Genetic Determination of Predispositions for Health-Related Conditions
A method, software, database and system for determining an optimal treatment for an illness in an individual and for determining the impact (e.g., side effects and intended benefits) of the treatment in the individual are presented in which an attribute profile of the individual containing genetic and non-genetic attributes is compared against a database containing combinations genetic and non-genetic attributes that are statistically associated with successful treatment of the illness in other individuals.
1 . A computer-implemented method comprising:
obtaining, from a database structure, genetic attributes of a plurality of individuals, behavioral attributes of the plurality of individuals, and health information of the plurality of individuals;
determining, from the genetic attributes and the health information, a subset of the genetic attributes that is correlated with a health condition;
determining, from the behavioral attributes and the health information, a subset of the behavioral attributes that is correlated with the health condition;
receiving further genetic attributes of a further individual;
determining, based on a degree of overlap between the further genetic attributes and the subset of the genetic attributes that is correlated with the health condition, a genetic predisposition of the further individual to exhibit the health condition;
identifying, from the subset of the behavioral attributes that is correlated with the health condition, behaviors that when modified have a statistically relevant impact on whether the further individual exhibits the health condition; and
providing, to a client device associated with the further individual, one or more of the behaviors.
2 . The computer-implemented method of claim 1 , wherein the subset of the genetic attributes that is correlated with the health condition comprise one or more single nucleotide polymorphisms.
3 . The computer-implemented method of claim 1 , wherein providing the one or more of the behaviors comprises providing the one or more of the behaviors ranked in order of their respective statistically relevant impacts on whether the further individual exhibits the health condition.
4 . The computer-implemented method of claim 1 , wherein providing the one or more of the behaviors comprises also providing a representation of the degree of overlap between the further genetic attributes and the subset of the genetic attributes that is correlated with the health condition.
5 . The computer-implemented method of claim 1 , wherein the subset of the genetic attributes are determined at least in part through attribute expansion of an initial number of genetic attributes correlated with the health condition into surrounding genetic regions.
6 . The computer-implemented method of claim 1 , wherein the health condition is a disease.
7 . The computer-implemented method of claim 1 , wherein the subset of the behavioral attributes have a causal impact on the health condition.
8 . The computer-implemented method of claim 1 , wherein determining the genetic predisposition of the further individual to exhibit the health condition is also based on a biological sex of the further individual.
9 . The computer-implemented method of claim 1 , wherein determining the subset of the genetic attributes that is correlated with the health condition comprises performing statistical tests on the genetic attributes from groups of the individuals to ascertain a strength of association between the subset of the genetic attributes and the health condition.
10 . The computer-implemented method of claim 1 , wherein at least some of the behavioral attributes of the plurality of individuals were self-reported.
11 . A computer-implemented method comprising:
receiving genetic attributes of an individual;
obtaining, from a database structure, a subset of genetic attributes from a population that is correlated with a health condition;
determining, based on a degree of overlap between the genetic attributes of the individual and the subset of genetic attributes that is correlated with the health condition, a genetic predisposition of the individual to exhibit the health condition;
obtaining, from the database structure, a subset of behavioral attributes from the population that is correlated with the health condition;
identifying, from the subset of behavioral attributes that is correlated with the health condition, behaviors that when modified have a statistically relevant impact on whether the individual exhibits the health condition; and
providing, to a client device associated with the individual, one or more of the behaviors.
12 . The computer-implemented method of claim 11 , wherein providing the one or more of the behaviors comprises providing the one or more of the behaviors ranked in order of their respective statistically relevant impacts on whether the individual exhibits the health condition.
13 . The computer-implemented method of claim 11 , wherein providing the one or more of the behaviors comprises also providing a representation of the degree of overlap between the genetic attributes of the individual and the subset of the genetic attributes that is correlated with the health condition.
14 . The computer-implemented method of claim 11 , wherein the subset of the genetic attributes are determined at least in part through attribute expansion of an initial number of genetic attributes correlated with the health condition into surrounding genetic regions.
15 . The computer-implemented method of claim 11 , wherein the health condition is a disease.
16 . The computer-implemented method of claim 11 , wherein the subset of the behavioral attributes have a causal impact on the health condition.
17 . The computer-implemented method of claim 11 , wherein determining the genetic predisposition of the individual to exhibit the health condition is also based on a biological sex of the individual.
18 . The computer-implemented method of claim 11 , wherein determining the subset of the genetic attributes that is correlated with the health condition comprises performing statistical tests on the genetic attributes from groups of the population to ascertain a strength of association between the subset of the genetic attributes and the health condition.
19 . The computer-implemented method of claim 11 , wherein at least some of the behavioral attributes were self-reported.
20 . A non-transitory computer-readable medium storing program instructions that, when executed by one or more processors of a computing system, cause the computing system to perform operations comprising:
receiving genetic attributes of an individual;
obtaining, from a database structure, a subset of genetic attributes from a population that is correlated with a health condition;
determining, based on a degree of overlap between the genetic attributes of the individual and the subset of genetic attributes that is correlated with the health condition, a genetic predisposition of the individual to exhibit the health condition;
obtaining, from the database structure, a subset of behavioral attributes from the population that is correlated with the health condition;
identifying, from the subset of behavioral attributes that is correlated with the health condition, behaviors that when modified have a statistically relevant impact on whether the individual exhibits the health condition; and
providing, to a client device associated with the individual, one or more of the behaviors.