Indazole-fused cyclic compound
A novel indazole compound, a preparation method therefor, and use thereof in the preparation of drugs for treating related diseases. Specifically disclosed are a compound of formula (II) and a pharmaceutically acceptable salt thereof.
1. A compound represented by formula (II) or a pharmaceutically acceptable salt thereof
wherein,
n is 1 or 2;
X is selected from N and CR 3 ;
Y is selected from —O— and —CH 2 —;
L is selected from —O—, —N(CH 3 )— and —NH—;
ring A is selected from phenyl, pyridyl, pyrazinyl and pyrimidyl, and the phenyl, pyridyl, pyrazinyl and pyrimidyl are each independently and optionally substituted by 1, 2 or 3 R a ;
R 1 is selected from CN and F;
R 2 is selected from C 1-6 alkyl, C 1-6 alkoxy and C 3-6 cycloalkyl, and the C 1-6 alkyl, C 1-6 alkoxy and C 3-6 cycloalkyl are each independently and optionally substituted by 1, 2 or 3 R b ;
R 3 is selected from D, F and H;
R a is each independently selected from H, D, F, Cl, Br, I, OH, CN, OCH 3 , OCH 2 CH 3 , C 1-4 alkyl,
R b is each independently selected from F, Cl, Br, I, CN, OH and OCH 3 .
2. The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein, ring A is selected from
and the
are each independently and optionally substituted by 1, 2 or 3 R a .
3. The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein, R a is each independently selected from H, D, F, Cl, OH, CN, OCH 3 and CH 3 .
4. The compound or the pharmaceutically acceptable salt thereof as claimed in claim 2 , wherein, ring A is selected from
5. The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein, R 2 is selected from C 1-3 alkyl and C 1-3 alkoxy, and the C 1-3 alkyl and C 1-3 alkoxy are each independently and optionally substituted by 1, 2 or 3 R b .
6. The compound or the pharmaceutically acceptable salt thereof as claimed in claim 5 , wherein, R 2 is selected from
7. The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein, the compound is selected from
8. A compound represented by the following formula or a pharmaceutically acceptable salt thereof, selected from
9. The compound or the pharmaceutically acceptable salt thereof as claimed in claim 8 , wherein, the compound is selected from
10. A method for treating breast cancer in a subject in need thereof, comprising: administering the compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 to the subject.
11. The method as claimed in claim 10 , wherein, the breast cancer is estrogen receptor positive breast cancer.