IP Library Granted Patent US 11,827,642
Granted Patent B2
US 11,827,642 · App. 17/983,747 · Granted Nov 28, 2023

Compositions useful for treating disorders related to KIT

Inventors: Brian L. Hodous (Cambridge, MA); Joseph L. Kim (Cambridge, MA); Kevin J. Wilson (Cambridge, MA); Douglas Wilson (Cambridge, MA); Yulian Zhang (Acton, MA)
Assignee: Blueprint Medicines Corporation
C07D487/04A61K31/496A61K31/53A61K31/5377A61K45/06C07D401/14C07D403/04C07D403/14C07D413/14C07D417/14
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Quick Facts
Patent No.
US 11,827,642
App. No.
17/983,747
Granted
Nov 28, 2023
Kind
B2
Abstract

Compounds and compositions useful for treating disorders related to mutant KIT are described herein.

Claims (7)

1. A method of treating indolent systemic mastocytosis in a patient in need thereof, wherein the method comprises administering to the patient a therapeutically effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein the patient is administered a pharmaceutical composition comprising a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

3. The method of claim 1 , wherein the patient has a mutation in Exon 17 in KIT.

4. The method of claim 3 , wherein the patient has a D816 mutation in Exon 17 in KIT.

5. The method of claim 4 , wherein the D816 mutation is D816V.

6. The method of claim 1 , wherein the patient is administered a therapeutically effective amount of the compound which is:

Assignments (3)
RELEASE OF SECURITY INTEREST (REEL/FRAME 064748/0552) Recorded Jul 24, 2025
From: TAO TALENTS, LLC
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 072249/0280 →
SECURITY INTEREST Recorded Aug 29, 2023
From: BLUEPRINT MEDICINES CORPORATION
To: TAO TALENTS, LLC
Reel/Frame 064748/0552 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 9, 2022
From: HODOUS, BRIAN L.; KIM, JOSEPH L.; WILSON, KEVIN J.; WILSON, DOUGLAS; ZHANG, YULIAN
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 061711/0030 →
Continuity (8)
Continuation 17070556 · Oct 14, 2020
Continuation 15973378 · May 7, 2018
Continuation 14887614 · Oct 20, 2015
Continuation 14515327 · Oct 15, 2014
Provisional Application 61975229 · Apr 4, 2014
Provisional Application 61931204 · Jan 24, 2014
Provisional Application 61892086 · Oct 17, 2013
Related Publication 20230129944A1 · Apr 27, 2023
Cited By (1)
US 12,624,043