Granted Patent
B2
US 12,290,559 · App. 17/986,286 · Granted May 6, 2025
Methods of vaccine administration
Assignee:
Zoetis Services LLC
A61K39/235A61K39/0225A61K39/099A61K39/12A61K39/155A61K39/175A61K39/23C07K14/005C12N7/00A61K39/00A61K2039/525A61K2039/5254A61K2039/542A61K2039/545A61K2039/552A61K2039/70C12N2710/10034C12N2710/10071C12N2710/10334C12N2750/14034C12N2750/14071C12N2750/14334C12N2760/18034C12N2760/18071C12N2760/18434C12N2760/18471C12N2770/20022
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Abstract
This invention relates to a method of treating a dog for canine diseases comprising administering to the dog therapeutically effective amounts of a vaccine, wherein the vaccine comprises viral antigens, a bacterin, or both, and wherein the vaccine is administered subcutaneously or orally according to the schedules provided herein.
Claims (13)
1. A method of vaccinating a dog against canine parainfluenza, the method comprising administering to the dog a therapeutically effective amount of a vaccine comprising modified live canine parainfluenza (CPI) virus, wherein the vaccine is administered orally in a first dose and orally in a second dose, and wherein said second dose being administered about 7 days to about 35 days following administration of said first dose.
2. The method of claim 1 , wherein said therapeutically amount of CPI is from 10 6 TCID 50 to about 10 8 TCID 50 inclusive, per dose.
3. The method of claim 1 , wherein said vaccine further comprises a therapeutically effective amount of Bordetella bronchiseptica extract.
4. The method of claim 3 , wherein the therapeutically effective amount of B. bronchiseptica extract is from about 3×10 6 to about 3×10 11 cells inclusive, per dose.
5. The method of claim 4 , wherein said therapeutically amount of CPI is from 10 6 TCID 50 to about 10 8 TCID 50 inclusive, per dose.
6. The method of claim 5 , wherein said second dose being administered about 21 days following administration of said first dose.
7. The method of claim 1 , further comprising administering to the dog an annual dose of said vaccine, wherein said annual dose is administered about one year after the first dose.
8. The method of claim 5 , further comprising administering to the dog an annual dose of said vaccine, wherein said annual dose is administered about one year after the first dose.
9. The method of claim 5 , wherein the vaccine is non-adjuvanted.
10. The method of claim 7 , wherein the vaccine in non-adjuvanted.
11. The method of any one of claim 3, 4, 5, or 9 , wherein antigens in said vaccine consist of said modified live CPI virus and B. bronchiseptica extract.
12. The method of any one of claims 1-10 , wherein said vaccine further comprises a therapeutically effective amount of modified live Canine Adenovirus type 2 (CAV-2) and wherein said vaccine elicits protective antibody titer in the serum of said dog, wherein said protective titer is at least 1:16 against CAV-1.
13. The method of claim 12 , wherein said therapeutically effective amount of modified live Canine Adenovirus type 2 (CAV-2) is from about 10 2 TCID 50 to about 10 8 TCID 50 , inclusive; or from about 10 3 TCID 50 to about 10 6 TCID 50 , inclusive; or from about 10 4 TCID 50 to about 10 5 TCID 50 , inclusive.
Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 1, 2025
From: TUCKER, CASSIUS M.; HAWORTH, JOHN D.
To: PFIZER INC.; PFIZER PRODUCTS INC.
Reel/Frame 070696/0875 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 1, 2025
From: PFIZER INC.
To: AH USA 42 LLC
Reel/Frame 070703/0536 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 1, 2025
From: ZOETIS LLC
To: ZOETIS SERVICES LLC
Reel/Frame 070703/0682 →
ADDRESS CHANGE OF ASSIGNEE
Recorded Apr 1, 2025
From: ZOETIS SERVICES LLC
To: ZOETIS SERVICES LLC
Reel/Frame 070703/0827 →
CORRECTIVE ASSIGNMENT TO CORRECT THE REMOVE ASSIGNEE PREVIOUSLY RECORDED AT REEL: 18792 FRAME: 428. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT.
Recorded Apr 1, 2025
From: TUCKER, CASSIUS M.; HAWORTH, JOHN D.
To: PFIZER INC.
Reel/Frame 070735/0316 →
Continuity (5)
Continuation
12521148
Provisional Application
60877322
· Dec 27, 2006
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