IP Library Granted Patent US 12,597,188
Granted Patent B2
US 12,597,188 · App. 18/059,154 · Granted Apr 7, 2026

Systems and methods for processing electronic images for physiology-compensated reconstruction

Inventors: Edward Karl Hahn, III (Foster City, CA); Michiel Schaap (Oegstgeest, NL); Daniel Rueckert (Munich, DE)
Assignee: Heartflow, Inc.
G06T11/003A61B6/032G06T7/0012G06T2207/30048
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Quick Facts
Patent No.
US 12,597,188
App. No.
18/059,154
Granted
Apr 7, 2026
Kind
B2
Abstract

A computer-implemented method for medical measurement reconstruction may comprise: receiving a measurement acquisition signal; based on the received measurement acquisition signal, creating a plurality of representations of the measurement acquisition signal, wherein each of the plurality of representations relates to a different aspect of the measurement acquisition signal; modifying one or more of the plurality of representations; and generating an output signal including the modified one or more of the plurality of representations.

Claims (34)

1 . A computer-implemented method for medical measurement reconstruction, the method comprising:

receiving a measurement acquisition signal, wherein the measurement acquisition signal is acquired from medical imaging;

based on the received measurement acquisition signal, creating a plurality of representations of the measurement acquisition signal, wherein each of the plurality of representations relates to a different aspect of the measurement acquisition signal;

modifying one or more of the plurality of representations, wherein the modifying the one or more of the plurality of representations addresses at least one physiology-caused artifact in the measurement acquisition signal caused by at least two of the group of: lumen physiology, attenuation dynamics, cardiac chamber physiology, cardiothoracic physiology, myocardial territory physiology, and flow of a contrast agent; and

generating an output signal including the modified one or more of the plurality of representations.

2 . The computer-implemented method of claim 1 , wherein the output signal includes a reconstruction of the measurement acquisition signal or wherein the output signal is used to generate a reconstruction of the measurement acquisition signal.

3 . The computer-implemented method of claim 1 , wherein the measurement acquisition signal includes a medical imaging signal.

4 . The computer-implemented method of claim 1 , wherein the plurality of representations include a representation of at least two of anatomy, motion, or a physiological process.

5 . The computer-implemented method of claim 4 , wherein the plurality of representations are created based on known information about the at least one of the anatomy, the motion, or the physiological process.

6 . The computer-implemented method of claim 1 , further comprising determining whether a stop condition is satisfied and, upon determining the stop condition is not satisfied, iterating at least one of the receiving, the creating, the modifying, or the generating step.

7 . The computer-implemented method of claim 1 , further comprising reconstructing an image using an estimate of dynamics.

8 . The computer-implemented method of claim 1 , further comprising modifying the representation based on a presence of an implanted hardware.

9 . The method of claim 1 , wherein the plurality of representations of the measurement acquisition signal is created by decomposing the measure acquisition signals.

10 . The method of claim 1 , wherein modifying the one or more of the plurality of representations includes estimating an attenuation map.

11 . The method of claim 1 , wherein generating the output signal includes segmenting a reconstructed image to generate an anatomic model and preparing an analysis using the anatomic model.

12 . The method of claim 11 , wherein the analysis includes determining, simulating, and calculating a fractional flow reserve.

13 . A system for processing electronic images for medical measurement reconstruction, comprising:

a data storage device storing instructions for medical measurement reconstruction; and

a processor configured to execute the instructions to perform operations comprising:

receiving a measurement acquisition signal, wherein the measurement acquisition signal is acquired from medical imaging modalities;

based on the received measurement acquisition signal, creating a plurality of representations of the measurement acquisition signal, wherein each of the plurality of representations relates to a different aspect of the measurement acquisition signal;

modifying one or more of the plurality of representations, wherein the modifying the one or more of the plurality of representations addresses at least one physiology-caused artifact in the measurement acquisition signal caused by at least two of the group of: lumen physiology, attenuation dynamics, cardiac chamber physiology, cardiothoracic physiology, myocardial territory physiology, and flow of a contrast agent; and

generating an output signal including the modified one or more of the plurality of representations.

14 . The system of claim 13 , wherein the output signal includes a reconstruction of the measurement acquisition signal or wherein the output signal is used to generate a reconstruction of the measurement acquisition signal.

15 . The system of claim 13 , wherein the plurality of representations include a representation of at least one of anatomy, motion, or a physiological process.

16 . The system of claim 15 , wherein the plurality of representations are created based on known information about the at least one of the anatomy, the motion, or the physiological process.

17 . The system of claim 13 , the operations further comprising reconstructing an image using an estimate of dynamics.

18 . A non-transitory computer-readable medium storing instructions that, when executed by one or more processors, cause the one or more processors to perform operations for medical measurement reconstruction, the operations comprising:

receiving a measurement acquisition signal, wherein the measurement acquisition signal is acquired from medical imaging modalities;

based on the received measurement acquisition signal, creating a plurality of representations of the measurement acquisition signal, wherein each of the plurality of representations relates to a different aspect of the measurement acquisition signal;

modifying one or more of the plurality of representations, wherein the modifying the one or more of the plurality of representations addresses at least one physiology-caused artifact in the measurement acquisition signal caused by at least two of the group of: lumen physiology, attenuation dynamics, cardiac chamber physiology, cardiothoracic physiology, myocardial territory physiology, and flow of a contrast agent; and

generating an output signal including the modified one or more of the plurality of representations.

19 . The non-transitory computer-readable medium of claim 18 , wherein the output signal includes a reconstruction of the measurement acquisition signal or wherein the output signal is used to generate a reconstruction of the measurement acquisition signal.

20 . The non-transitory computer-readable medium of claim 18 , wherein the plurality of representations include a representation of at least one of anatomy, motion, or a physiological process.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Sep 11, 2025
From: HAYFIN SERVICES LLP
To: HEARTFLOW, INC.
Reel/Frame 072876/0775 →
SECURITY INTEREST Recorded Jun 18, 2024
From: HEARTFLOW, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 067775/0966 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 29, 2022
From: HAHN, EDWARD KARL, III; SCHAAP, MICHIEL; RUECKERT, DANIEL
To: HEARTFLOW, INC.
Reel/Frame 061910/0817 →