Granted Patent B2

US 12,569,686 · App. 18/001,638 · Granted Mar 10, 2026

Inventors: Michael Scott Brandner (Andover, MN); Alan David Eskuri (Hanover, MN); Steven D. Goedeke (Forest Lake, MN); Michelle Leslie Kennefick (St. Paul, MN); Todd Alan Kerkow (Stacy, MN); David Christopher Olson (Eden Prairie, MN); Angela Rae Shaw (Hopkins, MN); Steven L. Waldhauser (Savage, MN); Michael Paul Cuchiara (Chapel Hill, NC); Hugo Andres Belalcazar (Minneapolis, MN)

Assignee: Cardionomix, Inc.

A61N1/36185A61N1/057A61N1/36114A61N1/36132A61N1/36146

Abstract

Claims (32)

1 . A method of selecting a combination of electrodes for use in neurostimulation, the method comprising:

testing combinations of electrodes in an electrode array to identify an atrial capture, wherein the atrial capture is indicated by at least one effect on an atrium;

excluding electrodes with the atrial capture to result in remaining electrodes of the electrode array;

testing combinations of the remaining electrodes of the electrode array for effect on cardiac contractility and/or relaxation and monitoring for undesired side effects during the testing of combinations of the remaining electrodes;

for each combination of the remaining electrodes, during the testing used to establish the effect on cardiac contractility and/or relaxation, measuring impedance across the respective electrode combination using a low-amplitude diagnostic pulse injected concurrently with the testing, and using the measured impedance as a basis for selecting the combination of electrodes;

selecting a combination of electrodes from the remaining electrodes, wherein the selected combination has both a desired effect on cardiac contractility and/or relaxation and does not have an undesired side effect; and

applying neurostimulation using the selected combination of electrodes to modulate autonomic nerve fibers surrounding a pulmonary artery to provide adjuvant cardiac therapy to a patient with a cardiovascular medical condition.

2 . The method of claim 1 , further comprising testing combinations of the remaining electrodes near the selected combination of electrodes.

3 . The method of claim 1 , further comprising testing the selected combination of electrodes to select stimulation parameters.

4 . The method of claim 3 , further comprising applying the stimulation parameters to the selected combination of electrodes to provide neurostimulation.

5 . The method of claim 4 , wherein the neurostimulation increases cardiac contractility and/or relaxation.

6 . The method of claim 1 , wherein the desired effect on cardiac contractility and/or relaxation is an increase in cardiac contractility and/or relaxation by between 5% and 50%.

7 . The method of claim 1 , wherein the undesired side effect comprises cough.

8 . The method of claim 1 , wherein the undesired side effect comprises affecting heart rate.

9 . The method of claim 1 , wherein selecting the combination of electrodes from the remaining electrodes further comprises, after selecting the combination of electrodes, evaluating impedance across the selected combination of electrodes to confirm proper electrode placement.

10 . The method of claim 1 , wherein selecting the combination of electrodes from the remaining electrodes further comprises evaluating energy used to create the effect.

11 . The method of claim 1 , wherein selecting the combination of electrodes from the remaining electrodes further comprises evaluating location of the remaining electrodes within the electrode array.

12 . A method of selecting a combination of electrodes for use in neurostimulation, the method comprising:

testing combinations of electrodes in an electrode array for an undesired effect; excluding electrodes with the undesired effect to result in remaining electrodes of

the electrode array;

testing combinations of the remaining electrodes of the electrode array for effect on cardiac contractility and/or relaxation;

for each combination of the remaining electrodes, during the testing used to establish the effect on cardiac contractility and/or relaxation, measuring impedance across the respective electrode combination using a low-amplitude diagnostic pulse injected concurrently with the testing, and using the measured impedance as a basis for selecting the combination of electrodes;

selecting a combination of electrodes from the remaining electrodes; and

applying neurostimulation using the selected combination of electrodes to modulate autonomic nerve fibers surrounding a pulmonary artery to provide adjuvant cardiac therapy to a patient with a cardiovascular medical condition.

13 . The method of claim 12 , wherein the undesired effect comprises atrial capture.

14 . The method of claim 12 , further comprising testing combinations of the remaining electrodes near the selected combination of electrodes.

15 . The method of claim 12 , further comprising testing the selected combination of electrodes to select stimulation parameters.

16 . The method of claim 12 , wherein selecting the combination of electrodes from the remaining electrodes comprises evaluating effect on cardiac contractility and/or relaxation closest to a desired effect, wherein the desired effect on cardiac contractility and/or relaxation is an increase in cardiac contractility and/or relaxation by between 5% and 50%.

17 . The method of claim 12 , wherein selecting the combination of electrodes from the remaining electrodes comprises evaluating a side effect, wherein evaluating a side effect comprises comparing the side effect to a threshold tolerance level.

18 . The method of claim 12 , wherein selecting the combination of electrodes from the remaining electrodes comprises, after selecting the combination of electrodes, evaluating impedance across the selected combination of electrodes to confirm proper electrode placement.

19 . The method of claim 12 , wherein selecting the combination of electrodes from the remaining electrodes comprises evaluating energy used to create the effect.

20 . The method of claim 12 , wherein selecting the combination of electrodes from the remaining electrodes is automatic.

Assignments (3)

Continuity (2)

References Cited (400)