Thermally and dimensionally stabilized electrospun compositions and methods of making same
Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.
1. A dimensionally stable nonwoven material comprising: two independent fiber populations;
a first population of fibers, the first population of fibers being thermally unstable fibers consisting of a poly (glycolic-co-lactic) acid (PLGA) copolymers having a monomer ratio of glycolide of from 80 to 95 and lactide of from 20 to 5; and
a second population of fibers, the second population of fibers being thermally stable fibers consisting of poly (paradioxanone) polymer (PPD);
wherein the thermally unstable fibers are present in the dimensionally stable nonwoven material in an amount of 49% or more;
wherein the thermally stable fibers are present in the dimensionally stable nonwoven material in an amount of from 13 to 49% by weight;
wherein the thermally unstable fibers are dimensionally unstable at a temperature of about 50° C.;
wherein the thermally stable fibers are dimensionally stable at a temperature of about 50° C.;
wherein the first population of fibers and the second population of fibers are comingled and distributed throughout the dimensionally stable nonwoven material;
wherein each fiber population is not a composite fiber wherein an individual fiber comprises nonstable and stabilizing elements; and
wherein said material does not decrease in size more than 10% at temperatures of 30° C. to 50° C.
2. The dimensionally stable nonwoven material of claim 1 , wherein the poly (paradioxanone) polymer (PPD) comprises at least 30 weight percent of the dimensionally stable nonwoven material.
3. The dimensionally stable nonwoven material of claim 1 , wherein porosity is 75% or greater.
4. The dimensionally stable nonwoven material of claim 1 , wherein porosity of the dimensionally stable nonwoven material increases as the first population of fibers is absorbed.
5. The dimensionally stable nonwoven material of claim 1 , further comprising one or more bioactive or therapeutic agents.
6. The dimensionally stable nonwoven material of claim 1 , wherein the dimensionally stable nonwoven material is made by a process comprising spun melt, spun bond, melt blowing, solution spinning, wet spinning, centrifugal melt spinning, liquid shear spinning, or electrospinning.
7. The dimensionally stable nonwoven material of claim 1 , wherein the thermally unstable fibers are present in an amount of from 49 to 85% by weight and the thermally stable fibers are present in an amount of from 15 to 49% by weight.
8. The dimensionally stable nonwoven material of claim 1 , wherein the thermally unstable fibers are present in an amount of from 80 to 85% by weight and the thermally stable fibers are present in an amount of from 15 to 20% by weight.
9. The dimensionally stable nonwoven material of claim 1 , wherein the thermally unstable fibers are present in an amount of from 60 to 80% by weight and the thermally stable fibers are present in an amount of from 20 to 40% by weight.
10. The dimensionally stable nonwoven material of claim 1 , wherein the thermally unstable fibers are present in an amount of from 65 to 70% by weight and the thermally stable fibers are present in an amount of from 30 to 35% by weight.
11. The dimensionally stable nonwoven material of claim 1 , wherein the thermally unstable fibers are present in an amount of from 49 to 60% by weight and the thermally stable fibers are present in an amount of from 40 to 51% by weight.
12. A method of forming a dimensionally stable nonwoven material, comprising:
a) dissolving thermally unstable poly (glycolic-co-lactic) acid (PLGA) copolymers having a monomer ratio of glycolide of from 80 to 95 and lactide of from 20 to 5 in a solvent, thereby forming a first solution;
b) dissolving thermally stable poly (paradioxanone) polymer (PPD) in a solvent, thereby forming a second solution; and
c) dispensing the first and second solutions onto a substrate to form a dimensionally stable nonwoven material comprising a first population of fibers and a second population of fibers, the first population of fibers being thermally unstable fibers formed from the first solution and the second population of fibers being thermally stable fibers formed from the second solution;
wherein the thermally unstable fibers are present in the dimensionally stable nonwoven material in an amount of 49% by weight or more;
wherein the thermally stable fibers are present in the dimensionally stable nonwoven material in an amount of from 13 to 49% by weight;
wherein the thermally unstable fibers are dimensionally unstable at a temperature of about 50° C.;
wherein the thermally stable fibers are dimensionally stable at a temperature of about 50° C.; and
wherein the first population of fibers and the second population of fibers are comingled and distributed throughout the dimensionally stable nonwoven material.