Granted Patent B2

US 12,397,128 · App. 17/971,540 · Granted Aug 26, 2025

Inventor: Alexander Poltorak (Monsey, NY)

Assignee: NeuroLight, Inc.

A61M21/00A61B5/0006A61B5/165A61B5/316A61B5/4836A61M21/02A61N1/36082G06F3/015G16H20/70A61M2021/0016A61M2021/0022A61M2021/0027A61M2021/0044A61M2021/005A61M2021/0055A61M2021/0066A61M2021/0072A61M2021/0077A61M2205/50A61M2205/52A61M2230/10A61N1/0456A61N1/0529A61N1/36025A61N1/3603A61N2/004G06F2203/011

Abstract

Claims (35)

1. A system for stimulating a subject, comprising:

at least one processor configured to:

process data representing electroencephalographic or magnetoencephalographic signals from a donor to produce a reduced dimensionality representation of the electroencephalographic or magnetoencephalographic signals having a reduced dimensionality with respect to the data representing electroencephalographic or magnetoencephalographic signals;

extract frequency and phase patterns of the reduced dimensionality representation; and

determine at least one of an audio stimulation pattern and a visual stimulation pattern adapted to induce the frequency and phase patterns of the reduced dimensionality representation in brainwaves of the subject; and

a stimulator configured to stimulate a subject with a stimulation signal comprising at least one of the audio stimulation pattern and the visual stimulation pattern, to entrain the brainwaves of the subject with the frequency and phase patterns of the reduced dimensionality representation.

2. A method of stimulating the subject using the system according to claim 1 , comprising:

acquiring electroencephalographic or magnetoencephalographic signals from a donor;

producing the reduced dimensionality representation;

extracting frequency and phase patterns of the reduced dimensionality representation;

determining at least one of the audio stimulation pattern and the visual stimulation pattern adapted to induce the frequency and phase patterns of the reduced dimensionality representation in the brainwaves of the subject; and

stimulating the subject with the at least one of the audio stimulation pattern and the visual stimulation pattern.

3. The system according to claim 1 , wherein the at least one of the audio stimulation pattern and the visual stimulation pattern is adapted to achieve entrainment of phase patterns by use of binaural beats.

4. The system according to claim 1 , further comprising a database of electroencephalographic or magnetoencephalographic data labelled with an emotional state of the donor concurrent with acquisition of the electroencephalographic or magnetoencephalographic signals from the donor, wherein the determined at least one of the audio stimulation pattern and the visual stimulation pattern is adapted to induce the identified emotional state in the subject.

5. The system according to claim 1 , wherein the at least one processor is further configured to produce the reduced dimensionality representation using an eigenvector-based multivariate analyzer.

6. The system according to claim 1 , wherein the at least one processor is further configured to determine the at least one of the audio stimulation pattern and the visual stimulation pattern through a deconvolution.

7. The system according to claim 1 , wherein the electroencephalographic or magnetoencephalographic signals from the donor are acquired over a range of time varying brain states of the donor.

8. The system according to claim 7 , wherein the stimulation signal is adapted to entrain the brainwaves of the subject with the frequency and phase patterns of the reduced dimensionality representation over the range of time varying brain states.

9. The system according to claim 1 , wherein the stimulation signal comprises the audio stimulation pattern.

10. The system according to claim 1 , wherein the stimulation signal comprises a binaural beats audio stimulation pattern.

11. The system according to claim 1 , wherein the stimulation signal comprises the visual stimulation pattern.

12. The system according to claim 1 , wherein the at least one processor is further configured to model a brain of the subject, and the stimulation signal is selectively dependent on the model of the subject's brain.

13. The system according to claim 1 , wherein the at least one processor is further configured to determine a frequency and phase pattern of the brainwaves of the subject's brain, and the stimulation signal is selectively dependent on the frequency and phase pattern of the subject's brain concurrent with a stimulation of the subject with the at least one of audio stimulation pattern and the visual stimulation pattern.

14. The system according to claim 1 , wherein the at least one processor is configured to process the data representing electroencephalographic or magnetoencephalographic signals employing a Gaussian process latent variable model (GPLVM) to probabilistically find a non-linear embedding of the data representing electroencephalographic or magnetoencephalographic signals using a kernel function to produce the reduced dimensionality representation.

15. The system according to claim 1 , wherein the at least one processor is configured to process the data representing electroencephalographic or magnetoencephalographic signals employing a Kernel principal component analysis (Kernel PCA) to produce the reduced dimensionality representation.

16. The system according to claim 1 , further comprising an input configured to receive the brainwaves of the subject contemporaneous with a stimulation of the subject with the at least one of audio stimulation pattern and the visual stimulation pattern, wherein the at least one processor is configured to determine at least one of the audio stimulation pattern and the visual stimulation pattern selectively dependent on the received brainwaves.

17. The system according to claim 1 , wherein the at least one processor is further configured to produce the reduced dimensionality representation of the electroencephalographic or magnetoencephalographic data using an eigenvector-based multivariate analysis, and determine the at least one of the audio stimulation pattern and the visual stimulation pattern through deconvolution.

18. A system for stimulating a subject, comprising:

at least one processor configured to:

execute a dimensionality reduction algorithm on data representing electroencephalographic or magnetoencephalographic signals from a donor which preserves frequency and phase patterns present in the electroencephalographic or magnetoencephalographic signals, to produce a reduced dimensionality representation with respect to the data representing electroencephalographic or magnetoencephalographic signals;

extract the frequency and phase patterns of the reduced dimensionality representation; and

define a sensory stimulation pattern adapted to entrain the frequency and phase patterns of the reduced dimensionality representation in brainwaves of the subject stimulated by the sensory stimulation pattern; and

a stimulator configured to stimulate the subject with the defined sensory stimulation pattern to thereby entrain the frequency and phase patterns of the reduced dimensionality representation in the brainwaves of the subject stimulated by the sensory stimulation pattern.

19. The system according to claim 18 , wherein the at least one processor is further configured to employ a Gaussian process latent variable model (GPLVM) to probabilistically find a non-linear embedding of the data representing electroencephalographic or magnetoencephalographic signals from the donor using a kernel function to produce the reduced dimensionality representation.

20. The system according to claim 18 , wherein the at least one processor is further configured to employ a Kernel principal component analysis (Kernel PCA) to produce the reduced dimensionality representation.

Assignments (1)

Continuity (7)

References Cited (400)