin-3-yl)methanol [2087];

N-(2,2-difluoroethyl)-6-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo [1,2-a]pyridine-3-carboxamide [2088];

5-(imidazo [1,2-a]pyrimidin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2089];

5-(4-fluoro-14 sop ropyl-2-methyl-1H-benzo [d] imidazol-6-yl)-N-(cis-4-(trifluoromethoxy) cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2090];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo [d] imidazol-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2091];

5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy) cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2092];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(cis-4-(trifluoromethoxy) cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2093];

5-(3-i sopropyl-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(cis-4-(trifluoromethoxy) cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2094];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2095];

5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2096];

5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2097];

5-(1-ethyl-1H-benzo [d] [1,2,3]triazol-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2098];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2099];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2100];

5-(2-methylimidazo [1,2-b] pyridazin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2101];

5-(3-methylimidazo [1,2-b] pyridazin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2102];

5-(3-(difluoromethyl)imidazo [1,2-b]pyridazin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2103];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2104];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-N-(cis-4-(trifluo romethoxy) cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2105];

piperidin-1-yl(5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)methanone [2106];

N-(2,2-difluoroethyl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3]-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2107];

N-(2-fluoro-2-methylpropyl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2108];

5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((R)-1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2109];

N-(3,3-difluorocyclobutyl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2110];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2111];

N-((1r,4r)-4-methoxycyclohexyl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2112];

N-(1-methylpiperidin-4-yl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2113];

N-(tetrahydro-2H-pyran-4-yl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2114];

N-(pyridin-3-yl)-5-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [2115];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2116];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2117];

8-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydrobenzo [f] [1,4] oxazepin-5(2H)-one [2118];

2,2-dimethyl-7-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [2119];

4,4-dimethyl-6-(2-((cis-4-(trifluoromethoxy)cyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroi soquinolin-1(2H)-one [2120];

5-(quinolin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2121];

5-(quinoxalin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2122];

5-(quinazolin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2123];

5-(3-((l-methylpipe ridin-4-yl)oxy)quinoxalin-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2124];

N-(cis-4-ethoxycyclohexyl)-5-(2-methylbenzo [d]thiazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2125];

N-(cis-4-ethoxycyclohexyl)-5-(thieno [3,2-c]pyridin-2-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2126];

N-(cis-4-ethoxycyclohexyl)-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2127];

N-(cis-4-ethoxycyclohexyl)-5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2128];

N-(cis-4-ethoxycyclohexyl)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2129];

N-(cis-4-ethoxycyclohexyl)-5-(8-fluoro-2-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2130];

N-(cis-4-ethoxycyclohexyl)-5-(8-fluoro-3-methylimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2131];

5-(3-(difluoromethyl)imidazo [1,2-a]pyridin-6-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2132];

(6-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-8-fluoroimidazo [1,2-a] pyridin-3-yl)methanol [2133];

N-(2,2-difluoroethyl)-6-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [2134];

N-(cis-4-ethoxycyclohexyl)-5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2135];

N-(cis-4-ethoxycyclohexyl)-5-(4-fluoro -1-i sopropyl-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2136];

N-(cis-4-ethoxycyclohexyl)-5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2137];

N-(cis-4-ethoxycyclohexyl)-5-(1-i sopropyl-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2138];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2139];

N-(cis-4-ethoxycyclohexyl)-5-(34 sopropyl-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2140];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2141];

N-(cis-4-ethoxycyclohexyl)-5-(8-fluoro-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2142];

N-(cis-4-ethoxycyclohexyl)-5-(1-methyl-1H-benzo[d] [1,2,3]triazol -6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2143];

N-(cis-4-ethoxycyclohexyl)-5-(1-ethyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2144];

N-(cis-4-ethoxycyclohexyl)-5-(imidazo [1,2-b] pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2145];

5-(3-chloroimidazo [1,2-b] pyridazin-6-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2146];

N-(cis-4-ethoxycyclohexyl)-5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2147];

N-(cis-4-ethoxycyclohexyl)-5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2148];

5-(3-(difluoromethyl)imidazo[1,2-b]pyridazin-6-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2149];

N-(cis-4-ethoxycyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2150];

N-(cis-4-ethoxycyclohexyl)-5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2151];

(5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(piperidin-1-yl)methanone [2152];

N-(2,2-difluoroethyl)-5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2153];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(2-fluoro-2-methylpropyl)pyrazolo [1,5-a]pyridine-3-carboxamide [2154];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((R)-1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2155];

N-(3,3-difluorocyclobutyl)-5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2156];

N-((3,3-difluorocyclobutyl)methyl)-5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2157];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrazolo [1,5-a] pyridine-3-carboxamide [2158];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1-methylpiperidin-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2159];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro -2H-pyran-4-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [2160];

5-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(pyridin-3-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [2161];

N-(cis-4-ethoxycyclohexyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2162];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-N-(cis-4-ethoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2163];

8-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3 ,4-dihydrobenzo [f] [1,4]oxazepin-5(2H)-one [2164];

7-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-2,2-dimethylchroman-4-one [2165];

6-(2-((cis-4-ethoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-4,4-dimethyl-3 ,4-dihydroisoquinolin-1 (2H)-one [2166];

N-(cis-4-ethoxycyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2167];

N-(cis-4-ethoxycyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2168];

N-(cis-4-ethoxycyclohexyl)-5-(quinazolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2169];

N-(cis-4-ethoxycyclohexyl)-5-(3-((1-methylpiperidin-4-yl)oxy)quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2170];

5-(imidazo [1,2-b]pyridazin-6-yl)-N-(cis-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2171];

N-(cis-4-(methoxy-d 3 )cyclohexyl)-5-(1-methyl-1H-benzo [d][1,2,3] - triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2172];

N-(cis-4-(methoxy-d 3 )cyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2173];

(R)-5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2174];

(R)-5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2175];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2176];

(R)-4-ethoxy-5-(imidazo[1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2177];

(R)-2-((5-(imidazo[1,2-a]pyridin-6-yl)-2-((1,1,1-trifluoropropan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-ypoxy)ethan-1-ol [2178];

cis-4-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2179];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-(cis-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2180];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2181];

2-((cis-4-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2182];

(R)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2183];

(R)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-N-(1-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2184];

N-(4,4-difluorocyclohexyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2185];

cis-4-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2186];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2187];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2188];

(R)-4-ethoxy-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2189];

cis-4-((4-ethoxy-5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2190];

cis-1-methyl-4-45-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2191];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2192];

(R)-4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2193];

(R)-4-methoxy-N-(1-methoxypropan-2-yl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2194];

4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1-methylpiperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2195];

(R)-4-ethoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2196];

cis-4-((4-ethoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2197];

N-(4,4-difluorocyclohexyl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2198];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2199];

N-(cis-4-(methoxy-d 3 )cyclohexyl)-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2200];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2201];

2-((cis-4-((5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2202];

N-(cis-4-(2-methoxyethoxy)cyclohexyl)-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2203];

(R)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2204];

(R)-4-methoxy-N-(1-methoxypropan-2-yl)-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2205];

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2206];

cis-4-((4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2207];

cis-4-((4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2208];

trans-4-44-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2209];

4-methoxy-N-(cis-4-(methoxy-d 3 )cyclohexyl)-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2210];

N-(cis-4-(difluoromethoxy)cyclohexyl)-4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2211];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2212];

2-((cis-4-((4-methoxy-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2213];

4-methoxy-N-(cis-4-(2-methoxyethoxy)cyclohexyl)-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2214];

4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(1,4-dioxaspiro [4.5] de can-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2215];

4-methoxy-N-(1-methylpiperidin-4-yl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2216];

4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(tetrahydro -2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2217];

(R)-4-ethoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2218];

cis-4-((4-ethoxy-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-01 [2219];

cis-4-((4-i sop ropoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2220];

N-(cis-4-(methoxy-d 3 )cyclohexyl)-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2221];

N-(cis-4-(2,2-difluoroethoxy)cyclohexyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2222];

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2223];

4-methoxy-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2224];

cis-4-((4-ethoxy-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-01 [2225];

N-(cis-4-(2-methoxyethoxy)cyclohexyl)-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2226];

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(quinolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2227];

cis-1-methyl-4-((5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2229];

2-((cis-4-((5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2229];

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2230];

cis-4-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2231];

cis-4-((4-ethoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2232];

cis-4-((5-(imidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2233];

cis-1-methyl-4-((5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-01 [2234];

cis-4-((5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2235];

trans-4-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2236];

trans-4-45-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2237];

trans-1-methyl-4-((5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-01 [2238];

cis-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2239];

N-(2-fluoro-2-methylpropyl)-5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2240];

N-(4,4-difluorocyclohexyl)-5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2241];

5-(imidazo [1,2-a] pyridin-6-yl)-4-methoxy-N-(cis-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2242];

5-(imidazo [1,2-a] pyridin-6-yl)-4-methoxy-N-(trans-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2243];

N-(cis-4-(difluoromethoxy)cyclohexyl)-5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2244];

N-(trans-4-(difluoromethoxy)cyclohexyl)-5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2245];

5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2246];

trans-4-((5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2247];

5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-methoxy-4-methylcyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2248];

trans-1-ethyl-4-((5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2249];

5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-(1,5-dioxaspiro [5 .5]undecan-9-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2250];

N-(5,12-dioxadispiro [2.2.56.23]tridecan-9-yl)-5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2251];

N-((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2252];

N-((3R,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2253];

cis-4-((4-ethoxy-5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2254];

N-(2-fluoro-2-methylpropyl)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2255];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2256];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-(trans-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2257];

N-(cis-4-(difluoromethoxy)cyclohexyl)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2258];

N-(trans-4-(difluoromethoxy)cyclohexyl)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2259];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2260];

trans-44(5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2261];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-(cis-4-methoxy-4-methylcyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2262];

trans-1-ethyl-4-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2263];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N4 1,5-dioxaspiro [5 .5]undecan-9-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2264];

N-(5, 12-dioxadispiro [2.2.5 6 .23]tridecan-9-yl)-5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2265];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-((3 S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2266];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-((3R,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2267];

N-(4,4-difluorocyclohexyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2268];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(2-fluoro-2-methylpropyl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2269];

(R)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2270];

(R)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2271];

N-(4,4-difluorocyclohexyl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2272];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-N-(cis-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2273];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(cis-4-(difluoromethoxy)cyclohexyl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2274];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2275];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N-(2-fluoro-2-methylpropyl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2276];

(R)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-4-methoxy-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2277];

(R)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-methoxy-N-(1-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2278];

N-(4,4-difluorocyclohexyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2279];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-methoxy-N-(cis-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2280];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N-(cis-4-(difluoromethoxy)cyclohexyl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2281];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-methoxy-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2282];

N-(2-fluoro-2-methylpropyl)-4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2283];

N-(4,4-difluorocyclohexyl)-4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2284];

4-methoxy-N-(cis-4-(methoxy-d 3 )cyclohexyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2285];

4-methoxy-N-(trans-4-(methoxy-d 3 )cyclohexyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2286];

N-(cis-4-(difluoromethoxy)cyclohexyl)-4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2287];

N-(trans-4-(difluoromethoxy)cyclohexyl)-4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2288];

4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2289];

4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,5-dioxaspiro[5.5]undecan-9-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2290];

N-(5,12-dioxadispiro[2.2.56.23]tridecan-9-yl)-4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2291];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2-fluoro-2-methylpropyl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2292];

(R)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2293];

(R)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-methoxypropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2294];

5-(1-(2,2-difluoroethyl)-1H-benzo [d] [1,2,3]triazol-6-yl)-4-methoxy-N-(cis-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2295];

5-(1-(2,2-difluoroethyl)-1H-benzo [d] [1,2,3]triazol-6-yl)-N-(cis-4-(difluoromethoxy)cyclohexyl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2296];

5-(1-(2,2-difluoroethyl)-1H-benzo [d] [1,2,3]triazol-6-yl)-4-methoxy-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2297];

N-(2-fluoro-2-methylpropyl)-5-(imidazo [1,2-b]pyridazin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2298];

(R)-5-(imidazo [1,2-b] pyridazin-6-yl)-4-methoxy-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2299];

(R)-5-(imidazo [1,2-b] pyridazin-6-yl)-4-methoxy-N-(1-methoxypropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2300];

N-(4,4-difluorocyclohexyl)-5-(imidazo [1,2-b] pyridazin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2301];

5-(imidazo [1,2-b]pyridazin-6-yl)-4-methoxy-N-(cis-4-(methoxy-d 3 )cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2302];

N-(cis-4-(difluoromethoxy)cyclohexyl)-5-(imidazo [1,2-b] pyridazin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2303];

5-(imidazo [1,2-b]pyridazin-6-yl)-4-methoxy-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2304];

N-(2-fluoro-2-methylpropyl)-4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2305];

4-methoxy-N-(cis-4-methoxycyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2306];

4-methoxy-N-(trans-4-(methoxy-d 3 )cyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2307];

N-(trans-4-(difluoromethoxy)cyclohexyl)-4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2308];

4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2309];

4-methoxy-N-(cis-4-methoxy-4-methylcyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2310];

trans-1-ethyl-4-44-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexan-1-01 P3111;

4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-N-(1,5-dioxaspiro[5.5]undecan-9-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2312];

N-(5,12-dioxadispiro[2.2.56.23]tridecan-9-yl)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2313];

(R)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-N-(tetrahydro-2H-pyran-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2314];

(S)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-N-(tetrahydro-2H-pyran-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2315];

N-((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2316];

N-((3R,4R)-3-fluorotetrahydro-2H-pyran-4-yl)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2317];

(3S,4R)-4-((4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol [2318];

4-methoxy-N-((3S,4R)-3-methoxytetrahydro-2H-pyran-4-yl)-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2319];

cis-4-((4-isopropoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2320];

(R)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-N-(tetrahydrofuran-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2321];

(S)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-N-(tetrahydrofuran-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2322];

N-((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2323];

N-((1R,5S,6s)-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2324];

N-(2-fluoro-2-methylpropyl)-4-methoxy-5-(pyrazolo[1,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2325];

(R)-4-methoxy-5-(pyrazolo[1,5-a]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2326];

(R)-4-methoxy-N-(1-methoxypropan-2-yl)-5-(pyrazolo[1,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2327];

4-methoxy-N-(cis-4-(methoxy-d 3 )cyclohexyl)-5-(pyrazolo[1,5-a]pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2328];

N-(cis-4-(difluoromethoxy)cyclohexyl)-4-methoxy-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2329];

4-methoxy-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(cis-4-(trifluoromethoxy)cyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2330];

(1s,3s)-3-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2331];

(1r,3r)-3-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2332];

((1r,3r)-3-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2333];

((1s,3s)-3-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2334];

N-((1r,3r)-3-((5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2335];

N-((1s,3s)-3-((5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2336];

N-((1r,3r)-3-((5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2337];

N-((1s,3s)-3-((5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2338];

1-((1r,3r)-3-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2339];

1-((1s,3s)-3-((5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2340];

(1s,3s)-3-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2341];

(1r,3r)-3-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2342];

(1s,4s)-4-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2343];

((1s,4s)-4-((5-(imidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2344];

N-((1s,4s)-4-((5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [2345];

N-((1r,4r)-4-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2346];

1-((1s,4s)-4-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2347];

N-((1r,40-4-45-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2348];

(1s,4s)-4-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2349];

(1s,4s)-1-ethyl-4-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2350];

1-(4-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2351];

(S)-5-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2352];

(R)-5-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2353];

1-(2-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [2354];

1-((3aR,5s,6aS)-5-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2355];

1-((3aR,5r,6aS)-5-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2356];

1-(7-((5-(imidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [2357];

5-(imidazo[1,2-a]pyridin-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2358];

5-(imidazo[1,2-a]pyridin-6-yl)-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2359];

(1s,3s)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2360];

(1r,3r)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2361];

((1s,3s)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2362];

((1r,3r)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2363];

N-((1r,3r)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2364];

N-((1s,3s)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2365];

N-((1s,3s)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2366];

N-((1r,3r)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2367];

1-((1r,3r)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [2368];

1-((1s,3s)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [2369];

(1r,3r)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2370];

(1s,3s)-3-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2371];

(1s,4s)-4-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2372];

((1s,4s)-4-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2373];

N-((1r,40-4-45-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2374];

N-((1s,4s)-4-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2375];

1-((1s,4s)-4-((5-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2376];

N-((1r,40-4-45-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2377];

(1r,40-4-45-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2378];

(1r,40-4-45-(imidazo[1,2-a]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2379];

(1s,4s)-4-((5-(imidazo [1,2-a]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2380];

(1s,4s)-1-ethyl-4-45-(imidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-01 [2381];

1-(4-((5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2382];

(S)-5-((5-(imidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2383];

(R)-5-((5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2384];

1-(2-((5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [2385];

1-((3aR,5s,6aS)-5-((5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2386];

1-((3aR,5r,6aS)-5-((5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)hexahydrocyclopenta[c] pyrrol-2(1H)-yl)ethan-1-one [2387];

1-(7-((5-(imidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [2388];

5-(imidazo [1,2-a] pyridin-6-yl)-4-methoxy-N-(2-oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2389];

5-(imidazo [1,2-a] pyridin-6-yl)-4-methoxy-N-(1,4-dioxaspiro [4.5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2390];

(1s,3s)-3-45-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2391];

(1r,3r)-3-((5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2392];

((1r,30-3-45-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2393];

((1s,3s)-3-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2394];

N-((1s,3s)-3-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2395];

N-((1r,3r)-3-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2396];

N-((1s,3s)-3-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2397];

N-((1r,3r)-3-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2398];

1-((1r,3r)-3-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2399];

1-((1s,3s)-3-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2400];

(1s,3s)-3-45-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2401];

(1r,3r)-3-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2402];

((1s,4s)-4-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2403];

(1s,4s)-4-45-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2404];

(1r,40-4-45-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2405];

1-(4-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2406];

(S)-5-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2407];

(R)-5-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2408];

5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2409];

(1s,3s)-3-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2410];

(1r,3r)-3-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2411];

((1s,3s)-3-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2412];

((1r,3r)-3-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2413];

N-((1s,3s)-3-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2414];

N-((1r,3r)-3-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2415];

N-((1s,3s)-3-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2416];

N-((1r,3r)-3-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2417];

1-((1r,3r)-3-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2418];

1-((1s,3s)-3-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2419];

(1s,3s)-3-((5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2420];

(1r,3r)-3-((5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2421];

(1s,4s)-4-((5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2422];

((l s,4s)-4-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2423];

N-((1r,40-4-45-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [2424];

N-((1s,4s)-4-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [2425];

1-((1s,4s)-4-((5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2426];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2427];

2-(((1r,40-4-45-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2428];

2-(((1s,4s)-4-((5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2429];

N-((1r,40-4-45-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2430];

(1s,4s)-4-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2431];

(1r,40-4-45-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2432];

(1s,4s)-4-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2433];

(1r,40-4-45-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2434];

(1s,4s)-1-ethyl-4-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2435];

1-(4-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2436];

(R)-5-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2437];

(S)-5-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2438];

1-(2-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [2439];

1-((3aR,5s,6aS)-5-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2440];

1-((3aR,5r,6aS)-5-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2441];

1-(7-((5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [2442];

5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2443];

5-(3-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2444];

(1s,3s)-3-45-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2445];

(1r,3r)-3-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2446];

((1s,3s)-3-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2447];

((1r, 3r)-3((5-(5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2448];

N-((1s,3s)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2449];

N-((1r,3r)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2450];

N-((1s,3s)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2451];

N-((1r,3r)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2452];

1-((1r,3r)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2453];

1-((1s,3s)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2454];

(1r,3r)-3-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2455];

(1s,3s)-3-45-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2456];

(1s,4s)-4-45-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2457];

((1s,4s)-4-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2458];

N-((1r,4r)-4-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2459];

N-((1s,4s)-4-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [2460];

1-((1s,4s)-4-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2461];

2-(((1r,4r)-4-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2462];

N-((1r,40-4-45-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2463];

(1s,4s)-1-ethyl-4-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-01 [2464];

1-(4-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2465];

(R)-5-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2466];

(S)-5-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2467];

1-(2-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [2468];

1-((3aR,5s,6aS)-5-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2469];

1-((3aR,5r,6aS)-5-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2470];

1-(7-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [2471];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(2-oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2472];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-(1,4-dioxaspiro [4.5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2473];

(1s,3s)-3-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2474];

(1r,3r)-3-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2475];

((l s,3s)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2476];

((1r,3r)-3-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2477];

N-((1s,3s)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2478];

N-((1r,3r)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2479];

N-((1s,3s)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2480];

N-((1r,3r)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2481];

1-((1 s,3 s)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [2482];

1-((1r,3r)-3-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [2483];

(1 s,3 s)-3-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2484];

(1r,3r)-3-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2485];

(1 s,4 s)-4-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2486];

((1 s,4 s)-4-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2487];

N-((1r,40-4-45-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2488];

N-((1 s,4 s)-4-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2489];

1-((1 s,4 s)-4-((5-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2490];

2-(((1r,40-4-45-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2491];

2-(((1 s,4 s)-4-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2492];

N-((1r,40-4-45-(8-fluoroimidazo [1,2-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2493];

(1r,4r) -44(5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2494];

(1 s,4 s)-4-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2495];

(1r,4r) -44(5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2496];

(1 s,4 s)-1-ethyl-4-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2497];

1-(4-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2498];

(S)-5-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2499];

(R)-5-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2500]; or a pharmaceutically acceptable salt thereof.

28 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

1-(2-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5] nonan-7-yl)ethan-1-one [2501];

1-((3aR,5s,6aS)-5-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2502];

1-((3aR,5r,6aS)-5-((5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2503];

1-(7-((5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5] nonan-2-yl)ethan-1-one [2504];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2505];

(1s,3s)-3-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2506];

(1r,3r)-3-((5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2507];

((1s,3s)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2508];

((1r,3 r) -3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino) -1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2509];

N-((1s,3s)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2510];

N-((1r,3r)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2511];

N-((1r,3r)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2512];

N-((1s,3s)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2513];

1-((1r,3r)-3-((5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2514];

1-((1s,3s)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2515];

(1r,3r)-3-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2516];

(1s,3s)-3-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2517];

(1s,4s)-4-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2518];

((1s,4s)-4-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2519];

N-((1s,4s)-4-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2520];

N-((1r,4r)-4-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2521];

1-((1s,4s)-4-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2522];

N-((1r,40-4-45-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2523];

(1s,4s)-4-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2524];

(1r,40-4-45-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2525];

(1s,4s)-1-ethyl-4-((5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexan-1-01 [2526];

1-(4-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2527];

(S)-5-((5-(imidazo [1,2-a] pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2528];

(R)-5-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2529];

1-(2-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [2530];

1-((3aR,5s,6aS)-5-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2531];

1-((3 aR,5 r,6aS)-5-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2532];

1-(7-((5-(imidazo [1,2-a]pyrimidin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [2533];

5-(imidazo [1,2-a] pyrimidin-6-yl)-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2534];

5-(imidazo [1,2-a] pyrimidin-6-yl)-N-(1,4-dioxaspiro [4 .5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2535];

(1 s,3 s)-3-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [2536];

(1r,3r)-3-((5-(imidazo [1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [2537];

((1 s,3 s)-3-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2538];

((1r,3r)-3-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2539];

N-((1 s,3 s)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2540];

N-((1r,3 r)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2541];

N-((1 s,3 s)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppropionamide [2542];

N-((1r,3r)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppropionamide [2543];

1-((1r,3r)-3-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [2544];

1-((1 s,3 s)-3-((5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [2545];

(1r,3r)-3-((5-(imidazo [1 ,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2546];

(1 s,3 s)-3-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2547];

(1 s,4 s)-4-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2548];

((1s,4s)-4-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2549];

N-((1s,4s)-4-((5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2550];

N-((1r,40-4-45-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2551];

1-((1s,4s)-4-((5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2552];

5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2553];

N-((1r,40-4-45-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2554];

(1r,40-4-45-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2555];

(1s,4s)-4-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2556];

(1r,40-4-45-(imidazo [1,2-a]pyrimidin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2557];

(1s,4s)-4-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2558];

(1s,4s)-1-ethyl-4-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexan-1-01 [2559];

1-(4-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2560];

(S)-5-((5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2561];

(R)-5-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2562];

1-(2-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [2563];

1-((3aR,5s,6aS)-5-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2564];

1-((3aR,5r,6aS)-5-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2565];

1-(7-((5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [2566];

5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2567];

5-(imidazo [1,2-a]pyrimidin-6-yl)-4-methoxy-N-(1,4-dioxaspiro [4.5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2568];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2569];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2570];

((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2571];

((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2572];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2573];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2574];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2575];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2576];

1-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2577];

1-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2578];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2579];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2580];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo [d] imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2581];

((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2582];

N-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2583];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2584];

1-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2585];

2-(((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2586];

2-(((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2587];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2588];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2589];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2590];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2591];

1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2592];

(S)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2593];

(R)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2594];

1-(2-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [2595];

1-((3aR,5s,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2596];

1-((3aR,5r,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2597];

1-(7-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [2598];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2599];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2600];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2601];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2602];

((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2603];

((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2604];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2605];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2606];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2607];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2608];

1-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2609];

1-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2610];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2611];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2612];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2613];

((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2614];

N-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2615];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2616];

1-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2617];

2-(((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2618];

2-(((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2619];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexypacetamide [2620];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2621];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2622];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2623];

1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2624];

(S)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2625];

(R)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2626];

1-(2-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [2627];

1-((3aR,5r,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2628];

1-((3aR,5s,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2629];

1-(7-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [2630];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2631];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2632];

3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2633];

(3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2634];

((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2635];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2636];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2637];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2638];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2639];

1-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2640];

1-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2641];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2642];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2643];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2644];

((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2645];

N-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2646];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2647];

1-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2648];

2-(((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2649];

2-(((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2650];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexypacetamide [2651];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2652];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2653];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2654];

1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2655];

(S)-5-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2656];

(R)-5-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2657];

1-(2-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [2658];

1-((3aR,5s,6aS)-5-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2659];

1-((3aR,5r,6aS)-5-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2660];

1-(7-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [2661];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2662];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2663];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2664];

3-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl-1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [2665];

((1 s , 3 s) -3-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl -1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2666];

(3-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl -1H-benzo [ d] imidazol -6-yl) -4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2667];

N-((1 s,3 s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl-1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2668];

N-((1 r,3 r)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl-1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2669];

N-((1 s,3 s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl-1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2670];

N-((1 r,3 r)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl-1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2671];

1-((1 r,3 r)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl -1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2672];

1-((1 s, 3 s)-3-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl-1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2673];

(1 s,3 s) -3-((5-(1-(2,2-difluoroethyl) -4-fluoro -2-methyl -1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2674];

(1 r, 3 r) -3-((5-(1-(2,2-difluoroethyl) -4-fluoro -2-methyl -1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2675];

(1 s ,4 s) -4-((5-(1-(2,2-difluoroethyl) -4-fluoro -2-methyl -1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2676];

((1 s ,4 s) -4-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl -1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2677];

N-((1 s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl-1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2678];

N-((1 r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl-1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2679];

1-((1 s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro -2-methyl-1H-benzo [d] imidazol -6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2680];

2-(((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2681];

2-(((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2682];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexypacetamide [2683];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2684];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2685];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2686];

1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2687];

(R)-5-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2688];

(S)-5-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2689];

1-(2-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [2690];

1-((3aR,5s,6aS)-5-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2691];

1-((3aR,5r,6aS)-5-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2692];

1-(7-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [2693];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1,4-dioxaspirop.51decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2694];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2695];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2696];

((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2697];

((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2698];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2699];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2700];

N-(3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2701];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2702];

1-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2703];

1-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2704];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2705];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2706];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2707];

((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2708];

N-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2709];

N-((1r,40-4-45-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2710];

1-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2711];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2712];

2-(((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)e than-1-ol [2713];

2-(((1 r,40-4-45-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2714];

N-((1 r,40-4-45-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2715];

(1 r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2716];

(1 s,4 s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2717];

(1 s,4 s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2718];

1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2719];

(S)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2720];

(R)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2721];

1-(2-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [2722];

1-((3 aR,5 s,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2723];

1-((3 aR,5 r,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2724];

1-(7-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [2725];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2726];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-N-(1,4-dioxaspiro [4 .5] de can-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2727];

(1 s,3 s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [2728];

(1 r,3 r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [2729];

((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2730];

((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2731];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2732];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2733];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2734];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2735];

1-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2736];

1-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2737];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2738];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2739];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2740];

((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2741];

N-((1r,40-4-45-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2742];

N-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2743];

1-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2744];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2745];

2-(((1r,40-4-45-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2746];

2-(((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2747];

N-((1r,40-4-45-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexypacetamide [2748];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2749];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2750];

(1r,40-4-45-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2751];

1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2752];

(S)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2753];

(R)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2754];

1-(2-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3.5]nonan-7-yl)ethan-1-one [2755];

1-((3aR,5r,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2756];

1-((3aR,5 s,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2757];

1-(7-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3.5]nonan-2-yl)ethan-1-one [2758];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-(2-oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2759];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-(1,4-dioxaspiro [4.5]decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2760];

(1s,3 s)-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2761];

(1r,30-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2762];

((1 s,3 s)-3-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2763];

((1 r,3 r)-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2764];

N-((1 r,3 r)-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2765];

N-((1 s,3 s)-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2766];

N-(3-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2767];

N-((1 r,3 r)-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2768];

1-((1 r,3 r)-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2769];

1-((1 s,3 s)-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2770];

(1 r,3 r)-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2771];

(1 s,3 s)-3-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2772];

(1 s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2773];

((1 s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2774];

N-((1 s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2775];

N-((1 r,40-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2776];

1-((1 s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2777];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-((1 s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2778];

2-(((1 r,40-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypoxy)e than-1-ol [2779];

2-(((1s,4 s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2780];

N-((1r,40-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2781];

(1r,4r) -44(5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-1)] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2782];

(1s,4 s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2783];

1444(5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2784];

(S)-5-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2785];

(R)-5-((5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2786];

1424(5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [2787];

1-((3aR,5 s,6aS)-5-45-(3-(2,2-difluoro ethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta [c]pyrrol-2 (1H)-yl)ethan-1-one [2788];

1-((3aR,5r,6aS)-5-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta [c]pyrrol-2 (1H)-yl)ethan-1-one [2789];

1474(5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [2790];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2791];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N-(1,4-dioxaspiro [4 .5] de can-8-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2792];

N 2 -(4,4-difluorocyclohexyl)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-N 4 -methyl-7H-pyrrolo [2,3-d] pyrimidine-2,4-diamine [2793];

(1r,4r) -44(5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2794];

(1s,4 s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2795];

((1r,40-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2796];

((1s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2797];

N-((1r,40-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2798];

N-((1s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2799];

1-((1r,40-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2800];

1-((1s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2801];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N 2 -((1s,4s)-4-methoxycyclohexyl)-N 4 -methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2802];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N 2 -((1s,4s)-4-(difluoromethoxy)cyclohexyl)-N 4 -methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2803];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N 2 -41r,4r) -4-(difluoromethoxy)cyclohexyl)-N 4 -methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2804];

(1s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2805];

(1r,40-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2806];

N-((1s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexypacetamide [2807];

N-((1r,40-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexypacetamide [2808];

1-((1s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)pyrrolidin-2-one [2809];

1-((1r,40-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)pyrrolidin-2-one [2810];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N 2 -((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-N 4 -methyl-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [2811];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N 2 -((3 S,4R)-3-fluoro-1-methylpiperidin-4-yl)-N 4 -methyl-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [2812];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N 2 -((3 S,4S)-3-fluoro-1-methylpiperidin-4-yl)-N 4 -methyl-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [2813];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N 2 -((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)-N 4 -methyl-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [2814];

1-(7-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 . 5 ]nonan-2-yl)ethan-1-one [2815];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b] pyridin-5-yl)-N 4 -methyl-N 2 -(2-oxaspiro [3 . 5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [2816];

(R)-5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo [4,5-b]pyridin-5-yl)-2-methoxy-N-(1, 1, 1-trifluoropropan-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [2817];

(1 s,3 s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [2818];

(1 r,3 r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [2819];

((1 r,3 r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2820];

((1 s,3 s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2821];

N-((1 s,3 s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2822];

N-((1 r,3 r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2823];

N-(3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2824];

N-((1 r,3 r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2825];

1-((1 r,3 r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2826];

1-((1 s,3 s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2827];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2828];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2829];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2830];

((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2831];

N-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2832];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2833];

1-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2834];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyrazin-6-yl)-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2835];

2-(((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2836];

2-(((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2837];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2838];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2839];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2840];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2841];

1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2842];

(S)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2843];

(R)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2844];

1-(2-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 . 5 ]nonan-7-yl)ethan-1-one [2845];

1-((3 aR,5 s,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2846];

1-((3 aR,5 r,6aS)-5-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2847];

1-(7-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 . 5 ]nonan-2-yl)ethan-1-one [2848];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-N-(2-oxaspiro [3 .5 ]nonan-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2849];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-N-(1,4-dioxaspiro [4 .5]decan-8-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [2850];

(1 s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2851];

(1 r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-1)] pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2852];

((1 s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2853];

((1 r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2854];

N-((1 s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2855];

N-((1 r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2856];

1-((1 s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2857];

1-((1 r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b] pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2858];

1-((1 s,4s)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo [4,5-b]pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)pyrrolidin-2-one

1-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyrazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)pyrrolidin-2-one [2860];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyrazin-6-yl)-N 2 -((1s,4s)-4-methoxycyclohexyl)-N 4 -methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2861];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyrazin-6-yl)-N 4 -methyl-N 2 -(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [2862];

(1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2863];

(1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2864];

((1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2865];

((1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2866];

N-((1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2867];

N-((1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2868];

N-((1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2869];

N-((1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide P8701;

1-((1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one P8711;

1-((1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one P8721;

(1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2873];

(1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2874];

(1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide P8751;

((1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2876];

N-((1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2877];

N-((1r,4r)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2878];

1-((1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2879];

5-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2880];

2-(((1s,4s)-4-45-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2881];

2-(((1r,4r)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2882];

N-((1r,40-4-45-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2883];

(1r,4r)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2884];

(1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2885];

(1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2886];

1-(4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2887];

(R)-5-45-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2888];

(S)-5-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2889];

1-(2-45-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [2890];

1-((3aR,5s,6aS)-5-45-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2891];

1-((3aR,5r,6aS)-5-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2892];

1-(7-45-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [2893];

5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2894];

5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2895];

(1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2896];

(1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2897];

((1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2898];

((1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2899];

N-((1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2900];

N-((1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [2901];

N-((1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2902];

N-((1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2903];

1-((1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [2904];

1-((1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [2905];

(1s,3s)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2906];

(1r,3r)-3-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2907];

(1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2908];

((1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2909];

N-((1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2910];

N-((1r,4r)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2911];

1-((1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2912];

5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(methoxy-d 3 )-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [2913];

2-(((1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2914];

2-(((1r,4r)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2915];

N-((1r,4r)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2916];

(1r,4r)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2917];

(1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2918];

(1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [2919];

(1r,4r)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2920];

(1s,4s)-4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2921];

1-(4-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2922];

(S)-5-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2923];

(R)-5-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2924];

1-(2-((5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [2925];

1-((3aR,5s,6aS)-5-45-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2926];

1-((3aR,5r,6aS)-5-((5-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta [c]pyrrol-2(1H)-yl)ethan-1-one [2927];

1-(7-((5-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5] nonan-2-yl)ethan-1-one [2928];

5-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-4-methoxy-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2929];

5-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-4-methoxy-N-(1,4-dioxaspiro [4.5] de can-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2930];

(1s,3s)-N,N,1-trimethyl-3-((5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [2931];

(1r,30-N,N,1-trimethyl-3-((5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [2932];

((1s,3s)-1-methyl-3-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)me thanone [2933];

((1r,3r)-1-methyl-3-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)methanone [2934];

N-((1s,3s)-1-methyl-3-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutypacetamide [2935];

N-((1r,3r)-1-methyl-3-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutypacetamide [2936];

N-((1s,3s)-1-methyl-3-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [2937];

N-((1r,3r)-1-methyl-3-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [2938];

1-((1r,3r)-1-methyl-3-((5-(3-methyl-[1,2,4]triazolo [4,3-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyppyrrolidin-2-one [2939];

1-((1s,3s)-1-methyl-3-45-(3-methyl41,2,41triazolo [4,3-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyppyrrolidin-2-one [2940];

(1s,3s)-1-methyl-3-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutan-1-ol [2941];

(1r,3r)-1-methyl-3-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutan-1-ol [2942];

(1s,4s)-N,N-dimethyl-4-((5-(3-methyl-[1,2,4]triazolo [4,3-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexane-1-carboxamide [2943];

((1s,4s)-4-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2944];

N-((1s,4s)-4-((5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexypacetamide [2945];

N-((1r,4r)-4-((5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexypacetamide [2946];

1-((1s,4s)-4-((5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2947];

2-(((1s,4s)-4-45-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2948];

2-(((1r,4r)-4-((5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2949];

N-((1r,4r)-1-methyl-4-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexypacetamide [2950];

(1r,4r)-1-methyl-4-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexan-1-ol [2951];

(1s,4s)-1-methyl-4-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexan-1-ol [2952];

(1s,4s)-1-ethyl-4-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexan-1-ol [2953];

1-(4-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2954];

(S)-1-methyl-5-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)piperidin-2-one [2955];

(R)-1-methyl-5-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)piperidin-2-one [2956];

1-(2-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [2957];

1-((3aR,5s,6aS)-5-45-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2958];

1-((3aR,5r,6aS)-5-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2959];

1-(7-((5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [2960];

5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2961];

5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-N-(1,4-dioxaspiro [4 .5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2962];

(1r,3r)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [2963];

(1 s,3 s)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [2964];

((1r,3r)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2965];

((1 s,3 s)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [2966];

N-((1 s,3 s)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2967];

N-((1r,3r)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [2968];

N-((1 s,3 s)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2969];

N-((1r,3r)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [2970];

1-((1r,3r)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a] pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2971];

1-((1 s,3 s)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [2972];

(1 s,3 s)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2973];

(1r,3r)-3-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [2974];

(1 s,4 s)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [2975];

((1 s,4 s)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [2976];

N-((1 s,4 s)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2977];

N-((1r,4r)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [2978];

1-((1s,4s)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [2979];

5-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-4-methoxy-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2980];

2-(((1s,4s)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2981];

2-(((1r,4r)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [2982];

N-((1r,4r)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [2983];

(1r,4r)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2984];

(1s,4s)-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2985];

(1s,4s)-1-ethyl-4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [2986];

(1r,40-4-44-(methoxy-d 3 )-5-(3-methyl41,2,41triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2987];

(1s,4s)-4-44-(methoxy-d 3 )-5-(3-methyl41,2,41triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [2988];

1-(4-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [2989];

(S)-5-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2990];

(R)-5-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [2991];

1-(2-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [2992];

1-((3aR,5s,6aS)-5-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2993];

1-((3aR,5r,6aS)-5-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [2994];

1-(7-((4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [2995];

4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a] pyridin-6-yl)-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2996];

4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a] pyridin-6-yl)-N-(1,4-dioxaspiro [4 .5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2997];

(1s,3s)-3-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1 -carboxamide [2998];

(1r,3r)-3-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [2999];

41r,3r)-3-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3000]; or a pharmaceutically acceptable salt thereof.

29 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

((1s,3 s)-3-((5-([1,2,4] triazolo [1,5-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3001];

N-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [3002];

N-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3003];

N-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl) amino)-1-methylcyclobutyl)propionamide [3004];

N-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3005];

1-((1r,3r)-3-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3006];

1-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl) amino)-1-methylcyclobutyl)pyrrolidin-2-one [3007];

(1s,3 s)-3-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3008];

(1r,3r)-3-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3009];

(1s,4s)-4-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3010];

((1s,4s)-4-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3011];

N-((1s,4s)-4-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3012];

N-((1r,4r)-4-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3013];

1-((1s,4s)-4-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3014];

2-(((1s,4s)-4-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3015];

2-(((1r,4r)-4-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3016];

N-((1r,40-4-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3017];

(1s,4s)-4-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3018];

(1r,4r)-4-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3019];

(1s,4s)-4-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [3020];

1-(4-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3021];

(S)-5-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3022];

(R)-5-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3023];

1-(2-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [3024];

1-((3aR,5r,6aS)-5-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3025];

1-((3aR,5s,6aS)-5-45-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3026];

1474(5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3027];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(2-oxaspiro [3 .5] nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3028];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-N-(1,4-dioxaspiro [4.5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3029];

(1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3030];

(1r,3r)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3031];

((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3032];

((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3033];

N-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3034];

N-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3035];

N-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3036];

N-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3037];

1-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3038];

1-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3039];

(1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3040];

(1r,3r)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3041];

(1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3042];

((1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3043];

N-((1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3044];

N-((1r,4r)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3045];

1-((1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3046];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3047];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-(methoxy-d 3 )-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3048];

2-(((1s,4s)-4-45-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3049];

2-(((1r,4r)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3050];

N-((1r,4r)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3051];

(1r,4r) -44(54 [1,2,4]triazolo [1,5-a] pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3052];

(1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3053];

(1r,4r)-4-((5-([1,2,4]triazolo [1,5-a] pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3054];

(1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3055];

(1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [3056];

1-(4-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3057];

(R)-5-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3058];

(S)-5-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3059];

1-(2-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5] nonan-7-yl)ethan-1-one [3060];

1-((3aR,5s,6aS)-5-45-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta [c]pyrrol-2(1H)-yl)ethan-1-one [3061];

1-((3aR,5r,6aS)-5-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta [c]pyrrol-2(1H)-yl)ethan-1-one [3062];

1-(7-((5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5] nonan-2-yl)ethan-1-one [3063];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3064];

5-([1,2,4]triazolo [1,5-a]pyridin-6-yl)-4-methoxy-N-(1,4-dioxaspiro [4 .5] de can-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3065];

(1s,3s)-N,N,1-trimethyl-3-((5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [3066];

(1r,30-N,N,1-trimethyl-3-((5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [3067];

((1r,3r)-1-methyl-3-((5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)methanone [3068];

((1s,3s)-1-methyl-3-((5-(1-methyl-1H-benzo[d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)methanone [3069];

N-((1s,3s)-1-methyl-3-((5-(1-methyl-1H-benzo [d] [1,2,3]triazol -6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutypacetamide [3070];

N-((1r,3r)-1-methyl-3-((5-(1-methyl-1H-benzo [d] [1,2,3]triazol -6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutypacetamide [3071];

N-((1s,3s)-1-methyl-3-((5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [3072];

N-((1r,3r)-1-methyl-3-((5-(1-methyl-1H-benzo [d] [1,2,3]triazol -6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [3073];

1-((1r,3r)-1-methyl-3-((5-(1-methyl-1H-benzo[d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyppyrrolidin-2-one [3074];

1-((1s,3s)-1-methyl-3-((5-(1-methyl-1H-benzo[d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyppyrrolidin-2-one [3075];

(1r,3r)-1-methyl-3-((5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutan-1-ol [3076];

(1s,3s)-1-methyl-3-((5-(1-methyl-1H-benzo [d] [1,2,3]triazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutan-1-ol [3077];

(1s,4s)-N,N-dimethyl-4-45-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexane-1-carboxamide [3078];

((1s,4s)-4-45-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3079];

N-((1r,4r)-4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3080];

N-((1s,4s)-4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3081];

1-((1s,4s)-4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3082];

2-(((1s,4s)-4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3083];

2-(((1r,4r)-4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3084];

N-((1r,4r)-1-methyl-4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3085];

(1r,4r)-1-methyl-4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [3086];

(1s,4s)-1-ethyl-4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [3087];

1-(4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3088];

(S)-1-methyl-5-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-2-one [3089];

(R)-1-methyl-5-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-2-one [3090];

1-(2-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [3091];

1-((3aR,5s,6aS)-5-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol- 2(1H)-yl)ethan-1-one [3092];

1-((3aR,5r,6aS)-5-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol- 2(1H)-yl)ethan-1-one [3093];

1-(7-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [3094];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3095];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3096];

(1s,3s)-3-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3097];

(1r,3r)-3-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3098];

((1r,3r)-3-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3099];

((1s,3s)-3-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3100];

N-((1s,3s)-3-44-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [3101];

N-((1r,3r)-3-44-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [3102];

N-((1s,3s)-3-44-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3103];

N-((1r,3r)-3-44-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3104];

1-((1r,3r)-3-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3105];

1-((1s,3s)-3-44-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3106];

(1s,3s)-3-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3107];

(1r,3r)-3-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3108];

(1s,4s)-4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3109];

((1s,4s)-4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3110];

N-((1s,4s)-4-44-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3111];

N-((1r,4r)-4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3112];

1-((1s,4s)-4-44-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3113];

4-methoxy-N-((1s,4s)-4-methoxycyclohexyl)-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3114];

4-(methoxy-d3)-N-((1s,4s)-4-methoxycyclohexyl)-5-(1-methyl-lH-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3115];

2-(((1s,4s)-4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3116];

2-(((1r,4r)-4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3117];

N-((1r,4r)-4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3118];

(1r,4r)-4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3119];

(1s,4s)-4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3120];

(1r,40-4-44-(methoxy-d 3 )-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3121];

(1s,4s)-4-44-(methoxy-d 3 )-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3122];

(1s,4s)-1-ethyl-4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [3123];

1-(4-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3124];

(R)-5-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3125];

(S)-5-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3126];

N-((1R,5S,6s)-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3127];

N-((1R,5S,60-3-oxabicyclo[3.1.0]hexan-6-yl)-4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3128];

1-(2-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [3129];

1-((3aR,5s,6aS)-5-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3130];

1-((3aR,5r,6aS)-5-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3131];

1-(7-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [3132];

4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3133];

4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3134];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3135];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3136];

((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3137];

((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3138];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [3139];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [3140];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3141];

N-((1r,3r)-3-((3-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-112-pyrrolo[3,2-c]pyridin-6-yl)amino)-1-methylcyclobutyl)propionamide [3142];

1-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3143];

1-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3144];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3145];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3146];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3147];

((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3148];

N-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3149];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3150];

1-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3151];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3152];

2-(((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3153];

2-(((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3154];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3155];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3156];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3157];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [3158];

1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3159];

(S)-5-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3160];

(R)-5-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3161];

1-(2-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [3162];

1-((3aR,5s,6aS)-5-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3163];

1-((3aR,5r,6aS)-5-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3164];

1-(7-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [3165];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3166];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3167];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3168];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3169];

((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3170];

((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3171];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [3172];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)acetamide [3173];

N-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3174];

N-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3175];

1-((1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3176];

1-((1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3177];

(1s,3s)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3178];

(1r,3r)-3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3179];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3180];

((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3181];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3182];

N-((1s,4s)-4-45-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3183];

1-((1s,4s)-4-45-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3184];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3185];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3186];

2-(((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3187];

2-(((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3188];

N-((1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexypacetamide [3189];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3190];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3191];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3192];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3193];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [3194];

1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3195];

(R)-5-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3196];

(S)-5-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3197];

1-(2-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7-azaspiro[3.5]nonan-7-yl)ethan-1-one [3198];

1-((3aR,5r,6aS)-5-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3199];

1-((3aR,5s,6aS)-5-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3200];

1-(7-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one [3201];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3202];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3203];

(1s,3s)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3204];

(1r,3r)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3205];

((1r,3r)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3206];

((1s,3s)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3207];

N-((1s,3s)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3208];

N-((1r,3r)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3209];

N-((1s,3s)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3210];

N-((1r,3r)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3211];

1-((1r,3r)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3212];

1-((1s,3s)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3213];

(1s,3s)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3214];

(1r,3r)-3-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3215];

(1s,4s)-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3216];

((1s,4s)-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3217];

N-((1s,4s)-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3218];

N-((1r,4r)-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3219];

1-((1s,4s)-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3220];

2-(((1s,4s)-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3221];

2-(((1r,4r)-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3222];

N-((1r,40-4-45-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3223];

(1s,4s)-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3224];

(1r,40-4-45-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3225];

(1s,4s)-1-ethyl-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-01 [3226];

1-(4-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3227];

(R)-5-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3228];

(S)-5-((5-(imidazo[1,2-b]pyridazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3229];

1-(2-((5-(imidazo [1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [3230];

1-((3 aR,5 s,6aS)-5-((5-(imidazo [1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1 H)-yl)ethan-1-one [3231];

1-((3aR,5r,6aS)-5-((5-(imidazo [1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1 H)-yl)ethan-1-one [3232];

1-(7-((5-(imidazo [1 ,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3233];

5-(imidazo [1 ,2-b]pyridazin-6-yl)-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3234];

5-(imidazo [1 ,2-b]pyridazin-6-yl)-N-(1 ,4-dioxaspiro [4.5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3235];

N 2 -(4,4-difluorocyclohexyl)-5-(imidazo [1 ,2-b]pyridazin-6-yl)-N 4 -methyl -7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3236];

(1 s,4s)-4-((5-(imidazo[1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3237];

(1 r,40-4-45-(imidazo [1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3238];

((1 r,40-4-45-(imidazo[1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3239];

((1 s,4s)-4-((5-(imidazo [1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3240];

N-((1 s,4s)-4-((5-(imidazo [1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3241];

N-((1 r,40-4-45-(imidazo [1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3242];

1-((1 r,40-4-45-(imidazo [1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3243];

1-((1 s,4s)-4-((5-(imidazo [1 ,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3244];

5-(imidazo [1 ,2-b]pyridazin-6-yl)-N 2 -((1 s,4s)-4-methoxycyclohexyl)-N 4 -methyl -7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3245];

N 2 -4 1 s,4s)-4-(difluoromethoxy)cyclohexyl)-5-(imidazo[1 ,2-b]pyridazin-6-yl)-N 4 -methyl -7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3246];

N 2 -((1r,4r) -4-(difluoromethoxy)cyclohexyl)-5-(imidazo [1,2-b] pyridazin-6-yl)-N 4 -methyl-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3247];

N-((1s,4s)-4-((5-(imidazo [1,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3248];

N-((1r,40-4-45-(imidazo [1,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3249];

1-((1s,4s)-4-((5-(imidazo [1,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)pyrrolidin-2-one [3250];

1-((1r,40-4-45-(imidazo [1,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexyl)pyrrolidin-2-one [3251];

(1s,4s)-4-((5-(imidazo [1,2-b] pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3252];

(1r,4r) -4-45-(imidazo [1,2-b] pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3253];

N 2 -((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(imidazo [1,2-b] pyridazin-6-yl)-N 4 -methyl-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3254];

N 2 -((3 S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(imidazo [1,2-b] pyridazin-6-yl)-N 4 -methyl-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3255];

N 2 -((3 S,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(imidazo [1,2-b] pyridazin-6-yl)-N 4 -methyl-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3256];

N 2 -((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(imidazo [1,2-b]pyridazin-6-yl)-N 4 -methyl-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3257];

1-(7-((5-(imidazo [1,2-b] pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5] nonan-2-yl)ethan-1-one [3258];

5-(imidazo [1,2-b]pyridazin-6-yl)-N 4 -methyl-N 2 -(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidine -2,4-diamine [3259];

(1s,3s)-N,N,1-trimethyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [3260];

(1r,30-N,N,1-trimethyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [3261];

((1s,3s)-1-methyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)methanone [3262];

((1r,3r)-1-methyl-3-45-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)methanone [3263];

N-((1s,3s)-1-methyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclobutypacetamide [3264];

N-((1r,3r)-1-methyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclobutypacetamide [3265];

N-((1s,3s)-1-methyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [3266];

N-((1r,3r)-1-methyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [3267];

1-((1r,3r)-1-methyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutyl)pyrrolidin-2-one [3268];

1-((1s,3s)-1-methyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutyl)pyrrolidin-2-one [3269];

(1s,3s)-1-methyl-3-45-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutan-1-ol [3270];

(1r,3r)-1-methyl-3-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutan-1-ol [3271];

(1s,4s)-N,N-dimethyl-4-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexane-1-carboxamide [3272];

((1s,4s)-4-((5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3273];

N-((1s,4s)-4-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3274];

N-((1r,4r)-4-((5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3275];

1-((1s,4s)-4-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3276];

N-((1r,40-4-methoxycyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3277];

N-((1r,4r)-4-(difluoromethoxy)cyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3278];

2-(((1r,4r)-4-((5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3279];

N-((1r,4r)-1-methyl-4-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3280];

(1s,4s)-1-ethyl-4-((5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-01 [3281];

1-(4-((5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3282];

(S)-1-methyl-5-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-2-one [3283];

(R)-1-methyl-5-45-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)piperidin-2-one [3284];

1-(2-45-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [3285];

1-((3aR,5s,6aS)-5-45-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3286];

1-((3aR,5r,6aS)-5-((5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3287];

1-(7-45-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3288];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3289];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(1,4-dioxaspiro [4.5] de can-8-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [3290];

4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3291];

(1r,30-3-44-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3292];

(1s,3s)-3-44-methoxy-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3293];

((1s,3s)-3-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3294];

((1r,30-3-44-methoxy-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3295];

N-((1s,3s)-3-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3296];

N-((1r,3r)-3-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3297];

N-((1 s,3 s)-3-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppropionamide [3298];

N-((1 r,3 r)-3-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppropionamide [3299];

1-((1 r,3 r)-3-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [3300];

1-((1 s,3 s)-3-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [3301];

(1 s,3 s)-3-((4-methoxy-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3302];

(1 r,3 r)-3-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3303];

(1 s,4s)-4-((4-methoxy-5-(pyrazolo [1,5-a] pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3304];

((1 s,4 s)-4-((4-methoxy -5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3305];

N-((1 s,4s)-4-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3306];

N-((1 r,4r)-4-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3307];

1-((1 s,4s)-4-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3308];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-N-((1 s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3309];

4-methoxy-N-((1 r,40-4-methoxycyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3310];

4-(methoxy-d 3 )-N-((1 s,4s)-4-methoxycyclohexyl)-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3311];

N-((1 r,4r)-4-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3312];

(1 r,4r) -4-44-(methoxy-d 3 )-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3313];

(1 s,4s)-4-44-(methoxy-d 3 )-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3314];

(1s,4s)-1-ethyl-4-44-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-01 [3315];

1-(4-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3316];

(S)-5-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3317];

(R)-5-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3318];

N-((1R,5S,6r)-3-oxabicyclo [3.1.0]hexan-6-yl)-4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3319];

N-((1R,5S,6s)-3-oxabicyclo [3.1.0]hexan-6-yl)-4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3320];

4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(2-oxaspiro [3.3]heptan-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3321];

1-(2-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [3322];

1-((3aR,5s,6aS)-5-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3323];

1-((3aR,5r,6aS)-5-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3324];

1-(7-((4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3325];

4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-(2-oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3326];

5-(4-methoxy-2-(((1s,4s)-4-methoxycyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-methylpyrazolo [1,5-a]pyridine-3-carboxamide [3327];

5-(2-(((1s,4s)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-methylpyrazolo [1,5-a] pyridine-3-carboxamide [3328];

5-(2-(((1r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-methylpyrazolo [1,5-a] pyridine-3-carboxamide [3329];

5-(2-(((1r,4r) -4-hydroxy-4-methylcyclohexyl)amino)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-methylpyrazolo [1,5-a]pyridine-3-carboxamide [3330];

5-(2-(((1s,4s)-4-hydroxy-4-methylcyclohexyl)amino)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-methylpyrazolo [1,5-a]pyridine-3-carboxamide [3331];

5-(2-(((1s,4s)-4-ethyl-4-hydroxycyclohexyl)amino)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-methylpyrazolo [1,5-a] pyridine-3-carboxamide [3332];

5-(2-((2-oxaspiro [3.5]nonan-7-yl)amino)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-methylpyrazolo [1,5-a]pyridine-3-carboxamide [3333];

(1s,3s)-3-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3334];

(1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3335];

((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3336];

((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3337];

N-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3338];

N-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3339];

N-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3340];

N-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3341];

1-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3342];

1-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3343];

(1s,3s)-3-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3344];

(1r,3r)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3345];

(1s,4s)-4-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3346];

((1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3347];

N-((1s,4s)-4-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3348];

N-((1r,4r)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3349];

1-((1s,4s)-4-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3350];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3351];

2-(((1s,4s)-4-45-([1,2,4]triazolo [1,5-a] pyridin-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3352];

2-(((1s,4s)-4-45-([1,2,4]triazolo [1,5-a] pyridin-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3353];

N-((1r,40-4-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3354];

(1r,4r)-4-((5-([1,2,4]triazolo [1,5-a] pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3355];

(1s,4s)-4-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3356];

(1s,4s)-4-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [3357];

1-(4-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3358];

(R)-5-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3359];

(S)-5-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3360];

1-(2-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [3361];

1-((3aR,5s,6aS)-5-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3362];

1-((3aR,5r,6aS)-5-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3363];

1-(7-45-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3364];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-N-(2-oxaspiro [3 .5] nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3365];

1-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-N-(1,4-dioxaspiro [4.5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3366];

(1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3367];

(1r,3r)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3368];

((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3369];

((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3370];

N-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3371];

N-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3372];

N-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3373];

N-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3374];

1-((1r,3r)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyppyrrolidin-2-one [3375];

1-((1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3376];

(1s,3s)-3-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3377];

(1r,3r)-3-((5-([1,2,4]triazolo [1,5-a] pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3378];

(1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3379];

((1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3380];

N-((1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3381];

N-((1r,4r)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3382];

1-((1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3383];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3384];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-(methoxy-d 3 )-N-((1s,4s)-4-methoxycyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3385];

2-(((1s,4s)-4-((5-([1,2,4]triazolo [1,5-a] pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3386];

2-(((1r,4r)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3387];

N-((1r,4r)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3388];

(1r,4r)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3389];

(1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3390];

(1r,4r)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3391];

(1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3392];

(1s,4s)-4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [3393];

1-(4-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3394];

(S)-5-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3395];

(R)-5-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3396];

1-(2-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5] nonan-7-yl)ethan-1-one [3397];

1-((3aR,5s,6aS)-5-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c] pyrrol-2(1H)-yl)ethan-1-one [3398];

1-((3aR,5r,6aS)-5-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta [c]pyrrol-2(1H)-yl)ethan-1-one [3399];

1-(7-((5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5] nonan-2-yl)ethan-1-one [3400];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3401];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-N-(1,4-dioxaspiro [4 .5] de can-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3402];

(1s,3 s)-N,N,1-trimethyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [3403];

(1r,30-N,N,1-trimethyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [3404];

((1r,3r)-1-methyl-3-((5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)methanone [3405];

((1s,3s)-1-methyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)methanone [3406];

N-((1r,3r)-1-methyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutypacetamide [3407];

N-((1s,3s)-1-methyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutypacetamide [3408];

N-((1s,3s)-1-methyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [3409];

N-((1r,3r)-1-methyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)propionamide [3410];

1-((1r,3r)-1-methyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)pyrrolidin-2-one [3411];

1-((1 s,3 s)-1-methyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)pyrrolidin-2-one [3412];

(1s,3 s) -1-methyl-3-((5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutan-1-01 [3413];

(1r,3r)-1-methyl-3-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutan-1-01 [3414];

(1s,4s)-N,N-dimethyl-4-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexane-1-carboxamide [3415];

((1s,4s)-4-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3416];

N-((1s,4s)-4-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-c1] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3417];

N-((1r,4r)-4-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-c1] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3418];

1-((1s,4s)-4-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-c1] pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3419];

N-((1r,40-4-methoxycyclohexyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo 2-amine [3420];

N-((1r,40-4-(difluoromethoxy)cyclohexyl)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-amine [3421];

2-(((1r,4r)-4-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-c1] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3422];

2-(((1s,4s)-4-((5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3423];

N-((1r,4r)-1-methyl-4-45-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexypacetamide [3424];

(1r,4r)-1-methyl-4-45-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexan-1-01 [3425];

(1s,4s)-1-methyl-4-45-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexan-1-01 [3426];

(1s,4s)-1-ethyl-4-45-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)cyclohexan-1-ol [3427];

1-(4-((5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3428];

(S)-1-methyl-5-45-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)piperidin-2-one [3429];

(R)-1-methyl-5-45-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)piperidin-2-one [3430];

1-(2-((5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [3431];

1-((3aR,5s,6aS)-5-((5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3432];

1-((3aR,5r,6aS)-5-((5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-cl]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3433];

1-(7-((5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3434];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3435];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N-(1,4-dioxaspiro [4.5] decan-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3436];

N 2 -(4,4-difluorocyclohexyl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine -2,4-diamine [3437];

((1s,4s)-4-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3438];

((1r,4r)-4-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3439];

(1s,4s)-N,N-dimethyl-4-44-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexane-1-carboxamide [3440];

(1r,40-N,N-dimethyl-4-44-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexane-1-carboxamide [3441];

N-((1s,4s)-4-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3442];

N-((1r,40-4-44-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3443];

1-((1s,4s)-4-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3444];

1-((1r,4r)-4-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3445];

N 2 -((1s,4s)-4-methoxycyclohexyl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3446];

N 2 -41s,4s)-4-(difluoromethoxy)cyclohexyl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3447];

N 2 -41r,4r)-4-(difluoromethoxy)cyclohexyl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3448];

N-((1s,4s)-1-methyl-4-44-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3449];

N-((1r,4r)-1-methyl-4-44-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3450];

1-((1 s,4s)-1-methyl-4-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3451];

1-((1 r,4r)-1-methyl-4-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3452];

(1 s,4s)-1-methyl-4-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [3453];

(1 r,4r)-1-methyl-4-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [3454];

N 2 -((3 R,4 S)-3-fluoro-1-methylpiperidin-4-yl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3455];

N 2 -((3 S,4R)-3-fluoro-1-methylpiperidin-4-yl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3456];

N 2 -((3 S,4 S)-3-fluoro-1-methylpiperidin-4-yl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3457];

N 2 -((3 R,4R)-3-fluoro-1-methylpiperidin-4-yl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3458];

(2-(4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)-2-azabicyclo [2 .2 .2]octan-4-yl)methanol [3459];

1-(7-((4-(methylamino)-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3460];

N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-N 2 -(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3461];

(1 s,3 s)-3-((5-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [3462];

(1 r,3 r)-3-((5-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N, 1-trimethylcyclobutane-1-carboxamide [3463];

((1 r,3 r)-3-((5-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3464];

((1 s,3 s)-3-((5-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3465];

N-((1 r,3 r)-3-((5-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3466];

N-((1 s,3 s)-3-((5-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3467];

N-((1s,3s)-3-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3468];

N-((1r,30-3-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3469];

1-((1r,30-3-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3470];

1-((1s,3s)-3-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3471];

(1s,3s)-3-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3472];

(1r,30-3-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3473];

(1s,4s)-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3474];

((1s,4s)-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3475];

N-((1s,4s)-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3476];

N-((1r,40-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3477];

1-((1s,4s)-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3478];

2-(((1r,40-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3479];

2-(((1s,4s)-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3480];

N-((1r,40-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3481];

(1s,4s)-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3482];

(1r,40-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3483];

(1s,4s)-4-45-(cinnolin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [3484];

1-(4-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3485];

(S)-5-45-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3486];

(R)-5-45-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3487];

1-(2-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-7-azaspiro [3 .5] nonan-7-yl)ethan-1-one [3488];

1-((3aR,5s,6aS)-5-45-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3489];

1-((3aR,5r,6aS)-5-45-(cinnolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3490];

1474(5-(cinnolin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-2-azaspiro [3.5] nonan-2-yl)ethan-1-one [3491];

5-(cinnolin-6-yl)-N-(2-oxaspiro [3 .5] nonan-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [3492];

5-(cinnolin-6-yl)-N-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3493];

(1s,3s)-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3494];

(1r,30-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3495];

((1r,30-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3496];

((1s,3s)-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3497];

N-((1s,3s)-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3498];

N-((1r,3 r)-3-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3499];

N-((1s,3s)-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3500]; or a pharmaceutically acceptable salt thereof.

30 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

N-((1r,3 r)-3-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3501];

1-((1r,30-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3502];

1-((1s,3s)-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3503];

(1s,3s)-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3504];

(1r,30-3-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3505];

(1s,4s)-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3506];

((1s,4s)-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3507];

N-((1s,4s)-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3508];

N-((1r,40-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3509];

1-((1s,4s)-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3510];

2-(((1s,4s)-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3511];

2-(((1r,40-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3512];

N-((1r,40-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3513];

(1s,4s)-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3514];

(1r,40-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3515];

(1r,40-4-45-(cinnolin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3516];

(1s,4s)-4-45-(cinnolin-6-yl)-4-(methoxy-d 3 )-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3517];

(1s,4s)-4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [3518];

1-(4-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3519];

(R)-5-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3520];

(S)-5-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3521];

1-(2-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [3522];

1-((3aR,5s,6aS)-5-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3523];

1-((3aR,5r,6aS)-5-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3524];

1-(7-45-(cinnolin-6-yl)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3525];

5-(cinnolin-6-yl)-4-methoxy-N-(2-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3526];

5-(cinnolin-6-yl)-4-methoxy-N-(1,4-dioxaspiro [4.5] de can-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3527];

(1s,3s)-N,N,1-trimethyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [3528];

(1r,30-N,N,1-trimethyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutane-1-carboxamide [3529];

((1r,3r)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)methanone [3530];

((1s,3s)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyl)(pyrrolidin-1-yl)methanone [3531];

N-((1s,3s)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutypacetamide [3532];

N-((1r,3r)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutypacetamide [3533];

N-((1s,3s)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutyl)propionamide [3534];

N-((1r,3r)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutyl)propionamide [3535];

1-((1r,3r)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyppyrrolidin-2-one [3536];

1-((1s,3s)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutyppyrrolidin-2-one [3537];

(1s,3s)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclobutan-1-ol [3538];

(1r,3r)-1-methyl-3-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclobutan-1-ol [3539];

(1s,4s)-N,N-dimethyl-4-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexane-1-carboxamide [3540];

pyrrolidin-1-yl((1s,4s)-4-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)methanone [3541];

N-((1s,4s)-4-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3542];

N-((1r,40-4-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3543];

1-((1s,4s)-4-((5-(quinoxalin-6-yl)-7H-pyrrolo[2,3-cl]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3544];

2-(((1r,40-4-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3545];

N-((1r,4r)-1-methyl-4-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)acetamide [3546];

(1r,4r)-1-methyl-4-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexan-1-ol [3547];

(1s,4s)-1-ethyl-4-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [3548];

1-(4-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3549];

(S)-1-methyl-5-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-2-one [3550];

(R)-1-methyl-5-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-2-one [3551];

1-(2-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [3552];

1-((3aR,5r,6aS)-5-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3553];

1-((3aR,5s,6aS)-5-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3554];

1-(7-45-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3555];

5-(quinoxalin-6-yl)-N-(2-oxaspiro [3 .5] nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3556];

5-(quinoxalin-6-yl)-N-(1,4-dioxaspiro [4.5] de can-8-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [3557];

(1r,30-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3558];

(1s,3s)-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-N,N,1-trimethylcyclobutane-1-carboxamide [3559];

((1s,3s)-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3560];

((1r,30-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)(pyrrolidin-1-yl)methanone [3561];

N-((1s,3s)-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3562];

N-((1r,30-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutypacetamide [3563];

N-((1s,3s)-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3564];

N-((1r,30-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)propionamide [3565];

1-((1r,30-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3566];

1-((1s,3s)-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutyl)pyrrolidin-2-one [3567];

(1s,3s)-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3568];

(1r,30-3-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclobutan-1-ol [3569];

(1s,4s)-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)-N,N-dimethylcyclohexane-1-carboxamide [3570];

((1s,4s)-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3571];

N-((1s,4s)-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3572];

N-((1r,40-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3573];

1-((1s,4s)-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3574];

4-methoxy-N-((1s,4s)-4-methoxycyclohexyl)-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3575];

2-(((1s,4s)-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3576];

2-(((1r,40-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)oxy)ethan-1-ol [3577];

N-((1r,40-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexyl)acetamide [3578];

(1r,40-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3579];

(1r,40-4-44-(methoxy-d 3 )-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3580];

(1s,4s)-4-44-(methoxy-d 3 )-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylcyclohexan-1-ol [3581];

(1s,4s)-1-ethyl-4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-yl)amino)cyclohexan-1-01 [3582];

1-(4-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)ethan-1-one [3583];

(R)-5-((4-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3584];

(S)-5-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-1-methylpiperidin-2-one [3585];

1-(2-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-7-azaspiro [3 .5]nonan-7-yl)ethan-1-one [3586];

1-((3aR,5r,6aS)-5-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3587];

1-((3aR,5s,6aS)-5-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethan-1-one [3588];

1-(7-44-methoxy-5-(quinoxalin-6-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)-2-azaspiro [3 .5]nonan-2-yl)ethan-1-one [3589];

4-methoxy-5-(quinoxalin-6-yl)-N-(2-oxaspiro [3 .5] nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3590];

4-methoxy-5-(quinoxalin-6-yl)-N-(1,4-dioxaspiro [4.5] de can-8-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3591];

(1s,4s)-N,N-dimethyl-4-44-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexane-1-carboxamide [3592];

(1r,40-N,N-dimethyl-4-44-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexane-1-carboxamide [3593];

((1s,4s)-4-((4-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3594];

((1r,4r)-4-((4-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)(pyrrolidin-1-yl)methanone [3595];

N-((1s,4s)-4-((4-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3596];

N-((1r,4r)-4-((4-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexypacetamide [3597];

1-((1s,4s)-4-((4-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3598];

1-((1r,4r)-4-((4-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3599];

N 2 -((1s,4s)-4-methoxycyclohexyl)-N 4 -methyl-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3600];

N-((1s,4s)-1-methyl-4-44-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3601];

N-((1r,40-1-methyl-4-44-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)acetamide [3602];

1-((1r,40-1-methyl-4-44-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3603];

1-((1 s,4 s)-1-methyl-4-((4-(methylamino)-5-(1,5-naphthyridin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexyl)pyrrolidin-2-one [3604];

N 4 -methyl-5-(1,5-naphthyridin-2-yl)-N 2 -(2-oxaspiro [3.5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3605];

5-(imidazo [1,2-a] pyridin-6-yl)-N-44 s,7 s)-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3606];

5-(imidazo [1,2-a] pyridin-6-yl)-N-((4r,7r) -1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3607];

5-(imidazo [1,2-a] pyridin-6-yl)-4-methoxy-N-44 s,7 s)-1-oxaspiro [3 . 5] nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3608];

5-(imidazo [1,2-a] pyridin-6-yl)-4-methoxy-N-44r,70-1-oxaspiro [3 .5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3609];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-44 s,7 s)-1-oxaspiro [3 . 5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3610];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-N-44r,7r) -1-oxaspiro [3 . 5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3611];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-44 s,7 s)-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3612];

5-(8-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-44r,7r) -1-oxaspiro [3 .5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3613];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-44 s,7 s)-1-oxaspiro [3 . 5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3614];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-N-44r,7r) -1-oxaspiro [3 . 5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3615];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-44r,7r) -1-oxaspiro [3 .5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3616];

5-(3-fluoroimidazo [1,2-a]pyridin-6-yl)-4-methoxy-N-44 s,7 s)-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3617];

5-(imidazo [1,2-a] pyrimidin-6-yl)-N-44 s,7 s)-1-oxaspiro [3 .5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3618];

5-(imidazo [1,2-a] pyrimidin-6-yl)-N-44r,70-1-oxaspiro [3 . 5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3619];

5-(imidazo [1,2-a] pyrimidin-6-yl)-4-methoxy-N-44r,70-1-oxaspiro [3 . 5 ]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3620];

5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxy-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3621];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3622];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3623];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3624];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-4-methoxy-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3625];

(1s,4s)-4-45-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-1-ethylcyclohexan-1-ol [3626];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N 2 -43S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-N 4 -methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3627];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N 2 -43R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-N 4 -methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3628];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N 4 -methyl-N 2 -44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3629];

5-(3-(2,2-difluoroethyl)-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-N 4 -methyl-N 2 -44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3630];

5-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-N-44s,7s)-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3631];

5-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-N-44r,70-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3632];

5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-methoxy-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3633];

4-methoxy-5-(3-methyl-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-N-44s,7s)-1-oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3634];

5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-N-44s,7s)-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3635];

5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3636];

5-([1,2,4]triazolo [4,3-a]pyridin-6-yl)-4-methoxy-N-44r,70-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3637];

4-methoxy-5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3638];

5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3639];

5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3640];

5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-methoxy-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine P6411;

5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-methoxy-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3642];

(1s,4s)-1-methyl-4-((5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [3643];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3644];

5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3645];

4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3646];

4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3647];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3648];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3649];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [3650];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-44s,7s)-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine P6511;

(1s,4s)-1-ethyl-4-((5-(imidazo[1,2-b]pyridazin-6-yl)-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [3652];

N 2 -43S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)-N 4 -methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3653];

N 2 -43R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)-N 4 -methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3654];

5-(imidazo [1,2-b]pyridazin-6-yl)-N 4 -methyl-N 2 -44s,7s)-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3655];

5-(imidazo [1,2-b]pyridazin-6-yl)-N 4 -methyl-N 2 -44r,70-1-oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3656];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-44s,7s)-1-oxaspiro [3 .5] nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3657];

5-(pyrazolo [1,5-a]pyridin-5-yl)-N-44r,70-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3658];

4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-44s,7s)-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3659];

4-methoxy-5-(pyrazolo [1,5-a]pyridin-5-yl)-N-44r,70-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3660];

5-(2-(((4s,7s)-1-oxaspiro [3.5]nonan-7-yl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-methylpyrazolo [1,5-a]pyridine-3-carboxamide [3661];

5-(2-(((4r,7r)-1-oxaspiro [3 .5] nonan-7-yl)amino)-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-methylpyrazolo [1,5-a]pyridine-3-carboxamide [3662];

5-(2-(((4s,7s)-1-oxaspiro [3.5]nonan-7-yl)amino)-4-methoxy-7H-pyrrolo [2,3-d] pyrimidin-5-yl)-N-methylpyrazolo [1,5-a] pyridine-3-carboxamide [3663];

5-(2-(((4r,7r)-1-oxaspiro [3 .5] nonan-7-yl)amino)-4-methoxy-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-methylpyrazolo [1,5-a]pyridine-3-carboxamide [3664];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-N-44s,7s)-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3665];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-N-44r,70-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3666];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-N-44s,7s)-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3667];

5-([1,2,4]triazolo [1,5-a]pyridin-7-yl)-4-methoxy-N-44r,70-1-oxaspiro [3 .5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3668];

(1s,4s)-1-ethyl-4-44-(methylamino)-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-yl)amino)cyclohexan-1-ol [3669];

N 2 -((3 S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidine -2,4-diamine [3670];

N 2 -43R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-N 4 -methyl-5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidine -2,4-diamine [3671];

N 4 -methyl-5-(pyrazolo [1,5-a] pyrimidin-5-yl)-N 2 -445,75)-1-oxaspiro [3 .5] nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidine-2,4-diamine [3672];

N 4 -methyl-5-(pyrazolo[1,5-a]pyrimidin-5-yl)-N 2 -44r,70-1-oxaspiro[3.5]nonan-7-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine [3673];

5-(quinoxalin-6-yl)-N-((4r,7r)-1-oxaspiro [3 .5] nonan-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [3674];

5-(quinoxalin-6-yl)-N-((4s,7s)-1-oxaspiro [3 .5] nonan-7-yl)-7H-pyrrolo [2,3-d] pyrimidin-2-amine [3675];

4-methoxy-5-(quinoxalin-6-yl)-N-((4s,7s)-1-oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3676];

4-methoxy-5-(quinoxalin-6-yl)-N-((4r,7r)-1-oxaspiro [3.5]nonan-7-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [3677]; or a pharmaceutically acceptable salt thereof.

31 . The compound of claim 12 , wherein the compound of Formula Ic is selected from the group consisting of:

2-(7H-pyrrolo [2,3-d] pyrimidin-5-yl)thieno [3,2-c] pyridine [55];

2-(7H-pyrrolo [2,3-d] pyrimidin-5-yl)thiazolo [5,4-b] pyridine [98];

5-(imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [99];

5-(3-fluoroimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [142];

5-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [185];

5-(8-fluoro -2-methylimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [230];

5-(8-fluoro -3-methylimidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [273];

5-(3-(difluoromethyl)imidazo [1,2-a] pyridin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [316];

(8-fluoro-6-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl)methanol [360];

N-(2,2-difluoroethyl)-6-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)imidazo[1,2-a]pyridine-3-carboxamide [404];

5-(imidazo[1,2-a]pyrimidin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [447];

5-(imidazo[1,2-a]pyrazin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [491];

5-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidine [495];

5-(4-fluoro-2-methyl-1-(1-methylpiperidin-4-yl)-1H-benzo [d]imidazol-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [541];

1-isopropyl-2-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridine [584];

1-isopropyl-2-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-imidazo[4,5-c]pyridine [627];

3-(2,2-difluoroethyl)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3H-imidazo[4,5-b]pyridine [630];

3-i sopropyl-2-methyl-5-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3H-imidazo [4,5-b] pyridine [673];

6-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)41,2,41triazolo [1,5-a]pyridine [716];

8-fluoro -6-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)-[1,2,4]triazolo [1,5-a]pyridine [761];

1-methyl-6-(7H-pyrrolo [2,3-d] pyrimidin-5-yl)-1H-benzo [d] [1,2,3]triazole [809];

1-ethyl-6-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1H-benzo [d] [1,2,3]triazole [852];

5-(imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [896];

5-(3-chloroimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [939];

5-(2-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [982];

5-(3-methylimidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d]pyrimidine [1025];

5-(3-(difluoromethyl)imidazo [1,2-b]pyridazin-6-yl)-7H-pyrrolo [2,3-d] pyrimidine [1068];

5-(pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d] pyrimidine [1111];

5-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo [1,5-a]pyridin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1158];

(5-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridin-3-yl)(pipe ridin-1-yl)methanone [1201];

N-(2,2-difluoroethyl)-5-(7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1246];

N-(2-fluoro-2-methylpropyl)-5-(7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1289];

(R)-5-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1332];

N-(3 ,3-difluorocyclobutyl)-5-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a] pyridine-3-carboxamide [1375];

N-((3,3-difluorocyclobutyl)methyl)-5-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1419];

N-(trans-4-methoxycyclohexyl)-5-(7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1462];

N-(1-methylpiperidin-4-yl)-5-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1505];

5-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1548];

N-(pyridin-3-yl)-5-(7H-pyrrolo [2,3-d] pyrimidin-5-yl)pyrazolo [1,5-a]pyridine-3-carboxamide [1592];

5-(pyrazolo [1,5-a]pyrimidin-5-yl)-7H-pyrrolo [2,3-d]pyrimidine [1635];

5-(3-cyclopropylpyrazolo [1,5-a] pyrimidin-5-yl)-7H-pyrrolo [2,3-d] pyrimidine [1682];

8-(7H-pyrrolo [2,3-d] pyrimidin -5-yl)-3 ,4-dihydrobenzo [f] [1 ,4] oxazepin -5 (2H)-one [1725];

2,2-dimethyl-7-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)chroman-4-one [1769];

4,4-dimethyl-6-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)-3,4-dihydroisoquinolin-1(2H)-one [1812];

6-(7H-pyrrolo [2,3-d] pyrimidin -5-yl)quinoline [1855];

6-(7H-pyrrolo [2,3-d] pyrimidin -5-yl)quinoxaline [1900];

6-(7H-pyrrolo [2,3-d] pyrimidin -5-yl)quinazoline [1943];

2-((l-methylpiperidin-4-yl)oxy)-7-(7H-pyrrolo [2,3-d]pyrimidin-5-yl)quinoxaline [1988]; or a pharmaceutically acceptable salt thereof.

32 . The compound of claim 15 , wherein the compound of Formula I is selected from the group consisting of:

N-(2-fluoro-2-methylpropyl)-5-(4-methoxyphenyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [1];

5-(2,4-dimethoxyphenyl)-N-(1-(methylsulfonyl)piperidin-4-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [2];

5-(2-((2-fluoro-2-methylpropyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-methylpyridin-2(1H)-one [3];

5-(2-((4,4-difluorocyclohexyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)-1-methylpyridin-2(1H)-one [4];

5-(6-(difluoromethyl)pyridin-3-yl)-N-(2-fluoro-2-methylpropyl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [5];

N-(2-fluoro-2-methylpropyl)-5-(6-methoxypyridin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-2-amine [6];

5-(6-(difluoromethoxy)pyridin -3-yl)-N-(2-fluoro -2-methylpropyl) -7H-pyrrolo [2,3-d] pyrimidin-2-amine [7];

5-(6-methoxypyridin-3-yl)-N-(trans-4-morpholinocyclohexyl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine [8];

N-(2-fluoro-2-methylpropyl)-5-(2-methoxypyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine [9]; or a pharmaceutically acceptable salt thereof.

33 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

34 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 12 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

35 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 15 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

36 . A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: a neurological disorder, diabetes, and cancer, the method comprising administering to the patient a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt.

37 . A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: a neurological disorder, diabetes, and cancer, the method comprising administering to the patient a therapeutically effective amount of a compound of claim 12 , or a pharmaceutically acceptable salt.

38 . A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: a neurological disorder, diabetes, and cancer, the method comprising administering to the patient a therapeutically effective amount of a compound of claim 15 , or a pharmaceutically acceptable salt.

Assignments (5)

RELEASE OF SECURITY INTEREST Recorded Mar 12, 2026

From: TMF GROUP NEW YORK, LLC, NOT INDIVIDUALLY BUT SOLELY AS COLLATERAL AGENT

To: BIOSPLICE THERAPEUTICS, INC.

Reel/Frame 075109/0434 →

SECURITY INTEREST Recorded May 10, 2024

From: BIOSPLICE THERAPEUTICS, INC.

To: VICKERS VENTURE FUND VI PTE. LTD.; VICKERS VENTURE FUND VI (PLAN) PTE. LTD.; VICKERS-SPLICE CO-INVESTMENT LLC; MED-PATHWAYS II LIMITED

Reel/Frame 067382/0001 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2022

From: MITTAPALLI, GOPI KUMAR; MAK, CHI CHING; HOFILENA, BRIAN JOSEPH; VAKITI, RAMKRISHNA REDDY; EASTMAN, BRIAN WALTER; MARAKOVITS, JOSEPH TIMOTHY; TURNER, LEWIS DANIEL

To: BIOSPLICE THERAPEUTICS, INC.

Reel/Frame 062053/0848 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2022

From: KC, SUNIL KUMAR; CHIRUTA, CHANDRAMOULI

To: SAMUMED, LLC

Reel/Frame 062054/0022 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2022

From: SAMUMED, LLC

To: BIOSPLICE THERAPEUTICS, INC.

Reel/Frame 062054/0117 →