Lipidated immune response modifier compound compositions, formulations, and methods
The compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide is a useful drug compound for enhancing immune response and can be used, for example, as a retrovirus vaccine adjuvant.
1. A pharmaceutical composition comprising:
a compound of formula:
a pharmaceutically acceptable carrier; and
an antigen comprising a retrovirus vaccine.
2. The pharmaceutical composition of claim 1 , wherein the antigen comprises a lentivirus vaccine.
3. The pharmaceutical composition of claim 1 , wherein the antigen comprises a human immunodeficiency virus (HIV) vaccine.
4. A pharmaceutical composition of claim 1 further comprising liposomes.
5. The pharmaceutical composition of claim 1 , wherein the compound and antigen are admixed into a single composition.
6. The pharmaceutical composition of claim 1 , wherein the compound and antigen are present in separate components of the composition to be administered in combination.
7. A method of enhancing the effectiveness of a vaccine antigen by administering as a vaccine adjuvant the compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide, or a pharmaceutically acceptable salt thereof.
8. The method of claim 7 wherein the compound is incorporated into a liposome formulation.