High-potency vitamin C and sugar alcohol topical formulations
Topical formulations of L-ascorbic acid dissolved in a combination of a sugar alcohol agent, and a non-aqueous skin-compatible solvent are provided. The formulations are storage stable for an extended period of time without significant degradation of the L-ascorbic acid in the composition, and have desirable physical properties. The topical formulations can include high concentrations of the L-ascorbic acid. Topical compositions of this disclosure find use in treating or preventing a variety of cosmetic and/or dermatological conditions as well as to reduce the appearance of chronological and/or environmentally-caused skin aging.
1. A storage stable topical liquid composition comprising:
a. 10% to 20% by weight ascorbic acid;
b. 5% to 10% by weight of xylitol; and
c. less than 10% by weight in total of one or more optional additional components;
d. dissolved in a non-aqueous skin-compatible solvent selected from the group consisting of 1,3 propanediol, 1,2 propanediol, 1,3 butanediol, 1,5 pentanediol, 1,2 hexanediol, 1,6 hexanediol, glycerol, and a combination thereof,
wherein the composition demonstrates less than 5 mol % degradation of the ascorbic acid after storage for 8 weeks at 40±2° C. in a sealed container.
2. The composition of claim 1 , wherein the composition comprises 7 to 10% by weight of xylitol.
3. The composition of claim 1 , wherein the composition comprises 15% by weight of ascorbic acid.
4. The composition of claim 1 , wherein the solvent is 1,3 propanediol, or a mixture of 1,3 propanediol and 1,2 hexanediol.
5. The composition of claim 1 , wherein the composition comprises the one or more additional components.
6. The composition of claim 1 , wherein the ascorbic acid is dissolved at a concentration that is above its maximum concentration in the solvent alone.
7. The composition of claim 1 , wherein the composition comprises:
e. 15% to 20% by weight ascorbic acid;
f. 7% to 10% by weight of xylitol; and
g. less than 10% by weight in total of one or more optional additional components;
h. dissolved in 1,3 propanediol, 1,2 propanediol, or a mixture of 1,3 propanediol and 1,2 hexanediol.
8. The composition of claim 7 , wherein the composition comprises 15% by weight of ascorbic acid.
9. The composition of claim 7 , wherein the composition comprises 7.5% by weight of xylitol.
10. The composition of claim 7 , wherein the composition, when applied to skin, reduces or eliminates pathogenic staphylococcus mutants while maintaining the integrity of Staphylococcus epidermis.
11. A ready-to-use topical preparation in a multi-use container which is pre-filled with a storage stable topical composition of claim 1 .
12. The composition of claim 1 , wherein the composition comprises:
a. 10% by weight ascorbic acid;
b. 5% by weight of xylitol; and
c. less than 10% by weight in total of one or more optional additional components;
d. wherein the solvent comprises 1,3 propanediol and 1,2-hexanediol.
13. A storage stable topical liquid composition consisting of:
a. 10% to 20% by weight ascorbic acid;
b. 5% to 10% by weight of xylitol; and
c. less than 10% by weight in total of one or more optional additional components;
d. dissolved in a mixture of 1,3-propanediol and 1,2-hexanediol, wherein the composition comprises 2.5% or less of urea.
14. The composition of claim 13 , wherein:
the ascorbic acid is 15% to 20% by weight of the composition; and
the xylitol is 7% to 10% by weight of the composition.
15. The composition of claim 13 , wherein:
the ascorbic acid is 10% by weight of the composition; and
the xylitol is 5% by weight of the composition.