USE OF 2'-FL FOR TREATMENT OF SYMPTOMS ASSOCIATED WITH AUTISM SPECTRUM DISORDER
Provided herein are compositions and methods for reducing a symptom of autism spectrum disorder in a subject such as a human infant or child. The method involves administering to the subject a composition comprising purified 2′-fucosyllactose.
1 . A method for reducing a symptom of autism spectrum disorder (ASD) in a subject, comprising administering to said subject a composition comprising purified 2′-fucosyllactose, wherein said subject comprises a symptom of ASD.
2 . The method of claim 2 , wherein said subject is a human.
3 . The method of claim 1 , wherein said subject is less than 7 years of age.
4 . The method of claim 1 , wherein said subject is less than 3 months of age.
5 . The method of claim 1 , wherein said subject is an adult.
6 . The method of claim 1 , wherein said symptom comprises gastrointestinal dysfunction, microbial disbiosis, mitochondrial dysfunction, thermal dysregulation, immune dysregulation, a social deficit, or a cognition deficit.
7 . The method of claim 1 , wherein the composition comprises a food product.
8 . The method of claim 11 , wherein the food product comprises a pureed food product.
9 . The method of claim 11 , wherein the food product comprises infant formula.
10 . The method of claim 1 , wherein said subject is administered 5-8 grams of 2′FL per day.
11 . The method of claim 1 , wherein interpersonal sociality is improved following administration of said 2′FL.
12 . A composition comprising 2′-FL for use in a treatment to reduce reducing a symptom of autism spectrum disorder in a subject.