COLLAGEN-BIOGLASS ARTICLES AND METHODS OF MAKING THE SAME
An article and a method of making the article. The article can include a conformable matrix comprising a mixture of collagen and bioactive glass; wherein the article is a conformable wound dressing. The method includes dissolving collagen in an acid solution; adding bioactive glass to the acid solution; mixing collagen and bioactive glass to increase or decrease the pH of the solution; and forming a mixture of collagen and bioactive glass.
1 . An article comprising,
a conformable matrix comprising a mixture of collagen and bioactive glass;
wherein the article is a conformable wound dressing.
2 . The article of claim 1 , wherein the article comprises a substrate.
3 . The article of claim 1 , wherein the conformable matrix has a conductivity of less than 3 mS/cm as determined by Method A.
4 . The article of claim 1 , wherein the conformable matrix is disposed on or within a carrier.
5 . The article of claim 1 , wherein the conformable matrix has a pH value more than 5.
6 . The article of claim 1 , wherein the conformable matrix further comprises glycerol.
7 . The article of claim 1 , wherein the conformable matrix is a gel, sponge, scaffold, foam or film.
8 . A method of making an article, comprising
dissolving collagen in an acid solution;
adding bioactive glass to the acid solution;
mixing collagen and bioactive glass to increase or decrease the pH of the solution; and
forming a mixture of collagen and bioactive glass.
9 . The method of claim 8 , further comprising forming the mixture into a gel, sheet, film, sponge, foam, or a plurality of pieces.
10 . The method of claim 8 , further comprising dehydrating the mixture.
11 . The method of claim 8 , wherein the dehydrating comprises freeze-drying, oven drying, critical point drying, or combination thereof.
12 . The method of claim 8 , further comprising adding the mixture on a substrate.
13 . The method of claim 8 , wherein the article is a conformable wound dressing.
14 . The method of claim 8 , wherein the mixture of collagen and bioactive glass has a less than 3 mS/cm conductivity determined by Method A.
15 . The method of claim 8 , further comprising disposing the mixture on or within a carrier.