Compositions and Methods for Treating Cancer
Methods of detecting, characterizing, and targeting myeloid-derived suppressor cells are disclosed. Some methods include the use of glycan-interacting antibodies, such as anti-STn antibodies. Methods of identifying subjects for treatment with glycan-interacting antibodies are included.
1 . A method of targeting one or more Myeloid-Derived Suppressor Cells (MDSCs) comprising contacting a subject or subject sample with a glycan-interacting antibody, wherein the subject or subject sample includes at least one MDSC.
2 . The method of claim 1 , wherein the glycan-interacting antibody binds to STn.
3 - 9 . (canceled)
10 . A method of treating a subject comprising administering an anti-STn antibody to the subject, wherein the subject has at least one tumor comprising an MDSC.
11 - 12 . (canceled)
13 . The method of claim 10 , wherein the anti-STn antibody is an IgG antibody.
14 . The method of claim 10 , wherein the anti-STn antibody comprises an antibody-drug conjugate (ADC).
15 . The method of claim 14 , wherein the ADC comprises at least one conjugate selected from one or more of an auristatin, a maytansine, a tubulysin, a vinca alkaloid, a pyrrolobenzodiazepine dimer, a camptothecin, a duocarmycin, an amanitin, a phosphoinositide 3-kinase (PI3K) inhibitor, and a mitogen-activated protein kinase kinase (MEK) inhibitor.
16 . The method of claim 15 , wherein the ADC comprises one or more polymer, wherein the one or more polymer connects the anti-STn antibody and the at least one conjugate.
17 . The method of claim 16 , wherein the one or more polymer comprises one or more of a poly(ethylene glycol) (PEG), a poly(N-(2-hydroxypropyl)methacrylamide) (polyHPMA), a poly(α-amino acid), a carbohydrate polymer, a glycopolysaccharide, a glycolipid, a glycoconjugate, a polyglycerol, a polyvinyl alcohol, a poly(acrylic acid), a polyketal, and a polyacetal.
18 . The method of claim 17 , wherein the one or more polymer comprises a poly(1-hydroxymethylethylene hydroxymethylformal) (PHF).
19 - 23 . (canceled)
24 . A method of identifying a candidate for anti-STn antibody treatment, the method comprising:
a. obtaining a sample from a subject;
b. identifying one or more MDSC in the sample; and
c. evaluating the one or more MDSC for STn expression using an anti-STn antibody.
25 . The method of claim 24 , wherein the sample is a tumor sample.
26 . The method of claim 24 , wherein the sample is a fluid sample.
27 . The method of claim 26 , wherein the fluid sample is selected from blood, plasma, lymph, saliva, and interstitial fluid.
28 - 42 . (canceled)